NEOGEN Real Peptide Serum Review

NEOGEN Real Peptide Serum
5.4
/ 10
Moisturizing
10.0 Humectancy icon Humectancy
0.9 Occlusivity icon Occlusivity
3Anti-wrinkle icon/ 10
Anti-wrinkle
Rich
in Antioxidants
Review

Does NEOGEN Real Peptide Serum Work?

 
According to CreamScan AI's analysis of the ingredient list, here’s what NEOGEN Real Peptide Serum has to offer:
 
✅ Strong humectant moisturizing. This lightweight, humectant-rich product, ideal for oily skin, has a moisturizing rating of 5.4 out of 10.
✅ Modest anti-wrinkle efficacy: NEOGEN Real Peptide Serum has an anti-wrinkle rating of 3.0 out of 10 so you may expect some, although limited, effect on wrinkles.
✅ Antioxidant protection

  

Key Benefits of NEOGEN Real Peptide Serum

 
These are the key benefits you can expect from using NEOGEN Real Peptide Serum:
 

🔵 Lightweight Humectant Moisturizer Ideal for Oily Skin

According to CreamScan analysis, NEOGEN Real Peptide Serum is quite moisturizing, with a moisturizing rating of 5.4 out of 10.

Is it more humectant or occlusive? Question icon The Humectancy (from 0 to 10) is based on the amount of humectants in the formula and indicates how well the product can attract moisture to the skin. Humectants are effective moisturizers that work well for all skin types. The Occlusivity (from 0 to 10) is based on the amount of occlusives in the formula and indicates how effective the product is at sealing moisture into the skin. Occlusive moisturizers are ideal for those with dry skin. Question icon The Humectancy (from 0 to 10) is based on the amount of humectants in the formula and indicates how well the product can attract moisture to the skin. Humectants are effective moisturizers that work well for all skin types. The Occlusivity (from 0 to 10) is based on the amount of occlusives in the formula and indicates how effective the product is at sealing moisture into the skin. Occlusive moisturizers are ideal for those with dry skin. Significantly more humectant. It has a low occlusivity of 0.9 out of 10 and a maximum humectancy of 10 out of 10, primarily due to the high content of Propanediol (est. ≈4.0%), Glycerin (est. ≈3.0%) and Niacinamide (est. ≈2.0%).

This humectant-rich product, when used alone as a moisturizer, is ideal for oily skin, offering significant hydration in a lightweight, fast-absorbing formula with a minimal amount of occlusive ingredients.

It’s also a great choice for people with normal skin who prefer lightweight moisturizers.

💧 A Humectant Boost for Any Skincare Routine

But it’s not limited to oily skin - such a humectant boost will also positively contribute to the moisturizing efficacy of any skincare routine when used as a step before applying the main moisturizer. This type of formulation is typically used in serums, where a light, fast-absorbing texture is key.

Please refer to the Ratings section below for details of the moisturizing rating calculation.

🟣 Modest Anti-Wrinkle Efficacy

According to CreamScan analysis, NEOGEN Real Peptide Serum has a modest level of anti-wrinkle efficacy, rated 3.0 out of 10.

It contains one ingredient with proven anti-wrinkle efficacy: Niacinamide (est. ≈2.0%),
 one of the most effective and well-researched anti-wrinkle ingredients. A clinical study involving 30 participants (Kawada et al.) confirmed that a cream with 4% niacinamide reduced the average depth of wrinkles around the eyes by 9% after 8 weeks of use, compared to a vehicle (the same formulation without niacinamide).
 
Among others, NEOGEN Real Peptide Serum also contains some ingredients often marketed as effective in reducing wrinkles, specifically Adenosine, Ubiquinone, Palmitoyl Tripeptide-5, Acetyl Hexapeptide-8, Copper Tripeptide-1, Tripeptide-1, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-1, and some others. However, the studies supporting the anti-wrinkle claims of these ingredients provide insufficient evidence of efficacy according to CreamScan Research Evaluation Standards.
 
While this does not categorically rule out the possibility that these ingredients may reduce wrinkles, their efficacy is not supported by convincing, vehicle-controlled, double-blind clinical studies - at least none that were available to the CreamScan team at the time of publication.
 
Therefore, these ingredients do not contribute to the anti-wrinkle rating.
 
📌 Moisturizers, when used regularly, are proven to prevent wrinkle formation and even reduce existing wrinkles. Therefore, this product, like any other moisturizer, can deliver some additional anti-wrinkle effects through its moisturizing action.
 

Please refer to the Ratings section below for details of the anti-wrinkle rating calculation.

🍀 Rich in Skin-Protecting Antioxidants

We estimate that NEOGEN Real Peptide Serum is rich (> 3%) in antioxidants, specifically Niacinamide (est. ≈2.0%).

A key benefit of antioxidants is their ability to reduce oxidative stress caused by free radicals and therefore prevent accelerated skin aging. Studies also show that antioxidants can protect against environmental damage such as UV radiation and pollution, and help reduce inflammation and skin redness.

📌 Please note that this is not a complete list of benefits. We are in the process of enhancing our AI model to incorporate anti-pigmentation, exfoliation and anti-acne ratings.

Pros & Cons of NEOGEN Real Peptide Serum

 
Here’s an overview of the pros and cons of NEOGEN Real Peptide Serum to help you decide if it’s the right choice for your skincare routine:
 

🟩 Pros:

✅ When used alone: Provides humectant-rich moisturizing ideal for oily skin
✅ As part of a routine: A humectant moisturizing boost, beneficial for any skin type
✅ Lightweight texture
Offers modest anti-wrinkle efficacy
✅ Rich in antioxidants that combat oxidative stress associated with accelerated skin aging and defend against environmental damage
 

⭕ Cons: 

✅ We couldn't find any
   

Summary: NEOGEN Real Peptide Serum

 
Based on the ingredient list analysis, CreamScan AI suggests that NEOGEN Real Peptide Serum
, when used alone, delivers lightweight, humectant-rich moisturizing, making it ideal for oily skin. As part of a moisturizing routine, it provides a humectant boost, beneficial for all skin types.
 
NEOGEN Real Peptide Serum contains ingredients with proven evidence of anti-wrinkle efficacy that may provide a modest anti-wrinkle effect. As a result, you can expect a positive, though not very significant, impact on wrinkles.
 
With its high antioxidant content, NEOGEN Real Peptide Serum helps protect against free radical damage and offers multiple benefits for all skin types, including preventing premature aging, defending against environmental damage, and calming inflammation.
 
📌 Fact check. At CreamScan, we are committed to accuracy and fairness. If you spot any errors or something that doesn’t seem right, please click here to let us know. We regularly update the ingredient lists and monitor the latest research on ingredient efficacy to ensure that our information remains as complete and precise as possible. The information provided here is for informational purposes only and does not substitute professional advice. We do not guarantee the efficacy or safety of any product, as individual results may vary.

 

Ingredients

Est. % Ingredient Origin Functions
70
6
4
3
2
1.5
1.3
1
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Est. %
Water
Function:
Origin:
Dipropylene Glycol
Function:
Origin:
Propanediol
Function:
Origin:
Glycerin
Function:
Origin:
Niacinamide
Function:
Origin:
Caprylic/Capric Triglyceride
Function:
Origin:
1,2-Hexanediol
Function:
Origin:
Hydroxyethyl Urea
Function:
Origin:
Diethoxyethyl Succinate
Function:
Origin:
Acrylates Copolymer
Function:
Origin:
Butylene Glycol
Function:
Origin:
Tromethamine
Function:
Origin:
Polyglyceryl-10 Laurate
Function:
Origin:
Charcoal Extract
Function:
Origin:
Xanthan Gum
Function:
Origin:
Ethylhexylglycerin
Function:
Origin:
Adenosine
Function:
Origin:
Cyamopsis Tetragonoloba (Guar) Gum
Function:
Origin:
Sodium Hyaluronate
Function:
Origin:
Agar
Function:
Origin:
Ubiquinone
Function:
Origin:
Nasturtium Officinale Extract
Function:
Origin:
Palmitoyl Tripeptide-5
Function:
Origin:
Ficus Indica Leaf Extract
Function:
Origin:
Rosa Indica Flower Extract
Function:
Origin:
Citrus Iyo Fruit Extract
Function:
Origin:
Carum Carvi (Caraway) Seed Oil
Function:
Origin:
Solanum Melongena (Eggplant) Fruit Extract
Function:
Origin:
Simmondsia Chinensis (Jojoba) Seed Oil
Function:
Origin:
Curcuma Longa (Turmeric) Root
Function:
Origin:
Coral Extract
Function:
Origin:
Ocimum Sanctum Leaf Extract
Function:
Origin:
Acetyl Hexapeptide-8
Function:
Origin:
Copper Tripeptide-1
Function:
Origin:
Tripeptide-1
Function:
Origin:
Tripeptide-29
Function:
Origin:
Palmitoyl Tetrapeptide-7
Function:
Origin:
Palmitoyl Tripeptide-1
Function:
Origin:
Palmitoyl Pentapeptide-4
Function:
Origin:
Hexapeptide-12
Function:
Origin:
Hexapeptide-9
Function:
Origin:
Tripeptide-2
Function:
Origin:
Nonapeptide-1
Function:
Origin:
Hexapeptide-11
Function:
Origin:

Ratings

All humectants
11.8
4
3
2
1
0.3
0.3
0.3
0.3
0.3
0.3
Benchmark
10
All occlusives
1.8
1.5
0.3
Benchmark
20
Moisturizing rating
5.4
Ingredient Est. % Benchmark Raiting
Humectancy All humectants 11.8 10
10.0
4
3
2
1
0.3
0.3
0.3
0.3
0.3
0.3
Occlusivity All occlusives 1.8 20
0.9
1.5
0.3
Moisturizing rating
5.4
Ingredient Est. % Benchmark Humectancy
4
3
2
1
0.3
0.3
0.3
0.3
0.3
0.3
All humectants 11.8 10
10
All humectants
11.8
4
3
2
1
0.3
0.3
0.3
0.3
0.3
0.3
Benchmark
10
Ingredient Est. % Benchmark Occlusivity
1.5
0.3
All occlusives 1.8 20
0.9
All occlusives
1.8
1.5
0.3
Benchmark
20
Ingredient
Ingredient anti-wrinkle power
when present at, %
in this formula est. %
Rating
6 /10 4 2 3
n/a
- 0.3 -
n/a
- 0.3 -
n/a
- 0.3 -
n/a
- 0.3 -
n/a
- 0.3 -
n/a
- 0.3 -
n/a
- 0.3 -
n/a
- 0.3 -
n/a
- 0.3 -
Total
3
Niacinamide
3
Ingredient anti-wrinkle power
6 /10
when present at, %
4
in this formula, est. %
2
Adenosine
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Ubiquinone
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Palmitoyl Tripeptide-5
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Acetyl Hexapeptide-8
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Copper Tripeptide-1
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Tripeptide-1
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Palmitoyl Tetrapeptide-7
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Palmitoyl Tripeptide-1
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Palmitoyl Pentapeptide-4
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Anti-wrinkle rating
3
Ingredient Est. % Benchmark
Rich in Antioxidants
2
0.3
0.3
0.3
0.3
0.3
0.3
0.3
All antioxidants 4.1 3 Rich in antioxidants
All antioxidants
4.1
Niacinamide
2
Sodium Hyaluronate
0.3
Ubiquinone
0.3
Nasturtium Officinale Extract
0.3
Rosa Indica Flower Extract
0.3
Solanum Melongena (Eggplant) Fruit Extract
0.3
Ocimum Sanctum Leaf Extract
0.3
Copper Tripeptide-1
0.3
Benchmark
3
Ingredient Est. % Benchmark
Rich in Soothing
2
0.3
0.3
0.3
All soothing 2.9 5 No
All soothing
2.9
2
0.3
0.3
0.3
Benchmark
5

Ingredients explained

Water
Est. %70
Function
Origin
WaterThe most used ingredient in skincare. Its concentration defines the product texture: rich creams may have about 50% of water while a light jelly about 90%. Water doesn’t moisturize the skin by itself and is used in skincare as a solvent for other ingredients.
Dipropylene Glycol
Est. %6
Function
Origin
Dipropylene GlycolA clear, colorless liquid that has several uses. One of its main functions is as a solvent. Dipropylene glycol is also used to reduce the thickness of skincare products.
Propanediol
Est. %4
Function
Origin
PropanediolAn excellent solvent capable of mixing water with normally water-insoluble ingredients. It also functions as a humectant due to its water-loving alcohol groups. Propanediol can control the viscosity of a product by reducing its thickness.
Glycerin
Est. %3
Function
Origin
Glycerin

The most popular moisturizing ingredient in the world. It is a powerful humectant – cheap yet very effective.

Niacinamide
Est. %2
Function
Origin
Niacinamide

Also known as vitamin B3, this ingredient is a true superstar with confirmed moisturizing, anti-acne, hyperpigmentation, and antioxidant benefits. Two studies confirm its significant anti-wrinkle efficacy.

Caprylic/Capric Triglyceride
Est. %1.5
Function
Origin
Caprylic/Capric TriglycerideA natural occlusive moisturizing and emollient ingredient, it is a blend of glycerin and two fatty acids, caprylic and capric acid. It creates an oil-based protective layer on the skin, thereby preventing water loss.
1,2-Hexanediol
Est. %1.3
Function
Origin
1,2-HexanediolA multi-functional formula helper. It is a well-studied preservtive against bacteria and can help pigments and fragrances disperse evenly in a formula.
Hydroxyethyl Urea
Est. %1
Function
Origin
Hydroxyethyl UreaHydroxyethyl urea is a synthetic derivative of regular urea (read about it here). This ingredient, similarly to urea, is humectant moisturizing and helps to retain more water to the skin’s surface, leaving it more moisturized. There aren't any studies that analyze the effects of this ingredient in great detail.
Diethoxyethyl Succinate
Est. %0.3
Function
Origin
Diethoxyethyl Succinate
Acrylates Copolymer
Est. %0.3
Function
Origin
Acrylates CopolymerA highly functional synthetic ingredient that forms a protective layer on the skin and reduces static buildup. It gives an emollient feel to the product, including a silky after-feel.
Butylene Glycol
Est. %0.3
Function
Origin
Butylene Glycol

A clear, colorless liquid humectant that draws moisture to the skin. The humectancy of butylene glycol, owed to its two hydroxyl groups, is quite considerable, although not as powerful as glycerin, which contains three hydroxyl groups.

Tromethamine
Est. %0.3
Function
Origin
TromethamineAn ingredient based on amino acids that is commonly used as a pH adjuster. It has a high pH, which means that it is basic (alkaline), so adding tromethamine to a skincare product will increase its overall pH level.
Polyglyceryl-10 Laurate
Est. %0.3
Function
Origin
Polyglyceryl-10 LaurateA vegetable glycerin or synthetically produced emulsifier and gentle cleansing agent. It won't leave skin feeling tight or dry when used to cleanse.
Charcoal Extract
Est. %0.3
Function
Origin
Charcoal Extract
Xanthan Gum
Est. %0.3
Function
Origin
Xanthan GumA natural multi-functional ingredient that originates from fermented sugars. Xanthan gum acts as a viscosity-building agent to thicken skincare products. It is also an excellent stabilizer and works well to hold other ingredients together.
Ethylhexylglycerin
Est. %0.3
Function
Origin
EthylhexylglycerinA preservative booster derived from glycerin. It is commonly paired with other preservatives to improve their efficacy. Ethylhexylglycerin is also a humectant due to its chemical base of glycerin.
Adenosine
Est. %0.3
Function
Origin
Adenosine

A key molecule responsible for energy transportation, signaling, and enzyme activity. Adenosine is a popular anti-wrinkle ingredient, however, the key study about its anti-wrinkle efficacy (1) does not meet CreamScan Research Evaluation Standards as it is not double-blind.

Cyamopsis Tetragonoloba (Guar) Gum
Est. %0.3
Function
Origin
Cyamopsis Tetragonoloba (Guar) GumA plant-based gum extracted from the seeds of guar or cluster bean. It is comprised of various polysaccharides and is used as a thickening and gelling agent.
Sodium Hyaluronate
Est. %0.3
Function
Origin
Sodium Hyaluronate

A sodium salt of famous hyaluronic acid. A potent humectant that hydrates the skin, supports collagen function, and fills out small wrinkles. Sodium hyaluronate also offers soothing and antioxidant properties.

Agar
Est. %0.3
Function
Origin
AgarA multifunctional jelly derived from red algae that can thicken water-based products.
Ubiquinone
Est. %0.3
Function
Origin
UbiquinoneAlso known as Coenzyme Q10, this bright orange antioxidant supports the skin's energy metabolism. It also offers some anti-pigment action. Dietary supplementation of Ubiquinone improves the appearance of wrinkles.
Nasturtium Officinale Extract
Est. %0.3
Function
Origin
Nasturtium Officinale ExtractAn extract from watercress, a spicy herb. It contains antioxidant and anti-inflammatory agents, as well as various sulfur-containing compounds - which are responsible for its mustard aroma.
Palmitoyl Tripeptide-5
Est. %0.3
Function
Origin
Palmitoyl Tripeptide-5

A small synthetic peptide that signals the skin to produce more collagen. It has been clinically tested and proven to reduce skin roughness and the appearance of wrinkles.

Ficus Indica Leaf Extract
Est. %0.3
Function
Origin
Ficus Indica Leaf Extract
Rosa Indica Flower Extract
Est. %0.3
Function
Origin
Rosa Indica Flower Extract
Citrus Iyo Fruit Extract
Est. %0.3
Function
Origin
Citrus Iyo Fruit Extract
Carum Carvi (Caraway) Seed Oil
Est. %0.3
Function
Origin
Carum Carvi (Caraway) Seed Oil
Solanum Melongena (Eggplant) Fruit Extract
Est. %0.3
Function
Origin
Solanum Melongena (Eggplant) Fruit ExtractAn under-researched extract obtained from the eggplant fruit. Eggplant contains plant pigments called anthocyanins and phenolic compounds, such as chlorogenic acid, which are excellent antioxidants.
Simmondsia Chinensis (Jojoba) Seed Oil
Est. %0.3
Function
Origin
Simmondsia Chinensis (Jojoba) Seed OilA liquid plant wax, also known as Jojoba oil, pressed from the seeds of Simmondsia chinensis. These seeds can contain up to 50% of liquid wax. It is used as an occlusive moisturizer, emollient, and emulsifier.
Curcuma Longa (Turmeric) Root
Est. %0.3
Function
Origin
Curcuma Longa (Turmeric) Root
Coral Extract
Est. %0.3
Function
Origin
Coral Extract
Ocimum Sanctum Leaf Extract
Est. %0.3
Function
Origin
Ocimum Sanctum Leaf ExtractAn extract derived from the leaves of Holy Basil, also known as Tulsi, a traditional herb used in Ayurveda medicine. It contains antioxidant and anti-inflammatory rosmarinic acid, galic acid, flavonoids, and a sweet-scented essential oil.
Acetyl Hexapeptide-8
Est. %0.3
Function
Origin
Acetyl Hexapeptide-8

A small synthetic peptide that is thought to act similarly to Botox by calming contractions of the facial muscles and reducing expression wrinkles. The effect is only temporary and it does not improve the skin structure in any way.

Copper Tripeptide-1
Est. %0.3
Function
Origin
Copper Tripeptide-1

A skin-identical, copper-binding peptide that promotes the synthesis of all structural elements in the skin.

Tripeptide-1
Est. %0.3
Function
Origin
Tripeptide-1

A small, skin-identical peptide that boosts collagen renewal in the skin and improves other structural proteins. It may have trouble penetrating the skin in this form, so palmitic acid or biotin is usually added to it.

Tripeptide-29
Est. %0.3
Function
Origin
Tripeptide-29
Palmitoyl Tetrapeptide-7
Est. %0.3
Function
Origin
Palmitoyl Tetrapeptide-7

A synthetic peptide that mimics the activity of immunoglobulin G and signals to the skin to stop the inflammation. It has been shown in studies to reduce wrinkles and enhance collagen content.

Palmitoyl Tripeptide-1
Est. %0.3
Function
Origin
Palmitoyl Tripeptide-1

A small peptide consisting of three amino acids with anti-wrinkle effects. Together with Palmitoyl Tetrapeptide-7, it is a part of the popular anti-wrinkle complex called Matrixyl™ 3000.

Palmitoyl Pentapeptide-4
Est. %0.3
Function
Origin
Palmitoyl Pentapeptide-4

A famous synthetically made peptide that works as a signal peptide, telling skin cells to create more collagen and other structural proteins. It has been clinically tested and found to be effective at reducing fine wrinkles.

Hexapeptide-12
Est. %0.3
Function
Origin
Hexapeptide-12
Hexapeptide-9
Est. %0.3
Function
Origin
Hexapeptide-9

Description is coming soon

Tripeptide-2
Est. %0.3
Function
Origin
Tripeptide-2
Nonapeptide-1
Est. %0.3
Function
Origin
Nonapeptide-1
Hexapeptide-11
Est. %0.3
Function
Origin
Hexapeptide-11

Description is coming soon