Peter Thomas Roth Peptide 21 Wrinkle Resist Serum

Peter Thomas Roth Peptide 21 Wrinkle Resist Serum
5.6
/ 10
Moisturizing
10.0 Humectancy icon Humectancy
1.2 Occlusivity icon Occlusivity
0.1Anti-wrinkle icon/ 10
Anti-wrinkle
$$$$

Review

Results you may expect from using Peter Thomas Roth Peptide 21 Wrinkle Resist Serum:

Based on the ingredient analysis by CreamScan, these are the key benefits you can expect from using Peter Thomas Roth Peptide 21 Wrinkle Resist Serum:

  • Moderate moisturizing. It has a moisturizing rating of 5.6 out of 10.
  • Little anti-wrinkle effect: Peter Thomas Roth Peptide 21 Wrinkle Resist Serum has an anti-wrinkle rating of 0.1 out of 10, so you may expect a positive, although insignificant, effect on wrinkles.

How moisturizing is it?

Quite moisturizing: Peter Thomas Roth Peptide 21 Wrinkle Resist Serum has a moisturizing rating of 5.6 out of 10.

Is it more humectant or occlusive? Significantly more humectant. It has a low occlusivity of 1.2 out of 10 and a maximum humectancy of 10 out of 10, primarily due to the high content of Glycerin (est. ≈6.0%).

Please refer to the Ratings section below for details of the moisturizing rating calculation.

Anti-wrinkle efficacy

According to CreamScan analysis, Peter Thomas Roth Peptide 21 Wrinkle Resist Serum has a minimal anti-wrinkle rating of 0.1 out of 10. It contains one ingredient with proven anti-wrinkle efficacy: Ascorbic Acid (est. ≈0.3%),
 or Vitamin C, a popular anti-wrinkle ingredient, yet with average efficacy confirmed by only one study.
 
Among others, Peter Thomas Roth Peptide 21 Wrinkle Resist Serum also contains some ingredients marketed as effective in reducing wrinkles, specifically Tripeptide-10 Citrulline, Acetyl Octapeptide-3, Palmitoyl Hexapeptide-12, Acetyl Hexapeptide-8, Palmitoyl Oligopeptide, Acetyl Tetrapeptide-9, Tripeptide-1, Palmitoyl Tetrapeptide-7, and some others. However, the studies supporting the anti-wrinkle claims of these ingredients provide insufficient evidence of efficacy according to CreamScan Research Evaluation Standards. Therefore, these ingredients do not contribute to the anti-wrinkle rating.
 
Please refer to the Ratings section below for details of the anti-wrinkle rating calculation.
 

Ingredients

Est. % Ingredient Origin Functions
65
6
4
3
2
1.5
1.3
1
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
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Ratings

All humectants
12.1
6
1.5
1.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Benchmark
10
All occlusives
2.3
2.0
0.3
Benchmark
20
Moisturizing rating
5.6
Ingredient Est. % Benchmark Raiting
Humectancy All humectants 12.1 10
10.0
6
1.5
1.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Occlusivity All occlusives 2.3 20
1.2
2.0
0.3
Moisturizing rating
5.6
Ingredient Est. % Benchmark Humectancy
6
1.5
1.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
All humectants 12.1 10
10
All humectants
12.1
6
1.5
1.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Benchmark
10
Ingredient Est. % Benchmark Occlusivity
2
0.3
All occlusives 2.3 20
1.2
All occlusives
2.3
2.0
0.3
Benchmark
20
Ingredient
Ingredient anti-wrinkle power
when present at, %
in this formula est. %
Rating
2.5 /10 5 0.3 0.1
n/a
- 0.3 -
n/a
- 0.3 -
n/a
- 0.3 -
n/a
- 0.3 -
n/a
- 0.3 -
n/a
- 0.3 -
n/a
- 0.3 -
n/a
- 0.3 -
n/a
- 0.3 -
n/a
- 0.3 -
n/a
- 0.3 -
n/a
- 0.3 -
n/a
- 0.3 -
n/a
- 0.3 -
Total
0.1
Ascorbic Acid
0.1
Ingredient anti-wrinkle power
2.5 /10
when present at, %
5
in this formula, est. %
0.3
Tripeptide-10 Citrulline
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Acetyl Octapeptide-3
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Palmitoyl Hexapeptide-12
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Acetyl Hexapeptide-8
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Palmitoyl Oligopeptide
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Acetyl Tetrapeptide-9
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Tripeptide-1
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Palmitoyl Tetrapeptide-7
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Dipeptide Diaminobutyroyl Benzylamide Diacetate
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Palmitoyl Tripeptide-5
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Trifluoroacetyl Tripeptide-2
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Palmitoyl Tripeptide-1
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Retinyl Palmitate
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Pseudoalteromonas Ferment Extract
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Anti-wrinkle rating
0.1
Ingredient Est. % Benchmark
Rich in Antioxidants
1.5
0.3
0.3
0.3
0.3
All antioxidants 2.7 3 No
All antioxidants
2.7
Mannitol
1.5
Ascorbic Acid
0.3
Palmitoyl Hexapeptide-12
0.3
Sodium Hyaluronate
0.3
Tocopheryl Acetate
0.3
Benchmark
3
Ingredient Est. % Benchmark
Rich in Soothing
1.5
0.3
All soothing 1.8 5 No
All soothing
1.8
1.5
0.3
Benchmark
5

Ingredients explained

Water
Est. %65
Function
Origin
The most used ingredient in skincare. Its concentration defines the product texture: rich creams may have about 50% of water while a light jelly about 90%. Water doesn’t moisturize the skin by itself and is used in skincare as a solvent for other ingredients.
Glycerin
Est. %6
Function
Origin

The most popular moisturizing ingredient in the world. It is a powerful humectant – cheap yet very effective.

Rosa Centifolia Flower Water
Est. %4
Function
Origin
Rosa centifolia flower water is fragrant water that is leftover after the steam distillation of the rose petals from the Rosa centifolia – the Provence rose or cabbage rose (referring to its rich, multi-petal flower head). Read more on rose oil here: Rosa Damascena Flower oil.
Isopropyl Myristate
Est. %3
Function
Origin
A fast-spreading, cost-effective, non-greasy emollient that is typically used for lubrication, spreadability, or to remove “tackiness” from a product. Isopropyl Myristate is listed as a common comedogenic ingredient by acne.org.
Squalane
Est. %2
Function
Origin
An occlusive moisturizing and emollient compound that forms part of the skin’s sebum. The main source of squalane had always been shark liver. Now, however, it is manufactured synthetically or derived from plant oils, such as olive and peanut oil.
Mannitol
Est. %1.5
Function
Origin
A sweet-tasting, sugar-derived, humectant alcohol that can stabilize a skincare formula and offer some antioxidant and soothing properties.
Butylene Glycol
Est. %1.3
Function
Origin
A clear, colorless liquid humectant that draws moisture to the skin. The humectancy of butylene glycol, owed to its two hydroxyl groups, is quite considerable, although not as powerful as glycerin, which contains three hydroxyl groups.
Natto Gum
Est. %1
Function
Origin
Description is coming soon
Tripeptide-10 Citrulline
Est. %0.3
Function
Origin
A synthetically made peptide that controls the proper formation of collagen strands in the skin. It was tested in a clinical trial and showed increased skin flexibility and collagen-repair activity.
Acetyl Octapeptide-3
Est. %0.3
Function
Origin
A synthetically made peptide with an effect similar to Botox - it relaxes the facial muscles and temporarily reduces the appearance of mimic wrinkles.
Palmitoyl Hexapeptide-12
Est. %0.3
Function
Origin
A short, synthetically made peptide similar to elastin fragments. It works as a signal peptide, stimulating the growth of skin cells and facilitating skin repair. It has been tested mostly in test-tube experiments so far.
Acetyl Tetrapeptide-11
Est. %0.3
Function
Origin
Description is coming soon
Acetyl Hexapeptide-8
Est. %0.3
Function
Origin
A small synthetic peptide that is thought to act similarly to Botox by calming contractions of the facial muscles and reducing expression wrinkles. The effect is only temporary and it does not improve the skin structure in any way.
Acetyl Hexapeptide-1
Est. %0.3
Function
Origin
Description is coming soon
Palmitoyl Oligopeptide
Est. %0.3
Function
Origin
This is an old INCI name that can refer to several other peptides. They are all short fragments of collagen or elastin and function as signal molecules, telling the skin to repair and restructure the dermis, resulting in anti-wrinkle activity.
Acetyl Tetrapeptide-9
Est. %0.3
Function
Origin
A synthetically made peptide that works as a signal peptide, increasing the production of collagen in the skin. There was a small clinical study on this peptide that resulted in firmer and thicker skin with fewer wrinkles.
Acetyl Tetrapeptide-2
Est. %0.3
Function
Origin
Description is coming soon
Tripeptide-1
Est. %0.3
Function
Origin
A small, skin-identical peptide that boosts collagen renewal in the skin and improves other structural proteins. It may have trouble penetrating the skin in this form, so palmitic acid or biotin is usually added to it.
Palmitoyl Tetrapeptide-7
Est. %0.3
Function
Origin
A synthetic peptide that mimics the activity of immunoglobulin G and signals to the skin to stop the inflammation. It has been shown in studies to reduce wrinkles and enhance collagen content.
Hexapeptide-11
Est. %0.3
Function
Origin
Description is coming soon
Dipeptide Diaminobutyroyl Benzylamide Diacetate
Est. %0.3
Function
Origin
A synthetically made peptide similar to the proteins in viper venom. Similarly to Botox, it works by inhibiting contractions of mimic muscles, thereby offering a short-term reduction in mimic wrinkles.
Palmitoyl Tripeptide-5
Est. %0.3
Function
Origin
A small synthetic peptide that signals the skin to produce more collagen. It has been clinically tested and proven to reduce skin roughness and the appearance of wrinkles.
Trifluoroacetyl Tripeptide-2
Est. %0.3
Function
Origin
A synthetically made peptide that was shown to slow down the degradation of elastin in the skin. It is said to be able to reduce sagging and wrinkles in different parts of the face, although this has not been well researched yet.
Palmitoyl Tripeptide-1
Est. %0.3
Function
Origin
A small peptide consisting of three amino acids with anti-wrinkle effects. Together with Palmitoyl Tetrapeptide-7, it is a part of the popular anti-wrinkle complex called Matrixyl™ 3000.
Sodium Polyglutamate
Est. %0.3
Function
Origin
Description is coming soon
Sodium Hyaluronate
Est. %0.3
Function
Origin
A sodium salt of famous hyaluronic acid. A potent humectant that hydrates the skin, supports collagen function, and fills out small wrinkles. Sodium hyaluronate also offers soothing and antioxidant properties.
Tocopheryl Acetate
Est. %0.3
Function
Origin
An antioxidant derivative of tocopherol (vitamin E). It helps to protect cells from free radicals and UV damage through the conversion to active vitamin E in the skin. It is more stable than tocopherol.
Retinyl Palmitate
Est. %0.3
Function
Origin
An esterified form of retinol – it combines retinol and palmitic acid into one molecule. Retinyl palmitate is less irritating than retinol but also much less effective in its anti-aging and acne-reducing effects.
Ascorbic Acid
Est. %0.3
Function
Origin

Also known as vitamin C, this multi-benefit ingredient has proven anti-wrinkle, antioxidant, and anti-pigmentation efficacy. It degrades easily when exposed to air and light, so it requires proper packaging to maintain its stability.

Hydrolyzed Soy Protein
Est. %0.3
Function
Origin
A mixture of proteins obtained from soybeans. It can have many different functions depending on the manufacturer, although it is most commonly used in skincare products as a humectant moisturizing ingredient.
Hydrolyzed Wheat Protein
Est. %0.3
Function
Origin
Wheat protein broken down into its individual amino acids. It is commonly used as a film-former and antistatic agent.
Lecithin
Est. %0.3
Function
Origin
A humectant, emollient, and emulsifier best suited for water-in-oil emulsions. Lecithin can come from sunflowers, soy, and eggs. The downside to lecithin is that it causes an extra burden on the formula’s preservative because it is nutritious.
Pseudoalteromonas Ferment Extract
Est. %0.3
Function
Origin
An ingredient obtained from a bacterial culture. According to the patent holder, it produces a special glycoprotein that promotes collagen and elastin synthesis and moisturizes the skin by drawing water to it.
Acrylates Copolymer
Est. %0.3
Function
Origin
A highly functional synthetic ingredient that forms a protective layer on the skin and reduces static buildup. It gives an emollient feel to the product, including a silky after-feel.
Magnesium Chloride
Est. %0.3
Function
Origin
A chloride salt with a bitter taste and the ability to thicken water-in-oil emulsions.
Polysorbate 20
Est. %0.3
Function
Origin
A viscous, amber-colored liquid that functions as a solubilizer to disperse small amounts of oil into a large water phase. Polysorbate 20 is frequently used to solubilize fragrance oils into water-based emulsions.
Dimethyl Isosorbide
Est. %0.3
Function
Origin
A solvent for active ingredients that is claimed to help them better penetrate the outer layer of skin. It also helps to reduce the thickness of a product.
Acrylates/C10-30 Alkyl Acrylate Crosspolymer
Est. %0.3
Function
Origin
A synthetic ingredient that is used to thicken water and alcohol. It results in a more lightweight formula and is commonly found in gel products.
Leuconostoc/Radish Root Ferment Filtrate
Est. %0.3
Function
Origin
A biotechnological fermentation ingredient that is created by feeding radish root to Leuconostoc kimchii. It allegedly contains organic acids and a mixture of peptides known as bacteriocins – which have antimicrobial activity.
PEG-8 Dimethicone
Est. %0.3
Function
Origin
Description is coming soon
Disodium Phosphate
Est. %0.3
Function
Origin
An inorganic ingredient primarily used in skincare products as a pH adjuster.
Carbomer
Est. %0.3
Function
Origin
A synthetic ingredient with the ability to gel water. When used in emulsions, such as lotions and creams, carbomer can also act as an emulsion stabilizer.
Dextran
Est. %0.3
Function
Origin
A naturally derived sucrose metabolite that thickens water and bulks emulsions.
Sodium Lactate
Est. %0.3
Function
Origin
A sodium salt of lactic acid. Its main function is as a humectant but it can also serve as a pH adjuster. Additionally, sodium lactate can also be used as a chemical exfoliant due to its close chemical relation to lactic acid.
Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate
Est. %0.3
Function
Origin
A small, peptide-like ingredient designed to improve skin firmness and hydration by stimulating the production of proteins and peptidoglycans in the skin.
Xanthan Gum
Est. %0.3
Function
Origin
A natural multi-functional ingredient that originates from fermented sugars. Xanthan gum acts as a viscosity-building agent to thicken skincare products. It is also an excellent stabilizer and works well to hold other ingredients together.
Triethanolamine
Est. %0.3
Function
Origin
A clear, colorless, and highly viscous liquid, this ingredient is an excellent pH adjuster. When it is necessary to neutralize an acidic solution or to generally increase the pH of a product, triethanolamine is a common choice.
Sodium Phosphate
Est. %0.3
Function
Origin
A sodium salt of phosphoric acid that increases pH.
Octyldodecanol
Est. %0.3
Function
Origin
An emollient fatty alcohol that spreads easily without leaving a greasy residue on the skin. It is also used as a solvent and dispersing agent for other ingredients.
Silica
Est. %0.3
Function
Origin
A widely used cosmetic ingredient with the same chemical composition as the sand found on beaches. A common function of silica is its ability to control viscosity. In certain chemical forms, it can effectively thicken cream-style products.
Sodium Propoxyhydroxypropyl Thiosulfate Silica
Est. %0.3
Function
Origin
Description is coming soon
Sodium Hydroxide
Est. %0.3
Function
Origin
An ingredient that is able to bring the pH of a product up, thereby making it less harsh on the skin.
Caprylyl Glycol
Est. %0.3
Function
Origin
An emollient that improves product spreadability and offers a silky feel on the skin. It also acts as a preservative booster that improves the efficacy of other preservatives. According to the manufacturer, it is also a humectant moisturizer.
Potassium Sorbate
Est. %0.3
Function
Origin
A preservative widely used in food and personal care products, available from natural sources or synthetically produced. Potassium sorbate works by inhibiting the growth of yeasts, molds, and some bacteria.
Sodium Benzoate
Est. %0.3
Function
Origin
A preservative that usually works in combination with other preservatives. It has to be at low pH (<5.5) to be effective.
Phenoxyethanol
Est. %0.3
Function
Origin
The most frequently used preservative in skincare. It is a clear, oil-like liquid synthetic substance that protects products from harmful bacteria and yeast, whilst still leaving skin microflora unharmed. It is confirmed by research to be harmless.