SK-II R.N.A. POWER Anti-Aging Face Cream Review

SK-II R.N.A. POWER Anti-Aging Face Cream
6.0
/ 10
Moisturizing
10.0 Humectancy icon Humectancy
2.0 Occlusivity icon Occlusivity
4.5Anti-wrinkle icon/ 10
Anti-wrinkle
Rich
in Antioxidants
Ingredients

SK-II R.N.A. POWER Anti-Aging Face Cream Ingredients

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Full Ingredient List (INCI):

Water, Glycerin, Galactomyces Ferment Filtrate, Isohexadecane, Niacinamide, Isopropyl Isostearate, Butylene Glycol, Butyrospermum Parkii (Shea) Butter, Caprylic/Capric Triglyceride, Pentylene Glycol, Dimethicone, Phytosteryl/Behenyl/Octyldodecyl Lauroyl Glutamate, Vinyl Dimethicone/Methicone Silsesquioxane Crosspolymer, Stearyl Alcohol, Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Cetyl Alcohol, Behenyl Alcohol, Panthenol, Tocopheryl Acetate, Benzyl Alcohol, Dimethiconol, Cetearyl Alcohol, Cetearyl Glucoside, Methylparaben, PEG-100 Stearate, Polymethylsilsesquioxane, Polysorbate 80, Stearic Acid, Disodium EDTA, Propylparaben, Sodium PEG-7 Olive Oil Carboxylate, Ethylparaben, Sorbitan Oleate, Chlorella Vulgaris Extract, PEG-7 Glyceryl Cocoate, Sodium Hydroxide, Fragrance, Acanthopanax Senticosus (Eleuthero) Root Extract, Hydrolyzed Soy Protein, Cynara Scolymus (Artichoke) Leaf Extract, Polyquaternium-7, Hydrolyzed Yeast Protein, Palmitoyl Pentapeptide-4, Methylsilanol Tri-PEG-8 Glyceryl Cocoate, Methicone, Titanium Dioxide (CI 77891), Iron Oxides (CI 77492)
Review

Does SK-II R.N.A. POWER Anti-Aging Face Cream Work?

 
According to CreamScan's analysis of the ingredient list, here’s what SK-II R.N.A. POWER Anti-Aging Face Cream has to offer:
 
✅ Significant moisturizing. It has a moisturizing rating of 6.0 out of 10.
✅ Considerable anti-wrinkle efficacy: SK-II R.N.A. POWER Anti-Aging Face Cream has an anti-wrinkle rating of 4.5 out of 10, indicating a moderate ability to reduce wrinkles.
✅ Antioxidant protection

  

Key Benefits of SK-II R.N.A. POWER Anti-Aging Face Cream

 
These are the key benefits you can expect from using SK-II R.N.A. POWER Anti-Aging Face Cream:
 

🔵 Lightweight Moisturizer Perfect for Combination and Oily Skin

According to CreamScan analysis, SK-II R.N.A. POWER Anti-Aging Face Cream is highly moisturizing, with a moisturizing rating of 6.0 out of 10.

Is it more humectant or occlusive? Significantly more humectant. It has a low occlusivity of 2.0 out of 10 and a maximum humectancy of 10 out of 10, primarily due to the high content of Glycerin (est. ≈9.0%), Galactomyces Ferment Filtrate (est. ≈6.0%) and Niacinamide (est. ≈3.0%).

This type of moisturizer is ideal for people with combination and oily skin who want maximum hydration in a relatively lightweight, non-greasy formula. It combines a significant amount of humectants with a limited amount of occlusive ingredients to boost moisturizing efficacy without feeling too heavy.

This product may also be a good choice for people with normal skin who prefer fast-absorbing textures, as it balances significant moisturizing potential with a relatively lightweight texture.

💧 A Humectant Boost for Any Skincare Routine

But it’s not limited to combination and oily skin - such a humectant boost will also positively contribute to the moisturizing efficacy of any skincare routine when used as a step before applying the main moisturizer. This type of formulation is typically used in serums, where a light, fast-absorbing texture is key.

Please refer to the Ratings section below for details of the moisturizing rating calculation.

🟣🟣 Considerable Anti-Wrinkle Efficacy

According to CreamScan analysis, SK-II R.N.A. POWER Anti-Aging Face Cream has a moderate anti-wrinkle rating of 4.5 out of 10.

It contains one ingredient with proven anti-wrinkle efficacy: Niacinamide (est. ≈3.0%),
 one of the most effective and well-researched anti-wrinkle ingredients. A clinical study involving 30 participants (Kawada et al.) confirmed that a cream with 4% niacinamide reduced the average depth of wrinkles around the eyes by 9% after 8 weeks of use, compared to a vehicle (the same formulation without niacinamide).
 
Among others, SK-II R.N.A. POWER Anti-Aging Face Cream also contains Palmitoyl Pentapeptide-4, an ingredient often marketed as effective in reducing wrinkles. However, the studies supporting the anti-wrinkle claims of Palmitoyl Pentapeptide-4 provide insufficient evidence of its efficacy according to CreamScan Research Evaluation Standards.
 
While this does not categorically rule out the possibility that Palmitoyl Pentapeptide-4 may reduce wrinkles, its efficacy is not supported by convincing, vehicle-controlled, double-blind clinical studies - at least none that were available to the CreamScan team at the time of publication.
 
Therefore, this ingredient does not contribute to the anti-wrinkle rating.
 
📌 Moisturizers, when used regularly, are proven to prevent wrinkle formation and even reduce existing wrinkles. Therefore, this product, like any other moisturizer, can deliver some additional anti-wrinkle effects through its moisturizing action.
 

Please refer to the Ratings section below for details of the anti-wrinkle rating calculation.

🍀 Rich in Skin-Protecting Antioxidants

We estimate that SK-II R.N.A. POWER Anti-Aging Face Cream is rich (> 3%) in antioxidants, specifically Niacinamide (est. ≈3.0%).

A key benefit of antioxidants is their ability to reduce oxidative stress caused by free radicals and therefore prevent accelerated skin aging. Studies also show that antioxidants can protect against environmental damage such as UV radiation and pollution, and help reduce inflammation and skin redness.

📌 Please note that this is not a complete list of benefits. We are in the process of enhancing our model to incorporate anti-pigmentation, exfoliation and anti-acne ratings.

Pros & Cons of SK-II R.N.A. POWER Anti-Aging Face Cream

 
Here’s an overview of the pros and cons of SK-II R.N.A. POWER Anti-Aging Face Cream to help you decide if it’s the right choice for your skincare routine:
 

🟩 Pros:

✅ When used alone: Provides humectant-rich moisturizing perfect for combination and oily skin
✅ Also a good choice for people with normal skin who prefer fast-absorbing textures
✅ As part of a routine: A humectant moisturizing boost, beneficial for any skin type
✅ Lightweight texture
Provides considerable anti-wrinkle efficacy thanks to Niacinamide
✅ Rich in antioxidants that combat oxidative stress associated with accelerated skin aging and defend against environmental damage
 

⭕ Cons: 

✅ We couldn't find any
   

Summary: SK-II R.N.A. POWER Anti-Aging Face Cream

 
Based on the ingredient list analysis, CreamScan AI suggests that SK-II R.N.A. POWER Anti-Aging Face Cream
, when used alone, delivers lightweight, humectant-rich moisturizing, perfect for combination and oily skin. It's also a great option for those with normal skin who prefer fast-absorbing textures. As part of a moisturizing routine, it provides a humectant boost, beneficial for all skin types.
 
SK-II R.N.A. POWER Anti-Aging Face Cream contains ingredients with solid, robust evidence of anti-wrinkle efficacy, in concentrations that may deliver a noticeable anti-wrinkle effect.
 
With its high antioxidant content, SK-II R.N.A. POWER Anti-Aging Face Cream helps protect against free radical damage and offers multiple benefits for all skin types, including preventing premature aging, defending against environmental damage, and calming inflammation.
 
📌 Fact check. At CreamScan, we are committed to accuracy and fairness. If you spot any errors or something that doesn’t seem right, please click here to let us know. We regularly update the ingredient lists and monitor the latest research on ingredient efficacy to ensure that our information remains as complete and precise as possible. The information provided here is for informational purposes only and does not substitute professional advice. We do not guarantee the efficacy or safety of any product, as individual results may vary.

 

Ingredient Breakdown

Est. % Ingredient Origin Functions
60
9
6
4
3
2.5
2
1.5
1.3
1
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Est. %
Water
Function:
Origin:
Glycerin
Function:
Origin:
Galactomyces Ferment Filtrate
Function:
Origin:
Isohexadecane
Function:
Origin:
Niacinamide
Function:
Origin:
Isopropyl Isostearate
Function:
Origin:
Butylene Glycol
Function:
Origin:
Butyrospermum Parkii (Shea) Butter
Function:
Origin:
Caprylic/Capric Triglyceride
Function:
Origin:
Pentylene Glycol
Function:
Origin:
Dimethicone
Function:
Origin:
Phytosteryl/Behenyl/Octyldodecyl Lauroyl Glutamate
Function:
Origin:
Vinyl Dimethicone/Methicone Silsesquioxane Crosspolymer
Function:
Origin:
Stearyl Alcohol
Function:
Origin:
Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer
Function:
Origin:
Cetyl Alcohol
Function:
Origin:
Behenyl Alcohol
Function:
Origin:
Panthenol
Function:
Origin:
Tocopheryl Acetate
Function:
Origin:
Benzyl Alcohol
Function:
Origin:
Dimethiconol
Function:
Origin:
Cetearyl Alcohol
Function:
Origin:
Cetearyl Glucoside
Function:
Origin:
Methylparaben
Function:
Origin:
PEG-100 Stearate
Function:
Origin:
Polymethylsilsesquioxane
Function:
Origin:
Polysorbate 80
Function:
Origin:
Stearic Acid
Function:
Origin:
Disodium EDTA
Function:
Origin:
Propylparaben
Function:
Origin:
Sodium PEG-7 Olive Oil Carboxylate
Function:
Origin:
Ethylparaben
Function:
Origin:
Sorbitan Oleate
Function:
Origin:
Chlorella Vulgaris Extract
Function:
Origin:
PEG-7 Glyceryl Cocoate
Function:
Origin:
Sodium Hydroxide
Function:
Origin:
Fragrance
Function:
Origin:
Acanthopanax Senticosus (Eleuthero) Root Extract
Function:
Origin:
Hydrolyzed Soy Protein
Function:
Origin:
Cynara Scolymus (Artichoke) Leaf Extract
Function:
Origin:
Polyquaternium-7
Function:
Origin:
Hydrolyzed Yeast Protein
Function:
Origin:
Palmitoyl Pentapeptide-4
Function:
Origin:
Methylsilanol Tri-PEG-8 Glyceryl Cocoate
Function:
Origin:
Methicone
Function:
Origin:
Titanium Dioxide (CI 77891)
Function:
Origin:
Iron Oxides (CI 77492)
Function:
Origin:

Ratings

All humectants
21.6
9
6
3
2
1
0.3
0.3
Benchmark
10
All occlusives
4.0
1.5
1.3
0.3
0.3
0.3
0.3
Benchmark
20
Moisturizing rating
6.0
Ingredient Est. % Benchmark Raiting
Humectancy All humectants 21.6 10
10.0
9
6
3
2
1
0.3
0.3
Occlusivity All occlusives 4.0 20
2.0
1.5
1.3
0.3
0.3
0.3
0.3
Moisturizing rating
6.0
Ingredient Est. % Benchmark Humectancy
9
6
3
2
1
0.3
0.3
All humectants 21.6 10
10
All humectants
21.6
9
6
3
2
1
0.3
0.3
Benchmark
10
Ingredient Est. % Benchmark Occlusivity
1.5
1.3
0.3
0.3
0.3
0.3
All occlusives 4.0 20
2.0
All occlusives
4.0
1.5
1.3
0.3
0.3
0.3
0.3
Benchmark
20
Ingredient
Ingredient anti-wrinkle power
when present at, %
in this formula est. %
Rating
6 /10 4 3 4.5
n/a
- 0.3 -
Total
4.5
Niacinamide
4.5
Ingredient anti-wrinkle power
6 /10
when present at, %
4
in this formula, est. %
3
Palmitoyl Pentapeptide-4
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Anti-wrinkle rating
4.5
Ingredient Est. % Benchmark
Rich in Antioxidants
3
0.3
0.3
0.3
All antioxidants 3.9 3 Rich in antioxidants
All antioxidants
3.9
Niacinamide
3
Tocopheryl Acetate
0.3
Chlorella Vulgaris Extract
0.3
Cynara Scolymus (Artichoke) Leaf Extract
0.3
Benchmark
3
Ingredient Est. % Benchmark
Rich in Soothing
3
0.3
0.3
All soothing 3.6 5 No
All soothing
3.6
3
0.3
0.3
Benchmark
5

Ingredients explained

Water
Est. %60
Function
Origin
WaterThe most used ingredient in skincare. Its concentration defines the product texture: rich creams may have about 50% of water while a light jelly about 90%. Water doesn’t moisturize the skin by itself and is used in skincare as a solvent for other ingredients.
Glycerin
Est. %9
Function
Origin
Glycerin

The most popular moisturizing ingredient in the world. It is a powerful humectant – cheap yet very effective.

Galactomyces Ferment Filtrate
Est. %6
Function
Origin
Galactomyces Ferment Filtrate
Isohexadecane
Est. %4
Function
Origin
IsohexadecaneA clear, colorless liquid that is commonly used as an emollient. It is made up of pure hydrocarbons and leaves a dry feeling on the skin upon application. It also increases the spreadability of a product.
Niacinamide
Est. %3
Function
Origin
Niacinamide

Also known as vitamin B3, this ingredient is a true superstar with confirmed moisturizing, anti-acne, hyperpigmentation, and antioxidant benefits. Two studies confirm its significant anti-wrinkle efficacy.

Isopropyl Isostearate
Est. %2.5
Function
Origin
Isopropyl IsostearateA synthetic ester that offers superior spreadability.
Butylene Glycol
Est. %2
Function
Origin
Butylene Glycol

A clear, colorless liquid humectant that draws moisture to the skin. The humectancy of butylene glycol, owed to its two hydroxyl groups, is quite considerable, although not as powerful as glycerin, which contains three hydroxyl groups.

Butyrospermum Parkii (Shea) Butter
Est. %1.5
Function
Origin
Butyrospermum Parkii (Shea) ButterA semi-solid, buttery fat extracted from the seeds of the Shea tree that is a wonderful occlusive and emollient ingredient mainly comprised of fatty acids. Shea butter contains a large amount of anti-inflammatory and antioxidant compounds.
Caprylic/Capric Triglyceride
Est. %1.3
Function
Origin
Caprylic/Capric TriglycerideA natural occlusive moisturizing and emollient ingredient, it is a blend of glycerin and two fatty acids, caprylic and capric acid. It creates an oil-based protective layer on the skin, thereby preventing water loss.
Pentylene Glycol
Est. %1
Function
Origin
Pentylene Glycol

A naturally or synthetically derived preservative that exhibits effective antifungal and antibacterial traits. It also acts as a booster for more traditional preservatives. Pentylene glycol can also serve as a moisturizing humectant and solvent.

Dimethicone
Est. %0.3
Function
Origin
DimethiconeThe most common silicone in skincare. It forms a silky, smooth film on the skin’s surface and can help to prevent water loss. It also aids in wound healing and can treat and soften scars. Dimethicone is considered to be very safe for use.
Phytosteryl/Behenyl/Octyldodecyl Lauroyl Glutamate
Est. %0.3
Function
Origin
Phytosteryl/Behenyl/Octyldodecyl Lauroyl Glutamate
Vinyl Dimethicone/Methicone Silsesquioxane Crosspolymer
Est. %0.3
Function
Origin
Vinyl Dimethicone/Methicone Silsesquioxane Crosspolymer
Stearyl Alcohol
Est. %0.3
Function
Origin
Stearyl AlcoholA natural fatty alcohol that thickens, stabilizes, and keeps emulsions a bright white color. It has many uses, the main one being as an emulsifier. It also acts as an opacifying agent and emollient.
Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer
Est. %0.3
Function
Origin
Sodium Acrylate/Sodium Acryloyldimethyl Taurate CopolymerA multi-functional ingredient that forms a polymeric network, thereby thickening the formula and preventing other ingredients from shifting around.
Cetyl Alcohol
Est. %0.3
Function
Origin
Cetyl AlcoholA waxy solid fatty alcohol derived from palm oil. It is most commonly used as a co-emulsifier and affects the final aesthetic of the product, leaving a soft and silky feeling on the skin. Cetyl alcohol is also used as a viscosity controlling agent.
Behenyl Alcohol
Est. %0.3
Function
Origin
Behenyl AlcoholA fatty alcohol with emollient properties. It is used as a co-emulsifier and thickener and tends to result in a product with a smooth and creamy application texture.
Panthenol
Est. %0.3
Function
Origin
PanthenolA popular soothing and moisturizing derivative of vitamin B5. Panthenol is particularly beneficial for dry, flaking, burned, or damaged skin. It is used to alleviate the symptoms of a rash, dermatitis, eczema, chapped lips, and sunburn.
Tocopheryl Acetate
Est. %0.3
Function
Origin
Tocopheryl Acetate

An antioxidant derivative of tocopherol (vitamin E). It helps to protect cells from free radicals and UV damage through the conversion to active vitamin E in the skin. It is more stable than tocopherol.

Benzyl Alcohol
Est. %0.3
Function
Origin
Benzyl Alcohol

A multifunctional ingredient that is supplied as a clear, colorless liquid. Its main function is as a flavoring agent and fragrance. It also acts as a broad-spectrum preservative, solvent, and viscosity-controlling agent that thins the product.

Dimethiconol
Est. %0.3
Function
Origin
DimethiconolA synthetic dimethicone with rich, non-tacky emolliency. It features the typical sensorial profile of silicones, with high spreadability and a luxurious, oil-free after-feel. Dimethiconol can also serve as an antifoaming agent.
Cetearyl Alcohol
Est. %0.3
Function
Origin
Cetearyl AlcoholA blend of cetyl alcohol and stearyl alcohol, the fatty alcohols that are derived from palm oil. It helps to create emulsions that give off a soft and silky emollient feel and also increase product thickness.
Cetearyl Glucoside
Est. %0.3
Function
Origin
Cetearyl GlucosideAn emulsifier that creates stable mixtures of oil in water that feel soft and spread easily. Cetearyl glucoside is sold with cetearyl alcohol as an emulsifier blend and also provides some body to the formula.
Methylparaben
Est. %0.3
Function
Origin
MethylparabenA preservative that keeps a product unspoiled. There has been a lot of controversy surrounding parabens, although the concentrations found in cosmetic formulations are generally considered to be safe.
PEG-100 Stearate
Est. %0.3
Function
Origin
PEG-100 StearateThis surfactant is more specifically classified as an emulsifier that produces oil-in-water emulsions. PEG-100 stearate can also be used as a cleansing agent.
Polymethylsilsesquioxane
Est. %0.3
Function
Origin
PolymethylsilsesquioxaneA type of spherical powder that functions on a ball-bearing effect in which the tiny microspheres roll around on the skin and create lubricity. Polymethylsilsesquioxane offers extra slip to skincare products and makes the skin feel soft and smooth.
Polysorbate 80
Est. %0.3
Function
Origin
Polysorbate 80A non-ionic surfactant, which means that it contains no chemical charges. It can be used as a mild cleansing agent in skin cleansing products but is more commonly used for its emulsifying abilities.
Stearic Acid
Est. %0.3
Function
Origin
Stearic AcidA saturated fatty acid found in vegetable butter and animal fats. It is an occlusive moisturizing and emollient ingredient and also helps to maintain the barrier function of the skin.
Disodium EDTA
Est. %0.3
Function
Origin
Disodium EDTAA synthetic chelator that helps to maintain the look and smell of a product by 'locking up' troublesome metal ions.
Propylparaben
Est. %0.3
Function
Origin
PropylparabenA preservative that keeps a product unspoiled. There has been a lot of controversy surrounding parabens, although the concentrations found in cosmetic formulations are generally considered to be safe.
Sodium PEG-7 Olive Oil Carboxylate
Est. %0.3
Function
Origin
Sodium PEG-7 Olive Oil Carboxylate
Ethylparaben
Est. %0.3
Function
Origin
EthylparabenA cost-effective preservative that belongs to the group of parabens. There has been a lot of controversy surrounding parabens, although the concentrations found in cosmetic formulations are generally considered to be safe.
Sorbitan Oleate
Est. %0.3
Function
Origin
Sorbitan OleateA vegetable-based ingredient that stabilizes mixtures of oil and water. Sorbitan oleate serves primarily as an emulsifier that produces water-in-oil emulsions.
Chlorella Vulgaris Extract
Est. %0.3
Function
Origin
Chlorella Vulgaris ExtractA dried mass of tiny, single-cell green algae. It is widely used as a food source or dietary supplement since it is rich in proteins, amino acids, minerals, and vitamins. This dark green extract is used as an antioxidant agent in skincare.
PEG-7 Glyceryl Cocoate
Est. %0.3
Function
Origin
PEG-7 Glyceryl Cocoate

A clear, pale yellow, oil-like emollient manufactured synthetically from coconut oil and polyethylene glycol. It is also used as an emulsifying agent.

Sodium Hydroxide
Est. %0.3
Function
Origin
Sodium Hydroxide

An ingredient that is able to bring the pH of a product up, thereby making it less harsh on the skin.

Fragrance
Est. %0.3
Function
Origin
FragranceUnder trade secret law, manufacturers have the right not to disclose what exactly went into the fragrance and use the unspecific word Fragrance or Parfum instead. Many fragrances are highly allergenic.
Acanthopanax Senticosus (Eleuthero) Root Extract
Est. %0.3
Function
Origin
Acanthopanax Senticosus (Eleuthero) Root Extract
Hydrolyzed Soy Protein
Est. %0.3
Function
Origin
Hydrolyzed Soy ProteinA mixture of proteins obtained from soybeans. It can have many different functions depending on the manufacturer, although it is most commonly used in skincare products as a humectant moisturizing ingredient.
Cynara Scolymus (Artichoke) Leaf Extract
Est. %0.3
Function
Origin
Cynara Scolymus (Artichoke) Leaf ExtractDerived from globe artichokes, this ingredient contains plenty of antioxidant compounds such as flavonoids, organic acids, and other polyphenols.
Polyquaternium-7
Est. %0.3
Function
Origin
Polyquaternium-7A positively-charged ingredient that forms films to protect the rest of the product.
Hydrolyzed Yeast Protein
Est. %0.3
Function
Origin
Hydrolyzed Yeast Protein
Palmitoyl Pentapeptide-4
Est. %0.3
Function
Origin
Palmitoyl Pentapeptide-4

A famous synthetically made peptide that works as a signal peptide, telling skin cells to create more collagen and other structural proteins. It has been clinically tested and found to be effective at reducing fine wrinkles.

Methylsilanol Tri-PEG-8 Glyceryl Cocoate
Est. %0.3
Function
Origin
Methylsilanol Tri-PEG-8 Glyceryl Cocoate
Methicone
Est. %0.3
Function
Origin
MethiconeA silicone oil that can function as an occlusive moisturizer and emollient. Occasionally, methicone is used as a surface modifier for various pigments to improve the longevity and vibrancy of colorants.
Titanium Dioxide (CI 77891)
Est. %0.3
Function
Origin
Titanium Dioxide (CI 77891)One of two the most commonly used mineral sunscreens. It can absorb UV light, including UVB – which causes burning, tanning, and even skin cancer. Also used as a colorant, titanium dioxide gives a product a bright white color.
Iron Oxides (CI 77492)
Est. %0.3
Function
Origin
Iron Oxides (CI 77492)Also known as iron (III) oxide, this ingredient is a yellow-colored pigment that can either be derived from minerals or produced synthetically. It adds yellow tones to cosmetic products.