Perricone MD Cold Plasma Plus+ Lip Therapy Review

Perricone MD Cold Plasma Plus+ Lip Therapy
5.8
/ 10
Moisturizing
1.5 Humectancy icon Humectancy
10.0 Occlusivity icon Occlusivity
Ingredients

Perricone MD Cold Plasma Plus+ Lip Therapy Ingredients

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Full Ingredient List (INCI):

Cocos Nucifera (Coconut) Oil, Beeswax, Simmondsia Chinensis (Jojoba) Seed Oil, Ricinus Communis (Castor) Seed Oil, Helianthus Annuus (Sunflower) Seed Oil, Polyethylene, Polyhydroxystearic Acid, Acrylates Copolymer, Ethylhexyl Palmitate, Vanillin, Argania Spinosa Kernel Oil, Astrocaryum Murumuru Seed Butter, Butyrospermum Parkii (Shea) Butter, Oryza Sativa (Rice) Bran Extract, 1,2-Hexanediol, Caprylyl Glycol, Phosphatidylcholine, Tocopherol, Glycine Soja (Soybean) Oil, Tribehenin, Rosmarinus Officinalis (Rosemary) Leaf Extract, Octyldodecanol, Sorbitan Isostearate, Helianthus Annuus (Sunflower) Extract, Silica Dimethyl Silylate, Quaternium-90 Bentonite, Butylene Glycol, Pentylene Glycol, Lactic Acid, Methyl Nicotinate, Propylene Carbonate, Sodium Hyaluronate, Palmitoyl Tripeptide-1, Caffeine, Niacin, Ascorbyl Palmitate, Citric Acid
Review

Does Perricone MD Cold Plasma Plus+ Lip Therapy Work?

 
According to CreamScan's analysis of the ingredient list, here’s what Perricone MD Cold Plasma Plus+ Lip Therapy has to offer:
 
✅ Strong occlusive moisturizing. This exceptionally occlusive moisturizer, ideal for dry and very dry skin, has a moderate moisturizing rating of 5.8 out of 10, impaired by the lack of humectants.

  

Key Benefits of Perricone MD Cold Plasma Plus+ Lip Therapy

 
These are the key benefits you can expect from using Perricone MD Cold Plasma Plus+ Lip Therapy:
 

🔵🔵🔵 Exceptionally Rich Moisturizer with the Right Occlusivity for Very Dry Skin

According to CreamScan analysis, Perricone MD Cold Plasma Plus+ Lip Therapy is quite moisturizing, with a moisturizing rating of 5.8 out of 10.

Is it more humectant or occlusive? Significantly more occlusive. It has a low Humectancy of 1.5 out of 10 and a maximum Occlusivity of 10 out of 10, primarily due to the high content of Cocos Nucifera (Coconut) Oil (est. ≈40.0%), Beeswax (est. ≈22.0%) and Simmondsia Chinensis (Jojoba) Seed Oil (est. ≈11.0%).

This type of product, when used as a standalone moisturizer, can deliver an exceptional level of occlusive hydration that is adequate for dry to very skin. The occlusive profile of Perricone MD Cold Plasma Plus+ Lip Therapy suggests a rich, thick texture, making it perfectly suited for dry skin.

Please refer to the Ratings section below for details of the moisturizing rating calculation.

📌 Please note that this is not a complete list of benefits. We are in the process of enhancing our model to incorporate anti-pigmentation, exfoliation and anti-acne ratings.

Things to Be Aware Of: Perricone MD Cold Plasma Plus+ Lip Therapy

 
CreamScan identified a few things to consider before adding Perricone MD Cold Plasma Plus+ Lip Therapy to your skincare routine:
 

⚠️ If It’s an Exfoliator, It May Increase Skin Photosensitivity Due to Lactic Acid

This product contains lactic acid, a popular AHA known for its ability to gently exfoliate and brighten the skin. It works by removing dead skin cells, revealing new, more delicate skin that is more vulnerable to sun damage.

In smaller quantities, lactic acid is often used as a pH adjuster and may not significantly contribute to exfoliation. However, at higher concentrations, it functions as an effective exfoliant with benefits and risks similar to other AHAs. Products with AHAs, including lactic acid, may increase skin sensitivity, making it more prone to sunburn or irritation when exposed to UV rays.

If this product is designed for exfoliation, applying a broad-spectrum sunscreen with at least SPF 30 daily is essential to protect your skin. Always check the label or the manufacturer’s website for specific usage instructions.

⚠️ Best for Very Dry Skin - May Be Too Thick for Other Skin Types

With exceptional occlusivity, this product is optimal for moisturizing dry and very dry skin but may be too thick for other skin types, including normal, and especially combination and oily skin.

If you have oily, combination, or normal skin and are considering purchasing this product for the first time, it might be a good idea to try a sample before buying.

⚠️ Needs to Be Paired with Extra Humectants for Optimal Moisturizing Efficacy

An ideal moisturizer for any skin type should balance the right level of occlusivity (depending on skin type) with a significant amount of humectants, while Perricone MD Cold Plasma Plus+ Lip Therapy contains a low level of humectants.

People with dry skin would definitely benefit from adding more humectants to their moisturizing routine beyond what this product offers. If this is your only moisturizer, it may be worth including a humectant-rich product, such as a serum, in your skincare routine.

⚠️ Questionable anti-wrinkle efficacy

If one of your main reasons for choosing Perricone MD Cold Plasma Plus+ Lip Therapy is its potential anti-aging effects, please note that, according to CreamScan analysis, it currently has a zero anti-wrinkle rating.

It contains some ingredients often marketed as effective in reducing wrinkles, specifically Palmitoyl Tripeptide-1, Caffeine, and Ascorbyl Palmitate. However, the studies supporting the anti-wrinkle claims of these ingredients provide insufficient evidence of efficacy according to CreamScan Research Evaluation Standards. 

While this does not categorically rule out the possibility that these ingredients may reduce wrinkles, their efficacy is not supported by convincing, vehicle-controlled, double-blind clinical studies - at least none that were available to the CreamScan team at the time of publication.

Therefore, these ingredients do not generate the anti-wrinkle rating.

📌 Moisturizers, when used regularly, are proven to prevent wrinkle formation and even reduce existing wrinkles. Therefore, this product, like any other moisturizer, can deliver some anti-wrinkle effects through its moisturizing action.

Please refer to the Ratings section below for details of the anti-wrinkle rating calculation.

Pros & Cons of Perricone MD Cold Plasma Plus+ Lip Therapy

 
Here’s an overview of the pros and cons of Perricone MD Cold Plasma Plus+ Lip Therapy to help you decide if it’s the right choice for your skincare routine:
 

🟩 Pros:

Exceptionally rich moisturizer with the right level of occlusivity to moisturize dry to very dry skin
 

⭕ Cons: 

⚠️ May feel too rich and thick on skin types other than dry
⚠️ Only if used as a standalone moisturizer - needs to be paired with extra humectants for optimal moisturizing efficacy
⚠️ Questionable anti-wrinkle efficacy
   

Summary: Perricone MD Cold Plasma Plus+ Lip Therapy

 
Based on the ingredient list analysis, CreamScan AI suggests that Perricone MD Cold Plasma Plus+ Lip Therapy
, as a moisturizer, provides an exceptional level of occlusive hydration that is adequate for dry to very skin, delivered in a rich, thick texture.
 
That said, there are some things about Perricone MD Cold Plasma Plus+ Lip Therapy worth noting.
 
With its high occlusivity, Perricone MD Cold Plasma Plus+ Lip Therapy is ideal for dry skin but may feel too thick on other skin types. If you have oily, combination, or normal skin, it’s a good idea to try a sample before purchasing.
 
If you use this product as your only moisturizer in a routine, please note that it contains only a small amount of humectants. Regardless of your skin type, adding extra humectants can enhance optimal moisturizing efficacy. Therefore, it may be worth pairing Perricone MD Cold Plasma Plus+ Lip Therapy with a humectant-rich product, such as a serum, in your skincare routine.
 
If one of your main reasons for considering Perricone MD Cold Plasma Plus+ Lip Therapy is its potential anti-aging effects, please note that, according to CreamScan analysis, its anti-wrinkle efficacy is questionable. None of the ingredients in this product provide substantial evidence of their anti-wrinkle efficacy according to CreamScan Research Evaluation Standards.
 
📌 Fact check. At CreamScan, we are committed to accuracy and fairness. If you spot any errors or something that doesn’t seem right, please click here to let us know. We regularly update the ingredient lists and monitor the latest research on ingredient efficacy to ensure that our information remains as complete and precise as possible. The information provided here is for informational purposes only and does not substitute professional advice. We do not guarantee the efficacy or safety of any product, as individual results may vary.

 

Ingredient Breakdown

Est. % Ingredient Origin Functions
40
22
11
6
4
3
2
1.5
1
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Est. %
Cocos Nucifera (Coconut) Oil
Function:
Origin:
Beeswax
Function:
Origin:
Simmondsia Chinensis (Jojoba) Seed Oil
Function:
Origin:
Ricinus Communis (Castor) Seed Oil
Function:
Origin:
Helianthus Annuus (Sunflower) Seed Oil
Function:
Origin:
Polyethylene
Function:
Origin:
Polyhydroxystearic Acid
Function:
Origin:
Acrylates Copolymer
Function:
Origin:
Ethylhexyl Palmitate
Function:
Origin:
Vanillin
Function:
Origin:
Argania Spinosa Kernel Oil
Function:
Origin:
Astrocaryum Murumuru Seed Butter
Function:
Origin:
Butyrospermum Parkii (Shea) Butter
Function:
Origin:
Oryza Sativa (Rice) Bran Extract
Function:
Origin:
1,2-Hexanediol
Function:
Origin:
Caprylyl Glycol
Function:
Origin:
Phosphatidylcholine
Function:
Origin:
Tocopherol
Function:
Origin:
Glycine Soja (Soybean) Oil
Function:
Origin:
Tribehenin
Function:
Origin:
Rosmarinus Officinalis (Rosemary) Leaf Extract
Function:
Origin:
Octyldodecanol
Function:
Origin:
Sorbitan Isostearate
Function:
Origin:
Helianthus Annuus (Sunflower) Extract
Function:
Origin:
Silica Dimethyl Silylate
Function:
Origin:
Quaternium-90 Bentonite
Function:
Origin:
Butylene Glycol
Function:
Origin:
Pentylene Glycol
Function:
Origin:
Lactic Acid
Function:
Origin:
Methyl Nicotinate
Function:
Origin:
Propylene Carbonate
Function:
Origin:
Sodium Hyaluronate
Function:
Origin:
Palmitoyl Tripeptide-1
Function:
Origin:
Caffeine
Function:
Origin:
Niacin
Function:
Origin:
Ascorbyl Palmitate
Function:
Origin:
Citric Acid
Function:
Origin:

Ratings

All humectants
1.5
0.3
0.3
0.3
0.3
0.3
Benchmark
10
All occlusives
84.8
40.0
22.0
11.0
6.0
4.0
0.3
0.3
0.3
0.3
0.3
0.3
Benchmark
20
Moisturizing rating
5.8
Ingredient Est. % Benchmark Raiting
Humectancy All humectants 1.5 10
1.5
0.3
0.3
0.3
0.3
0.3
Occlusivity All occlusives 84.8 20
10.0
40.0
22.0
11.0
6.0
4.0
0.3
0.3
0.3
0.3
0.3
0.3
Moisturizing rating
5.8
Ingredient Est. % Benchmark Humectancy
0.3
0.3
0.3
0.3
0.3
All humectants 1.5 10
1.5
All humectants
1.5
0.3
0.3
0.3
0.3
0.3
Benchmark
10
Ingredient Est. % Benchmark Occlusivity
40
22
11
6
4
0.3
0.3
0.3
0.3
0.3
0.3
All occlusives 84.8 20
10.0
All occlusives
84.8
40.0
22.0
11.0
6.0
4.0
0.3
0.3
0.3
0.3
0.3
0.3
Benchmark
20
Ingredient
Ingredient anti-wrinkle power
when present at, %
in this formula est. %
Rating
n/a
- 0.3 -
n/a
- 0.3 -
n/a
- 0.3 -
Total
0
Palmitoyl Tripeptide-1
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Caffeine
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Ascorbyl Palmitate
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Anti-wrinkle rating
0
Ingredient Est. % Benchmark
Rich in Antioxidants
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
All antioxidants 2.4 3 No
All antioxidants
2.4
Vanillin
0.3
Argania Spinosa Kernel Oil
0.3
Tocopherol
0.3
Glycine Soja (Soybean) Oil
0.3
Rosmarinus Officinalis (Rosemary) Leaf Extract
0.3
Sodium Hyaluronate
0.3
Caffeine
0.3
Ascorbyl Palmitate
0.3
Benchmark
3
Ingredient Est. % Benchmark
Rich in Soothing
0.3
0.3
0.3
All soothing 0.9 5 No
All soothing
0.9
0.3
0.3
0.3
Benchmark
5

Ingredients explained

Cocos Nucifera (Coconut) Oil
Est. %40
Function
Origin
Cocos Nucifera (Coconut) OilA famous occlusive moisturizing and emollient oil. It is derived from coconuts and may give a product a lovely coconut scent. Coconut oil is listed as a common comedogenic ingredient by acne.org.
Beeswax
Est. %22
Function
Origin
BeeswaxA waxy substance made by bees while they are building their honeycombs. It is an occlusive moisturizing and emollient ingredient with wound healing and antimicrobial properties similar to those of honey. Its bleached, purified form is called Cera alba.
Simmondsia Chinensis (Jojoba) Seed Oil
Est. %11
Function
Origin
Simmondsia Chinensis (Jojoba) Seed OilA liquid plant wax, also known as Jojoba oil, pressed from the seeds of Simmondsia chinensis. These seeds can contain up to 50% of liquid wax. It is used as an occlusive moisturizer, emollient, and emulsifier.
Ricinus Communis (Castor) Seed Oil
Est. %6
Function
Origin
Ricinus Communis (Castor) Seed OilA fatty oil extracted from the seeds of the castor bean plant with very unique fatty acid composition. It is used in skincare as an occlusive moisturizer and emollient that leaves the skin feeling soft and silky after application.
Helianthus Annuus (Sunflower) Seed Oil
Est. %4
Function
Origin
Helianthus Annuus (Sunflower) Seed OilA fatty oil expressed from sunflower seeds and one of the most commonly used oils in skincare. It has great emollient and occlusive moisturizing properties. Sunflower oil is one of the richest sources of vitamin E – an important skin antioxidant.
Polyethylene
Est. %3
Function
Origin
PolyethyleneCommonly used in dense plastic packaging, its primary function in skincare is as a film-forming agent, which protects the product from being easily rinsed away by water or sweat. It also controls viscosity by increasing the thickness of oily products.
Polyhydroxystearic Acid
Est. %2
Function
Origin
Polyhydroxystearic AcidA soft and malleable amber wax naturally derived from vegetable sources. It allows minerals to be very finely dispersed, which can improve SPF, decrease the white cast in sunscreens, and increase the color expression in pigmented products.
Acrylates Copolymer
Est. %1.5
Function
Origin
Acrylates CopolymerA highly functional synthetic ingredient that forms a protective layer on the skin and reduces static buildup. It gives an emollient feel to the product, including a silky after-feel.
Ethylhexyl Palmitate
Est. %1
Function
Origin
Ethylhexyl PalmitateA rich emollient without the oily after-feel, making it a popular replacement for mineral oil. It is derived from natural sources such as palm oil and palm kernel oil. Ethylhexyl palmitate is listed as a common comedogenic ingredient by acne.org.
Vanillin
Est. %0.3
Function
Origin
VanillinThe main component of vanilla bean extract. It has a sweet fragrance and flavor.
Argania Spinosa Kernel Oil
Est. %0.3
Function
Origin
Argania Spinosa Kernel OilA fatty oil from Moroccan argan tree kernels commonly used as an occlusive moisturizer and emollient. Its uniqueness comes from its compounds: vitamin E, phospholipids, phenolic compounds, and rare phytosterols with antioxidant and emollient effects.
Astrocaryum Murumuru Seed Butter
Est. %0.3
Function
Origin
Astrocaryum Murumuru Seed ButterA butter-like, occlusive moisturizing, and emollient fatty oil extracted from the seeds of Murumuru palm. It consists mainly of lauric and myristic acid, as well as smaller amounts of oleic acid.
Butyrospermum Parkii (Shea) Butter
Est. %0.3
Function
Origin
Butyrospermum Parkii (Shea) ButterA semi-solid, buttery fat extracted from the seeds of the Shea tree that is a wonderful occlusive and emollient ingredient mainly comprised of fatty acids. Shea butter contains a large amount of anti-inflammatory and antioxidant compounds.
Oryza Sativa (Rice) Bran Extract
Est. %0.3
Function
Origin
Oryza Sativa (Rice) Bran ExtractAn extract from rice bran, the brown outer part of the rice kernel. It contains emollient fatty acids and antioxidants such as tocopherols (vitamin E) and γ-oryzanol.
1,2-Hexanediol
Est. %0.3
Function
Origin
1,2-HexanediolA multi-functional formula helper. It is a well-studied preservtive against bacteria and can help pigments and fragrances disperse evenly in a formula.
Caprylyl Glycol
Est. %0.3
Function
Origin
Caprylyl GlycolAn emollient that improves product spreadability and offers a silky feel on the skin. It also acts as a preservative booster that improves the efficacy of other preservatives. According to the manufacturer, it is also a humectant moisturizer.
Phosphatidylcholine
Est. %0.3
Function
Origin
PhosphatidylcholineA special emulsifying lipid used to create delivery spheres called liposomes.
Tocopherol
Est. %0.3
Function
Origin
Tocopherol

Simply another name for vitamin E. Tocopherol is a fantastic ingredient and especially beneficial for dry and inflamed skin. It has occlusive moisturizing, emollient, antioxidant, and photoprotective properties.

Glycine Soja (Soybean) Oil
Est. %0.3
Function
Origin
Glycine Soja (Soybean) OilAn occlusive moisturizing oil expressed from soybeans. It does not leave an oily feeling on the skin due to its low content of saturated fatty acids. Glycine soja oil contains emollient fatty acids and a significant amount of antioxidants.
Tribehenin
Est. %0.3
Function
Origin
TribeheninA soft, pliable wax that serves as an occlusive moisturizer and emollient. It improves the spreadability of skincare products, including the increased payoff of stick products, and imparts a pleasant, smooth feel upon application.
Rosmarinus Officinalis (Rosemary) Leaf Extract
Est. %0.3
Function
Origin
Rosmarinus Officinalis (Rosemary) Leaf ExtractA soothing and astringent extract derived from the fragrant, spicy leaves of rosemary. It has strong antioxidant properties. Rosemary extract can reduce signs of inflammation and also acts as an emollient and antimicrobial agent.
Octyldodecanol
Est. %0.3
Function
Origin
OctyldodecanolAn emollient fatty alcohol that spreads easily without leaving a greasy residue on the skin. It is also used as a solvent and dispersing agent for other ingredients.
Sorbitan Isostearate
Est. %0.3
Function
Origin
Sorbitan IsostearateA mild yet powerful emulsifier primarily utilized to produce water-in-oil emulsions. It helps to create a particularly rich and substantial emulsion.
Helianthus Annuus (Sunflower) Extract
Est. %0.3
Function
Origin
Helianthus Annuus (Sunflower) ExtractAn emollient extract derived from sunflower seeds that is packed with skin-benefiting ingredients such as squalene, phytosterols, phospholipids, amino acids, and antioxidant vitamin E.
Silica Dimethyl Silylate
Est. %0.3
Function
Origin
Silica Dimethyl SilylateA synthetic 'filler' powder primarily used as a formula helper. It is added in skincare products to adjust their consistency and thickness.
Quaternium-90 Bentonite
Est. %0.3
Function
Origin
Quaternium-90 Bentonite
Butylene Glycol
Est. %0.3
Function
Origin
Butylene Glycol

A clear, colorless liquid humectant that draws moisture to the skin. The humectancy of butylene glycol, owed to its two hydroxyl groups, is quite considerable, although not as powerful as glycerin, which contains three hydroxyl groups.

Pentylene Glycol
Est. %0.3
Function
Origin
Pentylene Glycol

A naturally or synthetically derived preservative that exhibits effective antifungal and antibacterial traits. It also acts as a booster for more traditional preservatives. Pentylene glycol can also serve as a moisturizing humectant and solvent.

Lactic Acid
Est. %0.3
Function
Origin
Lactic AcidThe most popular AHA in skincare and less irritating than glycolic acid. It can be naturally found in sour milk. It is a humectant moisturizing, pH stabilizing, and gently exfoliating ingredient, able to soften dry, cracked, and peeling skin.
Methyl Nicotinate
Est. %0.3
Function
Origin
Methyl Nicotinate
Propylene Carbonate
Est. %0.3
Function
Origin
Propylene CarbonateA derivative of propylene glycol that is used most frequently as a solvent. Additionally, propylene carbonate serves as a viscosity controlling agent reducing the thickness of the products it is added to.
Sodium Hyaluronate
Est. %0.3
Function
Origin
Sodium Hyaluronate

A sodium salt of famous hyaluronic acid. A potent humectant that hydrates the skin, supports collagen function, and fills out small wrinkles. Sodium hyaluronate also offers soothing and antioxidant properties.

Palmitoyl Tripeptide-1
Est. %0.3
Function
Origin
Palmitoyl Tripeptide-1

A small peptide consisting of three amino acids with anti-wrinkle effects. Together with Palmitoyl Tetrapeptide-7, it is a part of the popular anti-wrinkle complex called Matrixyl™ 3000.

Caffeine
Est. %0.3
Function
Origin
CaffeineAn antioxidant compound that is obtained from coffee and tea leaves. It increases the microcirculation of blood in the skin and is claimed to be able to reduce the appearance of orange peel skin (although the research is lacking).
Niacin
Est. %0.3
Function
Origin
NiacinAn active form of vitamin B3 that is used to support and restore the healthy appearance of the skin, although it is less effective than Niacinamide.
Ascorbyl Palmitate
Est. %0.3
Function
Origin
Ascorbyl PalmitateA form of vitamin C derived from ascorbic acid and palmitic acid. It is more stable and less irritating than ascorbic acid. Unfortunately, Ascorbyl Palmitate lacks the studies to prove its anti-wrinkle efficacy.
Citric Acid
Est. %0.3
Function
Origin
Citric AcidA gently exfoliating AHA that helps to remove the top layer of dead skin cells. In comparison to other AHAs, citric acid has been shown to be one of the least effective. It is also very commonly used as a stabilizing and pH-controlling agent.