SkinBetter Science AlphaRet Overnight Cream Review

SkinBetter Science AlphaRet Overnight Cream
3.8
/ 10
Moisturizing
6.7 Humectancy icon Humectancy
0.9 Occlusivity icon Occlusivity
3.9Anti-wrinkle icon/ 10
Anti-wrinkle
Rich
in Antioxidants
Review

Does SkinBetter Science AlphaRet Overnight Cream Work?

 
According to CreamScan AI's analysis of the ingredient list, here’s what SkinBetter Science AlphaRet Overnight Cream has to offer:
 
  • Light moisturizing. It has a moisturizing rating of 3.8 out of 10.
  • Modest anti-wrinkle efficacy: SkinBetter Science AlphaRet Overnight Cream has an anti-wrinkle rating of 3.9 out of 10 so you may expect some, although limited, effect on wrinkles.
  • Antioxidant protection.

Key Benefits of SkinBetter Science AlphaRet Overnight Cream

 
These are the key benefits you can expect from using SkinBetter Science AlphaRet Overnight Cream:
 

Lightweight Moisturizer Well-Suited for Oily Skin

According to CreamScan analysis, SkinBetter Science AlphaRet Overnight Cream is lightly moisturizing, with a moisturizing rating of 3.8 out of 10.

Is it more humectant or occlusive? Significantly more humectant. It has a low occlusivity of 0.9 out of 10 and a high humectancy of 6.7 out of 10, primarily due to the high content of Pentylene Glycol (est. ≈3.0%).

This humectant-rich product, when used alone as a moisturizer, is well-suited for oily skin, providing moderate hydration in a lightweight, fast-absorbing formula with a minimal amount of occlusive ingredients.

It can also be a good option for people with normal skin who prefer lightweight moisturizers.

A Humectant Enhancement for Any Skincare Routine

But it’s not limited to oily skin - such a humectant enhancement will also positively contribute to the moisturizing efficacy of any skincare routine when used as a step before applying the main moisturizer. This type of formulation is typically used in serums, where a light, fast-absorbing texture is key.

Please refer to the Ratings section below for details of the moisturizing rating calculation.

Modest Anti-Wrinkle Efficacy

According to CreamScan analysis, SkinBetter Science AlphaRet Overnight Cream has a modest level of anti-wrinkle efficacy, rated 3.9 out of 10.

It contains 3 active ingredients with proven anti-wrinkle efficacy:

  • Ascorbyl Tetraisopalmitate (est. ≈1.3%),
     the only derivative of ascorbic acid with solid evidence of anti-wrinkle efficacy. A single clinical study involving 23 participants (Mariko et al.) demonstrated that a cream with 1% ATIP reduced the average depth of periorbital wrinkles by 6% after 8 weeks of use, compared to a vehicle (the same formulation without ATIP).
  • Glycolic Acid (est. ≈6.0%),
     a highly effective ingredient in peelings but with moderate anti-wrinkle efficacy in leave-on skincare products, as supported by a single clinical study. This study, involving 72 participants (Thibault et al.), demonstrated that a lotion with 5% GA reduced the fine wrinkling score by 6% after 34 days of use, compared to a vehicle (the same formulation without GA).
  • Niacinamide (est. ≈0.3%),
     one of the most effective and well-researched anti-wrinkle ingredients. A clinical study involving 30 participants (Kawada et al.) confirmed that a cream with 4% niacinamide reduced the average depth of wrinkles around the eyes by 9% after 8 weeks of use, compared to a vehicle (the same formulation without niacinamide).
Among others, SkinBetter Science AlphaRet Overnight Cream also contains some ingredients often marketed as effective in reducing wrinkles, specifically Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Ubiquinone, and Camellia Sinensis Leaf Extract. However, the studies supporting the anti-wrinkle claims of these ingredients provide insufficient evidence of efficacy according to CreamScan Research Evaluation Standards. Therefore, these ingredients do not contribute to the anti-wrinkle rating.
 
Moisturizers, when used regularly, are proven to prevent wrinkle formation and even reduce existing wrinkles. Therefore, this product, like any other moisturizer, can deliver some anti-wrinkle effects through its moisturizing action.
 

Please refer to the Ratings section below for details of the anti-wrinkle rating calculation.

Rich in Skin-Protecting Antioxidants

We estimate that SkinBetter Science AlphaRet Overnight Cream is rich (> 3%) in antioxidants, specifically Ascorbyl Tetraisopalmitate (est. ≈1.3%), Niacinamide (est. ≈0.3%), Hyaluronic Acid (est. ≈0.3%), and others.

A key benefit of antioxidants is their ability to reduce oxidative stress caused by free radicals and therefore prevent accelerated skin aging. Studies also show that antioxidants can protect against environmental damage such as UV radiation and pollution, and help reduce inflammation and skin redness.

Please note that this is not a complete list of benefits. We are in the process of enhancing our AI model to incorporate anti-pigmentation, exfoliation and anti-acne ratings.

Pros & Cons of SkinBetter Science AlphaRet Overnight Cream

 
Here’s an overview of the pros and cons of SkinBetter Science AlphaRet Overnight Cream to help you decide if it’s the right choice for your skincare routine:
 

Pros:

  • Humectant moisturizing well-suited for oily skin
  • Lightweight texture
  • A humectant moisturizing enhancement for any skincare routine
  • Offers modest anti-wrinkle efficacy
  • Rich in antioxidants that combat oxidative stress associated with accelerated skin aging and defend against environmental damage such as UV radiation and pollution

Cons: 

Ingredients

Est. % Ingredient Origin Functions
55
9
6
4
3
2.5
2
1.5
1.3
1
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Est. %
Water
Function:
Origin:
Sodium Glycolate
Function:
Origin:
Glycolic Acid
Function:
Origin:
Cetearyl Olivate
Function:
Origin:
Pentylene Glycol
Function:
Origin:
Cyclopentasiloxane
Function:
Origin:
Isohexadecane
Function:
Origin:
Sorbitan Olivate
Function:
Origin:
Ascorbyl Tetraisopalmitate
Function:
Origin:
Glycerin
Function:
Origin:
Ceresin
Function:
Origin:
Glycol Palmitate
Function:
Origin:
Butylene Glycol
Function:
Origin:
Niacinamide
Function:
Origin:
Squalane
Function:
Origin:
Methyl Gluceth-20
Function:
Origin:
Ethyl Lactyl Retinoate
Function:
Origin:
Palmitoyl Tripeptide-1
Function:
Origin:
Palmitoyl Tetrapeptide-7
Function:
Origin:
Ceramide NP
Function:
Origin:
Hyaluronic Acid
Function:
Origin:
Ubiquinone
Function:
Origin:
Tocopherol
Function:
Origin:
Bisabolol
Function:
Origin:
Tocopheryl Acetate
Function:
Origin:
Superoxide Dismutase
Function:
Origin:
Butyrospermum Parkii (Shea) Butter
Function:
Origin:
Allantoin Glycyrrhetinic Acid
Function:
Origin:
Sodium PCA
Function:
Origin:
Panthenol
Function:
Origin:
Camellia Sinensis Leaf Extract
Function:
Origin:
Portulaca Oleracea Extract
Function:
Origin:
Linoleic Acid
Function:
Origin:
Cholesterol
Function:
Origin:
Linolenic Acid
Function:
Origin:
Magnesium Aluminum Silicate
Function:
Origin:
Dimethyl Isosorbide
Function:
Origin:
Dimethicone
Function:
Origin:
Glyceryl Stearate
Function:
Origin:
PEG-100 Stearate
Function:
Origin:
Steareth-2
Function:
Origin:
Hydroxyethylcellulose
Function:
Origin:
Acacia Senegal Gum
Function:
Origin:
Xanthan Gum
Function:
Origin:
Hydrated Silica
Function:
Origin:
Carbomer
Function:
Origin:
Polysorbate 20
Function:
Origin:
Tromethamine
Function:
Origin:
Disodium EDTA
Function:
Origin:
Ethylhexylglycerin
Function:
Origin:
Phenoxyethanol
Function:
Origin:
Titanium Dioxide (CI 77891)
Function:
Origin:

Ratings

All humectants
6.7
3
1
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Benchmark
10
All occlusives
1.8
0.3
0.3
0.3
0.3
0.3
0.3
Benchmark
20
Moisturizing rating
3.8
Ingredient Est. % Benchmark Raiting
Humectancy All humectants 6.7 10
6.7
3
1
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Occlusivity All occlusives 1.8 20
0.9
0.3
0.3
0.3
0.3
0.3
0.3
Moisturizing rating
3.8
Ingredient Est. % Benchmark Humectancy
3
1
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
All humectants 6.7 10
6.7
All humectants
6.7
3
1
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Benchmark
10
Ingredient Est. % Benchmark Occlusivity
0.3
0.3
0.3
0.3
0.3
0.3
All occlusives 1.8 20
0.9
All occlusives
1.8
0.3
0.3
0.3
0.3
0.3
0.3
Benchmark
20
Ingredient
Ingredient anti-wrinkle power
when present at, %
in this formula est. %
Rating
2 /10 1 1.3 2
1.5 /10 5 6 1.5
6 /10 4 0.3 0.4
n/a
- 0.3 -
n/a
- 0.3 -
n/a
- 0.3 -
n/a
- 0.3 -
Total
3.9
Ascorbyl Tetraisopalmitate
2
Ingredient anti-wrinkle power
2 /10
when present at, %
1
in this formula, est. %
1.3
Glycolic Acid
1.5
Ingredient anti-wrinkle power
1.5 /10
when present at, %
5
in this formula, est. %
6
Niacinamide
0.4
Ingredient anti-wrinkle power
6 /10
when present at, %
4
in this formula, est. %
0.3
Palmitoyl Tripeptide-1
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Palmitoyl Tetrapeptide-7
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Ubiquinone
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Camellia Sinensis Leaf Extract
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Anti-wrinkle rating
3.9
Ingredient Est. % Benchmark
Rich in Antioxidants
1.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
All antioxidants 3.7 3 Rich in antioxidants
All antioxidants
3.7
Ascorbyl Tetraisopalmitate
1.3
Niacinamide
0.3
Hyaluronic Acid
0.3
Ubiquinone
0.3
Tocopherol
0.3
Tocopheryl Acetate
0.3
Superoxide Dismutase
0.3
Camellia Sinensis Leaf Extract
0.3
Portulaca Oleracea Extract
0.3
Benchmark
3
Ingredient Est. % Benchmark
Rich in Soothing
0.3
0.3
0.3
0.3
0.3
0.3
All soothing 1.8 5 No
All soothing
1.8
0.3
0.3
0.3
0.3
0.3
0.3
Benchmark
5

Ingredients explained

Water
Est. %55
Function
Origin
WaterThe most used ingredient in skincare. Its concentration defines the product texture: rich creams may have about 50% of water while a light jelly about 90%. Water doesn’t moisturize the skin by itself and is used in skincare as a solvent for other ingredients.
Sodium Glycolate
Est. %9
Function
Origin
Sodium Glycolate
Glycolic Acid
Est. %6
Function
Origin
Glycolic Acid

The second most used AHA (after lactic acid) known for its potent exfoliating and smoothing effects. It increases skin cell turnover, which is beneficial for treating acne. When used in peels, glycolic acid has confirmed anti-wrinkle efficacy, though it is less effective in leave-on products like creams and serums.

Cetearyl Olivate
Est. %4
Function
Origin
Cetearyl Olivate

A multifunctional ingredient derived from plants that primarily serves as an emulsifier. Supplied as a waxy ivory-colored flake, it can also be used as an emollient and slip modifier that gives a product an overall light, silky finish.

Pentylene Glycol
Est. %3
Function
Origin
Pentylene Glycol

A naturally or synthetically derived preservative that exhibits effective antifungal and antibacterial traits. It also acts as a booster for more traditional preservatives. Pentylene glycol can also serve as a moisturizing humectant and solvent.

Cyclopentasiloxane
Est. %2.5
Function
Origin
CyclopentasiloxaneA lightweight, fast-spreading emollient that leaves a very soft and silky after-feel on the skin. Supplied as a clear and colorless liquid, cyclopentasiloxane is often used as a solvent to dissolve other silicones in.
Isohexadecane
Est. %2
Function
Origin
IsohexadecaneA clear, colorless liquid that is commonly used as an emollient. It is made up of pure hydrocarbons and leaves a dry feeling on the skin upon application. It also increases the spreadability of a product.
Sorbitan Olivate
Est. %1.5
Function
Origin
Sorbitan OlivateAn ester of sorbitol (a type of sugar alcohol) and olive oil fatty acids. It is used as an emulsifying agent to stabilize oil droplets in water (or vice versa).
Ascorbyl Tetraisopalmitate
Est. %1.3
Function
Origin
Ascorbyl Tetraisopalmitate

Ascorbyl Tetraisopalmitate (ATIP) is an oil-soluble derivative of ascorbic acid, or vitamin C. It is more stable than ascorbic acid, with studies supporting its collagen-boosting and anti-pigment effects.

Glycerin
Est. %1
Function
Origin
Glycerin

The most popular moisturizing ingredient in the world. It is a powerful humectant – cheap yet very effective.

Ceresin
Est. %0.3
Function
Origin
CeresinA naturally-derived wax often used to create solid products.
Glycol Palmitate
Est. %0.3
Function
Origin
Glycol Palmitate
Butylene Glycol
Est. %0.3
Function
Origin
Butylene Glycol

A clear, colorless liquid humectant that draws moisture to the skin. The humectancy of butylene glycol, owed to its two hydroxyl groups, is quite considerable, although not as powerful as glycerin, which contains three hydroxyl groups.

Niacinamide
Est. %0.3
Function
Origin
Niacinamide

Also known as vitamin B3, this ingredient is a true superstar with confirmed moisturizing, anti-acne, hyperpigmentation, and antioxidant benefits. Two studies confirm its significant anti-wrinkle efficacy.

Squalane
Est. %0.3
Function
Origin
SqualaneAn occlusive moisturizing and emollient compound that forms part of the skin’s sebum. The main source of squalane had always been shark liver. Now, however, it is manufactured synthetically or derived from plant oils, such as olive and peanut oil.
Methyl Gluceth-20
Est. %0.3
Function
Origin
Methyl Gluceth-20A humectant synthetically derived from glucose. It takes on the form of a clear, syrupy liquid.
Ethyl Lactyl Retinoate
Est. %0.3
Function
Origin
Ethyl Lactyl Retinoate
Palmitoyl Tripeptide-1
Est. %0.3
Function
Origin
Palmitoyl Tripeptide-1

A small peptide consisting of three amino acids with anti-wrinkle effects. Together with Palmitoyl Tetrapeptide-7, it is a part of the popular anti-wrinkle complex called Matrixyl™ 3000.

Palmitoyl Tetrapeptide-7
Est. %0.3
Function
Origin
Palmitoyl Tetrapeptide-7

A synthetic peptide that mimics the activity of immunoglobulin G and signals to the skin to stop the inflammation. It has been shown in studies to reduce wrinkles and enhance collagen content.

Ceramide NP
Est. %0.3
Function
Origin
Ceramide NPAlso known as ceramide 3, it is the most common ceramide in our skin. It helps to restore the skin’s lipid barrier and alleviate the symptoms of dry and cracked skin. Research has shown that skin suffering from conditions such as AD lacks ceramides.
Hyaluronic Acid
Est. %0.3
Function
Origin
Hyaluronic Acid

A potent, skin-identical humectant moisturizing ingredient that is able to bind water 1000 times its own weight. The anti-aging benefits of hyaluronic acid are due to its ability to stimulate the synthesis of collagen in the skin.

Ubiquinone
Est. %0.3
Function
Origin
UbiquinoneAlso known as Coenzyme Q10, this bright orange antioxidant supports the skin's energy metabolism. It also offers some anti-pigment action. Dietary supplementation of Ubiquinone improves the appearance of wrinkles.
Tocopherol
Est. %0.3
Function
Origin
Tocopherol

Simply another name for vitamin E. Tocopherol is a fantastic ingredient and especially beneficial for dry and inflamed skin. It has occlusive moisturizing, emollient, antioxidant, and photoprotective properties.

Bisabolol
Est. %0.3
Function
Origin
Bisabolol

An anti-inflammatory compound found naturally in German chamomile essential oil. It has a pleasant, sweet, and floral scent. Bisabolol also has soothing and anti-inflammatory properties but can cause an allergic reaction in more sensitive individuals.

Tocopheryl Acetate
Est. %0.3
Function
Origin
Tocopheryl Acetate

An antioxidant derivative of tocopherol (vitamin E). It helps to protect cells from free radicals and UV damage through the conversion to active vitamin E in the skin. It is more stable than tocopherol.

Superoxide Dismutase
Est. %0.3
Function
Origin
Superoxide Dismutase
Butyrospermum Parkii (Shea) Butter
Est. %0.3
Function
Origin
Butyrospermum Parkii (Shea) ButterA semi-solid, buttery fat extracted from the seeds of the Shea tree that is a wonderful occlusive and emollient ingredient mainly comprised of fatty acids. Shea butter contains a large amount of anti-inflammatory and antioxidant compounds.
Allantoin Glycyrrhetinic Acid
Est. %0.3
Function
Origin
Allantoin Glycyrrhetinic Acid
Sodium PCA
Est. %0.3
Function
Origin
Sodium PCAOne of the most important parts of the skin's Natural Moisturizing Factor, a mixture of various compounds that keeps the skin’s surface well hydrated. Sodium PCA is used in skincare for its fantastic humectant properties.
Panthenol
Est. %0.3
Function
Origin
PanthenolA popular soothing and moisturizing derivative of vitamin B5. Panthenol is particularly beneficial for dry, flaking, burned, or damaged skin. It is used to alleviate the symptoms of a rash, dermatitis, eczema, chapped lips, and sunburn.
Camellia Sinensis Leaf Extract
Est. %0.3
Function
Origin
Camellia Sinensis Leaf Extract

An antioxidant green tea extract. In the deeper layers, it slows down the destruction of collagen, elastin, and hyaluronic acid – thus delaying the signs of aging. It also acts as an anti-acne, soothing, moisturizing, and emollient ingredient.

Portulaca Oleracea Extract
Est. %0.3
Function
Origin
Portulaca Oleracea ExtractDerived from green or common purslane, this moisturizing extract is particularly rich in alpha-linolenic acid, an omega-3 fatty acid, and contains antioxidant glutathione and vitamin E. As a herbal medicine, it is believed to treat headaches and inflammation.
Linoleic Acid
Est. %0.3
Function
Origin
Linoleic AcidA fatty acid isolated from various plant oils (notably evening primrose, safflower, grape seed, and sunflower oil). It is an occlusive moisturizer and emollient that doesn't leave an oily, sticky residue and is especially suitable for oily and acne-prone skin.
Cholesterol
Est. %0.3
Function
Origin
CholesterolAn emollient and important barrier repairing lipid, effective when combined with fatty acids and ceramides. Around 25% of the skin’s lipid layer is made up of cholesterol and it is found in the membrane of every single cell in our body.
Linolenic Acid
Est. %0.3
Function
Origin
Linolenic AcidAn essential polyunsaturated occlusive fatty acid isolated from various plant oils. It is necessary for the correct barrier function of the skin and moisturizes without leaving a sticky after-feel.
Magnesium Aluminum Silicate
Est. %0.3
Function
Origin
Magnesium Aluminum SilicateA naturally occurring clay that is hygroscopic, which means that it easily absorbs water. This ingredient is thus commonly used as an absorbent and emulsion stabilizer. It also modifies slip by improving the spreadability of the products it is used in.
Dimethyl Isosorbide
Est. %0.3
Function
Origin
Dimethyl IsosorbideA solvent for active ingredients that is claimed to help them better penetrate the outer layer of skin. It also helps to reduce the thickness of a product.
Dimethicone
Est. %0.3
Function
Origin
DimethiconeThe most common silicone in skincare. It forms a silky, smooth film on the skin’s surface and can help to prevent water loss. It also aids in wound healing and can treat and soften scars. Dimethicone is considered to be very safe for use.
Glyceryl Stearate
Est. %0.3
Function
Origin
Glyceryl StearateAn emollient and emulsifier typically derived from vegetable sources through a chemical reaction with glycerin. It provides stability, texture, and consistency to formulations. Its main function is to allow oil and water to mix.
PEG-100 Stearate
Est. %0.3
Function
Origin
PEG-100 StearateThis surfactant is more specifically classified as an emulsifier that produces oil-in-water emulsions. PEG-100 stearate can also be used as a cleansing agent.
Steareth-2
Est. %0.3
Function
Origin
Steareth-2A waxy, naturally derived or synthetic emulsifier that can handle extreme formula conditions such as a low pH. It offers emulsifying properties to a formula by helping oils and water to mix.
Hydroxyethylcellulose
Est. %0.3
Function
Origin
HydroxyethylcelluloseA naturally-derived thickener that can form clear gel textures without the slimy feeling, unlike some other natural gel-formers.
Acacia Senegal Gum
Est. %0.3
Function
Origin
Acacia Senegal GumA formula helper, also known as gum arabic, derived from the African Acacia tree. It is used in skincare formulas due to its good adhesive and film-forming properties.
Xanthan Gum
Est. %0.3
Function
Origin
Xanthan GumA natural multi-functional ingredient that originates from fermented sugars. Xanthan gum acts as a viscosity-building agent to thicken skincare products. It is also an excellent stabilizer and works well to hold other ingredients together.
Hydrated Silica
Est. %0.3
Function
Origin
Hydrated SilicaA form of silicone dioxide, the major component of sand, that contains varying amounts of water. It has several purposes but is most commonly used as an abrasive (as an eco-conscious alternative to polyethylene microbeads).
Carbomer
Est. %0.3
Function
Origin
CarbomerA synthetic ingredient with the ability to gel water. When used in emulsions, such as lotions and creams, carbomer can also act as an emulsion stabilizer.
Polysorbate 20
Est. %0.3
Function
Origin
Polysorbate 20A viscous, amber-colored liquid that functions as a solubilizer to disperse small amounts of oil into a large water phase. Polysorbate 20 is frequently used to solubilize fragrance oils into water-based emulsions.
Tromethamine
Est. %0.3
Function
Origin
TromethamineAn ingredient based on amino acids that is commonly used as a pH adjuster. It has a high pH, which means that it is basic (alkaline), so adding tromethamine to a skincare product will increase its overall pH level.
Disodium EDTA
Est. %0.3
Function
Origin
Disodium EDTAA synthetic chelator that helps to maintain the look and smell of a product by 'locking up' troublesome metal ions.
Ethylhexylglycerin
Est. %0.3
Function
Origin
EthylhexylglycerinA preservative booster derived from glycerin. It is commonly paired with other preservatives to improve their efficacy. Ethylhexylglycerin is also a humectant due to its chemical base of glycerin.
Phenoxyethanol
Est. %0.3
Function
Origin
PhenoxyethanolThe most frequently used preservative in skincare. It is a clear, oil-like liquid synthetic substance that protects products from harmful bacteria and yeast, whilst still leaving skin microflora unharmed. It is confirmed by research to be harmless.
Titanium Dioxide (CI 77891)
Est. %0.3
Function
Origin
Titanium Dioxide (CI 77891)One of two the most commonly used mineral sunscreens. It can absorb UV light, including UVB – which causes burning, tanning, and even skin cancer. Also used as a colorant, titanium dioxide gives a product a bright white color.