Palmitoyl Tripeptide-5

A small synthetic peptide that signals the skin to produce more collagen. It has been clinically tested and proven to reduce skin roughness and the appearance of wrinkles.
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Palmitoyl Tripeptide-5


Palmitoyl Tripeptide-5, previously known as Palmitoyl Tripeptide-3, or by its trade name Syn®-Coll, is a synthetic signal peptide consisting of three amino acids (Arg-Phe-Lys) with palmitic acid on one end for better oil solubility and skin absorption.

It has been created to mimic Thrombospondin I, a skin signal protein that binds to tissue growth factor beta (TGF-ß). Syn-Coll activates TGF-ß and starts a signal cascade which results in an increased production of collagen at the end. Several test-tube experiments confirm this theory.

It has also been tested on volunteers – 60 Chinese volunteers had a 2.5% cream applied over a period of 84 days and reported reduced skin roughness and anti-wrinkle effects. According to the manufacturer, the ingredient may also help with stretch marks.


Schagen, S. (2017). Topical Peptide Treatments with Effective Anti-Aging Results. Cosmetics, 4(2), 16.
Gorouhi, F.; Maibach, H. Role of topical peptides in preventing or treating aged skin. Int. J. Cosmet. Sci. 2009, 31, 327–345.
Pentapharm (Basel, Switzerland)