A small synthetic peptide that signals the skin to produce more collagen. It has been clinically tested and proven to reduce skin roughness and the appearance of wrinkles.
Functions
Anti-Wrinkle
Anti-Wrinkle
Anti-wrinkle ingredients prevent the formation or reduce the appearance of wrinkles.
Anti-Wrinkle
Anti-Wrinkle
Anti-wrinkle ingredients prevent the formation or reduce the appearance of wrinkles.
Origin
Botanical,
Botanical
Ingredients derived from plants, mosses, and lichens: extracts, oils, powders, juices and other types of processed plant materials.
Botanical,
Botanical
Ingredients derived from plants, mosses, and lichens: extracts, oils, powders, juices and other types of processed plant materials.
Synthetic
Synthetic
All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure.
Synthetic
Synthetic
All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure.
Palmitoyl Tripeptide-5, previously known as Palmitoyl Tripeptide-3, or by its trade name Syn®-Coll, is a synthetic signal peptide consisting of three amino acids (Arg-Phe-Lys) with palmitic acid on one end for better oil solubility and skin absorption.
It has been created to mimic Thrombospondin I, a skin signal protein that binds to tissue growth factor beta (TGF-ß). Syn-Coll activates TGF-ß and starts a signal cascade which results in an increased production of collagen at the end. Several test-tube experiments confirm this theory.
It has also been tested on volunteers – 60 Chinese volunteers had a 2.5% cream applied over a period of 84 days and reported reduced skin roughness and anti-wrinkle effects. According to the manufacturer, the ingredient may also help with stretch marks.
Science
1
Schagen, S. (2017). Topical Peptide Treatments with Effective Anti-Aging Results. Cosmetics, 4(2), 16.
2
Gorouhi, F.; Maibach, H. Role of topical peptides in preventing or treating aged skin. Int. J. Cosmet. Sci. 2009, 31, 327–345.
