Paula's Choice 25% Vitamin C + Glutathione Clinical Serum Review

Paula's Choice 25% Vitamin C + Glutathione Clinical Serum
4.5
/ 10
Moisturizing
6.7 Humectancy icon Humectancy
2.3 Occlusivity icon Occlusivity
0.1Anti-wrinkle icon/ 10
Anti-wrinkle
Rich
in Antioxidants
Ingredients

Paula's Choice 25% Vitamin C + Glutathione Clinical Serum Ingredients

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Full Ingredient List (INCI):

Water, Tetrahexyldecyl Ascorbate, Dimethicone, Glycerin, C9-12 Alkane, Ascorbyl Glucoside, Silica, Pyrus Malus (Apple) Fruit Extract, Hydrogenated Lecithin, Polyglyceryl-6 Polyricinoleate, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Xanthan Gum, Oryza Sativa (Rice) Bran Extract, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Cetyl Alcohol, Caprylyl Glycol, Lysine Carboxymethyl Cysteinate, Coco-Caprylate, Tocopherol, Glutathione, Sodium Citrate, Sodium Phytate, Hexylene Glycol, Ethylhexylglycerin, Helianthus Annuus (Sunflower) Seed Extract, Urea, Mannitol, Caprylic/Capric Triglyceride, Sodium PCA, Rosmarinus Officinalis (Rosemary) Leaf Extract, Polysorbate 60, Sorbitan Isostearate, Trehalose, Ascorbic Acid, Glucose, Vanilla Planifolia Fruit Extract, Polyquaternium-51, Ergothioneine, Triacetin, Sodium Hyaluronate, Phenoxyethanol
Review

Does Paula's Choice 25% Vitamin C + Glutathione Clinical Serum Work?

 
According to CreamScan's analysis of the ingredient list, here’s what Paula's Choice 25% Vitamin C + Glutathione Clinical Serum has to offer:
 
Moderate moisturizing. It has a moisturizing rating of 4.5 out of 10.
✅ Slight anti-wrinkle effect: Paula's Choice 25% Vitamin C + Glutathione Clinical Serum has an anti-wrinkle rating of 0.1 out of 10, so you may expect a positive, although insignificant, effect on wrinkles.
✅ Antioxidant protection

  

Key Benefits of Paula's Choice 25% Vitamin C + Glutathione Clinical Serum

 
These are the key benefits you can expect from using Paula's Choice 25% Vitamin C + Glutathione Clinical Serum:
 

🔵 Lightweight Moisturizer Well-Suited for Combination and Oily Skin

According to CreamScan analysis, Paula's Choice 25% Vitamin C + Glutathione Clinical Serum is quite moisturizing, with a moisturizing rating of 4.5 out of 10.

Is it more humectant or occlusive? Significantly more humectant. It has a low occlusivity of 2.3 out of 10 and a high humectancy of 6.7 out of 10, primarily due to the high content of Glycerin (est. ≈3.0%).

This type of moisturizer is well-suited for people with combination and oily skin who want significant hydration in a relatively lightweight, non-greasy formula. It combines a substantial amount of humectants with a limited amount of occlusive to enhance moisturizing efficacy without feeling too heavy.

This product may also be an option for people with normal skin who prefer fast-absorbing textures, as it balances significant moisturizing potential with a relatively lightweight texture.

💧 A Humectant Enhancement for Any Skincare Routine

But it’s not limited to combination and oily skin - such a humectant enhancement will also positively contribute to the moisturizing efficacy of any skincare routine when used as a step before applying the main moisturizer. This type of formulation is typically used in serums, where a light, fast-absorbing texture is key.

Please refer to the Ratings section below for details of the moisturizing rating calculation.

🟣 Slight Anti-Wrinkle Efficacy

According to CreamScan analysis, Paula's Choice 25% Vitamin C + Glutathione Clinical Serum has a slight anti-wrinkle rating of 0.1 out of 10.

It contains one ingredient with proven anti-wrinkle efficacy: Ascorbic Acid (est. ≈0.3%),
 or Vitamin C, a popular ingredient, yet with moderate anti-wrinkle efficacy, as confirmed by a single clinical study involving 20 participants (Humbert et al.). This study showed that a cream with a relatively high concentration of 5% ascorbic acid reduced the average wrinkle depth by 7% after 6 months of use, compared to a vehicle (the same formulation without ascorbic acid).
 
Among others, Paula's Choice 25% Vitamin C + Glutathione Clinical Serum also contains contains Tetrahexyldecyl Ascorbate and Ascorbyl Glucoside, two ingredients often marketed as effective in reducing wrinkles. However, the studies supporting the anti-wrinkle claims of these ingredients provide insufficient evidence of efficacy according to CreamScan Research Evaluation Standards.
 
While this does not categorically rule out the possibility that these ingredients may reduce wrinkles, their efficacy is not supported by convincing, vehicle-controlled, double-blind clinical studies - at least none that were available to the CreamScan team at the time of publication.
 
Therefore, these ingredients do not contribute to the anti-wrinkle rating.
 
📌 Moisturizers, when used regularly, are proven to prevent wrinkle formation and even reduce existing wrinkles. Therefore, this product, like any other moisturizer, can deliver some additional anti-wrinkle effects through its moisturizing action.
 

Please refer to the Ratings section below for details of the anti-wrinkle rating calculation.

🍀 Rich in Skin-Protecting Antioxidants

We estimate that Paula's Choice 25% Vitamin C + Glutathione Clinical Serum is rich (> 3%) in antioxidants, specifically Tetrahexyldecyl Ascorbate (est. ≈6.0%).

A key benefit of antioxidants is their ability to reduce oxidative stress caused by free radicals and therefore prevent accelerated skin aging. Studies also show that antioxidants can protect against environmental damage such as UV radiation and pollution, and help reduce inflammation and skin redness.

📌 Please note that this is not a complete list of benefits. We are in the process of enhancing our model to incorporate anti-pigmentation, exfoliation and anti-acne ratings.

Pros & Cons of Paula's Choice 25% Vitamin C + Glutathione Clinical Serum

 
Here’s an overview of the pros and cons of Paula's Choice 25% Vitamin C + Glutathione Clinical Serum to help you decide if it’s the right choice for your skincare routine:
 

🟩 Pros:

✅ When used alone: Provides humectant-rich moisturizing well-suited for combination and oily skin
Also an option for people with normal skin who prefer fast-absorbing textures
✅ As part of a routine: A humectant moisturizing enhancement, beneficial for any skin type
✅ Lightweight texture
Provides slight anti-wrinkle efficacy
✅ Rich in antioxidants that combat oxidative stress associated with accelerated skin aging and defend against environmental damage
 

⭕ Cons: 

✅ We couldn't find any
   

Summary: Paula's Choice 25% Vitamin C + Glutathione Clinical Serum

 
Based on the ingredient list analysis, CreamScan AI suggests that Paula's Choice 25% Vitamin C + Glutathione Clinical Serum
, when used alone, delivers lightweight, humectant-rich moisturizing, well-suited for combination and oily skin. It's also an option for those with normal skin who prefer fast-absorbing textures. As part of a moisturizing routine, it provides a humectant enhancement, beneficial for all skin types.
 
Paula's Choice 25% Vitamin C + Glutathione Clinical Serum contains ingredients with proven evidence of anti-wrinkle efficacy that may offer a slight anti-wrinkle effect. As a result, you can expect a positive, though relatively minimal, impact on wrinkles.
 
 
With its high antioxidant content, Paula's Choice 25% Vitamin C + Glutathione Clinical Serum helps protect against free radical damage and offers multiple benefits for all skin types, including preventing premature aging, defending against environmental damage, and calming inflammation.
 
📌 Fact check. At CreamScan, we are committed to accuracy and fairness. If you spot any errors or something that doesn’t seem right, please click here to let us know. We regularly update the ingredient lists and monitor the latest research on ingredient efficacy to ensure that our information remains as complete and precise as possible. The information provided here is for informational purposes only and does not substitute professional advice. We do not guarantee the efficacy or safety of any product, as individual results may vary.

 

Ingredient Breakdown

Est. % Ingredient Origin Functions
70
6
4
3
2
1.5
1.3
1
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Est. %
Water
Function:
Origin:
Tetrahexyldecyl Ascorbate
Function:
Origin:
Dimethicone
Function:
Origin:
Glycerin
Function:
Origin:
C9-12 Alkane
Function:
Origin:
Ascorbyl Glucoside
Function:
Origin:
Silica
Function:
Origin:
Pyrus Malus (Apple) Fruit Extract
Function:
Origin:
Hydrogenated Lecithin
Function:
Origin:
Polyglyceryl-6 Polyricinoleate
Function:
Origin:
Acrylates/C10-30 Alkyl Acrylate Crosspolymer
Function:
Origin:
Xanthan Gum
Function:
Origin:
Oryza Sativa (Rice) Bran Extract
Function:
Origin:
Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer
Function:
Origin:
Cetyl Alcohol
Function:
Origin:
Caprylyl Glycol
Function:
Origin:
Lysine Carboxymethyl Cysteinate
Function:
Origin:
Coco-Caprylate
Function:
Origin:
Tocopherol
Function:
Origin:
Glutathione
Function:
Origin:
Sodium Citrate
Function:
Origin:
Sodium Phytate
Function:
Origin:
Hexylene Glycol
Function:
Origin:
Ethylhexylglycerin
Function:
Origin:
Helianthus Annuus (Sunflower) Seed Extract
Function:
Origin:
Urea
Function:
Origin:
Mannitol
Function:
Origin:
Caprylic/Capric Triglyceride
Function:
Origin:
Sodium PCA
Function:
Origin:
Rosmarinus Officinalis (Rosemary) Leaf Extract
Function:
Origin:
Polysorbate 60
Function:
Origin:
Sorbitan Isostearate
Function:
Origin:
Trehalose
Function:
Origin:
Ascorbic Acid
Function:
Origin:
Glucose
Function:
Origin:
Vanilla Planifolia Fruit Extract
Function:
Origin:
Polyquaternium-51
Function:
Origin:
Ergothioneine
Function:
Origin:
Triacetin
Function:
Origin:
Sodium Hyaluronate
Function:
Origin:
Phenoxyethanol
Function:
Origin:

Ratings

All humectants
6.7
3
1
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Benchmark
10
All occlusives
4.6
4.0
0.3
0.3
Benchmark
20
Moisturizing rating
4.5
Ingredient Est. % Benchmark Raiting
Humectancy All humectants 6.7 10
6.7
3
1
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Occlusivity All occlusives 4.6 20
2.3
4.0
0.3
0.3
Moisturizing rating
4.5
Ingredient Est. % Benchmark Humectancy
3
1
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
All humectants 6.7 10
6.7
All humectants
6.7
3
1
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Benchmark
10
Ingredient Est. % Benchmark Occlusivity
4
0.3
0.3
All occlusives 4.6 20
2.3
All occlusives
4.6
4.0
0.3
0.3
Benchmark
20
Ingredient
Ingredient anti-wrinkle power
when present at, %
in this formula est. %
Rating
2.5 /10 5 0.3 0.1
n/a
- 6 -
n/a
- 1.5 -
Total
0.1
Ascorbic Acid
0.1
Ingredient anti-wrinkle power
2.5 /10
when present at, %
5
in this formula, est. %
0.3
Tetrahexyldecyl Ascorbate
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
6
Ascorbyl Glucoside
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
1.5
Anti-wrinkle rating
0.1
Ingredient Est. % Benchmark
Rich in Antioxidants
6
1.5
1
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
All antioxidants 10.9 3 Rich in antioxidants
All antioxidants
10.9
Tetrahexyldecyl Ascorbate
6
Ascorbyl Glucoside
1.5
Pyrus Malus (Apple) Fruit Extract
1
Ascorbic Acid
0.3
Tocopherol
0.3
Glutathione
0.3
Mannitol
0.3
Rosmarinus Officinalis (Rosemary) Leaf Extract
0.3
Vanilla Planifolia Fruit Extract
0.3
Ergothioneine
0.3
Sodium Hyaluronate
0.3
Benchmark
3
Ingredient Est. % Benchmark
Rich in Soothing
0.3
0.3
0.3
All soothing 0.9 5 No
All soothing
0.9
0.3
0.3
0.3
Benchmark
5

Ingredients explained

Water
Est. %70
Function
Origin
WaterThe most used ingredient in skincare. Its concentration defines the product texture: rich creams may have about 50% of water while a light jelly about 90%. Water doesn’t moisturize the skin by itself and is used in skincare as a solvent for other ingredients.
Tetrahexyldecyl Ascorbate
Est. %6
Function
Origin
Tetrahexyldecyl AscorbateA lipid-soluble form of vitamin C that is more stable and less irritating than ascorbic acid. According to a recent clinical study, THDA has all the capabilities of regular vitamin C, including anti-wrinkle and anti-pigment activity.
Dimethicone
Est. %4
Function
Origin
DimethiconeThe most common silicone in skincare. It forms a silky, smooth film on the skin’s surface and can help to prevent water loss. It also aids in wound healing and can treat and soften scars. Dimethicone is considered to be very safe for use.
Glycerin
Est. %3
Function
Origin
Glycerin

The most popular moisturizing ingredient in the world. It is a powerful humectant – cheap yet very effective.

C9-12 Alkane
Est. %2
Function
Origin
C9-12 Alkane
Ascorbyl Glucoside
Est. %1.5
Function
Origin
Ascorbyl GlucosideA derivative of vitamin C. It is more stable and less irritating than ascorbic acid. There are unfortunately no clinical studies on ascorbyl glucoside’s anti-pigment or anti-acne efficacy alone.
Silica
Est. %1.3
Function
Origin
SilicaA widely used cosmetic ingredient with the same chemical composition as the sand found on beaches. A common function of silica is its ability to control viscosity. In certain chemical forms, it can effectively thicken cream-style products.
Pyrus Malus (Apple) Fruit Extract
Est. %1
Function
Origin
Pyrus Malus (Apple) Fruit ExtractAn extract derived from apple fruit that has humectant moisturizing and antioxidant properties, as well as gentle anti-pigment effects. It contains humectant sugars, anti-pigment organic acids, and flavonoids.
Hydrogenated Lecithin
Est. %0.3
Function
Origin
Hydrogenated LecithinA version of plain lecithin that has been saturated with hydrogen atoms. This ingredient can be derived from plants, like soy or sunflower, from egg yolks, or made synthetically. Its major function is to emulsify water and oils.
Polyglyceryl-6 Polyricinoleate
Est. %0.3
Function
Origin
Polyglyceryl-6 Polyricinoleate
Acrylates/C10-30 Alkyl Acrylate Crosspolymer
Est. %0.3
Function
Origin
Acrylates/C10-30 Alkyl Acrylate CrosspolymerA synthetic ingredient that is used to thicken water and alcohol. It results in a more lightweight formula and is commonly found in gel products.
Xanthan Gum
Est. %0.3
Function
Origin
Xanthan GumA natural multi-functional ingredient that originates from fermented sugars. Xanthan gum acts as a viscosity-building agent to thicken skincare products. It is also an excellent stabilizer and works well to hold other ingredients together.
Oryza Sativa (Rice) Bran Extract
Est. %0.3
Function
Origin
Oryza Sativa (Rice) Bran ExtractAn extract from rice bran, the brown outer part of the rice kernel. It contains emollient fatty acids and antioxidants such as tocopherols (vitamin E) and γ-oryzanol.
Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer
Est. %0.3
Function
Origin
Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate CopolymerAn emulsion stabilizer and thickener that helps to create a pleasant, satiny, and light formula texture. It works by forming a gel-like network within water or oil, which both stabilizes other ingredients and produces a thickening effect.
Cetyl Alcohol
Est. %0.3
Function
Origin
Cetyl AlcoholA waxy solid fatty alcohol derived from palm oil. It is most commonly used as a co-emulsifier and affects the final aesthetic of the product, leaving a soft and silky feeling on the skin. Cetyl alcohol is also used as a viscosity controlling agent.
Caprylyl Glycol
Est. %0.3
Function
Origin
Caprylyl GlycolAn emollient that improves product spreadability and offers a silky feel on the skin. It also acts as a preservative booster that improves the efficacy of other preservatives. According to the manufacturer, it is also a humectant moisturizer.
Lysine Carboxymethyl Cysteinate
Est. %0.3
Function
Origin
Lysine Carboxymethyl Cysteinate
Coco-Caprylate
Est. %0.3
Function
Origin
Coco-CaprylateA naturally-derived or synthetically produced oil with a very light feel. An alternative to silicones, this ingredient spreads quickly and doesn't leave a residue on skin.
Tocopherol
Est. %0.3
Function
Origin
Tocopherol

Simply another name for vitamin E. Tocopherol is a fantastic ingredient and especially beneficial for dry and inflamed skin. It has occlusive moisturizing, emollient, antioxidant, and photoprotective properties.

Glutathione
Est. %0.3
Function
Origin
GlutathioneA naturally occurring tripeptide that combats free radicals and acts as a reducing agent.
Sodium Citrate
Est. %0.3
Function
Origin
Sodium CitrateA salt of citric acid that has a salty and tart flavor and is used as a fragrance. It is mildly basic, meaning that its addition to a skincare product can adjust the pH upward.
Sodium Phytate
Est. %0.3
Function
Origin
Sodium PhytateSodium phytate is a chelating agent that serves to remove heavy metal ions from water. Removing metal ions helps other ingredients, such as antioxidants and preservatives, to perform better and keep products from separating.
Hexylene Glycol
Est. %0.3
Function
Origin
Hexylene GlycolA multifunctional ingredient that is best known for its use as a solvent. It can dissolve both water-based ingredients and oils. For this reason, it can also function as an emulsifier, allowing oil and water ingredients to mix and remain stable.
Ethylhexylglycerin
Est. %0.3
Function
Origin
EthylhexylglycerinA preservative booster derived from glycerin. It is commonly paired with other preservatives to improve their efficacy. Ethylhexylglycerin is also a humectant due to its chemical base of glycerin.
Helianthus Annuus (Sunflower) Seed Extract
Est. %0.3
Function
Origin
Helianthus Annuus (Sunflower) Seed ExtractAn emollient extract from sunflower seeds that is packed with beneficial-for-skin ingredients such as squalene, phytosterols, phospholipids, amino acids, and antioxidant vitamin E.
Urea
Est. %0.3
Function
Origin
UreaUrea can be found in urine, skin, and other tissues as a degradation product of proteins. In concentrations below 5%, urea is humectant moisturizing. At concentrations above 10% it is keratolytic, that helps to break away old, flaking, and cracked skin.
Mannitol
Est. %0.3
Function
Origin
MannitolA sweet-tasting, sugar-derived, humectant alcohol that can stabilize a skincare formula and offer some antioxidant and soothing properties.
Caprylic/Capric Triglyceride
Est. %0.3
Function
Origin
Caprylic/Capric TriglycerideA natural occlusive moisturizing and emollient ingredient, it is a blend of glycerin and two fatty acids, caprylic and capric acid. It creates an oil-based protective layer on the skin, thereby preventing water loss.
Sodium PCA
Est. %0.3
Function
Origin
Sodium PCAOne of the most important parts of the skin's Natural Moisturizing Factor, a mixture of various compounds that keeps the skin’s surface well hydrated. Sodium PCA is used in skincare for its fantastic humectant properties.
Rosmarinus Officinalis (Rosemary) Leaf Extract
Est. %0.3
Function
Origin
Rosmarinus Officinalis (Rosemary) Leaf ExtractA soothing and astringent extract derived from the fragrant, spicy leaves of rosemary. It has strong antioxidant properties. Rosemary extract can reduce signs of inflammation and also acts as an emollient and antimicrobial agent.
Polysorbate 60
Est. %0.3
Function
Origin
Polysorbate 60An ester based on sorbitan. It is good for emulsifying water and oils together – specifically making oil-in-water emulsions. Polysorbate 60 is also said to give a product a notable fragrance.
Sorbitan Isostearate
Est. %0.3
Function
Origin
Sorbitan IsostearateA mild yet powerful emulsifier primarily utilized to produce water-in-oil emulsions. It helps to create a particularly rich and substantial emulsion.
Trehalose
Est. %0.3
Function
Origin
TrehaloseA sweet-tasting saccharide that can be found in various yeasts and fungi and that is manufactured from starch for cosmetic purposes. It is one of the most popular sugars in skincare and is mainly used for its humectant properties.
Ascorbic Acid
Est. %0.3
Function
Origin
Ascorbic Acid

Also known as vitamin C, this multi-benefit ingredient has proven anti-wrinkle, antioxidant, and anti-pigmentation efficacy. It degrades easily when exposed to air and light, so it requires proper packaging to maintain its stability.

Glucose
Est. %0.3
Function
Origin
GlucoseA simple sugar that is also one of two components of sucrose, or table sugar. It is used as a humectant in skincare products. Glucose is also used to flavor lip care cosmetics because of its mildly sweet taste.
Vanilla Planifolia Fruit Extract
Est. %0.3
Function
Origin
Vanilla Planifolia Fruit ExtractA fragrant and flavoring extract derived from vanilla pods. Vanillin is the main compound responsible for its scent and taste. Other compounds present in the vanilla pod are antioxidant and soothin tannins, polyphenols, and free amino acids.
Polyquaternium-51
Est. %0.3
Function
Origin
Polyquaternium-51A biocompatible phospholipid copolymer that is designed to mimic the lipid-based cell membrane found in human skin. Its main function is as a humectant moisturizer.
Ergothioneine
Est. %0.3
Function
Origin
ErgothioneineA naturally-occurring amino acid that functions as a powerful and versatile antioxidant.
Triacetin
Est. %0.3
Function
Origin
Triacetin
Sodium Hyaluronate
Est. %0.3
Function
Origin
Sodium Hyaluronate

A sodium salt of famous hyaluronic acid. A potent humectant that hydrates the skin, supports collagen function, and fills out small wrinkles. Sodium hyaluronate also offers soothing and antioxidant properties.

Phenoxyethanol
Est. %0.3
Function
Origin
PhenoxyethanolThe most frequently used preservative in skincare. It is a clear, oil-like liquid synthetic substance that protects products from harmful bacteria and yeast, whilst still leaving skin microflora unharmed. It is confirmed by research to be harmless.