Zinc Gluconate

One of the most commonly used ingredients in anti-acne products. It is an organic salt of zinc that helps to combat microbial infections, soothes and heals inflamed pimples, and regulates hormones in the skin.
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Zinc Gluconate


Zinc gluconate is one of the most commonly used ingredients in anti-acne products, and for a good reason.

Studies have shown that people suffering from acne have lower zinc levels in general, and therefore supplementation of zinc - both from the inside and on the outside - is a good idea. Let's break down exactly how Zinc Gluconate works.

Direct antimicrobial action: Zinc gluconate has been shown to inhibit the growth of the bad bacteria that populate acne zits, especially Propionibacterium acnes. Fewer bacteria means fewer infected sebaceous glands.

Anti-inflammatory action: Zinc gluconate can regulate inflammation in multiple ways, helping the skin to calm down and not overreact by creating a huge, painful zit. This anti-inflammatory and soothing effect may make it a suitable ingredient for other inflammatory skin problems too.

Hormone regulation: Zinc gluconate can block the skin enzymes that convert testosterone into dihydrotesterone, which in turn can calm the overactive sebaceous glands.

Healing support: Zinc gluconate can help skin cells divide and heal properly, as well as stimulate the immune cells in the skin, which all can result in improved skin healing.

Zinc gluconate is generally better tolerated than other forms of zinc (such as zinc sulfate) and most dermatological studies agree that it works best when combined with other anti-acne ingredients.


Cervantes, J., Eber, A. E., Perper, M., Nascimento, V. M., Nouri, K., & Keri, J. E. (2018). The role of zinc in the treatment of acne: A review of the literature. Dermatologic therapy, 31(1), 10.1111/dth.12576.
Poiraud, C., Quereux, G., Knol, A. C., Allix, R., Khammari, A., & Dreno, B. (2012). Zinc gluconate is an agonist of peroxisome proliferator-activated receptor-α in the epidermis. Experimental dermatology, 21(5), 347–351.
Poiraud, C., Quereux, G., Knol, A. C., Zuliani, T., Allix, R., Khammari, A., & Dreno, B. (2012). Human β-defensin-2 and psoriasin, two new innate immunity targets of zinc gluconate. European journal of dermatology : EJD, 22(5), 634–639.
Stéphan, F., & Revuz, J. (2004). Sels de zinc en dermatologie [Zinc salts in dermatology]. Annales de dermatologie et de venereologie, 131(5), 455–460.