Palmitoyl Tetrapeptide-7

A synthetic peptide that mimics the activity of immunoglobulin G and signals to the skin to stop the inflammation. It has been shown in studies to reduce wrinkles and enhance collagen content.
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Palmitoyl Tetrapeptide-7


Palmitoyl tetrapeptide-7 is a synthetically prepared peptide consisting of four amino acids (Glycine-Glutamine-Proline-Arginine) with palmitic acid on one end of the chain to enhance its lipid solubility and to transport through the skin’s lipid barrier. It is trademarked under the name Rigin™.

Structurally, it is a fragment of Immunoglobulin G and in the skin, it works as a signaling molecule with anti-inflammatory activity in UV-damaged areas. Its activity is comparable to DHEA (a steroid hormone produced in the adrenal glands).

Less inflammation also means less damage to the structural proteins such as collagen or elastin. In an in vivo study (a study involving volunteers) it was shown that it enhanced the skin’s protein matrix when compared to placebo.

In a clinical study, 60 volunteers were treated over a 12 month period with a commercial product containing this peptide and they saw a significant reduction in their facial wrinkles.


Schagen, S. (2017). Topical Peptide Treatments with Effective Anti-Aging Results. Cosmetics, 4(2), 16.
Zhang, L., & Falla, T. J. (2009). Cosmeceuticals and peptides. Clinics in Dermatology, 27(5), 485–494.
Mondon, P.; et al. Evaluation of dermal extracellular matrix and epidermal-dermal junction modifications using matrix-assisted laser desorption/ionization mass spectrometric imaging, in vivo reflectance confocal microscopy, echography, and histology: Effect of age and peptide applications. J. Cosmet. Dermatol. 2015, 14, 152–160.
Watson, R.E.; Ogden, S.; Cotterell, L.F.; Bowden, J.J.; Bastrilles, J.Y.; Long, S.P.; Griffiths, C.E. Effects of a cosmetic ‘anti-ageing’ product improves photoaged skin. Br. J. Dermatol. 2009, 161, 419–426