Perricone MD Essential Fx Acyl-Glutathione Deep Crease Serum

Perricone MD Essential Fx Acyl-Glutathione Deep Crease Serum
8.0
/ 10
Moisturizing
10.0 Humectancy icon Humectancy
5.9 Occlusivity icon Occlusivity
Rich
in Antioxidants

Review

Does Perricone MD Essential Fx Acyl-Glutathione Deep Crease Serum work?

Based on the ingredient list analysis by CreamScan AI, these are the key benefits you can expect from using Perricone MD Essential Fx Acyl-Glutathione Deep Crease Serum:

  • Intense moisturizing. It has a moisturizing rating of 8.0 out of 10.
  • Antioxidant protection.

Perfect moisturizer for normal to dry skin with a relatively lightweight texture

According to CreamScan analysis, Perricone MD Essential Fx Acyl-Glutathione Deep Crease Serum is intensely moisturizing, with a moisturizing rating of 8.0 out of 10.

Is it more humectant or occlusive? Significantly more humectant. It has a maximum humectancy of 10 out of 10, primarily due to the substantial concentration of Propanediol (est. ≈9.0%) and Glycerin (est. ≈2.0%), and a moderate occlusivity of 5.9 out of 10, mainly due to the high content of Squalane (est. ≈6.0%) and Dimethicone (est. ≈2.5%).

This type of moisturizer is ideal for people with normal skin. It combines a high concentration of humectants with a significant amount of occlusive ingredients to deliver effective dual-action moisturizing for normal skin.

This product may also be a good choice for people with normal to dry skin for daily hydration, as it balances significant moisturizing potential with a relatively lightweight texture.

Please refer to the Ratings section below for details of the moisturizing rating calculation.

Questionable anti-wrinkle efficacy

According to CreamScan analysis, Perricone MD Essential Fx Acyl-Glutathione Deep Crease Serum has a zero anti-wrinkle rating.

It contains some ingredients often marketed as effective in reducing wrinkles, specifically Tetrahexyldecyl Ascorbate, Dimethyl MEA, Palmitoyl Tripeptide-5, Acetyl Hexapeptide-8, Copper Gluconate, and Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine. However, the studies supporting the anti-wrinkle claims of these ingredients provide insufficient evidence of efficacy according to CreamScan Research Evaluation Standards. Therefore, these ingredients do not contribute to the anti-wrinkle rating.

Moisturizers, when used regularly, are proven to prevent wrinkle formation and even reduce existing wrinkles. Therefore, this product, like any other moisturizer, can deliver some anti-wrinkle effects through its moisturizing action.

Please refer to the Ratings section below for details of the anti-wrinkle rating calculation.

Rich in skin-protecting antioxidants

We estimate that Perricone MD Essential Fx Acyl-Glutathione Deep Crease Serum is rich (> 3%) in antioxidants, specifically S-Palmitoylglutathione (est. ≈3.0%).

A key benefit of antioxidants is their ability to reduce oxidative stress caused by free radicals and therefore prevent accelerated skin aging. Studies also show that antioxidants can protect against environmental damage such as UV radiation and pollution, and help reduce inflammation and skin redness.

Ingredients

Est. % Ingredient Origin Functions
60
9
6
4
3
2.5
2
1.5
1.3
1
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Est. %
Water
Function:
Origin:
Propanediol
Function:
Origin:
Squalane
Function:
Origin:
Hydrogenated Polyisobutene
Function:
Origin:
S-Palmitoylglutathione
Function:
Origin:
Dimethicone
Function:
Origin:
Glycerin
Function:
Origin:
Macadamia Ternifolia Seed Oil
Function:
Origin:
Xylitylglucoside
Function:
Origin:
Tetrahexyldecyl Ascorbate
Function:
Origin:
Dimethyl MEA
Function:
Origin:
Palmitoyl Tripeptide-5
Function:
Origin:
Acetyl Hexapeptide-8
Function:
Origin:
Anhydroxylitol
Function:
Origin:
Lactic Acid
Function:
Origin:
Xylitol
Function:
Origin:
Xanthan Gum
Function:
Origin:
Linum Usitatissimum (Linseed) Seed Oil
Function:
Origin:
Salvia Hispanica Seed Oil
Function:
Origin:
Tocopherol
Function:
Origin:
Ethylhexylglycerin
Function:
Origin:
Magnesium Aspartate
Function:
Origin:
Zinc Gluconate
Function:
Origin:
Alaria Esculenta Extract
Function:
Origin:
Glucose
Function:
Origin:
Sodium Hyaluronate
Function:
Origin:
Copper Gluconate
Function:
Origin:
Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate
Function:
Origin:
Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine
Function:
Origin:
Helianthus Annuus (Sunflower) Seed Oil
Function:
Origin:
Rosmarinus Officinalis (Rosemary) Leaf Extract
Function:
Origin:
Tetrasodium Glutamate Diacetate
Function:
Origin:
Magnesium Chloride
Function:
Origin:
Caprylic/Capric Triglyceride
Function:
Origin:
Acrylates/C10-30 Alkyl Acrylate Crosspolymer
Function:
Origin:
Caprylyl/Capryl Glucoside
Function:
Origin:
Caprylyl Glycol
Function:
Origin:
Potassium Sorbate
Function:
Origin:
Phenoxyethanol
Function:
Origin:
Fragrance
Function:
Origin:
Citronellol
Function:
Origin:
Hydroxycitronellal
Function:
Origin:
Limonene
Function:
Origin:
Linalool
Function:
Origin:

Ratings

All humectants
14.7
9
2
1.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Benchmark
10
All occlusives
11.8
6.0
2.5
1.5
0.3
0.3
0.3
0.3
0.3
0.3
Benchmark
20
Moisturizing rating
8.0
Ingredient Est. % Benchmark Raiting
Humectancy All humectants 14.7 10
10.0
9
2
1.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Occlusivity All occlusives 11.8 20
5.9
6.0
2.5
1.5
0.3
0.3
0.3
0.3
0.3
0.3
Moisturizing rating
8.0
Ingredient Est. % Benchmark Humectancy
9
2
1.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
All humectants 14.7 10
10
All humectants
14.7
9
2
1.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Benchmark
10
Ingredient Est. % Benchmark Occlusivity
6
2.5
1.5
0.3
0.3
0.3
0.3
0.3
0.3
All occlusives 11.8 20
5.9
All occlusives
11.8
6.0
2.5
1.5
0.3
0.3
0.3
0.3
0.3
0.3
Benchmark
20
Ingredient
Ingredient anti-wrinkle power
when present at, %
in this formula est. %
Rating
n/a
- 1 -
n/a
- 0.3 -
n/a
- 0.3 -
n/a
- 0.3 -
n/a
- 0.3 -
n/a
- 0.3 -
Total
0
Tetrahexyldecyl Ascorbate
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
1
Dimethyl MEA
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Palmitoyl Tripeptide-5
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Acetyl Hexapeptide-8
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Copper Gluconate
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Anti-wrinkle rating
0
Ingredient Est. % Benchmark
Rich in Antioxidants
3
1
0.3
0.3
0.3
0.3
All antioxidants 5.2 3 Rich in antioxidants
All antioxidants
5.2
S-Palmitoylglutathione
3
Tetrahexyldecyl Ascorbate
1
Salvia Hispanica Seed Oil
0.3
Tocopherol
0.3
Sodium Hyaluronate
0.3
Rosmarinus Officinalis (Rosemary) Leaf Extract
0.3
Benchmark
3
Ingredient Est. % Benchmark
Rich in Soothing
0.3
0.3
0.3
All soothing 0.9 5 No
All soothing
0.9
0.3
0.3
0.3
Benchmark
5

Ingredients explained

Water
Est. %60
Function
Origin
WaterThe most used ingredient in skincare. Its concentration defines the product texture: rich creams may have about 50% of water while a light jelly about 90%. Water doesn’t moisturize the skin by itself and is used in skincare as a solvent for other ingredients.
Propanediol
Est. %9
Function
Origin
PropanediolAn excellent solvent capable of mixing water with normally water-insoluble ingredients. It also functions as a humectant due to its water-loving alcohol groups. Propanediol can control the viscosity of a product by reducing its thickness.
Squalane
Est. %6
Function
Origin
SqualaneAn occlusive moisturizing and emollient compound that forms part of the skin’s sebum. The main source of squalane had always been shark liver. Now, however, it is manufactured synthetically or derived from plant oils, such as olive and peanut oil.
Hydrogenated Polyisobutene
Est. %4
Function
Origin
Hydrogenated PolyisobuteneA viscous liquid that makes a great oil base due to its smooth sensorial profile. It has emollient features, including good spreadability and little tack upon application. It also has the added benefit of being able to thicken products.
S-Palmitoylglutathione
Est. %3
Function
Origin
S-Palmitoylglutathione
Dimethicone
Est. %2.5
Function
Origin
DimethiconeThe most common silicone in skincare. It forms a silky, smooth film on the skin’s surface and can help to prevent water loss. It also aids in wound healing and can treat and soften scars. Dimethicone is considered to be very safe for use.
Glycerin
Est. %2
Function
Origin
Glycerin

The most popular moisturizing ingredient in the world. It is a powerful humectant – cheap yet very effective.

Macadamia Ternifolia Seed Oil
Est. %1.5
Function
Origin
Macadamia Ternifolia Seed OilAn occlusive moisturizing and emollient oil extracted from macadamia nuts. It is clear and pale yellow with a pleasant nutty aroma and contains oleic and palmitoleic fatty acids, tocopherols, phytosterols, squalene, and polyphenols.
Xylitylglucoside
Est. %1.3
Function
Origin
XylitylglucosideAn emollient extract from rice bran, the brown outer part of the rice kernel. It includes palmitic, stearic, oleic, linoleic acids, and antioxidants such as tocopherols and γ-oryzanol.
Tetrahexyldecyl Ascorbate
Est. %1
Function
Origin
Tetrahexyldecyl AscorbateA lipid-soluble form of vitamin C that is more stable and less irritating than ascorbic acid. According to a recent clinical study, THDA has all the capabilities of regular vitamin C, including anti-wrinkle and anti-pigment activity.
Dimethyl MEA
Est. %0.3
Function
Origin
Dimethyl MEA

Dimethyl MEA, also known as DMAE, or deanol, is a colorless liquid with a fishy smell. It can also be supplied as a crystalline white powder. Some studies suggest it may have some effects on skin firmness. Additionally, DMAE is used to regulate pH balance. It has the potential to be toxic.

Palmitoyl Tripeptide-5
Est. %0.3
Function
Origin
Palmitoyl Tripeptide-5

A small synthetic peptide that signals the skin to produce more collagen. It has been clinically tested and proven to reduce skin roughness and the appearance of wrinkles.

Acetyl Hexapeptide-8
Est. %0.3
Function
Origin
Acetyl Hexapeptide-8

A small synthetic peptide that is thought to act similarly to Botox by calming contractions of the facial muscles and reducing expression wrinkles. The effect is only temporary and it does not improve the skin structure in any way.

Anhydroxylitol
Est. %0.3
Function
Origin
AnhydroxylitolA derivative of xylitol, a naturally occurring sugar alcohol. It has humectant moisturizing properties.
Lactic Acid
Est. %0.3
Function
Origin
Lactic AcidThe most popular AHA in skincare and less irritating than glycolic acid. It can be naturally found in sour milk. It is a humectant moisturizing, pH stabilizing, and gently exfoliating ingredient, able to soften dry, cracked, and peeling skin.
Xylitol
Est. %0.3
Function
Origin
XylitolAn organic compound that is most well-known for its use as a sweetener that also protects your teeth from cavities. Xylitol is used in skincare as a moisturizing humectant and has been shown to improve the protective barrier function of the skin.
Xanthan Gum
Est. %0.3
Function
Origin
Xanthan GumA natural multi-functional ingredient that originates from fermented sugars. Xanthan gum acts as a viscosity-building agent to thicken skincare products. It is also an excellent stabilizer and works well to hold other ingredients together.
Linum Usitatissimum (Linseed) Seed Oil
Est. %0.3
Function
Origin
Linum Usitatissimum (Linseed) Seed OilAn emollient and occlusive fatty oil pressed from flax seeds. It is the richest source of linolenic fatty acid (it contains up to 50% of it) among vegetable oils.
Salvia Hispanica Seed Oil
Est. %0.3
Function
Origin
Salvia Hispanica Seed OilAn oil extracted from Chia seeds. It has a unique ratio of omega-3 and omega-6 fatty acids, making it the richest source of polyunsaturated fatty acids. It also contains antioxidant phytosterols and tocopherols (vitamin E).
Tocopherol
Est. %0.3
Function
Origin
Tocopherol

Simply another name for vitamin E. Tocopherol is a fantastic ingredient and especially beneficial for dry and inflamed skin. It has occlusive moisturizing, emollient, antioxidant, and photoprotective properties.

Ethylhexylglycerin
Est. %0.3
Function
Origin
EthylhexylglycerinA preservative booster derived from glycerin. It is commonly paired with other preservatives to improve their efficacy. Ethylhexylglycerin is also a humectant due to its chemical base of glycerin.
Magnesium Aspartate
Est. %0.3
Function
Origin
Magnesium AspartateA humectant salt of aspartic acid, a common amino acid found in the body. According to the manufacturer, magnesium aspartate in skincare products supports the supply of magnesium to skin cells.
Zinc Gluconate
Est. %0.3
Function
Origin
Zinc GluconateOne of the most commonly used ingredients in anti-acne products. It is an organic salt of zinc that helps to combat microbial infections, soothes and heals inflamed pimples, and regulates hormones in the skin.
Alaria Esculenta Extract
Est. %0.3
Function
Origin
Alaria Esculenta ExtractDerived from badderlocks, an edible seaweed, this extract is rich in film-forming alginates. It can be used as a formula helper.
Glucose
Est. %0.3
Function
Origin
GlucoseA simple sugar that is also one of two components of sucrose, or table sugar. It is used as a humectant in skincare products. Glucose is also used to flavor lip care cosmetics because of its mildly sweet taste.
Sodium Hyaluronate
Est. %0.3
Function
Origin
Sodium Hyaluronate

A sodium salt of famous hyaluronic acid. A potent humectant that hydrates the skin, supports collagen function, and fills out small wrinkles. Sodium hyaluronate also offers soothing and antioxidant properties.

Copper Gluconate
Est. %0.3
Function
Origin
Copper GluconateAn organic salt of copper that can aid in the wound healing process. The manufacturer claims it also has soothing and anti-inflammatory properties, although this has yet to be confirmed. Copper gluconate is also a perspective anti-wrinkle ingredient.
Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate
Est. %0.3
Function
Origin
Tetradecyl Aminobutyroylvalylaminobutyric Urea TrifluoroacetateA small, peptide-like ingredient designed to improve skin firmness and hydration by stimulating the production of proteins and peptidoglycans in the skin.
Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine
Est. %0.3
Function
Origin
Palmitoyl Dipeptide-5 Diaminobutyroyl HydroxythreonineA synthetically made peptide that was designed to target the dermo-epidermal junction, where it should stimulate the production of structural proteins. It has not been clinically tested yet.
Helianthus Annuus (Sunflower) Seed Oil
Est. %0.3
Function
Origin
Helianthus Annuus (Sunflower) Seed OilA fatty oil expressed from sunflower seeds and one of the most commonly used oils in skincare. It has great emollient and occlusive moisturizing properties. Sunflower oil is one of the richest sources of vitamin E – an important skin antioxidant.
Rosmarinus Officinalis (Rosemary) Leaf Extract
Est. %0.3
Function
Origin
Rosmarinus Officinalis (Rosemary) Leaf ExtractA soothing and astringent extract derived from the fragrant, spicy leaves of rosemary. It has strong antioxidant properties. Rosemary extract can reduce signs of inflammation and also acts as an emollient and antimicrobial agent.
Tetrasodium Glutamate Diacetate
Est. %0.3
Function
Origin
Tetrasodium Glutamate DiacetateA biodegradable chelating agent that chemically captures the heavy metal ions naturally present in water and disarms their harmful effects.
Magnesium Chloride
Est. %0.3
Function
Origin
Magnesium ChlorideA chloride salt with a bitter taste and the ability to thicken water-in-oil emulsions.
Caprylic/Capric Triglyceride
Est. %0.3
Function
Origin
Caprylic/Capric TriglycerideA natural occlusive moisturizing and emollient ingredient, it is a blend of glycerin and two fatty acids, caprylic and capric acid. It creates an oil-based protective layer on the skin, thereby preventing water loss.
Acrylates/C10-30 Alkyl Acrylate Crosspolymer
Est. %0.3
Function
Origin
Acrylates/C10-30 Alkyl Acrylate CrosspolymerA synthetic ingredient that is used to thicken water and alcohol. It results in a more lightweight formula and is commonly found in gel products.
Caprylyl/Capryl Glucoside
Est. %0.3
Function
Origin
Caprylyl/Capryl GlucosideA naturally-derived surfactant used for gentle cleansing and foam-boosting when combined with other surfactants.
Caprylyl Glycol
Est. %0.3
Function
Origin
Caprylyl GlycolAn emollient that improves product spreadability and offers a silky feel on the skin. It also acts as a preservative booster that improves the efficacy of other preservatives. According to the manufacturer, it is also a humectant moisturizer.
Potassium Sorbate
Est. %0.3
Function
Origin
Potassium SorbateA preservative widely used in food and personal care products, available from natural sources or synthetically produced. Potassium sorbate works by inhibiting the growth of yeasts, molds, and some bacteria.
Phenoxyethanol
Est. %0.3
Function
Origin
PhenoxyethanolThe most frequently used preservative in skincare. It is a clear, oil-like liquid synthetic substance that protects products from harmful bacteria and yeast, whilst still leaving skin microflora unharmed. It is confirmed by research to be harmless.
Fragrance
Est. %0.3
Function
Origin
FragranceUnder trade secret law, manufacturers have the right not to disclose what exactly went into the fragrance and use the unspecific word Fragrance or Parfum instead. Many fragrances are highly allergenic.
Citronellol
Est. %0.3
Function
Origin
Citronellol

A fragrant compound found naturally in many essential oils (mainly lemongrass). It can have a lemon or a rose scent. People with sensitive skin should try to avoid products with citronellol, or at least do a patch test before using it.

Hydroxycitronellal
Est. %0.3
Function
Origin
Hydroxycitronellal

A fragrant compound with a scent reminiscent of lilies and sweet tropical melon. It can be found in many different essential oils (such as palmarosa, ylang-ylang, and lemongrass essential oil) but is manufactured synthetically from citronellal.

Limonene
Est. %0.3
Function
Origin
Limonene

One of the most used fragrances in skincare products. It is produced from the peels of citrus fruits and has a fresh, pleasant, citrusy smell. People who are sensitive to citrus should try to avoid it, or at least do a patch test before using it.

Linalool
Est. %0.3
Function
Origin
LinaloolA fragrant, volatile compound naturally present in many essential oils. It has a pleasant scent and is often used in skincare products as a fragrance. People with sensitive skin should try to avoid it, or at least do a patch test before using it.