The Organic Pharmacy Retinol Night Serum Review

The Organic Pharmacy Retinol Night Serum
5.0
/ 10
Moisturizing
10.0 Humectancy icon Humectancy
0.0 Occlusivity icon Occlusivity
10Anti-wrinkle icon/ 10
Anti-wrinkle
Rich Skin Soothing icon
in Skin Soothers
Review

Does The Organic Pharmacy Retinol Night Serum Work?

 
According to CreamScan AI's analysis of the ingredient list, here’s what The Organic Pharmacy Retinol Night Serum has to offer:
 
✅ Strong humectant moisturizing. This lightweight, humectant-rich product, ideal for oily skin, has a moisturizing rating of 5.0 out of 10.
✅ Potent anti-wrinkle effect with the highest possible efficacy rating. With an anti-wrinkle rating of 10.0 out of 10, The Organic Pharmacy Retinol Night Serum is highly potent in reducing wrinkles.
✅ Soothing: The Organic Pharmacy Retinol Night Serum contains a high concentration of soothing ingredients, which may help to reduce irritation and calm the skin.

  

Key Benefits of The Organic Pharmacy Retinol Night Serum

 
These are the key benefits you can expect from using The Organic Pharmacy Retinol Night Serum:
 

🔵 Lightweight Purely Humectant Moisturizing, Ideal for Oily Skin

According to CreamScan analysis, The Organic Pharmacy Retinol Night Serum is quite moisturizing, with a moisturizing rating of 5.0 out of 10.

Is it more humectant or occlusive? It is purely humectant. It has zero occlusivity (we didn't find any occlusive ingredients on the ingredient list) and a maximum humectancy of 10 out of 10, primarily due to the high content of Glycerin (est. ≈6.0%) and Sodium Lactate (est. ≈4.0%).

This humectant-rich product, when used alone as a moisturizer, is ideal for oily skin, providing significant hydration in a lightweight, fast-absorbing formula without any occlusive ingredients.

❗️ Certain studies suggest that humectants alone may not effectively moisturize the skin. If you use this product as your only moisturizer, we recommend following it with one that contains at least some occlusive ingredients.

💧 A Humectant Boost for Any Skincare Routine

But it’s not limited to oily skin - such a humectant boost will also positively contribute to the moisturizing efficacy of any skincare routine when used as a step before applying the main moisturizer. This type of formulation is typically used in serums, where a light, fast-absorbing texture is key.

Please refer to the Ratings section below for details of the moisturizing rating calculation.

🟣🟣🟣 Potent Anti-Wrinkle Efficacy

According to CreamScan analysis, The Organic Pharmacy Retinol Night Serum has a maximum anti-wrinkle rating of 10.0 out of 10.

It contains one ingredient with proven anti-wrinkle efficacy: Retinol (est. ≈2.5%),
 the most effective non-prescription anti-wrinkle ingredient. Numerous clinical studies have shown its positive effects at concentrations as low as 0.1%. A study with 36 participants (Kafi et al.) confirmed that a lotion containing 0.4% retinol reduced wrinkle severity by 21% after 24 weeks of use, compared to the same formulation without retinol (vehicle).
 
Among others, The Organic Pharmacy Retinol Night Serum also contains Gluconolactone, an ingredient often marketed as effective in reducing wrinkles. However, the studies supporting the anti-wrinkle claims of Gluconolactone provide insufficient evidence of its efficacy according to CreamScan Research Evaluation Standards.
 
While this does not categorically rule out the possibility that Gluconolactone may reduce wrinkles, its efficacy is not supported by convincing, vehicle-controlled, double-blind clinical studies - at least none that were available to the CreamScan team at the time of publication.
 
Therefore, this ingredient does not contribute to the anti-wrinkle rating.
 

Please refer to the Ratings section below for details of the anti-wrinkle rating calculation.

🔴 Skin Soothing and Calming Potential

Based on the ingredient list analysis, The Organic Pharmacy Retinol Night Serum is rich (> 5%) in soothing ingredients, particularly Hamamelis Virginiana (Witch Hazel) Water (est. ≈75.0%).

When applied to the skin, compounds of soothing ingredients, such as triglycerides, phospholipids, fatty acids, phenolic compounds, and antioxidants, work together to soothe the skin through various mechanisms: reducing inflammation, promoting wound healing, repairing the skin barrier, and providing antimicrobial and antioxidant activities.

📌 Please note that this is not a complete list of benefits. We are in the process of enhancing our AI model to incorporate anti-pigmentation, exfoliation and anti-acne ratings.

Things to Be Aware Of: The Organic Pharmacy Retinol Night Serum

 
CreamScan AI identified a few things to consider before adding The Organic Pharmacy Retinol Night Serum to your skincare routine:
 

⚠️ May Increase Skin Photosensitivity Due to Retinol

This product contains retinol, which offers powerful anti-wrinkle benefits. The mechanism behind retinol’s action is boosting cell turnover. This process exposes new, more delicate skin, making it more vulnerable to sun damage.

As a result, using products with retinol may increase the skin's sensitivity, making it more prone to sunburn or irritation when exposed to UV rays.

To protect the skin, dermatologists recommend applying a broad-spectrum sunscreen with at least SPF 30 throughout the duration of retinol treatment, along with avoiding direct sun exposure. Retinol should be used at night, as it is sensitive to sunlight and can lose its potency when exposed to UV rays.

❗️Please always check the manufacturer's instructions for using the retinol-containing products, either on their website or product label.

⚠️ If It’s Your Only Moisturizer, It Needs to Be Paired with Some Occlusives

While humectants are highly effective at attracting water to the skin, studies (J. N. Kraft, C. W. Lynde) suggest they may not be efficient when used alone.

One major drawback of purely humectant moisturization is that the water attracted by humectants to the upper layers of the skin can evaporate completely into the environment through transepidermal water loss (TEWL). Adding occlusive ingredients helps seal this moisture into the skin and prevent further water loss.

If you’re using The Organic Pharmacy Retinol Night Serum as your only moisturizer, consider pairing it with one that contains at least some occlusive ingredients, such as oils, butters, or silicones. These work alongside humectants to create a protective barrier, locking in hydration and ensuring longer-lasting moisturization. The amount of occlusive needed depends on your skin type - the drier the skin, the more occlusives it requires.

If this product is used not as a standalone moisturizer but as part of your skincare routine, such as a toner or serum, it should be applied before your main moisturizer (unless it's a sunscreen), which will provide the necessary occlusivity on top of it.

Pros & Cons of The Organic Pharmacy Retinol Night Serum

 
Here’s an overview of the pros and cons of The Organic Pharmacy Retinol Night Serum to help you decide if it’s the right choice for your skincare routine:
 

🟩 Pros:

✅ When used alone: Provides humectant-rich moisturizing ideal for oily skin
✅ As part of a routine: A humectant moisturizing boost, beneficial for any skin type
✅ Lightweight texture
Delivers potent anti-wrinkle efficacy with the highest possible rating of 10 out of 10 thanks to Retinol
✅ Potentially soothing, as it contains a high concentration of soothing Hamamelis Virginiana (Witch Hazel) Water
 

⭕ Cons: 

⚠️ May increase skin photosensitivity due to retinol
⚠️ Only if used as a standalone moisturizer - it needs to be paired with occlusives to seal in humectants
   

Summary: The Organic Pharmacy Retinol Night Serum

 
Based on the ingredient list analysis, CreamScan AI suggests that The Organic Pharmacy Retinol Night Serum
 is highly effective in treating wrinkles, featuring ingredients with solid, robust evidence of anti-wrinkle efficacy, in concentrations that may deliver a significant anti-wrinkle effect.
 

When used alone, it delivers lightweight, humectant-rich moisturizing, making it ideal for oily skin. As part of a moisturizing routine, it provides a humectant boost, beneficial for all skin types.

With a high concentration of soothing ingredients, The Organic Pharmacy Retinol Night Serum has the potential to calm and comfort irritated skin. Whether you’re experiencing redness, irritation, or general sensitivity, its soothing properties may help restore balance and provide relief.
 
That said, there are some things about The Organic Pharmacy Retinol Night Serum worth noting.
 
Looking at its moisturizing profile, we found that it doesn’t contain any occlusive ingredients, potentially allowing the moisture attracted to the skin by humectants to evaporate. Therefore, if it’s used as the only moisturizer in a routine, it’s recommended to pair it with one that contains at least some occlusive ingredients, such as oils, butters, or silicones.
 
This product contains retinol, the most powerful and well-researched non-prescription anti-wrinkle ingredient. However, retinol can make your skin more prone to sun damage and increase sensitivity, so it’s recommended to use a broad-spectrum sunscreen with at least SPF 30 throughout the duration of retinol treatment.
 
❗️ Fact check. At CreamScan, we are committed to accuracy and fairness. If you spot any errors or something that doesn’t seem right, please click here to let us know. We regularly update the ingredient lists and monitor the latest research on ingredient efficacy to ensure that our information remains as complete and precise as possible.

 

Ingredients

Est. % Ingredient Origin Functions
75
6
4
3
2.7
2.6
2.5
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.15
0.3
Est. %
Hamamelis Virginiana (Witch Hazel) Water
Function:
Origin:
Glycerin
Function:
Origin:
Sodium Lactate
Function:
Origin:
Water
Function:
Origin:
Citrus Grandis Peel Oil
Function:
Origin:
Algin
Function:
Origin:
Retinol
Function:
Origin:
Dehydroacetic Acid
Function:
Origin:
Benzyl Alcohol
Function:
Origin:
Chondrus Crispus
Function:
Origin:
Xanthan Gum
Function:
Origin:
Lecithin
Function:
Origin:
Gluconolactone
Function:
Origin:
Sodium Benzoate
Function:
Origin:
Sorbic Acid
Function:
Origin:
Limonene
Function:
Origin:
Citral
Function:
Origin:
Linalool
Function:
Origin:

Ratings

All humectants
10.9
6
4
0.3
0.3
0.3
Benchmark
10
All occlusives
0.0
None
Benchmark
20
Moisturizing rating
5.0
Ingredient Est. % Benchmark Raiting
Humectancy All humectants 10.9 10
10.0
6
4
0.3
0.3
0.3
Occlusivity All occlusives 0.0 20
0.0
None
Moisturizing rating
5.0
Ingredient Est. % Benchmark Humectancy
6
4
0.3
0.3
0.3
All humectants 10.9 10
10
All humectants
10.9
6
4
0.3
0.3
0.3
Benchmark
10
Ingredient Est. % Benchmark Occlusivity
None
All occlusives 0.0 20
0.0
All occlusives
0.0
None
Benchmark
20
Ingredient
Ingredient anti-wrinkle power
when present at, %
in this formula est. %
Rating
10 /10 0.4 2.5 10
n/a
- 0.3 -
Total
10
Retinol
10
Ingredient anti-wrinkle power
10 /10
when present at, %
0.4
in this formula, est. %
2.5
Gluconolactone
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Anti-wrinkle rating
10
Ingredient Est. % Benchmark
Rich in Antioxidants
2.7
All antioxidants 2.7 3 No
All antioxidants
2.7
Citrus Grandis Peel Oil
2.7
Benchmark
3
Ingredient Est. % Benchmark
Rich in Soothing
75
All soothing 75 5 Rich in soothing
All soothing
75
75
Benchmark
5

Ingredients explained

Hamamelis Virginiana (Witch Hazel) Water
Est. %75
Function
Origin
Hamamelis Virginiana (Witch Hazel) WaterA fragrant, astringent essential water obtained by steeping and distilling the twigs and leaves of the witch hazel plant. It leaves the skin feeling tight and refreshed after application and helps with the healing of small cuts on the skin.
Glycerin
Est. %6
Function
Origin
Glycerin

The most popular moisturizing ingredient in the world. It is a powerful humectant – cheap yet very effective.

Sodium Lactate
Est. %4
Function
Origin
Sodium LactateA sodium salt of lactic acid. Its main function is as a humectant but it can also serve as a pH adjuster. Additionally, sodium lactate can also be used as a chemical exfoliant due to its close chemical relation to lactic acid.
Water
Est. %3
Function
Origin
WaterThe most used ingredient in skincare. Its concentration defines the product texture: rich creams may have about 50% of water while a light jelly about 90%. Water doesn’t moisturize the skin by itself and is used in skincare as a solvent for other ingredients.
Citrus Grandis Peel Oil
Est. %2.7
Function
Origin
Citrus Grandis Peel Oil

A fragrant essential oil obtained from pomelo peels - sometimes mislabeled as grapefruit. The high limonene content is responsible for its citrusy scent. It may induce sun allergies in people sensitive to citrus fruits.

Algin
Est. %2.6
Function
Origin
AlginA plant-based ingredient that can form gels when added to water, so it can thicken water-based products. Algin serves as a binding agent, where it helps hold the other ingredients in the product together and prevents them from separating.
Retinol
Est. %2.5
Function
Origin
Retinol

One of the most famous and well-researched anti-aging ingredients with a maximum anti-wrinkle power of 10 out of 10. It is proven to decrease wrinkles and help the skin regain its thickness, firmness, and texture. Retinol is also effective in treating pigmentation issues such as dark spots and acne.

Dehydroacetic Acid
Est. %0.3
Function
Origin
Dehydroacetic AcidA globally approved preservative ingredient. It is a powerful fungicide and a moderate bactericide, which makes it a broad-spectrum preservative. Because it is mildly effective against bacteria, it is often paired with stronger bactericides.
Benzyl Alcohol
Est. %0.3
Function
Origin
Benzyl Alcohol

A multifunctional ingredient that is supplied as a clear, colorless liquid. Its main function is as a flavoring agent and fragrance. It also acts as a broad-spectrum preservative, solvent, and viscosity-controlling agent that thins the product.

Chondrus Crispus
Est. %0.3
Function
Origin
Chondrus CrispusAn ingredient obtained from the red marine algae Irish moss. It contains a gel-forming algal polysaccharide carrageenan and is a rich source of antimicrobial iodine and sulfur. It also offers various antioxidants.
Xanthan Gum
Est. %0.3
Function
Origin
Xanthan GumA natural multi-functional ingredient that originates from fermented sugars. Xanthan gum acts as a viscosity-building agent to thicken skincare products. It is also an excellent stabilizer and works well to hold other ingredients together.
Lecithin
Est. %0.3
Function
Origin
LecithinA humectant, emollient, and emulsifier best suited for water-in-oil emulsions. Lecithin can come from sunflowers, soy, and eggs. The downside to lecithin is that it causes an extra burden on the formula’s preservative because it is nutritious.
Gluconolactone
Est. %0.3
Function
Origin
GluconolactoneA PHA derived from glucose. It has exfoliating and humectant properties and acts as a penetration enhancer for other ingredients. It has also been shown to assist in the treatment of acne and the prevention of photoaging.
Sodium Benzoate
Est. %0.3
Function
Origin
Sodium BenzoateA preservative that usually works in combination with other preservatives. It has to be at low pH (<5.5) to be effective.
Sorbic Acid
Est. %0.3
Function
Origin
Sorbic AcidAn organic acid that can be naturally found in the berries of the Mountain ash, although it is manufactured synthetically for skincare purposes. It is used as a preservative and antimicrobial agent, protecting a skincare product from spoiling.
Limonene
Est. %0.3
Function
Origin
Limonene

One of the most used fragrances in skincare products. It is produced from the peels of citrus fruits and has a fresh, pleasant, citrusy smell. People who are sensitive to citrus should try to avoid it, or at least do a patch test before using it.

Citral
Est. %0.15
Function
Origin
Citral

A fragrant compound found in many essential oils (especially lemon myrtle and lemongrass essential oil). It has a sweet, lemon-like scent. People with sensitive skin should try to avoid products with citral, or at least do a patch test before using.

Linalool
Est. %0.3
Function
Origin
LinaloolA fragrant, volatile compound naturally present in many essential oils. It has a pleasant scent and is often used in skincare products as a fragrance. People with sensitive skin should try to avoid it, or at least do a patch test before using it.