Perricone MD Neuropeptide Night Cream

Perricone MD Neuropeptide Night Cream
7.2
/ 10
Moisturizing
10.0 Humectancy icon Humectancy
4.4 Occlusivity icon Occlusivity

Review

Does Perricone MD Neuropeptide Night Cream work?

Based on the ingredient list analysis by CreamScan AI, these are the key benefits you can expect from using Perricone MD Neuropeptide Night Cream:

  • Significant moisturizing. It has a moisturizing rating of 7.2 out of 10.

Perfect moisturizer for normal to dry skin with a relatively lightweight texture

According to CreamScan analysis, Perricone MD Neuropeptide Night Cream is highly moisturizing, with a moisturizing rating of 7.2 out of 10.

Is it more humectant or occlusive? Significantly more humectant. It has a maximum humectancy of 10 out of 10, primarily due to the substantial concentration of Glycerin (est. ≈9.0%), and a moderate occlusivity of 4.4 out of 10, mainly due to the high content of Pentaerythrityl Tetraethylhexanoate (est. ≈4.0%) and Butyrospermum Parkii (Shea) Butter (est. ≈2.5%).

This type of moisturizer is ideal for people with normal skin. It combines a high concentration of humectants with a significant amount of occlusive ingredients to deliver effective dual-action moisturizing for normal skin.

This product may also be a good choice for people with normal to dry skin for daily hydration, as it balances significant moisturizing potential with a relatively lightweight texture.

Please refer to the Ratings section below for details of the moisturizing rating calculation.

Questionable anti-wrinkle efficacy

According to CreamScan analysis, Perricone MD Neuropeptide Night Cream has a zero anti-wrinkle rating.

It contains some ingredients often marketed as effective in reducing wrinkles, specifically Dimethyl MEA, Acetyl Hexapeptide-8, Tetrapeptide-21, Palmitoyl Tetrapeptide-7, and Palmitoyl Hexapeptide-12. However, the studies supporting the anti-wrinkle claims of these ingredients provide insufficient evidence of efficacy according to CreamScan Research Evaluation Standards. Therefore, these ingredients do not generate the anti-wrinkle rating.

Moisturizers, when used regularly, are proven to prevent wrinkle formation and even reduce existing wrinkles. Therefore, this product, like any other moisturizer, can deliver some anti-wrinkle effects through its moisturizing action.

Please refer to the Ratings section below for details of the anti-wrinkle rating calculation.

Ingredients

Est. % Ingredient Origin Functions
55
9
6
4
3
2.5
2
1.5
1.3
1
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Est. %
Water
Function:
Origin:
Glycerin
Function:
Origin:
Isononyl Isononanoate
Function:
Origin:
Pentaerythrityl Tetraethylhexanoate
Function:
Origin:
Cetearyl Alcohol
Function:
Origin:
Butyrospermum Parkii (Shea) Butter
Function:
Origin:
C12-20 Acid PEG-8 Ester
Function:
Origin:
Dimethyl Isosorbide
Function:
Origin:
C10-18 Triglycerides
Function:
Origin:
Isodecyl Salicylate
Function:
Origin:
Butylene Glycol
Function:
Origin:
Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer
Function:
Origin:
Squalane
Function:
Origin:
C12-15 Alkyl Benzoate
Function:
Origin:
Dimethicone
Function:
Origin:
Polymethyl Methacrylate
Function:
Origin:
Dimethyl MEA
Function:
Origin:
Acetyl Hexapeptide-8
Function:
Origin:
Pentapeptide-18
Function:
Origin:
Tetrapeptide-21
Function:
Origin:
Dipeptide-2
Function:
Origin:
Palmitoyl Tetrapeptide-7
Function:
Origin:
Palmitoyl Hexapeptide-12
Function:
Origin:
Tyrosine
Function:
Origin:
Tocopheryl Acetate
Function:
Origin:
Dipotassium Glycyrrhizate
Function:
Origin:
Hesperidin Methyl Chalcone
Function:
Origin:
Ceramide NG
Function:
Origin:
Fructose
Function:
Origin:
Allantoin
Function:
Origin:
Trehalose
Function:
Origin:
Maltose
Function:
Origin:
Glucose
Function:
Origin:
Sodium Hyaluronate
Function:
Origin:
Citric Acid
Function:
Origin:
Sodium Hydroxide
Function:
Origin:
Disodium EDTA
Function:
Origin:
Sodium Chloride
Function:
Origin:
Steareth-20
Function:
Origin:
Polysorbate 60
Function:
Origin:
Caprylyl Glycol
Function:
Origin:
Tribehenin
Function:
Origin:
Coco-Glucoside
Function:
Origin:
Pentylene Glycol
Function:
Origin:
Hexylene Glycol
Function:
Origin:
Urea
Function:
Origin:
PEG-10 Rapeseed Sterol
Function:
Origin:
Sodium Lactate
Function:
Origin:
Sodium PCA
Function:
Origin:
Phenoxyethanol
Function:
Origin:
Potassium Sorbate
Function:
Origin:
Fragrance
Function:
Origin:
Linalool
Function:
Origin:
Limonene
Function:
Origin:

Ratings

All humectants
13.2
9
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Benchmark
10
All occlusives
8.7
4.0
2.5
1.3
0.3
0.3
0.3
Benchmark
20
Moisturizing rating
7.2
Ingredient Est. % Benchmark Raiting
Humectancy All humectants 13.2 10
10.0
9
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Occlusivity All occlusives 8.7 20
4.4
4.0
2.5
1.3
0.3
0.3
0.3
Moisturizing rating
7.2
Ingredient Est. % Benchmark Humectancy
9
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
All humectants 13.2 10
10
All humectants
13.2
9
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Benchmark
10
Ingredient Est. % Benchmark Occlusivity
4
2.5
1.3
0.3
0.3
0.3
All occlusives 8.7 20
4.4
All occlusives
8.7
4.0
2.5
1.3
0.3
0.3
0.3
Benchmark
20
Ingredient
Ingredient anti-wrinkle power
when present at, %
in this formula est. %
Rating
n/a
- 0.3 -
n/a
- 0.3 -
n/a
- 0.3 -
n/a
- 0.3 -
n/a
- 0.3 -
Total
0
Dimethyl MEA
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Acetyl Hexapeptide-8
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Tetrapeptide-21
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Palmitoyl Tetrapeptide-7
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Palmitoyl Hexapeptide-12
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Anti-wrinkle rating
0
Ingredient Est. % Benchmark
Rich in Antioxidants
0.3
0.3
0.3
0.3
All antioxidants 1.2 3 No
All antioxidants
1.2
Palmitoyl Hexapeptide-12
0.3
Tocopheryl Acetate
0.3
Hesperidin Methyl Chalcone
0.3
Sodium Hyaluronate
0.3
Benchmark
3
Ingredient Est. % Benchmark
Rich in Soothing
0.3
0.3
0.3
All soothing 0.9 5 No
All soothing
0.9
0.3
0.3
0.3
Benchmark
5

Ingredients explained

Water
Est. %55
Function
Origin
WaterThe most used ingredient in skincare. Its concentration defines the product texture: rich creams may have about 50% of water while a light jelly about 90%. Water doesn’t moisturize the skin by itself and is used in skincare as a solvent for other ingredients.
Glycerin
Est. %9
Function
Origin
Glycerin

The most popular moisturizing ingredient in the world. It is a powerful humectant – cheap yet very effective.

Isononyl Isononanoate
Est. %6
Function
Origin
Isononyl IsononanoateAn ester of a branched fatty acid with a branched fatty alcohol. It is an easily spreadable emollient that has a silky, dry, non-greasy feel on the skin.
Pentaerythrityl Tetraethylhexanoate
Est. %4
Function
Origin
Pentaerythrityl TetraethylhexanoateAn occlusive moisturizer and emollient with a good lubricity that leaves behind a glossy sheen after application. It can also control viscosity by thickening skincare products and act as a binding agent to hold pressed powdered products together.
Cetearyl Alcohol
Est. %3
Function
Origin
Cetearyl AlcoholA blend of cetyl alcohol and stearyl alcohol, the fatty alcohols that are derived from palm oil. It helps to create emulsions that give off a soft and silky emollient feel and also increase product thickness.
Butyrospermum Parkii (Shea) Butter
Est. %2.5
Function
Origin
Butyrospermum Parkii (Shea) ButterA semi-solid, buttery fat extracted from the seeds of the Shea tree that is a wonderful occlusive and emollient ingredient mainly comprised of fatty acids. Shea butter contains a large amount of anti-inflammatory and antioxidant compounds.
C12-20 Acid PEG-8 Ester
Est. %2
Function
Origin
C12-20 Acid PEG-8 EsterA powerful synthetic emulsifier that is very gentle to the skin.
Dimethyl Isosorbide
Est. %1.5
Function
Origin
Dimethyl IsosorbideA solvent for active ingredients that is claimed to help them better penetrate the outer layer of skin. It also helps to reduce the thickness of a product.
C10-18 Triglycerides
Est. %1.3
Function
Origin
C10-18 TriglyceridesAn occlusive ingredient that helps lock in moisture. It provides a soft, smooth feel and melts at body temperature.
Isodecyl Salicylate
Est. %1
Function
Origin
Isodecyl Salicylate
Butylene Glycol
Est. %0.3
Function
Origin
Butylene Glycol

A clear, colorless liquid humectant that draws moisture to the skin. The humectancy of butylene glycol, owed to its two hydroxyl groups, is quite considerable, although not as powerful as glycerin, which contains three hydroxyl groups.

Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer
Est. %0.3
Function
Origin
Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate CopolymerAn emulsion stabilizer and thickener that helps to create a pleasant, satiny, and light formula texture. It works by forming a gel-like network within water or oil, which both stabilizes other ingredients and produces a thickening effect.
Squalane
Est. %0.3
Function
Origin
SqualaneAn occlusive moisturizing and emollient compound that forms part of the skin’s sebum. The main source of squalane had always been shark liver. Now, however, it is manufactured synthetically or derived from plant oils, such as olive and peanut oil.
C12-15 Alkyl Benzoate
Est. %0.3
Function
Origin
C12-15 Alkyl BenzoateA synthetic emollient ester. It works to improve the appearance of the skin by filling in the microcracks on the surface, thereby making the skin appear softer and smoother. It imparts a lightweight, velvety feel.
Dimethicone
Est. %0.3
Function
Origin
DimethiconeThe most common silicone in skincare. It forms a silky, smooth film on the skin’s surface and can help to prevent water loss. It also aids in wound healing and can treat and soften scars. Dimethicone is considered to be very safe for use.
Polymethyl Methacrylate
Est. %0.3
Function
Origin
Polymethyl MethacrylateA powdered ingredient with an impressive sensory profile that gives off a creamy, sometimes velvety feeling on the skin. It is made up of tiny microspheres that roll smoothly across the skin and create slip and high spreadability.
Dimethyl MEA
Est. %0.3
Function
Origin
Dimethyl MEA

Dimethyl MEA, also known as DMAE, or deanol, is a colorless liquid with a fishy smell. It can also be supplied as a crystalline white powder. Some studies suggest it may have some effects on skin firmness. Additionally, DMAE is used to regulate pH balance. It has the potential to be toxic.

Acetyl Hexapeptide-8
Est. %0.3
Function
Origin
Acetyl Hexapeptide-8

A small synthetic peptide that is thought to act similarly to Botox by calming contractions of the facial muscles and reducing expression wrinkles. The effect is only temporary and it does not improve the skin structure in any way.

Pentapeptide-18
Est. %0.3
Function
Origin
Pentapeptide-18

Description is coming soon

Tetrapeptide-21
Est. %0.3
Function
Origin
Tetrapeptide-21

A synthetically made peptide (similar to skin proteins) designed to increase the synthesis of collagen, HA, and fibronectin. It has been clinically proven to improve skin quality and elasticity, as well as the appearance of wrinkles.

Dipeptide-2
Est. %0.3
Function
Origin
Dipeptide-2
Palmitoyl Tetrapeptide-7
Est. %0.3
Function
Origin
Palmitoyl Tetrapeptide-7

A synthetic peptide that mimics the activity of immunoglobulin G and signals to the skin to stop the inflammation. It has been shown in studies to reduce wrinkles and enhance collagen content.

Palmitoyl Hexapeptide-12
Est. %0.3
Function
Origin
Palmitoyl Hexapeptide-12

A short, synthetically made peptide similar to elastin fragments. It works as a signal peptide, stimulating the growth of skin cells and facilitating skin repair. It has been tested mostly in test-tube experiments so far.

Tyrosine
Est. %0.3
Function
Origin
Tyrosine
Tocopheryl Acetate
Est. %0.3
Function
Origin
Tocopheryl Acetate

An antioxidant derivative of tocopherol (vitamin E). It helps to protect cells from free radicals and UV damage through the conversion to active vitamin E in the skin. It is more stable than tocopherol.

Dipotassium Glycyrrhizate
Est. %0.3
Function
Origin
Dipotassium GlycyrrhizateA licorice root derivative with powerful anti-inflammatory and soothing activities. It is often used as a flavoring agent in lip products.
Hesperidin Methyl Chalcone
Est. %0.3
Function
Origin
Hesperidin Methyl ChalconeAn antioxidant and soothing flavonoid compound that is found in abundance in citrus fruit peels. It has been chemically modified for better absorption.
Ceramide NG
Est. %0.3
Function
Origin
Ceramide NGA lipid that is mainly found on scalp skin and that helps with the barrier repair. It is one of the less popular ceramides and is usually used in combination with other ceramides for better barrier repair properties.
Fructose
Est. %0.3
Function
Origin
FructoseA natural sugar that moisturizes the skin by drawing water to the surface.
Allantoin
Est. %0.3
Function
Origin
AllantoinA fluffy, white powder that acts as a humectant due to its water-loving chemistry and as an exfoliant that helps to remove dead skin cells. It has also been shown to be very soothing to irritated and inflamed skin.
Trehalose
Est. %0.3
Function
Origin
TrehaloseA sweet-tasting saccharide that can be found in various yeasts and fungi and that is manufactured from starch for cosmetic purposes. It is one of the most popular sugars in skincare and is mainly used for its humectant properties.
Maltose
Est. %0.3
Function
Origin
Maltose
Glucose
Est. %0.3
Function
Origin
GlucoseA simple sugar that is also one of two components of sucrose, or table sugar. It is used as a humectant in skincare products. Glucose is also used to flavor lip care cosmetics because of its mildly sweet taste.
Sodium Hyaluronate
Est. %0.3
Function
Origin
Sodium Hyaluronate

A sodium salt of famous hyaluronic acid. A potent humectant that hydrates the skin, supports collagen function, and fills out small wrinkles. Sodium hyaluronate also offers soothing and antioxidant properties.

Citric Acid
Est. %0.3
Function
Origin
Citric AcidA gently exfoliating AHA that helps to remove the top layer of dead skin cells. In comparison to other AHAs, citric acid has been shown to be one of the least effective. It is also very commonly used as a stabilizing and pH-controlling agent.
Sodium Hydroxide
Est. %0.3
Function
Origin
Sodium Hydroxide

An ingredient that is able to bring the pH of a product up, thereby making it less harsh on the skin.

Disodium EDTA
Est. %0.3
Function
Origin
Disodium EDTAA synthetic chelator that helps to maintain the look and smell of a product by 'locking up' troublesome metal ions.
Sodium Chloride
Est. %0.3
Function
Origin
Sodium Chloride

You’re definitely familiar with sodium chloride, even if you don’t think you are. It’s table salt! Salt works well with some cleansing ingredients (surfactants) to thicken them into gels. It also acts as a stabilizer for water-in-oil emulsions.

Steareth-20
Est. %0.3
Function
Origin
Steareth-20A white to light brown reaction product of a clear gas and stearyl alcohol. Like the other steareth ingredients, steareth-20 is a waxy emulsifier that can help to form a stable emulsion, even in extreme conditions.
Polysorbate 60
Est. %0.3
Function
Origin
Polysorbate 60An ester based on sorbitan. It is good for emulsifying water and oils together – specifically making oil-in-water emulsions. Polysorbate 60 is also said to give a product a notable fragrance.
Caprylyl Glycol
Est. %0.3
Function
Origin
Caprylyl GlycolAn emollient that improves product spreadability and offers a silky feel on the skin. It also acts as a preservative booster that improves the efficacy of other preservatives. According to the manufacturer, it is also a humectant moisturizer.
Tribehenin
Est. %0.3
Function
Origin
TribeheninA soft, pliable wax that serves as an occlusive moisturizer and emollient. It improves the spreadability of skincare products, including the increased payoff of stick products, and imparts a pleasant, smooth feel upon application.
Coco-Glucoside
Est. %0.3
Function
Origin
Coco-GlucosideA mild cleansing and foaming agent. It can be used on its own as a gentle cleanser in a skin cleansing product or can be combined with more powerful cleansing agents, called anionic surfactants, to make them milder on the skin.
Pentylene Glycol
Est. %0.3
Function
Origin
Pentylene Glycol

A naturally or synthetically derived preservative that exhibits effective antifungal and antibacterial traits. It also acts as a booster for more traditional preservatives. Pentylene glycol can also serve as a moisturizing humectant and solvent.

Hexylene Glycol
Est. %0.3
Function
Origin
Hexylene GlycolA multifunctional ingredient that is best known for its use as a solvent. It can dissolve both water-based ingredients and oils. For this reason, it can also function as an emulsifier, allowing oil and water ingredients to mix and remain stable.
Urea
Est. %0.3
Function
Origin
UreaUrea can be found in urine, skin, and other tissues as a degradation product of proteins. In concentrations below 5%, urea is humectant moisturizing. At concentrations above 10% it is keratolytic, that helps to break away old, flaking, and cracked skin.
PEG-10 Rapeseed Sterol
Est. %0.3
Function
Origin
PEG-10 Rapeseed SterolPEG-10 Rapeseed Sterol is a mixture of polyethylene glycol (a water-soluble bulking and lubricating synthetic compound) and fat-soluble phytosterols from rapeseed oil. This mixture is used in skincare products to assist with the solubility and the of oil and water (emulsification).
Sodium Lactate
Est. %0.3
Function
Origin
Sodium LactateA sodium salt of lactic acid. Its main function is as a humectant but it can also serve as a pH adjuster. Additionally, sodium lactate can also be used as a chemical exfoliant due to its close chemical relation to lactic acid.
Sodium PCA
Est. %0.3
Function
Origin
Sodium PCAOne of the most important parts of the skin's Natural Moisturizing Factor, a mixture of various compounds that keeps the skin’s surface well hydrated. Sodium PCA is used in skincare for its fantastic humectant properties.
Phenoxyethanol
Est. %0.3
Function
Origin
PhenoxyethanolThe most frequently used preservative in skincare. It is a clear, oil-like liquid synthetic substance that protects products from harmful bacteria and yeast, whilst still leaving skin microflora unharmed. It is confirmed by research to be harmless.
Potassium Sorbate
Est. %0.3
Function
Origin
Potassium SorbateA preservative widely used in food and personal care products, available from natural sources or synthetically produced. Potassium sorbate works by inhibiting the growth of yeasts, molds, and some bacteria.
Fragrance
Est. %0.3
Function
Origin
FragranceUnder trade secret law, manufacturers have the right not to disclose what exactly went into the fragrance and use the unspecific word Fragrance or Parfum instead. Many fragrances are highly allergenic.
Linalool
Est. %0.3
Function
Origin
LinaloolA fragrant, volatile compound naturally present in many essential oils. It has a pleasant scent and is often used in skincare products as a fragrance. People with sensitive skin should try to avoid it, or at least do a patch test before using it.
Limonene
Est. %0.3
Function
Origin
Limonene

One of the most used fragrances in skincare products. It is produced from the peels of citrus fruits and has a fresh, pleasant, citrusy smell. People who are sensitive to citrus should try to avoid it, or at least do a patch test before using it.