Dr. Denese SkinScience Wrinkle RX 76% Peptide Solution Concentrate

Dr. Denese SkinScience Wrinkle RX 76% Peptide Solution Concentrate
3.9
/ 10
Moisturizing
7.2 Humectancy icon Humectancy
0.6 Occlusivity icon Occlusivity

Review

Results you may expect from using Dr. Denese SkinScience Wrinkle RX 76% Peptide Solution Concentrate:

Based on the ingredient analysis by CreamScan, these are the key benefits you can expect from using Dr. Denese SkinScience Wrinkle RX 76% Peptide Solution Concentrate:

  • Light moisturizing. It has a moisturizing rating of 3.9 out of 10.

How moisturizing is it?

Lightly moisturizing: Dr. Denese SkinScience Wrinkle RX 76% Peptide Solution Concentrate has a moisturizing rating of 3.9 out of 10.

Is it more humectant or occlusive? Significantly more humectant. It has a low occlusivity of 0.6 out of 10 and a high humectancy of 7.2 out of 10, primarily due to the high content of Glycerin (est. ≈3.0%).

Please refer to the Ratings section below for details of the moisturizing rating calculation.

Anti-wrinkle efficacy

According to CreamScan analysis, Dr. Denese SkinScience Wrinkle RX 76% Peptide Solution Concentrate has a zero anti-wrinkle rating.

It contains some ingredients marketed as effective in reducing wrinkles, specifically Malus Domestica Fruit Cell Culture Extract, Tripeptide-1, Caprooyl Tetrapeptide-3, Palmitoyl Oligopeptide, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-5, and Adenosine. However, the studies supporting the anti-wrinkle claims of these ingredients provide insufficient evidence of efficacy according to CreamScan Research Evaluation Standards. Therefore, these ingredients do not generate the anti-wrinkle rating.

Moisturizers, when used regularly, are proven to prevent wrinkle formation and even reduce existing wrinkles. Therefore, this product, like any other moisturizer, could deliver some anti-wrinkle effects through its moisturizing action.

Please refer to the Ratings section below for details of the anti-wrinkle rating calculation.

Ingredients

Est. % Ingredient Origin Functions
70
Water
6
Cyclomethicone
4
Caprylic Acid
3
Glycerin
2
Dipropylene Glycol
1.5
Sodium Hyaluronate
1.3
Dimethicone
1
PEG/PPG-19/19 Dimethicone
0.3
Hydrolyzed Rice Protein
0.3
Butylene Glycol
0.3
Lecithin
0.3
Acetyl sh-Heptapeptide-1
0.3
Malus Domestica Fruit Cell Culture Extract
0.3
rh-Polypeptide-79
0.3
Tripeptide-1
0.3
Caprooyl Tetrapeptide-3
0.3
Avena Sativa (Oat) Kernel Protein
0.3
Palmitoyl Oligopeptide
0.3
Palmitoyl Tetrapeptide-7
0.3
Palmitoyl Tripeptide-8
0.3
Palmitoyl Tripeptide-5
0.3
Oligopeptide-4
0.3
Diacetyl Boldine
0.3
Adenosine
0.3
Arginine
0.3
Dipotassium Glycyrrhizate
0.3
Tocopheryl Acetate
0.3
Guanidine HCl
0.3
Glucose
0.3
Dextran
0.3
Bis-PEG-18 Methyl Ether Dimethyl Silane
0.3
Dimethiconol
0.3
PPG-26-Buteth-26
0.3
PEG-40 Hydrogenated Castor Oil
0.3
Acrylates/C10-30 Alkyl Acrylate Crosspolymer
0.3
Sodium Phosphate
0.3
EDTA
0.3
Sodium Chloride
0.3
Sodium Polyacrylate
0.3
Methyl Gluceth-20
0.3
Disodium EDTA
0.3
Carbomer
0.3
Polysorbate 20
0.3
Polysorbate 80
0.3
Xanthan Gum
0.3
Citrus Aurantium Amara (Bitter Orange) Peel Oil
0.3
PVM/MA Copolymer
0.3
Caprylyl Glycol
0.3
Phenoxyethanol
Est. %
Water
Function:
Origin:
Cyclomethicone
Function:
Origin:
Caprylic Acid
Function:
Origin:
Glycerin
Function:
Origin:
Dipropylene Glycol
Function:
Origin:
Sodium Hyaluronate
Function:
Origin:
Dimethicone
Function:
Origin:
PEG/PPG-19/19 Dimethicone
Function:
Origin:
Hydrolyzed Rice Protein
Function:
Origin:
Butylene Glycol
Function:
Origin:
Lecithin
Function:
Origin:
Acetyl sh-Heptapeptide-1
Function:
Origin:
Malus Domestica Fruit Cell Culture Extract
Function:
Origin:
rh-Polypeptide-79
Function:
Origin:
Tripeptide-1
Function:
Origin:
Caprooyl Tetrapeptide-3
Function:
Origin:
Avena Sativa (Oat) Kernel Protein
Function:
Origin:
Palmitoyl Oligopeptide
Function:
Origin:
Palmitoyl Tetrapeptide-7
Function:
Origin:
Palmitoyl Tripeptide-8
Function:
Origin:
Palmitoyl Tripeptide-5
Function:
Origin:
Oligopeptide-4
Function:
Origin:
Diacetyl Boldine
Function:
Origin:
Adenosine
Function:
Origin:
Arginine
Function:
Origin:
Dipotassium Glycyrrhizate
Function:
Origin:
Tocopheryl Acetate
Function:
Origin:
Guanidine HCl
Function:
Origin:
Glucose
Function:
Origin:
Dextran
Function:
Origin:
Bis-PEG-18 Methyl Ether Dimethyl Silane
Function:
Origin:
Dimethiconol
Function:
Origin:
PPG-26-Buteth-26
Function:
Origin:
PEG-40 Hydrogenated Castor Oil
Function:
Origin:
Acrylates/C10-30 Alkyl Acrylate Crosspolymer
Function:
Origin:
Sodium Phosphate
Function:
Origin:
EDTA
Function:
Origin:
Sodium Chloride
Function:
Origin:
Sodium Polyacrylate
Function:
Origin:
Methyl Gluceth-20
Function:
Origin:
Disodium EDTA
Function:
Origin:
Carbomer
Function:
Origin:
Polysorbate 20
Function:
Origin:
Polysorbate 80
Function:
Origin:
Xanthan Gum
Function:
Origin:
Citrus Aurantium Amara (Bitter Orange) Peel Oil
Function:
Origin:
PVM/MA Copolymer
Function:
Origin:
Caprylyl Glycol
Function:
Origin:
Phenoxyethanol
Function:
Origin:

Ratings

All humectants
7.2
3
1.5
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Benchmark
10
All occlusives
1.3
1.3
Benchmark
20
Moisturizing rating
3.9
Ingredient Est. % Benchmark Raiting
Humectancy All humectants 7.2 10
7.2
3
1.5
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Occlusivity All occlusives 1.3 20
0.6
1.3
Moisturizing rating
3.9
Ingredient Est. % Benchmark Humectancy
3
1.5
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
All humectants 7.2 10
7.2
All humectants
7.2
3
1.5
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Benchmark
10
Ingredient Est. % Benchmark Occlusivity
1.3
All occlusives 1.3 20
0.6
All occlusives
1.3
1.3
Benchmark
20
Ingredient
Ingredient anti-wrinkle power
when present at, %
in this formula est. %
Rating
n/a
- 0.3 -
n/a
- 0.3 -
n/a
- 0.3 -
n/a
- 0.3 -
n/a
- 0.3 -
n/a
- 0.3 -
n/a
- 0.3 -
Total
0
Malus Domestica Fruit Cell Culture Extract
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Tripeptide-1
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Caprooyl Tetrapeptide-3
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Palmitoyl Oligopeptide
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Palmitoyl Tetrapeptide-7
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Palmitoyl Tripeptide-5
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Adenosine
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Anti-wrinkle rating
0
Ingredient Est. % Benchmark
Rich in Antioxidants
1.5
0.3
0.3
0.3
All antioxidants 2.4 3 No
All antioxidants
2.4
Sodium Hyaluronate
1.5
Malus Domestica Fruit Cell Culture Extract
0.3
rh-Polypeptide-79
0.3
Tocopheryl Acetate
0.3
Benchmark
3
Ingredient Est. % Benchmark
Rich in Soothing
0.3
All soothing 0.3 5 No
All soothing
0.3
0.3
Benchmark
5

Ingredients explained

Water
Est. %70
Function
Origin
WaterThe most used ingredient in skincare. Its concentration defines the product texture: rich creams may have about 50% of water while a light jelly about 90%. Water doesn’t moisturize the skin by itself and is used in skincare as a solvent for other ingredients.
Cyclomethicone
Est. %6
Function
Origin
CyclomethiconeA blend of emollient silicones that leaves a smooth and non-greasy after-feel. Unlike other types of oils, it does not leave any residue on the skin, which is part of what makes it so popular.
Caprylic Acid
Est. %4
Function
Origin
Caprylic AcidDescription is coming soon
Glycerin
Est. %3
Function
Origin
Glycerin

The most popular moisturizing ingredient in the world. It is a powerful humectant – cheap yet very effective.

Dipropylene Glycol
Est. %2
Function
Origin
Dipropylene GlycolA clear, colorless liquid that has several uses. One of its main functions is as a solvent. Dipropylene glycol is also used to reduce the thickness of skincare products.
Sodium Hyaluronate
Est. %1.5
Function
Origin
Sodium Hyaluronate

A sodium salt of famous hyaluronic acid. A potent humectant that hydrates the skin, supports collagen function, and fills out small wrinkles. Sodium hyaluronate also offers soothing and antioxidant properties.

Dimethicone
Est. %1.3
Function
Origin
DimethiconeThe most common silicone in skincare. It forms a silky, smooth film on the skin’s surface and can help to prevent water loss. It also aids in wound healing and can treat and soften scars. Dimethicone is considered to be very safe for use.
PEG/PPG-19/19 Dimethicone
Est. %1
Function
Origin
PEG/PPG-19/19 DimethiconeDescription is coming soon
Hydrolyzed Rice Protein
Est. %0.3
Function
Origin
Hydrolyzed Rice ProteinA protein derived from rice bran with film-forming abilities. It can help increase moisturization in skin.
Butylene Glycol
Est. %0.3
Function
Origin
Butylene GlycolA clear, colorless liquid humectant that draws moisture to the skin. The humectancy of butylene glycol, owed to its two hydroxyl groups, is quite considerable, although not as powerful as glycerin, which contains three hydroxyl groups.
Lecithin
Est. %0.3
Function
Origin
LecithinA humectant, emollient, and emulsifier best suited for water-in-oil emulsions. Lecithin can come from sunflowers, soy, and eggs. The downside to lecithin is that it causes an extra burden on the formula’s preservative because it is nutritious.
Acetyl sh-Heptapeptide-1
Est. %0.3
Function
Origin
Acetyl sh-Heptapeptide-1Description is coming soon
Malus Domestica Fruit Cell Culture Extract
Est. %0.3
Function
Origin
Malus Domestica Fruit Cell Culture ExtractAn extract that comes from a certain apple cultivar. It is claimed to have superior properties over any other apple extracts and the patent holder claims that it has anti-wrinkle activity.
rh-Polypeptide-79
Est. %0.3
Function
Origin
rh-Polypeptide-79Description is coming soon
Tripeptide-1
Est. %0.3
Function
Origin
Tripeptide-1

A small, skin-identical peptide that boosts collagen renewal in the skin and improves other structural proteins. It may have trouble penetrating the skin in this form, so palmitic acid or biotin is usually added to it.

Caprooyl Tetrapeptide-3
Est. %0.3
Function
Origin
Caprooyl Tetrapeptide-3

A synthetically made peptide that was designed to emulate the skin growth factor. It is said to boost the production of the skin's structural elements and the dermo-epidermal junction, although this has not been independently tested.

Avena Sativa (Oat) Kernel Protein
Est. %0.3
Function
Origin
Avena Sativa (Oat) Kernel ProteinDescription is coming soon
Palmitoyl Oligopeptide
Est. %0.3
Function
Origin
Palmitoyl Oligopeptide

This is an old INCI name that can refer to several other peptides. They are all short fragments of collagen or elastin and function as signal molecules, telling the skin to repair and restructure the dermis, resulting in anti-wrinkle activity.

Palmitoyl Tetrapeptide-7
Est. %0.3
Function
Origin
Palmitoyl Tetrapeptide-7

A synthetic peptide that mimics the activity of immunoglobulin G and signals to the skin to stop the inflammation. It has been shown in studies to reduce wrinkles and enhance collagen content.

Palmitoyl Tripeptide-8
Est. %0.3
Function
Origin
Palmitoyl Tripeptide-8

Description is coming soon

Palmitoyl Tripeptide-5
Est. %0.3
Function
Origin
Palmitoyl Tripeptide-5

A small synthetic peptide that signals the skin to produce more collagen. It has been clinically tested and proven to reduce skin roughness and the appearance of wrinkles.

Oligopeptide-4
Est. %0.3
Function
Origin
Oligopeptide-4Description is coming soon
Diacetyl Boldine
Est. %0.3
Function
Origin
Diacetyl BoldineDescription is coming soon
Adenosine
Est. %0.3
Function
Origin
Adenosine

A key molecule responsible for energy transportation, signaling, and enzyme activity. Adenosine is a popular anti-wrinkle ingredient, however, the key study about its anti-wrinkle efficacy (1) does not meet CreamScan Research Evaluation Standards as it is not double-blind.

Arginine
Est. %0.3
Function
Origin
ArginineA humectant amino acid used to attract water to the skin’s surface. It is a part of the skin's Natural Moisturizing Factor, a mixture of various compounds that keeps the skin’s surface well hydrated. Arginine can also be used as a pH adjuster.
Dipotassium Glycyrrhizate
Est. %0.3
Function
Origin
Dipotassium GlycyrrhizateA licorice root derivative with powerful anti-inflammatory and soothing activities. It is often used as a flavoring agent in lip products.
Tocopheryl Acetate
Est. %0.3
Function
Origin
Tocopheryl Acetate

An antioxidant derivative of tocopherol (vitamin E). It helps to protect cells from free radicals and UV damage through the conversion to active vitamin E in the skin. It is more stable than tocopherol.

Guanidine HCl
Est. %0.3
Function
Origin
Guanidine HClDescription is coming soon
Glucose
Est. %0.3
Function
Origin
GlucoseA simple sugar that is also one of two components of sucrose, or table sugar. It is used as a humectant in skincare products. Glucose is also used to flavor lip care cosmetics because of its mildly sweet taste.
Dextran
Est. %0.3
Function
Origin
DextranA naturally derived sucrose metabolite that thickens water and bulks emulsions.
Bis-PEG-18 Methyl Ether Dimethyl Silane
Est. %0.3
Function
Origin
Bis-PEG-18 Methyl Ether Dimethyl SilaneA silicone with the unusual trait of being able to disperse in water. It moisturizes the skin as a humectant and leaves a soft and smooth after-feel. This ingredient also has foam-boosting properties.
Dimethiconol
Est. %0.3
Function
Origin
DimethiconolA synthetic dimethicone with rich, non-tacky emolliency. It features the typical sensorial profile of silicones, with high spreadability and a luxurious, oil-free after-feel. Dimethiconol can also serve as an antifoaming agent.
PPG-26-Buteth-26
Est. %0.3
Function
Origin
PPG-26-Buteth-26A water-loving surfactant, which means it can act as an emulsifier, solubilizer, and cleansing agent. As an emulsifier, it helps to create oil-in-water emulsions.
PEG-40 Hydrogenated Castor Oil
Est. %0.3
Function
Origin
PEG-40 Hydrogenated Castor OilA castor oil-derived ingredient often used to incorporate small amounts of oil (such as a fragrance) into a water-based product. PEG-4 HCO is a gold-standard solubilizer and can be used in low amounts due to its ability to solubilize things so well.
Acrylates/C10-30 Alkyl Acrylate Crosspolymer
Est. %0.3
Function
Origin
Acrylates/C10-30 Alkyl Acrylate CrosspolymerA synthetic ingredient that is used to thicken water and alcohol. It results in a more lightweight formula and is commonly found in gel products.
Sodium Phosphate
Est. %0.3
Function
Origin
Sodium PhosphateA sodium salt of phosphoric acid that increases pH.
EDTA
Est. %0.3
Function
Origin
EDTAA synthetically produced ingredient that binds certain metal ions. It can help prevent product discoloration or poor performance in rinse-off products used in 'hard' water.
Sodium Chloride
Est. %0.3
Function
Origin
Sodium Chloride

You’re definitely familiar with sodium chloride, even if you don’t think you are. It’s table salt! Salt works well with some cleansing ingredients (surfactants) to thicken them into gels. It also acts as a stabilizer for water-in-oil emulsions.

Sodium Polyacrylate
Est. %0.3
Function
Origin
Sodium PolyacrylateThis white powder is primarily used as a viscosity controlling agent. It is added to the water phase, which then thickens to form a clear gel. Sodium polyacrylate can also serve as an emollient, absorbent, and emulsion stabilizer.
Methyl Gluceth-20
Est. %0.3
Function
Origin
Methyl Gluceth-20A humectant synthetically derived from glucose. It takes on the form of a clear, syrupy liquid.
Disodium EDTA
Est. %0.3
Function
Origin
Disodium EDTAA synthetic chelator that helps to maintain the look and smell of a product by 'locking up' troublesome metal ions.
Carbomer
Est. %0.3
Function
Origin
CarbomerA synthetic ingredient with the ability to gel water. When used in emulsions, such as lotions and creams, carbomer can also act as an emulsion stabilizer.
Polysorbate 20
Est. %0.3
Function
Origin
Polysorbate 20A viscous, amber-colored liquid that functions as a solubilizer to disperse small amounts of oil into a large water phase. Polysorbate 20 is frequently used to solubilize fragrance oils into water-based emulsions.
Polysorbate 80
Est. %0.3
Function
Origin
Polysorbate 80A non-ionic surfactant, which means that it contains no chemical charges. It can be used as a mild cleansing agent in skin cleansing products but is more commonly used for its emulsifying abilities.
Xanthan Gum
Est. %0.3
Function
Origin
Xanthan GumA natural multi-functional ingredient that originates from fermented sugars. Xanthan gum acts as a viscosity-building agent to thicken skincare products. It is also an excellent stabilizer and works well to hold other ingredients together.
Citrus Aurantium Amara (Bitter Orange) Peel Oil
Est. %0.3
Function
Origin
Citrus Aurantium Amara (Bitter Orange) Peel OilA fragrant essential oil obtained from bitter orange fruit peels that almost exclusively consists of limonene. It has a sweet, fresh, citrus scent.
PVM/MA Copolymer
Est. %0.3
Function
Origin
PVM/MA CopolymerDescription is coming soon
Caprylyl Glycol
Est. %0.3
Function
Origin
Caprylyl GlycolAn emollient that improves product spreadability and offers a silky feel on the skin. It also acts as a preservative booster that improves the efficacy of other preservatives. According to the manufacturer, it is also a humectant moisturizer.
Phenoxyethanol
Est. %0.3
Function
Origin
PhenoxyethanolThe most frequently used preservative in skincare. It is a clear, oil-like liquid synthetic substance that protects products from harmful bacteria and yeast, whilst still leaving skin microflora unharmed. It is confirmed by research to be harmless.