Perricone MD Essential Fx Acyl-Glutathione Intensive Overnight Moisturizer

Perricone MD Essential Fx Acyl-Glutathione Intensive Overnight Moisturizer
7.6
/ 10
Moisturizing
5.2 Humectancy icon Humectancy
10.0 Occlusivity icon Occlusivity
6Anti-wrinkle icon/ 10
Anti-wrinkle
Rich
in Antioxidants
$$$$

Review

Results you may expect from using Perricone MD Essential Fx Acyl-Glutathione Intensive Overnight Moisturizer:

Based on the ingredient analysis by CreamScan, these are the key benefits you can expect from using Perricone MD Essential Fx Acyl-Glutathione Intensive Overnight Moisturizer:

  • Significant moisturizing. It has a moisturizing rating of 7.6 out of 10.
  • Significant anti-wrinkle efficacy. With an anti-wrinkle rating of 6.0 out of 10, Perricone MD Essential Fx Acyl-Glutathione Intensive Overnight Moisturizer is effective in minimizing wrinkles.
  • Antioxidant protection.

How moisturizing is it?

Highly moisturizing: Perricone MD Essential Fx Acyl-Glutathione Intensive Overnight Moisturizer has a moisturizing rating of 7.6 out of 10.

Is it more humectant or occlusive? Significantly more occlusive. It has a moderate humectancy of 5.2 out of 10, primarily due to the substantial concentration of Niacinamide (est. ≈4.0%), and a maximum occlusivity of 10 out of 10, mainly due to the high content of Butyrospermum Parkii (Shea) Butter (est. ≈9.0%) and Myristyl Myristate (est. ≈6.0%).

Please refer to the Ratings section below for details of the moisturizing rating calculation.

Anti-wrinkle efficacy

According to CreamScan analysis, Perricone MD Essential Fx Acyl-Glutathione Intensive Overnight Moisturizer has a high anti-wrinkle rating of 6.0 out of 10. It contains one ingredient with proven anti-wrinkle efficacy: Niacinamide (est. ≈4.0%),
 one of the most effective and well-researched anti-wrinkle ingredients.
 
Among others, Perricone MD Essential Fx Acyl-Glutathione Intensive Overnight Moisturizer also contains Copper Gluconate, an ingredient marketed as effective in reducing wrinkles. However, the studies supporting the anti-wrinkle claims of Copper Gluconate provide insufficient evidence of its efficacy according to CreamScan Research Evaluation Standards. Therefore, this ingredient does not contribute to the anti-wrinkle rating.
 

Please refer to the Ratings section below for details of the anti-wrinkle rating calculation.

Antioxidant benefits

We estimate that Perricone MD Essential Fx Acyl-Glutathione Intensive Overnight Moisturizer is rich (> 3%) in antioxidants, specifically Niacinamide (est. ≈4.0%).

A key benefit of antioxidants is their ability to reduce oxidative stress caused by free radicals and therefore prevent accelerated skin aging. Studies also show that antioxidants can protect against environmental damage such as UV radiation and pollution, and help reduce inflammation and skin redness.

Ingredients

Est. % Ingredient Origin Functions
65
9
6
4
3
2.5
2
1.5
1.3
1
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
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Ratings

All humectants
5.2
4
0.3
0.3
0.3
0.3
Benchmark
10
All occlusives
20.7
9.0
6.0
2.5
2.0
0.3
0.3
0.3
0.3
Benchmark
20
Moisturizing rating
7.6
Ingredient Est. % Benchmark Raiting
Humectancy All humectants 5.2 10
5.2
4
0.3
0.3
0.3
0.3
Occlusivity All occlusives 20.7 20
10.0
9.0
6.0
2.5
2.0
0.3
0.3
0.3
0.3
Moisturizing rating
7.6
Ingredient Est. % Benchmark Humectancy
4
0.3
0.3
0.3
0.3
All humectants 5.2 10
5.2
All humectants
5.2
4
0.3
0.3
0.3
0.3
Benchmark
10
Ingredient Est. % Benchmark Occlusivity
9
6
2.5
2
0.3
0.3
0.3
0.3
All occlusives 20.7 20
10.0
All occlusives
20.7
9.0
6.0
2.5
2.0
0.3
0.3
0.3
0.3
Benchmark
20
Ingredient
Ingredient anti-wrinkle power
when present at, %
in this formula est. %
Rating
6 /10 4 4 6
n/a
- 0.3 -
Total
6
Niacinamide
6
Ingredient anti-wrinkle power
6 /10
when present at, %
4
in this formula, est. %
4
Copper Gluconate
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Anti-wrinkle rating
6
Ingredient Est. % Benchmark
Rich in Antioxidants
4
1
0.3
0.3
All antioxidants 5.6 3 Rich in antioxidants
All antioxidants
5.6
Niacinamide
4
S-Palmitoylglutathione
1
Salvia Hispanica Seed Oil
0.3
Rosmarinus Officinalis (Rosemary) Leaf Extract
0.3
Benchmark
3
Ingredient Est. % Benchmark
Rich in Soothing
4
0.3
0.3
0.3
All soothing 4.9 5 No
All soothing
4.9
4
0.3
0.3
0.3
Benchmark
5

Ingredients explained

Water
Est. %65
Function
Origin
The most used ingredient in skincare. Its concentration defines the product texture: rich creams may have about 50% of water while a light jelly about 90%. Water doesn’t moisturize the skin by itself and is used in skincare as a solvent for other ingredients.
Butyrospermum Parkii (Shea) Butter
Est. %9
Function
Origin
A semi-solid, buttery fat extracted from the seeds of the Shea tree that is a wonderful occlusive and emollient ingredient mainly comprised of fatty acids. Shea butter contains a large amount of anti-inflammatory and antioxidant compounds.
Myristyl Myristate
Est. %6
Function
Origin
An occlusive moisturizing and emollient ester that is derived from vegetables. This soft, wax-like ester produces a soft and creamy sensorial profile. Myristyl myristate is listed as a common comedogenic ingredient by acne.org.
Niacinamide
Est. %4
Function
Origin

Also known as vitamin B3, this ingredient is a true superstar with confirmed moisturizing, anti-acne, hyperpigmentation, and antioxidant benefits. Two studies confirm its significant anti-wrinkle efficacy.

C12-15 Alkyl Benzoate
Est. %3
Function
Origin
A synthetic emollient ester. It works to improve the appearance of the skin by filling in the microcracks on the surface, thereby making the skin appear softer and smoother. It imparts a lightweight, velvety feel.
Stearic Acid
Est. %2.5
Function
Origin
A saturated fatty acid found in vegetable butter and animal fats. It is an occlusive moisturizing and emollient ingredient and also helps to maintain the barrier function of the skin.
Dimethicone
Est. %2
Function
Origin
The most common silicone in skincare. It forms a silky, smooth film on the skin’s surface and can help to prevent water loss. It also aids in wound healing and can treat and soften scars. Dimethicone is considered to be very safe for use.
Sodium Acrylates Copolymer
Est. %1.5
Function
Origin
A synthetic polymer that can come in various forms and is often used to create light gel-like textures. Some versions can also create a light film on the skin.
Palmitoyl Glycine
Est. %1.3
Function
Origin
Description is coming soon
S-Palmitoylglutathione
Est. %1
Function
Origin
Description is coming soon
Ethylhexylglycerin
Est. %0.3
Function
Origin
A preservative booster derived from glycerin. It is commonly paired with other preservatives to improve their efficacy. Ethylhexylglycerin is also a humectant due to its chemical base of glycerin.
Myristyl Laurate
Est. %0.3
Function
Origin
Description is coming soon
Ribose
Est. %0.3
Function
Origin
Ribose is a simple sugar that is present in all living things. It has moderate humectant moisturizing properties in skincare, but is not used very often. It is manufactured from yeast or chemically derived from other sugars for use in cosmetic products.
Lecithin
Est. %0.3
Function
Origin
A humectant, emollient, and emulsifier best suited for water-in-oil emulsions. Lecithin can come from sunflowers, soy, and eggs. The downside to lecithin is that it causes an extra burden on the formula’s preservative because it is nutritious.
Lactic Acid
Est. %0.3
Function
Origin
The most popular AHA in skincare and less irritating than glycolic acid. It can be naturally found in sour milk. It is a humectant moisturizing, pH stabilizing, and gently exfoliating ingredient, able to soften dry, cracked, and peeling skin.
Linum Usitatissimum (Linseed) Seed Oil
Est. %0.3
Function
Origin
An emollient and occlusive fatty oil pressed from flax seeds. It is the richest source of linolenic fatty acid (it contains up to 50% of it) among vegetable oils.
Macadamia Integrifolia Seed Oil
Est. %0.3
Function
Origin
Extracted from macadamia nuts, this emollient and occlusive moisturizing oil is composed mostly of oleic and palmitoleic fatty acids. It is suitable for dry and eczema-prone skin.
Salvia Hispanica Seed Oil
Est. %0.3
Function
Origin
An oil extracted from Chia seeds. It has a unique ratio of omega-3 and omega-6 fatty acids, making it the richest source of polyunsaturated fatty acids. It also contains antioxidant phytosterols and tocopherols (vitamin E).
Magnesium Aspartate
Est. %0.3
Function
Origin
A humectant salt of aspartic acid, a common amino acid found in the body. According to the manufacturer, magnesium aspartate in skincare products supports the supply of magnesium to skin cells.
Zinc Gluconate
Est. %0.3
Function
Origin
One of the most commonly used ingredients in anti-acne products. It is an organic salt of zinc that helps to combat microbial infections, soothes and heals inflamed pimples, and regulates hormones in the skin.
Copper Gluconate
Est. %0.3
Function
Origin
An organic salt of copper that can aid in the wound healing process. The manufacturer claims it also has soothing and anti-inflammatory properties, although this has yet to be confirmed. Copper gluconate is also a perspective anti-wrinkle ingredient.
Helianthus Annuus (Sunflower) Seed Oil
Est. %0.3
Function
Origin
A fatty oil expressed from sunflower seeds and one of the most commonly used oils in skincare. It has great emollient and occlusive moisturizing properties. Sunflower oil is one of the richest sources of vitamin E – an important skin antioxidant.
Rosmarinus Officinalis (Rosemary) Leaf Extract
Est. %0.3
Function
Origin
A soothing and astringent extract derived from the fragrant, spicy leaves of rosemary. It has strong antioxidant properties. Rosemary extract can reduce signs of inflammation and also acts as an emollient and antimicrobial agent.
Tetrasodium Glutamate Diacetate
Est. %0.3
Function
Origin
A biodegradable chelating agent that chemically captures the heavy metal ions naturally present in water and disarms their harmful effects.
Sodium Hydroxide
Est. %0.3
Function
Origin

An ingredient that is able to bring the pH of a product up, thereby making it less harsh on the skin.

Glyceryl Stearate
Est. %0.3
Function
Origin
An emollient and emulsifier typically derived from vegetable sources through a chemical reaction with glycerin. It provides stability, texture, and consistency to formulations. Its main function is to allow oil and water to mix.
PEG-100 Stearate
Est. %0.3
Function
Origin
This surfactant is more specifically classified as an emulsifier that produces oil-in-water emulsions. PEG-100 stearate can also be used as a cleansing agent.
Phenoxyethanol
Est. %0.3
Function
Origin
The most frequently used preservative in skincare. It is a clear, oil-like liquid synthetic substance that protects products from harmful bacteria and yeast, whilst still leaving skin microflora unharmed. It is confirmed by research to be harmless.
Fragrance
Est. %0.3
Function
Origin
Under trade secret law, manufacturers have the right not to disclose what exactly went into the fragrance and use the unspecific word Fragrance or Parfum instead. Many fragrances are highly allergenic.
Citronellol
Est. %0.3
Function
Origin
A fragrant compound found naturally in many essential oils (mainly lemongrass). It can have a lemon or a rose scent. People with sensitive skin should try to avoid products with citronellol, or at least do a patch test before using it.
Hydroxycitronellal
Est. %0.3
Function
Origin
A fragrant compound with a scent reminiscent of lilies and sweet tropical melon. It can be found in many different essential oils (such as palmarosa, ylang-ylang, and lemongrass essential oil) but is manufactured synthetically from citronellal.
Limonene
Est. %0.3
Function
Origin
One of the most used fragrances in skincare products. It is produced from the peels of citrus fruits and has a fresh, pleasant, citrusy smell. People who are sensitive to citrus should try to avoid it, or at least do a patch test before using it.
Linalool
Est. %0.3
Function
Origin
A fragrant, volatile compound naturally present in many essential oils. It has a pleasant scent and is often used in skincare products as a fragrance. People with sensitive skin should try to avoid it, or at least do a patch test before using it.