Replenix Enriched Nighttime Bio-Therapy

Replenix Enriched Nighttime Bio-Therapy
6.0
/ 10
Moisturizing
10.0 Humectancy icon Humectancy
2.0 Occlusivity icon Occlusivity
3Anti-wrinkle icon/ 10
Anti-wrinkle
Rich
in Antioxidants
$$$$

Review

Results you may expect from using Replenix Enriched Nighttime Bio-Therapy:

Based on the ingredient analysis by CreamScan, these are the key benefits you can expect from using Replenix Enriched Nighttime Bio-Therapy:

  • Significant moisturizing. It has a moisturizing rating of 6.0 out of 10.
  • Some anti-wrinkle efficacy: Replenix Enriched Nighttime Bio-Therapy has an anti-wrinkle rating of 3.0 out of 10 so you may expect some, although limited, effect on wrinkles.
  • Antioxidant protection.

How moisturizing is it?

Highly moisturizing: Replenix Enriched Nighttime Bio-Therapy has a moisturizing rating of 6.0 out of 10.

Is it more humectant or occlusive? Significantly more humectant. It has a low occlusivity of 2.0 out of 10 and a maximum humectancy of 10 out of 10, primarily due to the high content of Glycerin (est. ≈9.0%), Butylene Glycol (est. ≈6.0%) and Niacinamide (est. ≈2.0%).

Please refer to the Ratings section below for details of the moisturizing rating calculation.

Anti-wrinkle efficacy

According to CreamScan analysis, Replenix Enriched Nighttime Bio-Therapy has a slight anti-wrinkle rating of 3.0 out of 10. It contains one ingredient with proven anti-wrinkle efficacy: Niacinamide (est. ≈2.0%), 
 one of the most effective and well-researched anti-wrinkle ingredients.
 
Among others, Replenix Enriched Nighttime Bio-Therapy also contains some ingredients marketed as effective in reducing wrinkles, specifically Malus Domestica Fruit Cell Culture Extract, Tetrapeptide-21, and Caffeine. However, the studies supporting the anti-wrinkle claims of these ingredients provide insufficient evidence of efficacy according to CreamScan Research Evaluation Standards. Therefore, these ingredients do not contribute to the anti-wrinkle rating.
 
Moisturizers, when used regularly, are proven to prevent wrinkle formation and even reduce existing wrinkles. Therefore, this product, like any other moisturizer, could deliver additional anti-wrinkle efficacy through its moisturizing action.
 

Please refer to the Ratings section below for details of the anti-wrinkle rating calculation.

Antioxidant benefits

We estimate that Replenix Enriched Nighttime Bio-Therapy is rich (> 3%) in antioxidants, specifically Niacinamide (est. ≈2.0%).

A key benefit of antioxidants is their ability to reduce oxidative stress caused by free radicals and therefore prevent accelerated skin aging. Studies also show that antioxidants can protect against environmental damage such as UV radiation and pollution, and help reduce inflammation and skin redness.

Ingredients

Est. % Ingredient Origin Functions
60
9
6
4
3
2.5
2
1.5
1.3
1
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
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Ratings

All humectants
20.4
9
6
2
1.5
1.3
0.3
0.3
Benchmark
10
All occlusives
4.0
4.0
Benchmark
20
Moisturizing rating
6.0
Ingredient Est. % Benchmark Raiting
Humectancy All humectants 20.4 10
10.0
9
6
2
1.5
1.3
0.3
0.3
Occlusivity All occlusives 4.0 20
2.0
4.0
Moisturizing rating
6.0
Ingredient Est. % Benchmark Humectancy
9
6
2
1.5
1.3
0.3
0.3
All humectants 20.4 10
10
All humectants
20.4
9
6
2
1.5
1.3
0.3
0.3
Benchmark
10
Ingredient Est. % Benchmark Occlusivity
4
All occlusives 4.0 20
2.0
All occlusives
4.0
4.0
Benchmark
20
Ingredient
Ingredient anti-wrinkle power
when present at, %
in this formula est. %
Rating
6 /10 4 2 3
n/a
- 0.3 -
n/a
- 0.3 -
n/a
- 0.3 -
Total
3
Niacinamide
3
Ingredient anti-wrinkle power
6 /10
when present at, %
4
in this formula, est. %
2
Malus Domestica Fruit Cell Culture Extract
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Tetrapeptide-21
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Caffeine
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Anti-wrinkle rating
3
Ingredient Est. % Benchmark
Rich in Antioxidants
2
1.5
1.3
0.3
0.3
0.3
0.3
0.3
All antioxidants 6.3 3 Rich in antioxidants
All antioxidants
6.3
Niacinamide
2
Sodium Hyaluronate
1.5
Hydrolyzed Sodium Hyaluronate
1.3
Tocopheryl Acetate
0.3
Camellia Sinensis Polyphenols
0.3
Malus Domestica Fruit Cell Culture Extract
0.3
Resveratrol
0.3
Caffeine
0.3
Benchmark
3
Ingredient Est. % Benchmark
Rich in Soothing
2
0.3
All soothing 2.3 5 No
All soothing
2.3
2
0.3
Benchmark
5

Ingredients explained

Water
Est. %60
Function
Origin
The most used ingredient in skincare. Its concentration defines the product texture: rich creams may have about 50% of water while a light jelly about 90%. Water doesn’t moisturize the skin by itself and is used in skincare as a solvent for other ingredients.
Glycerin
Est. %9
Function
Origin

The most popular moisturizing ingredient in the world. It is a powerful humectant – cheap yet very effective.

Butylene Glycol
Est. %6
Function
Origin
A clear, colorless liquid humectant that draws moisture to the skin. The humectancy of butylene glycol, owed to its two hydroxyl groups, is quite considerable, although not as powerful as glycerin, which contains three hydroxyl groups.
Dimethicone
Est. %4
Function
Origin
The most common silicone in skincare. It forms a silky, smooth film on the skin’s surface and can help to prevent water loss. It also aids in wound healing and can treat and soften scars. Dimethicone is considered to be very safe for use.
C12-15 Alkyl Benzoate
Est. %3
Function
Origin
A synthetic emollient ester. It works to improve the appearance of the skin by filling in the microcracks on the surface, thereby making the skin appear softer and smoother. It imparts a lightweight, velvety feel.
Hydrogenated Polyisobutene
Est. %2.5
Function
Origin
A viscous liquid that makes a great oil base due to its smooth sensorial profile. It has emollient features, including good spreadability and little tack upon application. It also has the added benefit of being able to thicken products.
Niacinamide
Est. %2
Function
Origin

Also known as vitamin B3, this ingredient is a true superstar with confirmed moisturizing, anti-acne, hyperpigmentation, and antioxidant benefits. Two studies confirm its significant anti-wrinkle efficacy.

Sodium Hyaluronate
Est. %1.5
Function
Origin
A sodium salt of famous hyaluronic acid. A potent humectant that hydrates the skin, supports collagen function, and fills out small wrinkles. Sodium hyaluronate also offers soothing and antioxidant properties.
Hydrolyzed Sodium Hyaluronate
Est. %1.3
Function
Origin
A very small-molecule version of regular sodium hyaluronate. It is a powerful humectant skin-identical ingredient that absorbs into the skin and offers plumping, smoothing, and anti-wrinkle effects.
Cetearyl Alcohol
Est. %1
Function
Origin
A blend of cetyl alcohol and stearyl alcohol, the fatty alcohols that are derived from palm oil. It helps to create emulsions that give off a soft and silky emollient feel and also increase product thickness.
Cetearyl Glucoside
Est. %0.3
Function
Origin
An emulsifier that creates stable mixtures of oil in water that feel soft and spread easily. Cetearyl glucoside is sold with cetearyl alcohol as an emulsifier blend and also provides some body to the formula.
Ceramide NP
Est. %0.3
Function
Origin
Also known as ceramide 3, it is the most common ceramide in our skin. It helps to restore the skin’s lipid barrier and alleviate the symptoms of dry and cracked skin. Research has shown that skin suffering from conditions such as AD lacks ceramides.
Ceramide AP
Est. %0.3
Function
Origin
Previously called Ceramide 6 II, Ceramide AP is one of the most common ceramides in the skin. Research has shown that dry, flaky skin has significantly less Ceramide AP. Its application helps to treat dry skin by restoring balance in the skin lipids.
Ceramide EOP
Est. %0.3
Function
Origin
Formerly called Ceramide 1, this ingredient is a skin-identical wax-like lipid with an ultra-long fatty acid chain. It restores and stabilizes the skin’s lipid matrix and helps to treat dry and flaky skin, especially when combined with other ceramides.
Ceramide NS
Est. %0.3
Function
Origin
A wax-like lipid natural to the skin’s lipid matrix. It is less frequently used but, in combination with other ceramides, can help to restore balance in the skin’s lipid barrier.
Phytosphingosine
Est. %0.3
Function
Origin
A key component of ceramides NP, AP, and EOP. It has barrier repair properties and stimulates the production of the skin’s Natural Moisturizing Factor. Phytosphingosine has strong antimicrobial and anti-inflammatory activity, which can be used to treat acne.
Cholesterol
Est. %0.3
Function
Origin
An emollient and important barrier repairing lipid, effective when combined with fatty acids and ceramides. Around 25% of the skin’s lipid layer is made up of cholesterol and it is found in the membrane of every single cell in our body.
Sodium Lauroyl Lactylate
Est. %0.3
Function
Origin
A multifunctional ingredient that produces foamy cleansers and allows oil and water to mix.
Polyacrylamide
Est. %0.3
Function
Origin
A synthetic ingredient that can thicken products instantly while still keeping them light and often gel-like.
C13-14 Isoparaffin
Est. %0.3
Function
Origin
A lightweight petroleum derivative. It is a very thin liquid that functions as an emollient and a solvent for other liquids (such as thicker oils or silicones).
Laureth-7
Est. %0.3
Function
Origin
A mild but effective functional ingredient. It can emulsify (efficiently mix water and oil) without needing too much in a formula.
Tocopheryl Acetate
Est. %0.3
Function
Origin
An antioxidant derivative of tocopherol (vitamin E). It helps to protect cells from free radicals and UV damage through the conversion to active vitamin E in the skin. It is more stable than tocopherol.
Camellia Sinensis Polyphenols
Est. %0.3
Function
Origin
Description is coming soon
Malus Domestica Fruit Cell Culture Extract
Est. %0.3
Function
Origin
An extract that comes from a certain apple cultivar. It is claimed to have superior properties over any other apple extracts and the patent holder claims that it has anti-wrinkle activity.
PEG-40 Stearate
Est. %0.3
Function
Origin
This PEG, or polyethylene glycol, is excellent at emulsifying water and oil together to form oil-in-water emulsions. Due to its water-loving nature, PEG-40 stearate can also act as a cleansing agent.
Stearyl Alcohol
Est. %0.3
Function
Origin
A natural fatty alcohol that thickens, stabilizes, and keeps emulsions a bright white color. It has many uses, the main one being as an emulsifier. It also acts as an opacifying agent and emollient.
Behenyl Alcohol
Est. %0.3
Function
Origin
A fatty alcohol with emollient properties. It is used as a co-emulsifier and thickener and tends to result in a product with a smooth and creamy application texture.
Cetyl Alcohol
Est. %0.3
Function
Origin
A waxy solid fatty alcohol derived from palm oil. It is most commonly used as a co-emulsifier and affects the final aesthetic of the product, leaving a soft and silky feeling on the skin. Cetyl alcohol is also used as a viscosity controlling agent.
Tetrapeptide-21
Est. %0.3
Function
Origin

A synthetically made peptide (similar to skin proteins) designed to increase the synthesis of collagen, HA, and fibronectin. It has been clinically proven to improve skin quality and elasticity, as well as the appearance of wrinkles.

Resveratrol
Est. %0.3
Function
Origin
A famous plant-based polyphenol found mainly in red grapes. It is a potent antioxidant, soothing, and wound healing ingredient.
Caffeine
Est. %0.3
Function
Origin
An antioxidant compound that is obtained from coffee and tea leaves. It increases the microcirculation of blood in the skin and is claimed to be able to reduce the appearance of orange peel skin (although the research is lacking).
Lecithin
Est. %0.3
Function
Origin
A humectant, emollient, and emulsifier best suited for water-in-oil emulsions. Lecithin can come from sunflowers, soy, and eggs. The downside to lecithin is that it causes an extra burden on the formula’s preservative because it is nutritious.
Glyceryl Stearate
Est. %0.3
Function
Origin
An emollient and emulsifier typically derived from vegetable sources through a chemical reaction with glycerin. It provides stability, texture, and consistency to formulations. Its main function is to allow oil and water to mix.
Xanthan Gum
Est. %0.3
Function
Origin
A natural multi-functional ingredient that originates from fermented sugars. Xanthan gum acts as a viscosity-building agent to thicken skincare products. It is also an excellent stabilizer and works well to hold other ingredients together.
Carbomer
Est. %0.3
Function
Origin
A synthetic ingredient with the ability to gel water. When used in emulsions, such as lotions and creams, carbomer can also act as an emulsion stabilizer.
Phenoxyethanol
Est. %0.3
Function
Origin
The most frequently used preservative in skincare. It is a clear, oil-like liquid synthetic substance that protects products from harmful bacteria and yeast, whilst still leaving skin microflora unharmed. It is confirmed by research to be harmless.
Sorbic Acid
Est. %0.3
Function
Origin
An organic acid that can be naturally found in the berries of the Mountain ash, although it is manufactured synthetically for skincare purposes. It is used as a preservative and antimicrobial agent, protecting a skincare product from spoiling.
Caprylyl Glycol
Est. %0.3
Function
Origin
An emollient that improves product spreadability and offers a silky feel on the skin. It also acts as a preservative booster that improves the efficacy of other preservatives. According to the manufacturer, it is also a humectant moisturizer.
Potassium Hydroxide
Est. %0.3
Function
Origin
A very alkaline ingredient, meaning that it has a high pH. Potassium hydroxide is therefore useful in bringing a low pH in a cosmetic product up to a more neutral, skin-safe level.
Titanium Dioxide (CI 77891)
Est. %0.3
Function
Origin
One of two the most commonly used mineral sunscreens. It can absorb UV light, including UVB – which causes burning, tanning, and even skin cancer. Also used as a colorant, titanium dioxide gives a product a bright white color.
Disodium EDTA
Est. %0.3
Function
Origin
A synthetic chelator that helps to maintain the look and smell of a product by 'locking up' troublesome metal ions.