Osmosis Beauty Replenish Antioxidant Infusion Serum Review

Osmosis Beauty Replenish Antioxidant Infusion Serum
4.2
/ 10
Moisturizing
7.9 Humectancy icon Humectancy
0.4 Occlusivity icon Occlusivity
3Anti-wrinkle icon/ 10
Anti-wrinkle
Rich
in Antioxidants
Ingredients

Osmosis Beauty Replenish Antioxidant Infusion Serum Ingredients

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Full Ingredient List (INCI):

Water, Phosphatidylcholine, Glycerin, Alcohol Denat., Niacinamide, Polyglyceryl-4 Caprate, Lactic Acid, Pyridoxine HCl, Panthenol, Chlorella Vulgaris Extract, Palmitoyl Tripeptide-38, Fulvic Acid, Beta-Glucan, Thioctic Acid, Ubiquinone, Glutathione, Ergothioneine, Astaxanthin, Polygonum Cuspidatum Extract, Tocopherol, Camellia Oleifera Leaf Extract, Ginkgo Biloba Leaf Extract, Vitis Vinifera (Grape) Seed Extract, Olea Europaea (Olive) Leaf Extract, Citrus Grandis Peel Oil, Citrus Limon (Lemon) Peel Oil, Santalum Austrocaledonicum Wood Oil, Glycine Soja (Soybean) Oil, Lonicera Caprifolium (Honeysuckle) Flower Extract, Lonicera Japonica (Honeysuckle) Flower Extract, Caprylic/Capric Triglyceride, Xanthan Gum, Hydroxypropyl Cyclodextrin, Potassium Sorbate, Benzyl Alcohol
Review

Does Osmosis Beauty Replenish Antioxidant Infusion Serum Work?

 
According to CreamScan's analysis of the ingredient list, here’s what Osmosis Beauty Replenish Antioxidant Infusion Serum has to offer:
 
Moderate moisturizing. It has a moisturizing rating of 4.2 out of 10.
✅ Modest anti-wrinkle efficacy: Osmosis Beauty Replenish Antioxidant Infusion Serum has an anti-wrinkle rating of 3.0 out of 10 so you may expect some, although limited, effect on wrinkles.
✅ Antioxidant protection

  

Key Benefits of Osmosis Beauty Replenish Antioxidant Infusion Serum

 
These are the key benefits you can expect from using Osmosis Beauty Replenish Antioxidant Infusion Serum:
 

🔵 Lightweight Moisturizer Well-Suited for Oily Skin

According to CreamScan analysis, Osmosis Beauty Replenish Antioxidant Infusion Serum is quite moisturizing, with a moisturizing rating of 4.2 out of 10.

Is it more humectant or occlusive? Significantly more humectant. It has a low occlusivity of 0.4 out of 10 and a high humectancy of 7.9 out of 10, primarily due to the high content of Glycerin (est. ≈4.0%) and Niacinamide (est. ≈2.0%).

This humectant-rich product, when used alone as a moisturizer, is well-suited for oily skin, providing moderate hydration in a lightweight, fast-absorbing formula with a minimal amount of occlusive ingredients.

It can also be a good option for people with normal skin who prefer lightweight moisturizers.

💧 A Humectant Enhancement for Any Skincare Routine

But it’s not limited to oily skin - such a humectant enhancement will also positively contribute to the moisturizing efficacy of any skincare routine when used as a step before applying the main moisturizer. This type of formulation is typically used in serums, where a light, fast-absorbing texture is key.

Please refer to the Ratings section below for details of the moisturizing rating calculation.

🟣 Modest Anti-Wrinkle Efficacy

According to CreamScan analysis, Osmosis Beauty Replenish Antioxidant Infusion Serum has a modest level of anti-wrinkle efficacy, rated 3.0 out of 10.

It contains one ingredient with proven anti-wrinkle efficacy: Niacinamide (est. ≈2.0%),
 one of the most effective and well-researched anti-wrinkle ingredients. A clinical study involving 30 participants (Kawada et al.) confirmed that a cream with 4% niacinamide reduced the average depth of wrinkles around the eyes by 9% after 8 weeks of use, compared to a vehicle (the same formulation without niacinamide).
 
Among others, Osmosis Beauty Replenish Antioxidant Infusion Serum contains some ingredients often marketed as effective in reducing wrinkles, specifically Palmitoyl Tripeptide-38, Beta-Glucan, Ubiquinone, and Olea Europaea (Olive) Leaf Extract. However, the studies supporting the anti-wrinkle claims of these ingredients provide insufficient evidence of efficacy according to CreamScan Research Evaluation Standards.
 
While this does not categorically rule out the possibility that these ingredients may reduce wrinkles, their efficacy is not supported by convincing, vehicle-controlled, double-blind clinical studies - at least none that were available to the CreamScan team at the time of publication.
 
Therefore, these ingredients do not contribute to the anti-wrinkle rating.
 
📌 Moisturizers, when used regularly, are proven to prevent wrinkle formation and even reduce existing wrinkles. Therefore, this product, like any other moisturizer, can deliver some additional anti-wrinkle effects through its moisturizing action.
 

Please refer to the Ratings section below for details of the anti-wrinkle rating calculation.

🍀 Rich in Skin-Protecting Antioxidants

We estimate that Osmosis Beauty Replenish Antioxidant Infusion Serum is rich (> 3%) in antioxidants, specifically Niacinamide (est. ≈2.0%).

A key benefit of antioxidants is their ability to reduce oxidative stress caused by free radicals and therefore prevent accelerated skin aging. Studies also show that antioxidants can protect against environmental damage such as UV radiation and pollution, and help reduce inflammation and skin redness.

📌 Please note that this is not a complete list of benefits. We are in the process of enhancing our model to incorporate anti-pigmentation, exfoliation and anti-acne ratings.

Things to Be Aware Of: Osmosis Beauty Replenish Antioxidant Infusion Serum

 
CreamScan identified a few things to consider before adding Osmosis Beauty Replenish Antioxidant Infusion Serum to your skincare routine:
 

⚠️ If It’s an Exfoliator, It May Increase Skin Photosensitivity Due to Lactic Acid

This product contains lactic acid, a popular AHA known for its ability to gently exfoliate and brighten the skin. It works by removing dead skin cells, revealing new, more delicate skin that is more vulnerable to sun damage.

In smaller quantities, lactic acid is often used as a pH adjuster and may not significantly contribute to exfoliation. However, at higher concentrations, it functions as an effective exfoliant with benefits and risks similar to other AHAs. Products with AHAs, including lactic acid, may increase skin sensitivity, making it more prone to sunburn or irritation when exposed to UV rays.

If this product is designed for exfoliation, applying a broad-spectrum sunscreen with at least SPF 30 daily is essential to protect your skin. Always check the label or the manufacturer’s website for specific usage instructions.

Pros & Cons of Osmosis Beauty Replenish Antioxidant Infusion Serum

 
Here’s an overview of the pros and cons of Osmosis Beauty Replenish Antioxidant Infusion Serum to help you decide if it’s the right choice for your skincare routine:
 

🟩 Pros:

✅ When used alone: Provides humectant-rich moisturizing well-suited for oily skin
✅ As part of a routine: A humectant moisturizing enhancement, beneficial for any skin type
✅ Lightweight texture
Offers modest anti-wrinkle efficacy
✅ Rich in antioxidants that combat oxidative stress associated with accelerated skin aging and defend against environmental damage
 

⭕ Cons: 

✅ We couldn't find any
   

Summary: Osmosis Beauty Replenish Antioxidant Infusion Serum

 
Based on the ingredient list analysis, CreamScan AI suggests that Osmosis Beauty Replenish Antioxidant Infusion Serum
, when used alone, delivers lightweight, humectant-rich moisturizing that is well-suited for oily skin. As part of a moisturizing routine, it provides a humectant enhancement, beneficial for all skin types.
 
Osmosis Beauty Replenish Antioxidant Infusion Serum contains ingredients with proven evidence of anti-wrinkle efficacy that may provide a modest anti-wrinkle effect. As a result, you can expect a positive, though not very significant, impact on wrinkles.
 
With its high antioxidant content, Osmosis Beauty Replenish Antioxidant Infusion Serum helps protect against free radical damage and offers multiple benefits for all skin types, including preventing premature aging, defending against environmental damage, and calming inflammation.
 
That said, there are some things about Osmosis Beauty Replenish Antioxidant Infusion Serum worth noting.
 
📌 Fact check. At CreamScan, we are committed to accuracy and fairness. If you spot any errors or something that doesn’t seem right, please click here to let us know. We regularly update the ingredient lists and monitor the latest research on ingredient efficacy to ensure that our information remains as complete and precise as possible. The information provided here is for informational purposes only and does not substitute professional advice. We do not guarantee the efficacy or safety of any product, as individual results may vary.

 

Ingredient Breakdown

Est. % Ingredient Origin Functions
75
6
4
3
2
1.5
1.3
1
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Est. %
Water
Function:
Origin:
Phosphatidylcholine
Function:
Origin:
Glycerin
Function:
Origin:
Alcohol Denat.
Function:
Origin:
Niacinamide
Function:
Origin:
Polyglyceryl-4 Caprate
Function:
Origin:
Lactic Acid
Function:
Origin:
Pyridoxine HCl
Function:
Origin:
Panthenol
Function:
Origin:
Chlorella Vulgaris Extract
Function:
Origin:
Palmitoyl Tripeptide-38
Function:
Origin:
Fulvic Acid
Function:
Origin:
Beta-Glucan
Function:
Origin:
Thioctic Acid
Function:
Origin:
Ubiquinone
Function:
Origin:
Glutathione
Function:
Origin:
Ergothioneine
Function:
Origin:
Astaxanthin
Function:
Origin:
Polygonum Cuspidatum Extract
Function:
Origin:
Tocopherol
Function:
Origin:
Camellia Oleifera Leaf Extract
Function:
Origin:
Ginkgo Biloba Leaf Extract
Function:
Origin:
Vitis Vinifera (Grape) Seed Extract
Function:
Origin:
Olea Europaea (Olive) Leaf Extract
Function:
Origin:
Citrus Grandis Peel Oil
Function:
Origin:
Citrus Limon (Lemon) Peel Oil
Function:
Origin:
Santalum Austrocaledonicum Wood Oil
Function:
Origin:
Glycine Soja (Soybean) Oil
Function:
Origin:
Lonicera Caprifolium (Honeysuckle) Flower Extract
Function:
Origin:
Lonicera Japonica (Honeysuckle) Flower Extract
Function:
Origin:
Caprylic/Capric Triglyceride
Function:
Origin:
Xanthan Gum
Function:
Origin:
Hydroxypropyl Cyclodextrin
Function:
Origin:
Potassium Sorbate
Function:
Origin:
Benzyl Alcohol
Function:
Origin:

Ratings

All humectants
7.9
4
2
1.3
0.3
0.3
Benchmark
10
All occlusives
0.9
0.3
0.3
0.3
Benchmark
20
Moisturizing rating
4.2
Ingredient Est. % Benchmark Raiting
Humectancy All humectants 7.9 10
7.9
4
2
1.3
0.3
0.3
Occlusivity All occlusives 0.9 20
0.4
0.3
0.3
0.3
Moisturizing rating
4.2
Ingredient Est. % Benchmark Humectancy
4
2
1.3
0.3
0.3
All humectants 7.9 10
7.9
All humectants
7.9
4
2
1.3
0.3
0.3
Benchmark
10
Ingredient Est. % Benchmark Occlusivity
0.3
0.3
0.3
All occlusives 0.9 20
0.4
All occlusives
0.9
0.3
0.3
0.3
Benchmark
20
Ingredient
Ingredient anti-wrinkle power
when present at, %
in this formula est. %
Rating
6 /10 4 2 3
n/a
- 0.3 -
n/a
- 0.3 -
n/a
- 0.3 -
n/a
- 0.3 -
Total
3
Niacinamide
3
Ingredient anti-wrinkle power
6 /10
when present at, %
4
in this formula, est. %
2
Palmitoyl Tripeptide-38
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Beta-Glucan
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Ubiquinone
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Olea Europaea (Olive) Leaf Extract
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Anti-wrinkle rating
3
Ingredient Est. % Benchmark
Rich in Antioxidants
2
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
All antioxidants 6.5 3 Rich in antioxidants
All antioxidants
6.5
Niacinamide
2
Chlorella Vulgaris Extract
0.3
Beta-Glucan
0.3
Thioctic Acid
0.3
Ubiquinone
0.3
Glutathione
0.3
Ergothioneine
0.3
Astaxanthin
0.3
Tocopherol
0.3
Camellia Oleifera Leaf Extract
0.3
Ginkgo Biloba Leaf Extract
0.3
Vitis Vinifera (Grape) Seed Extract
0.3
Olea Europaea (Olive) Leaf Extract
0.3
Citrus Grandis Peel Oil
0.3
Glycine Soja (Soybean) Oil
0.3
Lonicera Japonica (Honeysuckle) Flower Extract
0.3
Benchmark
3
Ingredient Est. % Benchmark
Rich in Soothing
2
0.3
0.3
0.3
0.3
0.3
0.3
All soothing 3.8 5 No
All soothing
3.8
2
0.3
0.3
0.3
0.3
0.3
0.3
Benchmark
5

Ingredients explained

Water
Est. %75
Function
Origin
WaterThe most used ingredient in skincare. Its concentration defines the product texture: rich creams may have about 50% of water while a light jelly about 90%. Water doesn’t moisturize the skin by itself and is used in skincare as a solvent for other ingredients.
Phosphatidylcholine
Est. %6
Function
Origin
PhosphatidylcholineA special emulsifying lipid used to create delivery spheres called liposomes.
Glycerin
Est. %4
Function
Origin
Glycerin

The most popular moisturizing ingredient in the world. It is a powerful humectant – cheap yet very effective.

Alcohol Denat.
Est. %3
Function
Origin
Alcohol Denat.

Denatured alcohol is ethanol that contains additives that make it unsafe to consume. It is mainly used as a solvent and an antimicrobial agent. A major drawback to alcohol denat. is that it dries out the skin.

Niacinamide
Est. %2
Function
Origin
Niacinamide

Also known as vitamin B3, this ingredient is a true superstar with confirmed moisturizing, anti-acne, hyperpigmentation, and antioxidant benefits. Two studies confirm its significant anti-wrinkle efficacy.

Polyglyceryl-4 Caprate
Est. %1.5
Function
Origin
Polyglyceryl-4 CaprateA natural surfactant that softens the appearance of skin and forms oil and water mixtures.
Lactic Acid
Est. %1.3
Function
Origin
Lactic AcidThe most popular AHA in skincare and less irritating than glycolic acid. It can be naturally found in sour milk. It is a humectant moisturizing, pH stabilizing, and gently exfoliating ingredient, able to soften dry, cracked, and peeling skin.
Pyridoxine HCl
Est. %1
Function
Origin
Pyridoxine HClA B-vitamin that helps regulate sebum production.
Panthenol
Est. %0.3
Function
Origin
PanthenolA popular soothing and moisturizing derivative of vitamin B5. Panthenol is particularly beneficial for dry, flaking, burned, or damaged skin. It is used to alleviate the symptoms of a rash, dermatitis, eczema, chapped lips, and sunburn.
Chlorella Vulgaris Extract
Est. %0.3
Function
Origin
Chlorella Vulgaris ExtractA dried mass of tiny, single-cell green algae. It is widely used as a food source or dietary supplement since it is rich in proteins, amino acids, minerals, and vitamins. This dark green extract is used as an antioxidant agent in skincare.
Palmitoyl Tripeptide-38
Est. %0.3
Function
Origin
Palmitoyl Tripeptide-38

A small synthetic peptide that increases the production of collagen, fibronectin, and hyaluronic acid in the skin. It has also been shown to reduce wrinkles in combination with other anti-aging ingredients.

Fulvic Acid
Est. %0.3
Function
Origin
Fulvic Acid
Beta-Glucan
Est. %0.3
Function
Origin
Beta-GlucanA special polysaccharide obtained from cereals, mushrooms, yeast, bacteria, and some species of seaweed. It is a promising anti-wrinkle, wound healing, antioxidant, and moisturizing ingredient.
Thioctic Acid
Est. %0.3
Function
Origin
Thioctic Acid
Ubiquinone
Est. %0.3
Function
Origin
UbiquinoneAlso known as Coenzyme Q10, this bright orange antioxidant supports the skin's energy metabolism. It also offers some anti-pigment action. Dietary supplementation of Ubiquinone improves the appearance of wrinkles.
Glutathione
Est. %0.3
Function
Origin
GlutathioneA naturally occurring tripeptide that combats free radicals and acts as a reducing agent.
Ergothioneine
Est. %0.3
Function
Origin
ErgothioneineA naturally-occurring amino acid that functions as a powerful and versatile antioxidant.
Astaxanthin
Est. %0.3
Function
Origin
AstaxanthinA red natural pigment from the family of antioxidant carotenoids that occurs in many natural sources such as lobster and algae. It is mainly used as a colorant and soothing ingredient.
Polygonum Cuspidatum Extract
Est. %0.3
Function
Origin
Polygonum Cuspidatum Extract
Tocopherol
Est. %0.3
Function
Origin
Tocopherol

Simply another name for vitamin E. Tocopherol is a fantastic ingredient and especially beneficial for dry and inflamed skin. It has occlusive moisturizing, emollient, antioxidant, and photoprotective properties.

Camellia Oleifera Leaf Extract
Est. %0.3
Function
Origin
Camellia Oleifera Leaf ExtractAn emollient extract derived from the leaves of the Tea-oil Camellia, which is native to Southeast Asia. It contains astringent and wound-healing tannins that create a tightening feeling on the skin and can speed up the healing process of small cuts.
Ginkgo Biloba Leaf Extract
Est. %0.3
Function
Origin
Ginkgo Biloba Leaf ExtractAn antioxidant, astringent and soothing extract derived from Ginkgo biloba tree leaves, a rare Chinese tree that is endangered in the wild, but grown nowadays as a decorative tree in parks. When taken orally, the extract can improve memory and brain function.
Vitis Vinifera (Grape) Seed Extract
Est. %0.3
Function
Origin
Vitis Vinifera (Grape) Seed ExtractA potent antioxidant and emollient extract derived from grape seeds. It contains antioxidant flavonoids, tannins, proanthocyanidins, phytosterols, carotenoids, and vitamin E. It is often used in skincare products aimed at soothing and healing irritated skin.
Olea Europaea (Olive) Leaf Extract
Est. %0.3
Function
Origin
Olea Europaea (Olive) Leaf ExtractAn antioxidant and fragrant extract from the leaves of the olive tree. It contains a promising anti-aging compound called Oleuropein, and a prospective anti-pigment compound called Cornoside.
Citrus Grandis Peel Oil
Est. %0.3
Function
Origin
Citrus Grandis Peel Oil

A fragrant essential oil obtained from pomelo peels - sometimes mislabeled as grapefruit. The high limonene content is responsible for its citrusy scent. It may induce sun allergies in people sensitive to citrus fruits.

Citrus Limon (Lemon) Peel Oil
Est. %0.3
Function
Origin
Citrus Limon (Lemon) Peel Oil

A fragrant essential oil extracted from the rind or peel of a lemon. It is mainly comprised of limonene (up to 70%) and has a fresh, citrusy scent. Lemon peel oil may cause a sun-induced skin rash in people with a sensitivity towards citrus fruits.

Santalum Austrocaledonicum Wood Oil
Est. %0.3
Function
Origin
Santalum Austrocaledonicum Wood Oil
Glycine Soja (Soybean) Oil
Est. %0.3
Function
Origin
Glycine Soja (Soybean) OilAn occlusive moisturizing oil expressed from soybeans. It does not leave an oily feeling on the skin due to its low content of saturated fatty acids. Glycine soja oil contains emollient fatty acids and a significant amount of antioxidants.
Lonicera Caprifolium (Honeysuckle) Flower Extract
Est. %0.3
Function
Origin
Lonicera Caprifolium (Honeysuckle) Flower ExtractA fragrant extract derived from the flowers of the Italian honeysuckle. It has a pleasant, sweet, floral scent. Not much is known about its compounds and their functions.
Lonicera Japonica (Honeysuckle) Flower Extract
Est. %0.3
Function
Origin
Lonicera Japonica (Honeysuckle) Flower ExtractAn extract from the white flowers of the Japanese honeysuckle. Apart from an essential oil responsible for its jasmine-like scent, the extract also contains antioxidant and anti-inflammatory iridoids, flavonoids, and phenolic acids.
Caprylic/Capric Triglyceride
Est. %0.3
Function
Origin
Caprylic/Capric TriglycerideA natural occlusive moisturizing and emollient ingredient, it is a blend of glycerin and two fatty acids, caprylic and capric acid. It creates an oil-based protective layer on the skin, thereby preventing water loss.
Xanthan Gum
Est. %0.3
Function
Origin
Xanthan GumA natural multi-functional ingredient that originates from fermented sugars. Xanthan gum acts as a viscosity-building agent to thicken skincare products. It is also an excellent stabilizer and works well to hold other ingredients together.
Hydroxypropyl Cyclodextrin
Est. %0.3
Function
Origin
Hydroxypropyl CyclodextrinA white crystalline powder that can reduce odors coming from other ingredients in a product.
Potassium Sorbate
Est. %0.3
Function
Origin
Potassium SorbateA preservative widely used in food and personal care products, available from natural sources or synthetically produced. Potassium sorbate works by inhibiting the growth of yeasts, molds, and some bacteria.
Benzyl Alcohol
Est. %0.3
Function
Origin
Benzyl Alcohol

A multifunctional ingredient that is supplied as a clear, colorless liquid. Its main function is as a flavoring agent and fragrance. It also acts as a broad-spectrum preservative, solvent, and viscosity-controlling agent that thins the product.