DefenAge 24/7 Barrier Balance Anti-Aging Cream Review

DefenAge 24/7 Barrier Balance Anti-Aging Cream
8.8
/ 10
Moisturizing
7.6 Humectancy icon Humectancy
10.0 Occlusivity icon Occlusivity
4.5Anti-wrinkle icon/ 10
Anti-wrinkle
Rich
in Antioxidants
Review

Does DefenAge 24/7 Barrier Balance Anti-Aging Cream Work?

 
According to CreamScan AI's analysis of the ingredient list, here’s what DefenAge 24/7 Barrier Balance Anti-Aging Cream has to offer:
 
✅ Intense moisturizing. It has a moisturizing rating of 8.8 out of 10.
✅ Considerable anti-wrinkle efficacy: DefenAge 24/7 Barrier Balance Anti-Aging Cream has an anti-wrinkle rating of 4.5 out of 10, indicating a moderate ability to reduce wrinkles.
✅ Antioxidant protection

  

Key Benefits of DefenAge 24/7 Barrier Balance Anti-Aging Cream

 
These are the key benefits you can expect from using DefenAge 24/7 Barrier Balance Anti-Aging Cream:
 

🔵🔵🔵 Exceptionally Rich Moisturizer Well-Suited for Dry to Very Dry Skin

According to CreamScan analysis, DefenAge 24/7 Barrier Balance Anti-Aging Cream is intensely moisturizing, with a moisturizing rating of 8.8 out of 10.

Is it more humectant or occlusive? Rather occlusive. It has a high humectancy of 7.6 out of 10, primarily due to the substantial concentration of Niacinamide (est. ≈3.0%) and Yeast Extract (est. ≈2.5%), and a maximum occlusivity of 10 out of 10, mainly due to the significant content of Carthamus Tinctorius (Safflower) Oleosomes (est. ≈9.0%) and Butyrospermum Parkii (Shea) Butter (est. ≈6.0%).

This type of moisturizer is well-suited for people with dry to very dry skin who want intense hydration. It combines a significant concentration of humectants with an exceptional level of occlusive ingredients to provide effective dual-action moisturizing specifically for dry skin.

The occlusive profile of DefenAge 24/7 Barrier Balance Anti-Aging Cream suggests a rich, thick texture, making it perfectly suited for dry skin.

Please refer to the Ratings section below for details of the moisturizing rating calculation.

🟣🟣 Considerable Anti-Wrinkle Efficacy

According to CreamScan analysis, DefenAge 24/7 Barrier Balance Anti-Aging Cream has a moderate anti-wrinkle rating of 4.5 out of 10.

It contains one ingredient with proven anti-wrinkle efficacy: Niacinamide (est. ≈3.0%),
 one of the most effective and well-researched anti-wrinkle ingredients. A clinical study involving 30 participants (Kawada et al.) confirmed that a cream with 4% niacinamide reduced the average depth of wrinkles around the eyes by 9% after 8 weeks of use, compared to a vehicle (the same formulation without niacinamide).
 
Among others, DefenAge 24/7 Barrier Balance Anti-Aging Cream also contains Ubiquinone, an ingredient often marketed as effective in reducing wrinkles. However, the studies supporting the anti-wrinkle claims of Ubiquinone provide insufficient evidence of its efficacy according to CreamScan Research Evaluation Standards.
 
While this does not categorically rule out the possibility that Ubiquinone may reduce wrinkles, its efficacy is not supported by convincing, vehicle-controlled, double-blind clinical studies - at least none that were available to the CreamScan team at the time of publication.
 
Therefore, this ingredient does not contribute to the anti-wrinkle rating.
 
📌 Moisturizers, when used regularly, are proven to prevent wrinkle formation and even reduce existing wrinkles. Therefore, this product, like any other moisturizer, can deliver some additional anti-wrinkle effects through its moisturizing action.
 

Please refer to the Ratings section below for details of the anti-wrinkle rating calculation.

🍀 Rich in Skin-Protecting Antioxidants

We estimate that DefenAge 24/7 Barrier Balance Anti-Aging Cream is rich (> 3%) in antioxidants, specifically Carthamus Tinctorius (Safflower) Oleosomes (est. ≈9.0%) and Niacinamide (est. ≈3.0%).

A key benefit of antioxidants is their ability to reduce oxidative stress caused by free radicals and therefore prevent accelerated skin aging. Studies also show that antioxidants can protect against environmental damage such as UV radiation and pollution, and help reduce inflammation and skin redness.

📌 Please note that this is not a complete list of benefits. We are in the process of enhancing our AI model to incorporate anti-pigmentation, exfoliation and anti-acne ratings.

Things to Be Aware Of: DefenAge 24/7 Barrier Balance Anti-Aging Cream

 
CreamScan AI identified a few things to consider before adding DefenAge 24/7 Barrier Balance Anti-Aging Cream to your skincare routine:
 

⚠️ Best for Very Dry Skin - May Be Too Thick for Other Skin Types

With exceptional occlusivity, this product is optimal for moisturizing dry and very dry skin but may be too thick for other skin types, including normal, and especially combination and oily skin.

If you have oily, combination, or normal skin and are considering purchasing this product for the first time, it might be a good idea to try a sample before buying.

Pros & Cons of DefenAge 24/7 Barrier Balance Anti-Aging Cream

 
Here’s an overview of the pros and cons of DefenAge 24/7 Barrier Balance Anti-Aging Cream to help you decide if it’s the right choice for your skincare routine:
 

🟩 Pros:

Very rich moisturizer perfect for dry and very dry skin: exceptionally occlusive and humectant-packed
Provides considerable anti-wrinkle efficacy thanks to Niacinamide
✅ Rich in antioxidants that combat oxidative stress associated with accelerated skin aging and defend against environmental damage
 

⭕ Cons: 

⚠️ May feel too rich and thick on skin types other than dry
   

Summary: DefenAge 24/7 Barrier Balance Anti-Aging Cream

 
Based on the ingredient list analysis, CreamScan AI suggests that DefenAge 24/7 Barrier Balance Anti-Aging Cream
 is a well-suited moisturizer for dry to very dry skin, combining a high concentration of humectants and occlusive ingredients in a rich, thick texture.
 
DefenAge 24/7 Barrier Balance Anti-Aging Cream contains ingredients with solid, robust evidence of anti-wrinkle efficacy, in concentrations that may deliver a noticeable anti-wrinkle effect.
 
With its high antioxidant content, DefenAge 24/7 Barrier Balance Anti-Aging Cream helps protect against free radical damage and offers multiple benefits for all skin types, including preventing premature aging, defending against environmental damage, and calming inflammation.
 
That said, there are some things about DefenAge 24/7 Barrier Balance Anti-Aging Cream worth noting.
 
With its high occlusivity, DefenAge 24/7 Barrier Balance Anti-Aging Cream is ideal for dry skin but may feel too thick on other skin types. If you have oily, combination, or normal skin, it’s a good idea to try a sample before purchasing.
 
📌 Fact check. At CreamScan, we are committed to accuracy and fairness. If you spot any errors or something that doesn’t seem right, please click here to let us know. We regularly update the ingredient lists and monitor the latest research on ingredient efficacy to ensure that our information remains as complete and precise as possible. The information provided here is for informational purposes only and does not substitute professional advice. We do not guarantee the efficacy or safety of any product, as individual results may vary.

 

Ingredients

Est. % Ingredient Origin Functions
65
9
6
4
3
2.5
2
1.5
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Est. %
Water
Function:
Origin:
Carthamus Tinctorius (Safflower) Oleosomes
Function:
Origin:
Butyrospermum Parkii (Shea) Butter
Function:
Origin:
Macadamia Integrifolia Seed Oil
Function:
Origin:
Niacinamide
Function:
Origin:
Yeast Extract
Function:
Origin:
Ammonium Acryloyldimethyltaurate Crosspolymer
Function:
Origin:
Helianthus Annuus (Sunflower) Seed Oil
Function:
Origin:
Phospholipids
Function:
Origin:
Alpha-Arbutin
Function:
Origin:
Hyaluronic Acid
Function:
Origin:
Ophiopogon Japonicus Root Extract
Function:
Origin:
Hydrolyzed Candida Saitoana Extract
Function:
Origin:
Sea Whip Extract
Function:
Origin:
Lycium Chinense Fruit Extract
Function:
Origin:
Vaccinium Angustifolium (Blueberry) Fruit Extract
Function:
Origin:
Vaccinium Macrocarpon (Cranberry) Fruit Extract
Function:
Origin:
Rosmarinus Officinalis (Rosemary) Leaf Extract
Function:
Origin:
Panthenol
Function:
Origin:
Serum Albumin
Function:
Origin:
Tocopheryl Acetate
Function:
Origin:
Ubiquinone
Function:
Origin:
Alanyl Glutamine
Function:
Origin:
Leuconostoc/Radish Root Ferment Filtrate
Function:
Origin:
Xanthan Gum
Function:
Origin:
Phytic Acid
Function:
Origin:
Polysorbate 20
Function:
Origin:
Caprylic/Capric Triglyceride
Function:
Origin:
Phenoxyethanol
Function:
Origin:
Caprylyl Glycol
Function:
Origin:
Ethylhexylglycerin
Function:
Origin:
Hexylene Glycol
Function:
Origin:
Potassium Sorbate
Function:
Origin:
Sodium Chloride
Function:
Origin:

Ratings

All humectants
7.6
3
2.5
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Benchmark
10
All occlusives
20.8
9.0
6.0
4.0
1.5
0.3
Benchmark
20
Moisturizing rating
8.8
Ingredient Est. % Benchmark Raiting
Humectancy All humectants 7.6 10
7.6
3
2.5
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Occlusivity All occlusives 20.8 20
10.0
9.0
6.0
4.0
1.5
0.3
Moisturizing rating
8.8
Ingredient Est. % Benchmark Humectancy
3
2.5
0.3
0.3
0.3
0.3
0.3
0.3
0.3
All humectants 7.6 10
7.6
All humectants
7.6
3
2.5
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Benchmark
10
Ingredient Est. % Benchmark Occlusivity
9
6
4
1.5
0.3
All occlusives 20.8 20
10.0
All occlusives
20.8
9.0
6.0
4.0
1.5
0.3
Benchmark
20
Ingredient
Ingredient anti-wrinkle power
when present at, %
in this formula est. %
Rating
6 /10 4 3 4.5
n/a
- 0.3 -
Total
4.5
Niacinamide
4.5
Ingredient anti-wrinkle power
6 /10
when present at, %
4
in this formula, est. %
3
Ubiquinone
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Anti-wrinkle rating
4.5
Ingredient Est. % Benchmark
Rich in Antioxidants
9
3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
All antioxidants 14.7 3 Rich in antioxidants
All antioxidants
14.7
Carthamus Tinctorius (Safflower) Oleosomes
9
Niacinamide
3
Alpha-Arbutin
0.3
Hyaluronic Acid
0.3
Ophiopogon Japonicus Root Extract
0.3
Lycium Chinense Fruit Extract
0.3
Vaccinium Angustifolium (Blueberry) Fruit Extract
0.3
Vaccinium Macrocarpon (Cranberry) Fruit Extract
0.3
Rosmarinus Officinalis (Rosemary) Leaf Extract
0.3
Tocopheryl Acetate
0.3
Ubiquinone
0.3
Benchmark
3
Ingredient Est. % Benchmark
Rich in Soothing
3
0.3
0.3
0.3
0.3
All soothing 4.2 5 No
All soothing
4.2
3
0.3
0.3
0.3
0.3
Benchmark
5

Ingredients explained

Water
Est. %65
Function
Origin
WaterThe most used ingredient in skincare. Its concentration defines the product texture: rich creams may have about 50% of water while a light jelly about 90%. Water doesn’t moisturize the skin by itself and is used in skincare as a solvent for other ingredients.
Carthamus Tinctorius (Safflower) Oleosomes
Est. %9
Function
Origin
Carthamus Tinctorius (Safflower) OleosomesMicroscopic droplets of safflower oil surrounded by a membrane. Oleosomes are able to create a very stable emulsion and are better absorbed by the skin. Safflower oil offers occlusive, emollient, and antioxidant properties.
Butyrospermum Parkii (Shea) Butter
Est. %6
Function
Origin
Butyrospermum Parkii (Shea) ButterA semi-solid, buttery fat extracted from the seeds of the Shea tree that is a wonderful occlusive and emollient ingredient mainly comprised of fatty acids. Shea butter contains a large amount of anti-inflammatory and antioxidant compounds.
Macadamia Integrifolia Seed Oil
Est. %4
Function
Origin
Macadamia Integrifolia Seed OilExtracted from macadamia nuts, this emollient and occlusive moisturizing oil is composed mostly of oleic and palmitoleic fatty acids. It is suitable for dry and eczema-prone skin.
Niacinamide
Est. %3
Function
Origin
Niacinamide

Also known as vitamin B3, this ingredient is a true superstar with confirmed moisturizing, anti-acne, hyperpigmentation, and antioxidant benefits. Two studies confirm its significant anti-wrinkle efficacy.

Yeast Extract
Est. %2.5
Function
Origin
Yeast ExtractAlso labeled as faex extract, this is a natural ingredient derived from fresh yeast. It is used in skincare as a humectant. Yeast extract also helps to shield injured or exposed skin and can aid in the skin’s wound healing process.
Ammonium Acryloyldimethyltaurate Crosspolymer
Est. %2
Function
Origin
Ammonium Acryloyldimethyltaurate Crosspolymer
Helianthus Annuus (Sunflower) Seed Oil
Est. %1.5
Function
Origin
Helianthus Annuus (Sunflower) Seed OilA fatty oil expressed from sunflower seeds and one of the most commonly used oils in skincare. It has great emollient and occlusive moisturizing properties. Sunflower oil is one of the richest sources of vitamin E – an important skin antioxidant.
Phospholipids
Est. %0.3
Function
Origin
PhospholipidsA large group of lipids that are an essential component of every single cell membrane in the body. They have excellent emollient properties. Phospholipids are also utilized in the manufacturing of ‘fancy’ formulations such as liposomes.
Alpha-Arbutin
Est. %0.3
Function
Origin
Alpha-Arbutin
Hyaluronic Acid
Est. %0.3
Function
Origin
Hyaluronic Acid

A potent, skin-identical humectant moisturizing ingredient that is able to bind water 1000 times its own weight. The anti-aging benefits of hyaluronic acid are due to its ability to stimulate the synthesis of collagen in the skin.

Ophiopogon Japonicus Root Extract
Est. %0.3
Function
Origin
Ophiopogon Japonicus Root ExtractA moisturizing extract derived from the roots of the dwarf lilyturf, also known as mondo grass. It is rich in humectant polysaccharides and contains anti-inflammatory and antioxidant compounds.
Hydrolyzed Candida Saitoana Extract
Est. %0.3
Function
Origin
Hydrolyzed Candida Saitoana Extract
Sea Whip Extract
Est. %0.3
Function
Origin
Sea Whip ExtractAn extract derived from soft sea corals called sea fans or sea whips. It allegedly contains some anti-inflammatory terpenoid compounds.
Lycium Chinense Fruit Extract
Est. %0.3
Function
Origin
Lycium Chinense Fruit ExtractDerived from Goji berries, also known as wolfberries, this extract is packed with potent antioxidant polysaccharides, vitamins B and C, carotenoids (mainly zeaxanthin), flavonoids, and phytosterols.
Vaccinium Angustifolium (Blueberry) Fruit Extract
Est. %0.3
Function
Origin
Vaccinium Angustifolium (Blueberry) Fruit ExtractObtained from the fruits of the lowbush blueberry, this purple-blue extract is rich in antioxidant vitamin C and anthocyanins.
Vaccinium Macrocarpon (Cranberry) Fruit Extract
Est. %0.3
Function
Origin
Vaccinium Macrocarpon (Cranberry) Fruit ExtractA bright red extract derived from cranberry fruits that is rich in powerful antioxidant anthocyanins, as well as astringent tannins.
Rosmarinus Officinalis (Rosemary) Leaf Extract
Est. %0.3
Function
Origin
Rosmarinus Officinalis (Rosemary) Leaf ExtractA soothing and astringent extract derived from the fragrant, spicy leaves of rosemary. It has strong antioxidant properties. Rosemary extract can reduce signs of inflammation and also acts as an emollient and antimicrobial agent.
Panthenol
Est. %0.3
Function
Origin
PanthenolA popular soothing and moisturizing derivative of vitamin B5. Panthenol is particularly beneficial for dry, flaking, burned, or damaged skin. It is used to alleviate the symptoms of a rash, dermatitis, eczema, chapped lips, and sunburn.
Serum Albumin
Est. %0.3
Function
Origin
Serum Albumin
Tocopheryl Acetate
Est. %0.3
Function
Origin
Tocopheryl Acetate

An antioxidant derivative of tocopherol (vitamin E). It helps to protect cells from free radicals and UV damage through the conversion to active vitamin E in the skin. It is more stable than tocopherol.

Ubiquinone
Est. %0.3
Function
Origin
UbiquinoneAlso known as Coenzyme Q10, this bright orange antioxidant supports the skin's energy metabolism. It also offers some anti-pigment action. Dietary supplementation of Ubiquinone improves the appearance of wrinkles.
Alanyl Glutamine
Est. %0.3
Function
Origin
Alanyl Glutamine
Leuconostoc/Radish Root Ferment Filtrate
Est. %0.3
Function
Origin
Leuconostoc/Radish Root Ferment FiltrateA biotechnological fermentation ingredient that is created by feeding radish root to Leuconostoc kimchii. It allegedly contains organic acids and a mixture of peptides known as bacteriocins – which have antimicrobial activity.
Xanthan Gum
Est. %0.3
Function
Origin
Xanthan GumA natural multi-functional ingredient that originates from fermented sugars. Xanthan gum acts as a viscosity-building agent to thicken skincare products. It is also an excellent stabilizer and works well to hold other ingredients together.
Phytic Acid
Est. %0.3
Function
Origin
Phytic AcidPhytic acid is found in rice and is seen as a cousin of alpha-hydroxy acids. As a chelator, it can bind to certain metals that may cause discoloration in products or reduce the efficacy of other ingredients.
Polysorbate 20
Est. %0.3
Function
Origin
Polysorbate 20A viscous, amber-colored liquid that functions as a solubilizer to disperse small amounts of oil into a large water phase. Polysorbate 20 is frequently used to solubilize fragrance oils into water-based emulsions.
Caprylic/Capric Triglyceride
Est. %0.3
Function
Origin
Caprylic/Capric TriglycerideA natural occlusive moisturizing and emollient ingredient, it is a blend of glycerin and two fatty acids, caprylic and capric acid. It creates an oil-based protective layer on the skin, thereby preventing water loss.
Phenoxyethanol
Est. %0.3
Function
Origin
PhenoxyethanolThe most frequently used preservative in skincare. It is a clear, oil-like liquid synthetic substance that protects products from harmful bacteria and yeast, whilst still leaving skin microflora unharmed. It is confirmed by research to be harmless.
Caprylyl Glycol
Est. %0.3
Function
Origin
Caprylyl GlycolAn emollient that improves product spreadability and offers a silky feel on the skin. It also acts as a preservative booster that improves the efficacy of other preservatives. According to the manufacturer, it is also a humectant moisturizer.
Ethylhexylglycerin
Est. %0.3
Function
Origin
EthylhexylglycerinA preservative booster derived from glycerin. It is commonly paired with other preservatives to improve their efficacy. Ethylhexylglycerin is also a humectant due to its chemical base of glycerin.
Hexylene Glycol
Est. %0.3
Function
Origin
Hexylene GlycolA multifunctional ingredient that is best known for its use as a solvent. It can dissolve both water-based ingredients and oils. For this reason, it can also function as an emulsifier, allowing oil and water ingredients to mix and remain stable.
Potassium Sorbate
Est. %0.3
Function
Origin
Potassium SorbateA preservative widely used in food and personal care products, available from natural sources or synthetically produced. Potassium sorbate works by inhibiting the growth of yeasts, molds, and some bacteria.
Sodium Chloride
Est. %0.3
Function
Origin
Sodium Chloride

You’re definitely familiar with sodium chloride, even if you don’t think you are. It’s table salt! Salt works well with some cleansing ingredients (surfactants) to thicken them into gels. It also acts as a stabilizer for water-in-oil emulsions.