Palmitoyl Tripeptide-38

A small synthetic peptide that increases the production of collagen, fibronectin, and hyaluronic acid in the skin. It has also been shown to reduce wrinkles in combination with other anti-aging ingredients.
Palmitoyl Tripeptide-38


Palmitoyl Tripeptide-38 is a short peptide with three amino acids (Lys-Met-Lys) with a palmitic acid on one end for better solubility in oils and increased skin absorption. It is used under the trademarked name MATRIXYL™ synthe'6 and is said to be a pro‐collagen lipopeptide able to increase the production of collagen, fibronectin, and hyaluronic acid.

There have been two clinical evaluations of this ingredient in a mixture with other anti-aging ingredients and both have reported good anti-wrinkle results.

For Palmitoyl Tripeptide-38 as an ingredient on its own, we only have the results from the manufacturer’s tests based on user reviews. 25 women reported various decreases in signs of aging after using a 2% cream.


Sanz, M.T.; et al. Biorevitalizing effect of a novel facial serum containing apple stem cell extract, pro-collagen lipopeptide, creatine, and urea on skin aging signs. J. Cosmet. Dermatol. 2016, 15, 24–30.
Herndon, J.H., Jr.; Jiang, L.; Kononov, T.; Fox, T. An Open Label Clinical Trial of a Multi-Ingredient Anti-Aging Moisturizer Designed to Improve the Appearance of Facial Skin. J. Drugs Dermatol. 2015, 14, 699–704.
Sederma. Matrixyl synthe’ 6. Sederma, Inc. Claim Substantiation Sheet, 2010.