ISDIN A.G.E. Reverse Day Review

ISDIN A.G.E. Reverse Day
6.0
/ 10
Moisturizing
10.0 Humectancy icon Humectancy
2.1 Occlusivity icon Occlusivity
6.1Anti-wrinkle icon/ 10
Anti-wrinkle
Rich
in Antioxidants
Rich Skin Soothing icon
in Skin Soothers
Ingredients

ISDIN A.G.E. Reverse Day Ingredients

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Full Ingredient List (INCI):

Butylene Glycol, Isodecyl Neopentanoate, Propanediol, Niacinamide, Glycerin, Betaine, Caprylic/Capric Triglyceride, Silica, Dimethicone, Hydrogenated Polyisobutene, Stearyl Alcohol, Octyldodecanol, Dipentaerythrityl Hexacaprylate/Hexacaprate, Tridecyl Trimellitate, Phenylpropanol, Ammonium Acryloyldimethyltaurate/VP Copolymer, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Caprylyl Glycol, Fragrance, Cetearyl Alcohol, Potassium Olivoyl Hydrolyzed Oat Protein, Glyceryl Stearate, Carnosine, Tridecyl Stearate, Neopentyl Glycol Dicaprylate/Dicaprate, Glyceryl Oleate, Pentylene Glycol, Sodium Hyaluronate Crosspolymer, Disodium EDTA, PEG-8, Alteromonas Ferment Extract, Hydroxypropyl Cyclodextrin, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Tocopherol, Benzyl Alcohol, Potassium Sorbate, Sodium Benzoate, Ascorbyl Palmitate, Magnesium Chloride, Alcohol Denat., Ascorbic Acid, Citric Acid, Palmitoyl Tripeptide-38, Yellow 6 (CI 15985), Yellow 5 (CI 19140)
Review

Does ISDIN A.G.E. Reverse Day Work?

 
According to CreamScan's analysis of the ingredient list, here’s what ISDIN A.G.E. Reverse Day has to offer:
 
✅ Significant moisturizing. It has a moisturizing rating of 6.0 out of 10.
✅ Significant anti-wrinkle efficacy. With an anti-wrinkle rating of 6.1 out of 10, ISDIN A.G.E. Reverse Day is effective in minimizing wrinkles.
✅ Soothing: ISDIN A.G.E. Reverse Day contains a high concentration of soothing ingredients, which may help to reduce irritation and calm the skin.
✅ Antioxidant protection

  

Key Benefits of ISDIN A.G.E. Reverse Day

 
These are the key benefits you can expect from using ISDIN A.G.E. Reverse Day:
 

🔵 Lightweight Moisturizer Perfect for Combination and Oily Skin

According to CreamScan analysis, ISDIN A.G.E. Reverse Day is highly moisturizing, with a moisturizing rating of 6.0 out of 10.

Is it more humectant or occlusive? Significantly more humectant. It has a low occlusivity of 2.1 out of 10 and a maximum humectancy of 10 out of 10, primarily due to the high content of Butylene Glycol (est. ≈40.0%), Propanediol (est. ≈11.0%) and Niacinamide (est. ≈5.0%).

This type of moisturizer is ideal for people with combination and oily skin who want maximum hydration in a relatively lightweight, non-greasy formula. It combines a significant amount of humectants with a limited amount of occlusive ingredients to boost moisturizing efficacy without feeling too heavy.

This product may also be a good choice for people with normal skin who prefer fast-absorbing textures, as it balances significant moisturizing potential with a relatively lightweight texture.

💧 A Humectant Boost for Any Skincare Routine

But it’s not limited to combination and oily skin - such a humectant boost will also positively contribute to the moisturizing efficacy of any skincare routine when used as a step before applying the main moisturizer. This type of formulation is typically used in serums, where a light, fast-absorbing texture is key.

Please refer to the Ratings section below for details of the moisturizing rating calculation.

🟣🟣 Significant Anti-Wrinkle Efficacy

According to CreamScan analysis, ISDIN A.G.E. Reverse Day has a high anti-wrinkle rating of 6.1 out of 10.

It contains 2 active ingredients with proven anti-wrinkle efficacy:

1️⃣ Niacinamide (est. ≈5.0%),
 one of the most effective and well-researched anti-wrinkle ingredients. A clinical study involving 30 participants (Kawada et al.) confirmed that a cream with 4% niacinamide reduced the average depth of wrinkles around the eyes by 9% after 8 weeks of use, compared to a vehicle (the same formulation without niacinamide).
 
2️⃣ Ascorbic Acid (est. ≈0.3%),
 or Vitamin C, a popular ingredient, yet with moderate anti-wrinkle efficacy, as confirmed by a single clinical study involving 20 participants (Humbert et al.). This study showed that a cream with a relatively high concentration of 5% ascorbic acid reduced the average wrinkle depth by 7% after 6 months of use, compared to a vehicle (the same formulation without ascorbic acid).
 
Among others, ISDIN A.G.E. Reverse Day also contains some ingredients marketed often as effective in reducing wrinkles, specifically Alteromonas Ferment Extract, Ascorbyl Palmitate, and Palmitoyl Tripeptide-38. However, the studies supporting the anti-wrinkle claims of these ingredients provide insufficient evidence of efficacy according to CreamScan Research Evaluation Standards.
 
While this does not categorically rule out the possibility that these ingredients may reduce wrinkles, their efficacy is not supported by convincing, vehicle-controlled, double-blind clinical studies - at least none that were available to the CreamScan team at the time of publication.
 
Therefore, these ingredients do not contribute to the anti-wrinkle rating.
 

Please refer to the Ratings section below for details of the anti-wrinkle rating calculation.

🍀 Rich in Skin-Protecting Antioxidants

We estimate that ISDIN A.G.E. Reverse Day is rich (> 3%) in antioxidants, specifically Niacinamide (est. ≈5.0%).

A key benefit of antioxidants is their ability to reduce oxidative stress caused by free radicals and therefore prevent accelerated skin aging. Studies also show that antioxidants can protect against environmental damage such as UV radiation and pollution, and help reduce inflammation and skin redness.

🔴 Skin Soothing and Calming Potential

Based on the ingredient list analysis, ISDIN A.G.E. Reverse Day is rich (> 5%) in soothing ingredients, particularly Niacinamide (est. ≈5.0%).

When applied to the skin, compounds of soothing ingredients, such as triglycerides, phospholipids, fatty acids, phenolic compounds, and antioxidants, work together to soothe the skin through various mechanisms: reducing inflammation, promoting wound healing, repairing the skin barrier, and providing antimicrobial and antioxidant activities.

📌 Please note that this is not a complete list of benefits. We are in the process of enhancing our model to incorporate anti-pigmentation, exfoliation and anti-acne ratings.

Pros & Cons of ISDIN A.G.E. Reverse Day

 
Here’s an overview of the pros and cons of ISDIN A.G.E. Reverse Day to help you decide if it’s the right choice for your skincare routine:
 

🟩 Pros:

✅ When used alone: Provides humectant-rich moisturizing perfect for combination and oily skin
✅ Also a good choice for people with normal skin who prefer fast-absorbing textures
✅ As part of a routine: A humectant moisturizing boost, beneficial for any skin type
✅ Lightweight texture
Delivers signficant anti-wrinkle efficacy thanks to Niacinamide and Ascorbic Acid
✅ Rich in antioxidants that combat oxidative stress associated with accelerated skin aging and defend against environmental damage
✅ Potentially soothing, as it contains a high concentration of soothing ingredients, specifically Niacinamide
 

⭕ Cons: 

✅ We couldn't find any
   

Summary: ISDIN A.G.E. Reverse Day

 
Based on the ingredient list analysis, CreamScan AI suggests that ISDIN A.G.E. Reverse Day
 is specifically effective in treating wrinkles, containing ingredients with solid, robust evidence of anti-wrinkle efficacy.
 

When used alone, it delivers lightweight, humectant-rich moisturizing, perfect for combination and oily skin. It's also a great option for those with normal skin who prefer fast-absorbing textures. As part of a moisturizing routine, it provides a humectant boost, beneficial for all skin types.

Rich in antioxidants, ISDIN A.G.E. Reverse Day helps protect against free radical damage and offers multiple benefits for all skin types, including preventing premature aging, defending against environmental damage, and calming inflammation. This product is also formulated with a high concentration of soothing ingredients, offering the potential to calm and comfort irritated skin. Whether you’re experiencing redness, irritation, or general sensitivity, its soothing properties may help restore balance and provide relief.
 
📌 Fact check. At CreamScan, we are committed to accuracy and fairness. If you spot any errors or something that doesn’t seem right, please click here to let us know. We regularly update the ingredient lists and monitor the latest research on ingredient efficacy to ensure that our information remains as complete and precise as possible. The information provided here is for informational purposes only and does not substitute professional advice. We do not guarantee the efficacy or safety of any product, as individual results may vary.

 

Ingredient Breakdown

Est. % Ingredient Origin Functions
40
22
11
5
4
3
2
1.5
1
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Est. %
Butylene Glycol
Function:
Origin:
Isodecyl Neopentanoate
Function:
Origin:
Propanediol
Function:
Origin:
Niacinamide
Function:
Origin:
Glycerin
Function:
Origin:
Betaine
Function:
Origin:
Caprylic/Capric Triglyceride
Function:
Origin:
Silica
Function:
Origin:
Dimethicone
Function:
Origin:
Hydrogenated Polyisobutene
Function:
Origin:
Stearyl Alcohol
Function:
Origin:
Octyldodecanol
Function:
Origin:
Dipentaerythrityl Hexacaprylate/Hexacaprate
Function:
Origin:
Tridecyl Trimellitate
Function:
Origin:
Phenylpropanol
Function:
Origin:
Ammonium Acryloyldimethyltaurate/VP Copolymer
Function:
Origin:
Acrylates/C10-30 Alkyl Acrylate Crosspolymer
Function:
Origin:
Caprylyl Glycol
Function:
Origin:
Fragrance
Function:
Origin:
Cetearyl Alcohol
Function:
Origin:
Potassium Olivoyl Hydrolyzed Oat Protein
Function:
Origin:
Glyceryl Stearate
Function:
Origin:
Carnosine
Function:
Origin:
Tridecyl Stearate
Function:
Origin:
Neopentyl Glycol Dicaprylate/Dicaprate
Function:
Origin:
Glyceryl Oleate
Function:
Origin:
Pentylene Glycol
Function:
Origin:
Sodium Hyaluronate Crosspolymer
Function:
Origin:
Disodium EDTA
Function:
Origin:
PEG-8
Function:
Origin:
Alteromonas Ferment Extract
Function:
Origin:
Hydroxypropyl Cyclodextrin
Function:
Origin:
Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate
Function:
Origin:
Tocopherol
Function:
Origin:
Benzyl Alcohol
Function:
Origin:
Potassium Sorbate
Function:
Origin:
Sodium Benzoate
Function:
Origin:
Ascorbyl Palmitate
Function:
Origin:
Magnesium Chloride
Function:
Origin:
Alcohol Denat.
Function:
Origin:
Ascorbic Acid
Function:
Origin:
Citric Acid
Function:
Origin:
Palmitoyl Tripeptide-38
Function:
Origin:
Yellow 6 (CI 15985)
Function:
Origin:
Yellow 5 (CI 19140)
Function:
Origin:

Ratings

All humectants
64.2
40
11
5
4
3
0.3
0.3
0.3
0.3
Benchmark
10
All occlusives
4.2
2.0
1.0
0.3
0.3
0.3
0.3
Benchmark
20
Moisturizing rating
6.0
Ingredient Est. % Benchmark Raiting
Humectancy All humectants 64.2 10
10.0
40
11
5
4
3
0.3
0.3
0.3
0.3
Occlusivity All occlusives 4.2 20
2.1
2.0
1.0
0.3
0.3
0.3
0.3
Moisturizing rating
6.0
Ingredient Est. % Benchmark Humectancy
40
11
5
4
3
0.3
0.3
0.3
0.3
All humectants 64.2 10
10
All humectants
64.2
40
11
5
4
3
0.3
0.3
0.3
0.3
Benchmark
10
Ingredient Est. % Benchmark Occlusivity
2
1
0.3
0.3
0.3
0.3
All occlusives 4.2 20
2.1
All occlusives
4.2
2.0
1.0
0.3
0.3
0.3
0.3
Benchmark
20
Ingredient
Ingredient anti-wrinkle power
when present at, %
in this formula est. %
Rating
6 /10 4 5 6
2.5 /10 5 0.3 0.1
n/a
- 0.3 -
n/a
- 0.3 -
n/a
- 0.3 -
Total
6.1
Niacinamide
6
Ingredient anti-wrinkle power
6 /10
when present at, %
4
in this formula, est. %
5
Ascorbic Acid
0.1
Ingredient anti-wrinkle power
2.5 /10
when present at, %
5
in this formula, est. %
0.3
Alteromonas Ferment Extract
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Ascorbyl Palmitate
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Palmitoyl Tripeptide-38
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Anti-wrinkle rating
6.1
Ingredient Est. % Benchmark
Rich in Antioxidants
5
0.3
0.3
0.3
0.3
All antioxidants 6.2 3 Rich in antioxidants
All antioxidants
6.2
Niacinamide
5
Ascorbic Acid
0.3
Carnosine
0.3
Tocopherol
0.3
Ascorbyl Palmitate
0.3
Benchmark
3
Ingredient Est. % Benchmark
Rich in Soothing
5
0.3
All soothing 5.3 5 Rich in soothing
All soothing
5.3
5
0.3
Benchmark
5

Ingredients explained

Butylene Glycol
Est. %40
Function
Origin
Butylene Glycol

A clear, colorless liquid humectant that draws moisture to the skin. The humectancy of butylene glycol, owed to its two hydroxyl groups, is quite considerable, although not as powerful as glycerin, which contains three hydroxyl groups.

Isodecyl Neopentanoate
Est. %22
Function
Origin
Isodecyl NeopentanoateA super lightweight ester that softens the appearance of skin.
Propanediol
Est. %11
Function
Origin
PropanediolAn excellent solvent capable of mixing water with normally water-insoluble ingredients. It also functions as a humectant due to its water-loving alcohol groups. Propanediol can control the viscosity of a product by reducing its thickness.
Niacinamide
Est. %5
Function
Origin
Niacinamide

Also known as vitamin B3, this ingredient is a true superstar with confirmed moisturizing, anti-acne, hyperpigmentation, and antioxidant benefits. Two studies confirm its significant anti-wrinkle efficacy.

Glycerin
Est. %4
Function
Origin
Glycerin

The most popular moisturizing ingredient in the world. It is a powerful humectant – cheap yet very effective.

Betaine
Est. %3
Function
Origin
BetaineAn ingredient derived from the sucrose in sugar beets. It has a negative chemical charge and a positive chemical charge on the same molecule. This allows betaine to be hygroscopic or humectant and thus provide moisturization by drawing water to the skin.
Caprylic/Capric Triglyceride
Est. %2
Function
Origin
Caprylic/Capric TriglycerideA natural occlusive moisturizing and emollient ingredient, it is a blend of glycerin and two fatty acids, caprylic and capric acid. It creates an oil-based protective layer on the skin, thereby preventing water loss.
Silica
Est. %1.5
Function
Origin
SilicaA widely used cosmetic ingredient with the same chemical composition as the sand found on beaches. A common function of silica is its ability to control viscosity. In certain chemical forms, it can effectively thicken cream-style products.
Dimethicone
Est. %1
Function
Origin
DimethiconeThe most common silicone in skincare. It forms a silky, smooth film on the skin’s surface and can help to prevent water loss. It also aids in wound healing and can treat and soften scars. Dimethicone is considered to be very safe for use.
Hydrogenated Polyisobutene
Est. %0.3
Function
Origin
Hydrogenated PolyisobuteneA viscous liquid that makes a great oil base due to its smooth sensorial profile. It has emollient features, including good spreadability and little tack upon application. It also has the added benefit of being able to thicken products.
Stearyl Alcohol
Est. %0.3
Function
Origin
Stearyl AlcoholA natural fatty alcohol that thickens, stabilizes, and keeps emulsions a bright white color. It has many uses, the main one being as an emulsifier. It also acts as an opacifying agent and emollient.
Octyldodecanol
Est. %0.3
Function
Origin
OctyldodecanolAn emollient fatty alcohol that spreads easily without leaving a greasy residue on the skin. It is also used as a solvent and dispersing agent for other ingredients.
Dipentaerythrityl Hexacaprylate/Hexacaprate
Est. %0.3
Function
Origin
Dipentaerythrityl Hexacaprylate/Hexacaprate
Tridecyl Trimellitate
Est. %0.3
Function
Origin
Tridecyl Trimellitate
Phenylpropanol
Est. %0.3
Function
Origin
PhenylpropanolPhenylpropanol is a naturally occurring component of many essential oils. It is a colourless, oily liquid with a sweet, floral, balsamic scent. It is used in skincare as a solvent for oil-soluble ingredients and as a fragrance component.
Ammonium Acryloyldimethyltaurate/VP Copolymer
Est. %0.3
Function
Origin
Ammonium Acryloyldimethyltaurate/VP CopolymerA polymeric ingredient that creates lightweight and refreshing gel textures. It also works as a viscosity controlling agent.
Acrylates/C10-30 Alkyl Acrylate Crosspolymer
Est. %0.3
Function
Origin
Acrylates/C10-30 Alkyl Acrylate CrosspolymerA synthetic ingredient that is used to thicken water and alcohol. It results in a more lightweight formula and is commonly found in gel products.
Caprylyl Glycol
Est. %0.3
Function
Origin
Caprylyl GlycolAn emollient that improves product spreadability and offers a silky feel on the skin. It also acts as a preservative booster that improves the efficacy of other preservatives. According to the manufacturer, it is also a humectant moisturizer.
Fragrance
Est. %0.3
Function
Origin
FragranceUnder trade secret law, manufacturers have the right not to disclose what exactly went into the fragrance and use the unspecific word Fragrance or Parfum instead. Many fragrances are highly allergenic.
Cetearyl Alcohol
Est. %0.3
Function
Origin
Cetearyl AlcoholA blend of cetyl alcohol and stearyl alcohol, the fatty alcohols that are derived from palm oil. It helps to create emulsions that give off a soft and silky emollient feel and also increase product thickness.
Potassium Olivoyl Hydrolyzed Oat Protein
Est. %0.3
Function
Origin
Potassium Olivoyl Hydrolyzed Oat Protein
Glyceryl Stearate
Est. %0.3
Function
Origin
Glyceryl StearateAn emollient and emulsifier typically derived from vegetable sources through a chemical reaction with glycerin. It provides stability, texture, and consistency to formulations. Its main function is to allow oil and water to mix.
Carnosine
Est. %0.3
Function
Origin
CarnosineA skin-identical dipeptide that acts as a powerful antioxidant. It protects our skin from harmful glycation and can enhance the activity of other active ingredients in the skincare product.
Tridecyl Stearate
Est. %0.3
Function
Origin
Tridecyl Stearate
Neopentyl Glycol Dicaprylate/Dicaprate
Est. %0.3
Function
Origin
Neopentyl Glycol Dicaprylate/DicaprateAn emollient blend of a compound used in the production of lubricants and caprylic and capric fatty acids.
Glyceryl Oleate
Est. %0.3
Function
Origin
Glyceryl OleateA nonionic surfactant that can be used as an emulsifier, emulsion stabilizer, and thickener in both skin cleansers and leave-on skincare products.
Pentylene Glycol
Est. %0.3
Function
Origin
Pentylene Glycol

A naturally or synthetically derived preservative that exhibits effective antifungal and antibacterial traits. It also acts as a booster for more traditional preservatives. Pentylene glycol can also serve as a moisturizing humectant and solvent.

Sodium Hyaluronate Crosspolymer
Est. %0.3
Function
Origin
Sodium Hyaluronate CrosspolymerA modified version of regular hyaluronic acid. It attracts large volumes of water, thereby making it an effective humectant moisturizing ingredient.
Disodium EDTA
Est. %0.3
Function
Origin
Disodium EDTAA synthetic chelator that helps to maintain the look and smell of a product by 'locking up' troublesome metal ions.
PEG-8
Est. %0.3
Function
Origin
PEG-8A synthetic liquid that serves as a humectant. It also works as a solvent because of its ability to dissolve a wide range of ingredients.
Alteromonas Ferment Extract
Est. %0.3
Function
Origin
Alteromonas Ferment ExtractAn (allegedly) anti-wrinkle mixture of exopolysaccharides from marine microorganisms.
Hydroxypropyl Cyclodextrin
Est. %0.3
Function
Origin
Hydroxypropyl CyclodextrinA white crystalline powder that can reduce odors coming from other ingredients in a product.
Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate
Est. %0.3
Function
Origin
Tetradecyl Aminobutyroylvalylaminobutyric Urea TrifluoroacetateA small, peptide-like ingredient designed to improve skin firmness and hydration by stimulating the production of proteins and peptidoglycans in the skin.
Tocopherol
Est. %0.3
Function
Origin
Tocopherol

Simply another name for vitamin E. Tocopherol is a fantastic ingredient and especially beneficial for dry and inflamed skin. It has occlusive moisturizing, emollient, antioxidant, and photoprotective properties.

Benzyl Alcohol
Est. %0.3
Function
Origin
Benzyl Alcohol

A multifunctional ingredient that is supplied as a clear, colorless liquid. Its main function is as a flavoring agent and fragrance. It also acts as a broad-spectrum preservative, solvent, and viscosity-controlling agent that thins the product.

Potassium Sorbate
Est. %0.3
Function
Origin
Potassium SorbateA preservative widely used in food and personal care products, available from natural sources or synthetically produced. Potassium sorbate works by inhibiting the growth of yeasts, molds, and some bacteria.
Sodium Benzoate
Est. %0.3
Function
Origin
Sodium BenzoateA preservative that usually works in combination with other preservatives. It has to be at low pH (<5.5) to be effective.
Ascorbyl Palmitate
Est. %0.3
Function
Origin
Ascorbyl PalmitateA form of vitamin C derived from ascorbic acid and palmitic acid. It is more stable and less irritating than ascorbic acid. Unfortunately, Ascorbyl Palmitate lacks the studies to prove its anti-wrinkle efficacy.
Magnesium Chloride
Est. %0.3
Function
Origin
Magnesium ChlorideA chloride salt with a bitter taste and the ability to thicken water-in-oil emulsions.
Alcohol Denat.
Est. %0.3
Function
Origin
Alcohol Denat.

Denatured alcohol is ethanol that contains additives that make it unsafe to consume. It is mainly used as a solvent and an antimicrobial agent. A major drawback to alcohol denat. is that it dries out the skin.

Ascorbic Acid
Est. %0.3
Function
Origin
Ascorbic Acid

Also known as vitamin C, this multi-benefit ingredient has proven anti-wrinkle, antioxidant, and anti-pigmentation efficacy. It degrades easily when exposed to air and light, so it requires proper packaging to maintain its stability.

Citric Acid
Est. %0.3
Function
Origin
Citric AcidA gently exfoliating AHA that helps to remove the top layer of dead skin cells. In comparison to other AHAs, citric acid has been shown to be one of the least effective. It is also very commonly used as a stabilizing and pH-controlling agent.
Palmitoyl Tripeptide-38
Est. %0.3
Function
Origin
Palmitoyl Tripeptide-38

A small synthetic peptide that increases the production of collagen, fibronectin, and hyaluronic acid in the skin. It has also been shown to reduce wrinkles in combination with other anti-aging ingredients.

Yellow 6 (CI 15985)
Est. %0.3
Function
Origin
Yellow 6 (CI 15985)A petroleum-derived reddish-yellow dye, also known as Sunset Yellow. It is the third most used pigment in food, cosmetics, and drugs.
Yellow 5 (CI 19140)
Est. %0.3
Function
Origin
Yellow 5 (CI 19140)A bright yellow colorant that is often also listed as FD&C Yellow 5.