Perricone MD Cold Plasma Plus+ Sub-D/Neck

Perricone MD Cold Plasma Plus+ Sub-D/Neck
5.5
/ 10
Moisturizing
9.5 Humectancy icon Humectancy
1.5 Occlusivity icon Occlusivity
2.1Anti-wrinkle icon/ 10
Anti-wrinkle
Rich
in Antioxidants
$$$$

Review

Results you may expect from using Perricone MD Cold Plasma Plus+ Sub-D/Neck:

Based on the ingredient analysis by CreamScan, these are the key benefits you can expect from using Perricone MD Cold Plasma Plus+ Sub-D/Neck:

  • Moderate moisturizing. It has a moisturizing rating of 5.5 out of 10.
  • Some anti-wrinkle efficacy: Perricone MD Cold Plasma Plus+ Sub-D/Neck has an anti-wrinkle rating of 2.1 out of 10 so you may expect some, although limited, effect on wrinkles.
  • Antioxidant protection.

How moisturizing is it?

Quite moisturizing: Perricone MD Cold Plasma Plus+ Sub-D/Neck has a moisturizing rating of 5.5 out of 10.

Is it more humectant or occlusive? Significantly more humectant. It has a low occlusivity of 1.5 out of 10 and a very high humectancy of 9.5 out of 10, primarily due to the high content of Glycerin (est. ≈4.0%) and Propanediol (est. ≈3.0%).

Please refer to the Ratings section below for details of the moisturizing rating calculation.

Anti-wrinkle efficacy

According to CreamScan analysis, Perricone MD Cold Plasma Plus+ Sub-D/Neck has a slight anti-wrinkle rating of 2.1 out of 10.

It contains 2 active ingredients with proven anti-wrinkle efficacy:

  • Niacinamide (est. ≈1.3%),
     one of the most effective and well-researched anti-wrinkle ingredients.
  • Glycolic Acid (est. ≈0.3%),
     highly effective in peelings, yet with below-average anti-wrinkle efficacy when used in leave-on skincare products.
Among others, Perricone MD Cold Plasma Plus+ Sub-D/Neck also contains some ingredients marketed as effective in reducing wrinkles, specifically Tetrahexyldecyl Ascorbate, Palmitoyl Tripeptide-5, Caffeine, and Copper Gluconate. However, the studies supporting the anti-wrinkle claims of these ingredients provide insufficient evidence of efficacy according to CreamScan Research Evaluation Standards. Therefore, these ingredients do not contribute to the anti-wrinkle rating.
 
Moisturizers, when used regularly, are proven to prevent wrinkle formation and even reduce existing wrinkles. Therefore, this product, like any other moisturizer, could deliver additional anti-wrinkle efficacy through its moisturizing action.
 

Please refer to the Ratings section below for details of the anti-wrinkle rating calculation.

Antioxidant benefits

We estimate that Perricone MD Cold Plasma Plus+ Sub-D/Neck is rich (> 3%) in antioxidants, specifically Niacinamide (est. ≈1.3%), Tetrahexyldecyl Ascorbate (est. ≈0.3%), Tocopherol (est. ≈0.3%), and others.

A key benefit of antioxidants is their ability to reduce oxidative stress caused by free radicals and therefore prevent accelerated skin aging. Studies also show that antioxidants can protect against environmental damage such as UV radiation and pollution, and help reduce inflammation and skin redness.

Ingredients

Est. % Ingredient Origin Functions
55
9
6
4
3
2.5
2
1.5
1.3
1
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
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Ratings

All humectants
9.5
4
3
1.3
0.3
0.3
0.3
0.3
Benchmark
10
All occlusives
3.1
1.0
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Benchmark
20
Moisturizing rating
5.5
Ingredient Est. % Benchmark Raiting
Humectancy All humectants 9.5 10
9.5
4
3
1.3
0.3
0.3
0.3
0.3
Occlusivity All occlusives 3.1 20
1.5
1.0
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Moisturizing rating
5.5
Ingredient Est. % Benchmark Humectancy
4
3
1.3
0.3
0.3
0.3
0.3
All humectants 9.5 10
9.5
All humectants
9.5
4
3
1.3
0.3
0.3
0.3
0.3
Benchmark
10
Ingredient Est. % Benchmark Occlusivity
1
0.3
0.3
0.3
0.3
0.3
0.3
0.3
All occlusives 3.1 20
1.5
All occlusives
3.1
1.0
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Benchmark
20
Ingredient
Ingredient anti-wrinkle power
when present at, %
in this formula est. %
Rating
6 /10 4 1.3 2
1.5 /10 5 0.3 0.1
n/a
- 0.3 -
n/a
- 0.3 -
n/a
- 0.3 -
n/a
- 0.3 -
Total
2.1
Niacinamide
2
Ingredient anti-wrinkle power
6 /10
when present at, %
4
in this formula, est. %
1.3
Glycolic Acid
0.1
Ingredient anti-wrinkle power
1.5 /10
when present at, %
5
in this formula, est. %
0.3
Tetrahexyldecyl Ascorbate
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Palmitoyl Tripeptide-5
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Caffeine
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Copper Gluconate
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Anti-wrinkle rating
2.1
Ingredient Est. % Benchmark
Rich in Antioxidants
1.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
All antioxidants 3.4 3 Rich in antioxidants
All antioxidants
3.4
Niacinamide
1.3
Tetrahexyldecyl Ascorbate
0.3
Tocopherol
0.3
Glycine Soja (Soybean) Oil
0.3
Caffeine
0.3
Sodium Hyaluronate
0.3
Rosmarinus Officinalis (Rosemary) Leaf Extract
0.3
Sodium Metabisulfite
0.3
Benchmark
3
Ingredient Est. % Benchmark
Rich in Soothing
1.3
1
0.3
0.3
0.3
All soothing 3.2 5 No
All soothing
3.2
1.3
1
0.3
0.3
0.3
Benchmark
5

Ingredients explained

Water
Est. %55
Function
Origin
The most used ingredient in skincare. Its concentration defines the product texture: rich creams may have about 50% of water while a light jelly about 90%. Water doesn’t moisturize the skin by itself and is used in skincare as a solvent for other ingredients.
Hydrogenated Polyisobutene
Est. %9
Function
Origin
A viscous liquid that makes a great oil base due to its smooth sensorial profile. It has emollient features, including good spreadability and little tack upon application. It also has the added benefit of being able to thicken products.
Isononyl Isononanoate
Est. %6
Function
Origin
An ester of a branched fatty acid with a branched fatty alcohol. It is an easily spreadable emollient that has a silky, dry, non-greasy feel on the skin.
Glycerin
Est. %4
Function
Origin

The most popular moisturizing ingredient in the world. It is a powerful humectant – cheap yet very effective.

Propanediol
Est. %3
Function
Origin
An excellent solvent capable of mixing water with normally water-insoluble ingredients. It also functions as a humectant due to its water-loving alcohol groups. Propanediol can control the viscosity of a product by reducing its thickness.
Acetyl Carnitine HCl
Est. %2.5
Function
Origin
Description is coming soon
Dimethyl MEA
Est. %2
Function
Origin
Dimethyl MEA is a chemical compound with many names - it can also be listed as DMAE, deanol or 2-dimethylaminoethanol. It is described as a colorless liquid with a fishy smell. DMAE is added to skincare products to regulate the pH balance, but can potentially be toxic.
Cetearyl Alcohol
Est. %1.5
Function
Origin
A blend of cetyl alcohol and stearyl alcohol, the fatty alcohols that are derived from palm oil. It helps to create emulsions that give off a soft and silky emollient feel and also increase product thickness.
Niacinamide
Est. %1.3
Function
Origin

Also known as vitamin B3, this ingredient is a true superstar with confirmed moisturizing, anti-acne, hyperpigmentation, and antioxidant benefits. Two studies confirm its significant anti-wrinkle efficacy.

Jojoba Esters
Est. %1
Function
Origin
A mixture of various wax esters from jojoba oil. It is used in skincare products as a fantastic emollient, soothing, and occlusive moisturizing agent that won't leave a sticky, oily feeling on the skin.
Hydrogenated Vegetable Glycerides
Est. %0.3
Function
Origin
An ingredient made from various vegetable oils. It consists solely of emollient saturated triglycerides and is aimed at very dry skin.
Dimethicone
Est. %0.3
Function
Origin
The most common silicone in skincare. It forms a silky, smooth film on the skin’s surface and can help to prevent water loss. It also aids in wound healing and can treat and soften scars. Dimethicone is considered to be very safe for use.
Glycolic Acid
Est. %0.3
Function
Origin

The second most used AHA (after lactic acid) known for its potent exfoliating and smoothing effects. It increases skin cell turnover, which is beneficial for treating acne. When used in peels, glycolic acid has confirmed anti-wrinkle efficacy, though it is less effective in leave-on products like creams and serums.

PEG-100 Stearate
Est. %0.3
Function
Origin
This surfactant is more specifically classified as an emulsifier that produces oil-in-water emulsions. PEG-100 stearate can also be used as a cleansing agent.
Glyceryl Stearate
Est. %0.3
Function
Origin
An emollient and emulsifier typically derived from vegetable sources through a chemical reaction with glycerin. It provides stability, texture, and consistency to formulations. Its main function is to allow oil and water to mix.
Phosphatidylcholine
Est. %0.3
Function
Origin
A special emulsifying lipid used to create delivery spheres called liposomes.
Tetrahexyldecyl Ascorbate
Est. %0.3
Function
Origin
A lipid-soluble form of vitamin C that is more stable and less irritating than ascorbic acid. According to a recent clinical study, THDA has all the capabilities of regular vitamin C, including anti-wrinkle and anti-pigment activity.
Palmitoyl Tripeptide-5
Est. %0.3
Function
Origin

A small synthetic peptide that signals the skin to produce more collagen. It has been clinically tested and proven to reduce skin roughness and the appearance of wrinkles.

Xanthan Gum
Est. %0.3
Function
Origin
A natural multi-functional ingredient that originates from fermented sugars. Xanthan gum acts as a viscosity-building agent to thicken skincare products. It is also an excellent stabilizer and works well to hold other ingredients together.
Echium Plantagineum Seed Oil
Est. %0.3
Function
Origin
An emollient and occlusive oil from the Purple Viper’s Bugloss plant. It contains oleic, linoleic, alpha-linolenic acids, as well as very rare polyunsaturated called stearidonic acid. It is suitable for all skin types.
Acetyl Tyrosine
Est. %0.3
Function
Origin
Acetyl tyrosine is a derivative of the amino acid tyrosine. It is used as a tanning agent in skincare, helping pigment cells (melanosomes) to produce more dark skin pigment.
Squalane
Est. %0.3
Function
Origin
An occlusive moisturizing and emollient compound that forms part of the skin’s sebum. The main source of squalane had always been shark liver. Now, however, it is manufactured synthetically or derived from plant oils, such as olive and peanut oil.
Phytic Acid
Est. %0.3
Function
Origin
Phytic acid is found in rice and is seen as a cousin of alpha-hydroxy acids. As a chelator, it can bind to certain metals that may cause discoloration in products or reduce the efficacy of other ingredients.
Ethylhexylglycerin
Est. %0.3
Function
Origin
A preservative booster derived from glycerin. It is commonly paired with other preservatives to improve their efficacy. Ethylhexylglycerin is also a humectant due to its chemical base of glycerin.
Helianthus Annuus (Sunflower) Seed Oil
Est. %0.3
Function
Origin
A fatty oil expressed from sunflower seeds and one of the most commonly used oils in skincare. It has great emollient and occlusive moisturizing properties. Sunflower oil is one of the richest sources of vitamin E – an important skin antioxidant.
Tocopherol
Est. %0.3
Function
Origin
Simply another name for vitamin E. Tocopherol is a fantastic ingredient and especially beneficial for dry and inflamed skin. It has occlusive moisturizing, emollient, antioxidant, and photoprotective properties.
Lecithin
Est. %0.3
Function
Origin
A humectant, emollient, and emulsifier best suited for water-in-oil emulsions. Lecithin can come from sunflowers, soy, and eggs. The downside to lecithin is that it causes an extra burden on the formula’s preservative because it is nutritious.
Zinc Gluconate
Est. %0.3
Function
Origin
One of the most commonly used ingredients in anti-acne products. It is an organic salt of zinc that helps to combat microbial infections, soothes and heals inflamed pimples, and regulates hormones in the skin.
Magnesium Aspartate
Est. %0.3
Function
Origin
A humectant salt of aspartic acid, a common amino acid found in the body. According to the manufacturer, magnesium aspartate in skincare products supports the supply of magnesium to skin cells.
Glycine Soja (Soybean) Oil
Est. %0.3
Function
Origin
An occlusive moisturizing oil expressed from soybeans. It does not leave an oily feeling on the skin due to its low content of saturated fatty acids. Glycine soja oil contains emollient fatty acids and a significant amount of antioxidants.
Caffeine
Est. %0.3
Function
Origin
An antioxidant compound that is obtained from coffee and tea leaves. It increases the microcirculation of blood in the skin and is claimed to be able to reduce the appearance of orange peel skin (although the research is lacking).
Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate
Est. %0.3
Function
Origin
A small, peptide-like ingredient designed to improve skin firmness and hydration by stimulating the production of proteins and peptidoglycans in the skin.
Sodium Hyaluronate
Est. %0.3
Function
Origin
A sodium salt of famous hyaluronic acid. A potent humectant that hydrates the skin, supports collagen function, and fills out small wrinkles. Sodium hyaluronate also offers soothing and antioxidant properties.
Palmitoyl Carnitine
Est. %0.3
Function
Origin
Description is coming soon
Copper Gluconate
Est. %0.3
Function
Origin
An organic salt of copper that can aid in the wound healing process. The manufacturer claims it also has soothing and anti-inflammatory properties, although this has yet to be confirmed. Copper gluconate is also a perspective anti-wrinkle ingredient.
Rosmarinus Officinalis (Rosemary) Leaf Extract
Est. %0.3
Function
Origin
A soothing and astringent extract derived from the fragrant, spicy leaves of rosemary. It has strong antioxidant properties. Rosemary extract can reduce signs of inflammation and also acts as an emollient and antimicrobial agent.
Carrageenan
Est. %0.3
Function
Origin
A gum-like thickener derived from a species of red algae called Irish moss. It helps to form a soft film on the skin, and aids in stabilizing product forms.
Disodium EDTA
Est. %0.3
Function
Origin
A synthetic chelator that helps to maintain the look and smell of a product by 'locking up' troublesome metal ions.
Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer
Est. %0.3
Function
Origin
An emulsion stabilizer and thickener that helps to create a pleasant, satiny, and light formula texture. It works by forming a gel-like network within water or oil, which both stabilizes other ingredients and produces a thickening effect.
Cetearyl Glucoside
Est. %0.3
Function
Origin
An emulsifier that creates stable mixtures of oil in water that feel soft and spread easily. Cetearyl glucoside is sold with cetearyl alcohol as an emulsifier blend and also provides some body to the formula.
Sclerotium Gum
Est. %0.3
Function
Origin
A thickener with a silky, velvety feel that many manufacturers use as an alternative to silicones.
Caprylyl Glycol
Est. %0.3
Function
Origin
An emollient that improves product spreadability and offers a silky feel on the skin. It also acts as a preservative booster that improves the efficacy of other preservatives. According to the manufacturer, it is also a humectant moisturizer.
Polysorbate 60
Est. %0.3
Function
Origin
An ester based on sorbitan. It is good for emulsifying water and oils together – specifically making oil-in-water emulsions. Polysorbate 60 is also said to give a product a notable fragrance.
Phenoxyethanol
Est. %0.3
Function
Origin
The most frequently used preservative in skincare. It is a clear, oil-like liquid synthetic substance that protects products from harmful bacteria and yeast, whilst still leaving skin microflora unharmed. It is confirmed by research to be harmless.
Potassium Sorbate
Est. %0.3
Function
Origin
A preservative widely used in food and personal care products, available from natural sources or synthetically produced. Potassium sorbate works by inhibiting the growth of yeasts, molds, and some bacteria.
Fragrance
Est. %0.3
Function
Origin
Under trade secret law, manufacturers have the right not to disclose what exactly went into the fragrance and use the unspecific word Fragrance or Parfum instead. Many fragrances are highly allergenic.
Silica
Est. %0.3
Function
Origin
A widely used cosmetic ingredient with the same chemical composition as the sand found on beaches. A common function of silica is its ability to control viscosity. In certain chemical forms, it can effectively thicken cream-style products.
Titanium Dioxide (CI 77891)
Est. %0.3
Function
Origin
One of two the most commonly used mineral sunscreens. It can absorb UV light, including UVB – which causes burning, tanning, and even skin cancer. Also used as a colorant, titanium dioxide gives a product a bright white color.
Iron Oxides (CI 77491)
Est. %0.3
Function
Origin
A red colorant also known as red iron oxide. This is an EU-approved colorant used in a wide variety of products.
Sodium Benzoate
Est. %0.3
Function
Origin
A preservative that usually works in combination with other preservatives. It has to be at low pH (<5.5) to be effective.
Sodium Metabisulfite
Est. %0.3
Function
Origin
A preservative that is especially effective at preventing fungus and mold growth. It is normally combined with a strong bactericidal preservative in order to achieve broad-spectrum protection. Sodium metabisulfite is also used as an antioxidant.
Benzyl Benzoate
Est. %0.3
Function
Origin
A fragrance ingredient with a fruity and woody scent. It is considered an allergen according to the International Fragrance Association (IFRA), which means that care must be taken when determining usage levels in skincare products.
Limonene
Est. %0.3
Function
Origin
One of the most used fragrances in skincare products. It is produced from the peels of citrus fruits and has a fresh, pleasant, citrusy smell. People who are sensitive to citrus should try to avoid it, or at least do a patch test before using it.

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