Perricone MD Neuropeptide Firming & Illuminating Under-Eye Cream Review

Perricone MD Neuropeptide Firming & Illuminating Under-Eye Cream
7.0
/ 10
Moisturizing
10.0 Humectancy icon Humectancy
4.1 Occlusivity icon Occlusivity
3Anti-wrinkle icon/ 10
Anti-wrinkle
Rich
in Antioxidants
Ingredients

Perricone MD Neuropeptide Firming & Illuminating Under-Eye Cream Ingredients

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Full Ingredient List (INCI):

Water, Butylene Glycol, Glycerin, Dimethicone, Cyclopentasiloxane, Stearic Acid, Niacinamide, 1,2-Hexanediol, Cetearyl Alcohol, Sucrose Distearate, Cyclohexasiloxane, Caprylic/Capric Triglyceride, Behenic Acid, Polyglyceryl-10 Myristate, Cetyl Ethylhexanoate, Simmondsia Chinensis (Jojoba) Seed Oil, Macadamia Ternifolia Seed Oil, Argania Spinosa Kernel Oil, Titanium Dioxide (CI 77891), Dipeptide-2, Palmitoyl Tetrapeptide-7, Acetyl Tetrapeptide-9, Ceramide NP, Phytosteryl Isostearate, Hydrogenated Lecithin, Paeonia Suffruticosa Root Extract, Scutellaria Baicalensis Root Extract, Hesperidin Methyl Chalcone, Allantoin, Tocopheryl Acetate, Lactobacillus/Soybean Ferment Extract, Xanthan Gum, Adenosine, Viscum Album (Mistletoe) Leaf Extract, Imperata Cylindrica Root Extract, Synthetic Fluorphlogopite, Mannitol, Carbomer, Sodium Hydroxide, Disodium EDTA, Behenyl Alcohol, Batyl Alcohol, Ammonium Acryloyldimethyltaurate/VP Copolymer, Glyceryl Stearate, Steareth-20, Tin Oxide
Review

Does Perricone MD Neuropeptide Firming & Illuminating Under-Eye Cream Work?

 
According to CreamScan's analysis of the ingredient list, here’s what Perricone MD Neuropeptide Firming & Illuminating Under-Eye Cream has to offer:
 
✅ Significant moisturizing. It has a moisturizing rating of 7.0 out of 10.
✅ Modest anti-wrinkle efficacy: Perricone MD Neuropeptide Firming & Illuminating Under-Eye Cream has an anti-wrinkle rating of 3.0 out of 10 so you may expect some, although limited, effect on wrinkles.
✅ Antioxidant protection

  

Key Benefits of Perricone MD Neuropeptide Firming & Illuminating Under-Eye Cream

 
These are the key benefits you can expect from using Perricone MD Neuropeptide Firming & Illuminating Under-Eye Cream:
 

🔵🔵 Perfect Moisturizer for Normal to Dry Skin with a Balanced Texture, Neither Too Light nor Too Heavy

According to CreamScan analysis, Perricone MD Neuropeptide Firming & Illuminating Under-Eye Cream is highly moisturizing, with a moisturizing rating of 7.0 out of 10.

Is it more humectant or occlusive? Significantly more humectant. It has a maximum humectancy of 10 out of 10, primarily due to the substantial concentration of Butylene Glycol (est. ≈9.0%) and Glycerin (est. ≈6.0%), and a moderate occlusivity of 4.1 out of 10, mainly due to the high content of Dimethicone (est. ≈4.0%) and Stearic Acid (est. ≈2.5%).

This type of moisturizer is ideal for people with normal skin who want maximum hydration in a formula with a balanced texture - neither too light nor too heavy. It combines a very high concentration of humectants with a moderate amount of occlusive ingredients to deliver effective dual-action moisturizing for normal skin.

This product may also be a good choice for people with normal to dry skin for daily hydration.

Please refer to the Ratings section below for details of the moisturizing rating calculation.

🟣 Modest Anti-Wrinkle Efficacy

According to CreamScan analysis, Perricone MD Neuropeptide Firming & Illuminating Under-Eye Cream has a modest level of anti-wrinkle efficacy, rated 3.0 out of 10.

It contains one ingredient with proven anti-wrinkle efficacy: Niacinamide (est. ≈2.0%),
 one of the most effective and well-researched anti-wrinkle ingredients. A clinical study involving 30 participants (Kawada et al.) confirmed that a cream with 4% niacinamide reduced the average depth of wrinkles around the eyes by 9% after 8 weeks of use, compared to a vehicle (the same formulation without niacinamide).
 
Among others, Perricone MD Neuropeptide Firming & Illuminating Under-Eye Cream contains some ingredients often marketed as effective in reducing wrinkles, specifically Palmitoyl Tetrapeptide-7, Acetyl Tetrapeptide-9, Adenosine, and Imperata Cylindrica Root Extract. However, the studies supporting the anti-wrinkle claims of these ingredients provide insufficient evidence of efficacy according to CreamScan Research Evaluation Standards.
 
While this does not categorically rule out the possibility that these ingredients may reduce wrinkles, their efficacy is not supported by convincing, vehicle-controlled, double-blind clinical studies - at least none that were available to the CreamScan team at the time of publication.
 
Therefore, these ingredients do not contribute to the anti-wrinkle rating.
 
📌 Moisturizers, when used regularly, are proven to prevent wrinkle formation and even reduce existing wrinkles. Therefore, this product, like any other moisturizer, can deliver some additional anti-wrinkle effects through its moisturizing action.
 

Please refer to the Ratings section below for details of the anti-wrinkle rating calculation.

🍀 Rich in Skin-Protecting Antioxidants

We estimate that Perricone MD Neuropeptide Firming & Illuminating Under-Eye Cream is rich (> 3%) in antioxidants, specifically Niacinamide (est. ≈2.0%).

A key benefit of antioxidants is their ability to reduce oxidative stress caused by free radicals and therefore prevent accelerated skin aging. Studies also show that antioxidants can protect against environmental damage such as UV radiation and pollution, and help reduce inflammation and skin redness.

📌 Please note that this is not a complete list of benefits. We are in the process of enhancing our model to incorporate anti-pigmentation, exfoliation and anti-acne ratings.

Pros & Cons of Perricone MD Neuropeptide Firming & Illuminating Under-Eye Cream

 
Here’s an overview of the pros and cons of Perricone MD Neuropeptide Firming & Illuminating Under-Eye Cream to help you decide if it’s the right choice for your skincare routine:
 

🟩 Pros:

✅ Perfect for moisturizing normal skin
Balanced texture, neither too light nor too heavy
Offers modest anti-wrinkle efficacy
✅ Rich in antioxidants that combat oxidative stress associated with accelerated skin aging and defend against environmental damage
 

⭕ Cons: 

✅ We couldn't find any
   

Summary: Perricone MD Neuropeptide Firming & Illuminating Under-Eye Cream

 
Based on the ingredient list analysis, CreamScan AI suggests that Perricone MD Neuropeptide Firming & Illuminating Under-Eye Cream
 is an ideal moisturizer for normal skin, combining a very high concentration of humectants with a significant amount of occlusive ingredients in a balanced texture - neither too light nor too heavy.
 
Perricone MD Neuropeptide Firming & Illuminating Under-Eye Cream contains ingredients with proven evidence of anti-wrinkle efficacy that may provide a modest anti-wrinkle effect. As a result, you can expect a positive, though not very significant, impact on wrinkles.
 
With its high antioxidant content, Perricone MD Neuropeptide Firming & Illuminating Under-Eye Cream helps protect against free radical damage and offers multiple benefits for all skin types, including preventing premature aging, defending against environmental damage, and calming inflammation.
 
📌 Fact check. At CreamScan, we are committed to accuracy and fairness. If you spot any errors or something that doesn’t seem right, please click here to let us know. We regularly update the ingredient lists and monitor the latest research on ingredient efficacy to ensure that our information remains as complete and precise as possible. The information provided here is for informational purposes only and does not substitute professional advice. We do not guarantee the efficacy or safety of any product, as individual results may vary.

 

Ingredient Breakdown

Est. % Ingredient Origin Functions
60
9
6
4
3
2.5
2
1.5
1.3
1
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Est. %
Water
Function:
Origin:
Butylene Glycol
Function:
Origin:
Glycerin
Function:
Origin:
Dimethicone
Function:
Origin:
Cyclopentasiloxane
Function:
Origin:
Stearic Acid
Function:
Origin:
Niacinamide
Function:
Origin:
1,2-Hexanediol
Function:
Origin:
Cetearyl Alcohol
Function:
Origin:
Sucrose Distearate
Function:
Origin:
Cyclohexasiloxane
Function:
Origin:
Caprylic/Capric Triglyceride
Function:
Origin:
Behenic Acid
Function:
Origin:
Polyglyceryl-10 Myristate
Function:
Origin:
Cetyl Ethylhexanoate
Function:
Origin:
Simmondsia Chinensis (Jojoba) Seed Oil
Function:
Origin:
Macadamia Ternifolia Seed Oil
Function:
Origin:
Argania Spinosa Kernel Oil
Function:
Origin:
Titanium Dioxide (CI 77891)
Function:
Origin:
Dipeptide-2
Function:
Origin:
Palmitoyl Tetrapeptide-7
Function:
Origin:
Acetyl Tetrapeptide-9
Function:
Origin:
Ceramide NP
Function:
Origin:
Phytosteryl Isostearate
Function:
Origin:
Hydrogenated Lecithin
Function:
Origin:
Paeonia Suffruticosa Root Extract
Function:
Origin:
Scutellaria Baicalensis Root Extract
Function:
Origin:
Hesperidin Methyl Chalcone
Function:
Origin:
Allantoin
Function:
Origin:
Tocopheryl Acetate
Function:
Origin:
Lactobacillus/Soybean Ferment Extract
Function:
Origin:
Xanthan Gum
Function:
Origin:
Adenosine
Function:
Origin:
Viscum Album (Mistletoe) Leaf Extract
Function:
Origin:
Imperata Cylindrica Root Extract
Function:
Origin:
Synthetic Fluorphlogopite
Function:
Origin:
Mannitol
Function:
Origin:
Carbomer
Function:
Origin:
Sodium Hydroxide
Function:
Origin:
Disodium EDTA
Function:
Origin:
Behenyl Alcohol
Function:
Origin:
Batyl Alcohol
Function:
Origin:
Ammonium Acryloyldimethyltaurate/VP Copolymer
Function:
Origin:
Glyceryl Stearate
Function:
Origin:
Steareth-20
Function:
Origin:
Tin Oxide
Function:
Origin:

Ratings

All humectants
18.5
9
6
2
0.3
0.3
0.3
0.3
0.3
Benchmark
10
All occlusives
8.3
4.0
2.5
0.3
0.3
0.3
0.3
0.3
0.3
Benchmark
20
Moisturizing rating
7.0
Ingredient Est. % Benchmark Raiting
Humectancy All humectants 18.5 10
10.0
9
6
2
0.3
0.3
0.3
0.3
0.3
Occlusivity All occlusives 8.3 20
4.1
4.0
2.5
0.3
0.3
0.3
0.3
0.3
0.3
Moisturizing rating
7.0
Ingredient Est. % Benchmark Humectancy
9
6
2
0.3
0.3
0.3
0.3
0.3
All humectants 18.5 10
10
All humectants
18.5
9
6
2
0.3
0.3
0.3
0.3
0.3
Benchmark
10
Ingredient Est. % Benchmark Occlusivity
4
2.5
0.3
0.3
0.3
0.3
0.3
0.3
All occlusives 8.3 20
4.1
All occlusives
8.3
4.0
2.5
0.3
0.3
0.3
0.3
0.3
0.3
Benchmark
20
Ingredient
Ingredient anti-wrinkle power
when present at, %
in this formula est. %
Rating
6 /10 4 2 3
n/a
- 0.3 -
n/a
- 0.3 -
n/a
- 0.3 -
n/a
- 0.3 -
Total
3
Niacinamide
3
Ingredient anti-wrinkle power
6 /10
when present at, %
4
in this formula, est. %
2
Palmitoyl Tetrapeptide-7
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Acetyl Tetrapeptide-9
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Adenosine
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Imperata Cylindrica Root Extract
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Anti-wrinkle rating
3
Ingredient Est. % Benchmark
Rich in Antioxidants
2
0.3
0.3
0.3
0.3
0.3
All antioxidants 3.5 3 Rich in antioxidants
All antioxidants
3.5
Niacinamide
2
Argania Spinosa Kernel Oil
0.3
Scutellaria Baicalensis Root Extract
0.3
Hesperidin Methyl Chalcone
0.3
Tocopheryl Acetate
0.3
Mannitol
0.3
Benchmark
3
Ingredient Est. % Benchmark
Rich in Soothing
2
0.3
0.3
0.3
0.3
0.3
0.3
All soothing 3.8 5 No
All soothing
3.8
2
0.3
0.3
0.3
0.3
0.3
0.3
Benchmark
5

Ingredients explained

Water
Est. %60
Function
Origin
WaterThe most used ingredient in skincare. Its concentration defines the product texture: rich creams may have about 50% of water while a light jelly about 90%. Water doesn’t moisturize the skin by itself and is used in skincare as a solvent for other ingredients.
Butylene Glycol
Est. %9
Function
Origin
Butylene Glycol

A clear, colorless liquid humectant that draws moisture to the skin. The humectancy of butylene glycol, owed to its two hydroxyl groups, is quite considerable, although not as powerful as glycerin, which contains three hydroxyl groups.

Glycerin
Est. %6
Function
Origin
Glycerin

The most popular moisturizing ingredient in the world. It is a powerful humectant – cheap yet very effective.

Dimethicone
Est. %4
Function
Origin
DimethiconeThe most common silicone in skincare. It forms a silky, smooth film on the skin’s surface and can help to prevent water loss. It also aids in wound healing and can treat and soften scars. Dimethicone is considered to be very safe for use.
Cyclopentasiloxane
Est. %3
Function
Origin
CyclopentasiloxaneA lightweight, fast-spreading emollient that leaves a very soft and silky after-feel on the skin. Supplied as a clear and colorless liquid, cyclopentasiloxane is often used as a solvent to dissolve other silicones in.
Stearic Acid
Est. %2.5
Function
Origin
Stearic AcidA saturated fatty acid found in vegetable butter and animal fats. It is an occlusive moisturizing and emollient ingredient and also helps to maintain the barrier function of the skin.
Niacinamide
Est. %2
Function
Origin
Niacinamide

Also known as vitamin B3, this ingredient is a true superstar with confirmed moisturizing, anti-acne, hyperpigmentation, and antioxidant benefits. Two studies confirm its significant anti-wrinkle efficacy.

1,2-Hexanediol
Est. %1.5
Function
Origin
1,2-HexanediolA multi-functional formula helper. It is a well-studied preservtive against bacteria and can help pigments and fragrances disperse evenly in a formula.
Cetearyl Alcohol
Est. %1.3
Function
Origin
Cetearyl AlcoholA blend of cetyl alcohol and stearyl alcohol, the fatty alcohols that are derived from palm oil. It helps to create emulsions that give off a soft and silky emollient feel and also increase product thickness.
Sucrose Distearate
Est. %1
Function
Origin
Sucrose Distearate
Cyclohexasiloxane
Est. %0.3
Function
Origin
CyclohexasiloxaneA clear silicone fluid with very low viscosity that is commonly used as a solvent and emollient. It has excellent spreadability, rubs in quickly, and leaves a silky smooth after-feel on the skin.
Caprylic/Capric Triglyceride
Est. %0.3
Function
Origin
Caprylic/Capric TriglycerideA natural occlusive moisturizing and emollient ingredient, it is a blend of glycerin and two fatty acids, caprylic and capric acid. It creates an oil-based protective layer on the skin, thereby preventing water loss.
Behenic Acid
Est. %0.3
Function
Origin
Behenic AcidA naturally-occuring ingredient from certain plant oils, behenic acid acts as an emulsifier and surfactant and provides a soft cushiony feeling.
Polyglyceryl-10 Myristate
Est. %0.3
Function
Origin
Polyglyceryl-10 MyristateA solubilizer that can help incorporate small amounts of oil to an otherwise watery product while providing lightweight skin feel.
Cetyl Ethylhexanoate
Est. %0.3
Function
Origin
Cetyl EthylhexanoateA clear, pale yellow liquid, that functions as an emollient and a solvent, meaning that it is useful for dissolving oil-soluble ingredients.
Simmondsia Chinensis (Jojoba) Seed Oil
Est. %0.3
Function
Origin
Simmondsia Chinensis (Jojoba) Seed OilA liquid plant wax, also known as Jojoba oil, pressed from the seeds of Simmondsia chinensis. These seeds can contain up to 50% of liquid wax. It is used as an occlusive moisturizer, emollient, and emulsifier.
Macadamia Ternifolia Seed Oil
Est. %0.3
Function
Origin
Macadamia Ternifolia Seed OilAn occlusive moisturizing and emollient oil extracted from macadamia nuts. It is clear and pale yellow with a pleasant nutty aroma and contains oleic and palmitoleic fatty acids, tocopherols, phytosterols, squalene, and polyphenols.
Argania Spinosa Kernel Oil
Est. %0.3
Function
Origin
Argania Spinosa Kernel OilA fatty oil from Moroccan argan tree kernels commonly used as an occlusive moisturizer and emollient. Its uniqueness comes from its compounds: vitamin E, phospholipids, phenolic compounds, and rare phytosterols with antioxidant and emollient effects.
Titanium Dioxide (CI 77891)
Est. %0.3
Function
Origin
Titanium Dioxide (CI 77891)One of two the most commonly used mineral sunscreens. It can absorb UV light, including UVB – which causes burning, tanning, and even skin cancer. Also used as a colorant, titanium dioxide gives a product a bright white color.
Dipeptide-2
Est. %0.3
Function
Origin
Dipeptide-2
Palmitoyl Tetrapeptide-7
Est. %0.3
Function
Origin
Palmitoyl Tetrapeptide-7

A synthetic peptide that mimics the activity of immunoglobulin G and signals to the skin to stop the inflammation. It has been shown in studies to reduce wrinkles and enhance collagen content.

Acetyl Tetrapeptide-9
Est. %0.3
Function
Origin
Acetyl Tetrapeptide-9

A synthetically made peptide that works as a signal peptide, increasing the production of collagen in the skin.

Ceramide NP
Est. %0.3
Function
Origin
Ceramide NPAlso known as ceramide 3, it is the most common ceramide in our skin. It helps to restore the skin’s lipid barrier and alleviate the symptoms of dry and cracked skin. Research has shown that skin suffering from conditions such as AD lacks ceramides.
Phytosteryl Isostearate
Est. %0.3
Function
Origin
Phytosteryl Isostearate
Hydrogenated Lecithin
Est. %0.3
Function
Origin
Hydrogenated LecithinA version of plain lecithin that has been saturated with hydrogen atoms. This ingredient can be derived from plants, like soy or sunflower, from egg yolks, or made synthetically. Its major function is to emulsify water and oils.
Paeonia Suffruticosa Root Extract
Est. %0.3
Function
Origin
Paeonia Suffruticosa Root ExtractA soothing extract obtained from a hybrid species of tree peony that contains various active compounds such as astringent tannins, terpenes, and paeonols.
Scutellaria Baicalensis Root Extract
Est. %0.3
Function
Origin
Scutellaria Baicalensis Root ExtractA powerful antioxidant, soothing, and astringent extract derived from the roots of Baikal/Chinese skullcap. It contains various unique flavonoids that are believed to soothe irritated and inflamed skin and protect from UV-induced oxidative damage.
Hesperidin Methyl Chalcone
Est. %0.3
Function
Origin
Hesperidin Methyl ChalconeAn antioxidant and soothing flavonoid compound that is found in abundance in citrus fruit peels. It has been chemically modified for better absorption.
Allantoin
Est. %0.3
Function
Origin
AllantoinA fluffy, white powder that acts as a humectant due to its water-loving chemistry and as an exfoliant that helps to remove dead skin cells. It has also been shown to be very soothing to irritated and inflamed skin.
Tocopheryl Acetate
Est. %0.3
Function
Origin
Tocopheryl Acetate

An antioxidant derivative of tocopherol (vitamin E). It helps to protect cells from free radicals and UV damage through the conversion to active vitamin E in the skin. It is more stable than tocopherol.

Lactobacillus/Soybean Ferment Extract
Est. %0.3
Function
Origin
Lactobacillus/Soybean Ferment ExtractA biotechnological ingredient that is essentially soy milk fermented with lactic acid bacteria. It may help to treat skin pigmentation but more research is needed to support this claim.
Xanthan Gum
Est. %0.3
Function
Origin
Xanthan GumA natural multi-functional ingredient that originates from fermented sugars. Xanthan gum acts as a viscosity-building agent to thicken skincare products. It is also an excellent stabilizer and works well to hold other ingredients together.
Adenosine
Est. %0.3
Function
Origin
Adenosine

A key molecule responsible for energy transportation, signaling, and enzyme activity. Adenosine is a popular anti-wrinkle ingredient, however, the key study about its anti-wrinkle efficacy (1) does not meet CreamScan Research Evaluation Standards as it is not double-blind.

Viscum Album (Mistletoe) Leaf Extract
Est. %0.3
Function
Origin
Viscum Album (Mistletoe) Leaf Extract
Imperata Cylindrica Root Extract
Est. %0.3
Function
Origin
Imperata Cylindrica Root ExtractAn extract obtained from cogongrass roots. According to the patent holder, it contains significant amounts of potassium, a humectant and anti-wrinkle compound, as well as sulfur-containing proteins.
Synthetic Fluorphlogopite
Est. %0.3
Function
Origin
Synthetic FluorphlogopiteAlso known as synthetic mica, this ingredient’s best property is its ability to form thin, sheet-like crystals. This gives products (mostly makeup) great slip.
Mannitol
Est. %0.3
Function
Origin
MannitolA sweet-tasting, sugar-derived, humectant alcohol that can stabilize a skincare formula and offer some antioxidant and soothing properties.
Carbomer
Est. %0.3
Function
Origin
CarbomerA synthetic ingredient with the ability to gel water. When used in emulsions, such as lotions and creams, carbomer can also act as an emulsion stabilizer.
Sodium Hydroxide
Est. %0.3
Function
Origin
Sodium Hydroxide

An ingredient that is able to bring the pH of a product up, thereby making it less harsh on the skin.

Disodium EDTA
Est. %0.3
Function
Origin
Disodium EDTAA synthetic chelator that helps to maintain the look and smell of a product by 'locking up' troublesome metal ions.
Behenyl Alcohol
Est. %0.3
Function
Origin
Behenyl AlcoholA fatty alcohol with emollient properties. It is used as a co-emulsifier and thickener and tends to result in a product with a smooth and creamy application texture.
Batyl Alcohol
Est. %0.3
Function
Origin
Batyl AlcoholA fatty alcohol that can co-emulsify and provide moisturization to the skin.
Ammonium Acryloyldimethyltaurate/VP Copolymer
Est. %0.3
Function
Origin
Ammonium Acryloyldimethyltaurate/VP CopolymerA polymeric ingredient that creates lightweight and refreshing gel textures. It also works as a viscosity controlling agent.
Glyceryl Stearate
Est. %0.3
Function
Origin
Glyceryl StearateAn emollient and emulsifier typically derived from vegetable sources through a chemical reaction with glycerin. It provides stability, texture, and consistency to formulations. Its main function is to allow oil and water to mix.
Steareth-20
Est. %0.3
Function
Origin
Steareth-20A white to light brown reaction product of a clear gas and stearyl alcohol. Like the other steareth ingredients, steareth-20 is a waxy emulsifier that can help to form a stable emulsion, even in extreme conditions.
Tin Oxide
Est. %0.3
Function
Origin
Tin OxideA multi-functional mineral that increases the physical space a product takes up, increases the viscosity of liquid products, and, when used as an opacifying agent, makes a transparent or translucent product become opaque or solid in color.