Tripeptide-10 Citrulline

A synthetically made peptide that controls the proper formation of collagen strands in the skin. It was tested in a clinical trial and showed increased skin flexibility and collagen-repair activity.
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Tripeptide-10 Citrulline


Tripeptide-10 Citrulline, trademarked as Decorinyl™, consists of three amino acids (lysine, aspartate, and isoleucine) bound to citrulline molecule, which is another amino acid.

It mimics the amino acid sequence of decorin, a peptide that binds to collagen fibrils. By binding to collagen strands, it controls their growth and uniformity. Aging skin gradually loses its decorin, leaving the collagen strands disordered and fragile.

A clinical study was performed on 22 female volunteers that assessed the tripeptide’s activity at a concentration of 0,01%. The study reported more supple and flexible skin in the treated group, as well as an interesting microscopic observation of the collagen strands – after treatment, they were more uniform in thickness and more similar to the collagen in youthful skin.


Puig, A., Antón, J. M. G., & Mangues, M. (2008). A new decorin-like tetrapeptide for optimal organization of collagen fibres. International Journal of Cosmetic Science, 30(2), 97–104.