Numbuzin No. 2 Protein 43% Creamy Serum

Numbuzin No. 2 Protein 43% Creamy Serum
4.5
/ 10
Moisturizing
7.4 Humectancy icon Humectancy
1.6 Occlusivity icon Occlusivity
1.5Anti-wrinkle icon/ 10
Anti-wrinkle

Review

Does Numbuzin No. 2 Protein 43% Creamy Serum work?

Based on the ingredient list analysis by CreamScan AI, these are the key benefits you can expect from using Numbuzin No. 2 Protein 43% Creamy Serum:

  • Moderate moisturizing. It has a moisturizing rating of 4.5 out of 10.
  • Little anti-wrinkle effect: Numbuzin No. 2 Protein 43% Creamy Serum has an anti-wrinkle rating of 1.5 out of 10, so you may expect a positive, although insignificant, effect on wrinkles.

Lightweight moisturizer well-suited for oily skin and a humectant enhancement for any skincare routine

According to CreamScan analysis, Numbuzin No. 2 Protein 43% Creamy Serum is quite moisturizing, with a moisturizing rating of 4.5 out of 10.

Is it more humectant or occlusive? Significantly more humectant. It has a low occlusivity of 1.6 out of 10 and a high humectancy of 7.4 out of 10, primarily due to the high content of Butylene Glycol (est. ≈4.0%).

This humectant-rich product, when used alone as a moisturizer, is well-suited for oily skin, providing moderate hydration in a lightweight, fast-absorbing formula with a minimal amount of occlusive ingredients. It can also be a good option for people with normal skin who prefer lightweight moisturizers.

Such a humectant engancement will also positively contribute to the moisturizing efficacy of any skincare routine when used as a step before applying the main moisturizer. This type of formulation is typically used in serums, where a light, fast-absorbing texture is key.

Please refer to the Ratings section below for details of the moisturizing rating calculation.

Little anti-wrinkle efficacy

According to CreamScan analysis, Numbuzin No. 2 Protein 43% Creamy Serum has a minimal anti-wrinkle rating of 1.5 out of 10.

It contains one ingredient with proven anti-wrinkle efficacy: Niacinamide (est. ≈1.0%), 
 one of the most effective and well-researched anti-wrinkle ingredients. A clinical study involving 30 participants (Kawada et al.) confirmed that a cream with 4% niacinamide reduced the average depth of wrinkles around the eyes by 9% after 8 weeks of use, compared to a vehicle (the same formulation without niacinamide).
 
Among others, Numbuzin No. 2 Protein 43% Creamy Serum also contains contains Adenosine and Lactobacillus Ferment, two ingredients often marketed as effective in reducing wrinkles. However, the studies supporting the anti-wrinkle claims of these ingredients provide insufficient evidence of efficacy according to CreamScan Research Evaluation Standards. Therefore, these ingredients do not contribute to the anti-wrinkle rating.
 
Moisturizers, when used regularly, are proven to prevent wrinkle formation and even reduce existing wrinkles. Therefore, this product, like any other moisturizer, can deliver some anti-wrinkle effects through its moisturizing action.
 

Please refer to the Ratings section below for details of the anti-wrinkle rating calculation.

Ingredients

Est. % Ingredient Origin Functions
60
9
6
4
3
2.5
2
1.5
1.3
1
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Est. %
Avena Sativa (Oat) Protein Extract
Function:
Origin:
Water
Function:
Origin:
Cyclopentasiloxane
Function:
Origin:
Butylene Glycol
Function:
Origin:
Cetearyl Ethylhexanoate
Function:
Origin:
Cyclohexasiloxane
Function:
Origin:
Phenyl Trimethicone
Function:
Origin:
Cetyl PCA
Function:
Origin:
Hydrogenated Polyisobutene
Function:
Origin:
Niacinamide
Function:
Origin:
Panthenol
Function:
Origin:
1,2-Hexanediol
Function:
Origin:
Glycerin
Function:
Origin:
Erythritol
Function:
Origin:
Limnanthes Alba (Meadowfoam) Seed Oil
Function:
Origin:
Sodium Chloride
Function:
Origin:
Allantoin
Function:
Origin:
Ethylhexylglycerin
Function:
Origin:
Tocopheryl Acetate
Function:
Origin:
Adenosine
Function:
Origin:
Dextrin
Function:
Origin:
Theobroma Cacao (Cocoa) Extract
Function:
Origin:
Pantolactone
Function:
Origin:
Ceramide NP
Function:
Origin:
Cholesterol
Function:
Origin:
Palmitic Acid
Function:
Origin:
Oryza Sativa (Rice) Seed Protein
Function:
Origin:
Stearic Acid
Function:
Origin:
Hydrolyzed Milk Protein
Function:
Origin:
Lactobacillus Ferment
Function:
Origin:
Glycine Soja (Soybean) Protein
Function:
Origin:
Hydrolyzed Lupine Protein
Function:
Origin:
Glucose
Function:
Origin:
Hydrolyzed Corn Protein
Function:
Origin:
Hydrolyzed Rice Protein
Function:
Origin:
Hydrolyzed Soy Protein
Function:
Origin:
Hydrolyzed Sweet Almond Protein
Function:
Origin:
Hydrolyzed Vegetable Protein
Function:
Origin:
Myristic Acid
Function:
Origin:
Hydrolyzed Pea Protein
Function:
Origin:
Arachidic Acid
Function:
Origin:
Lauric Acid
Function:
Origin:
Sodium Succinate
Function:
Origin:
Disodium EDTA
Function:
Origin:
Fragrance
Function:
Origin:

Ratings

All humectants
7.4
4
1
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Benchmark
10
All occlusives
3.2
2.0
0.3
0.3
0.3
0.3
Benchmark
20
Moisturizing rating
4.5
Ingredient Est. % Benchmark Raiting
Humectancy All humectants 7.4 10
7.4
4
1
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Occlusivity All occlusives 3.2 20
1.6
2.0
0.3
0.3
0.3
0.3
Moisturizing rating
4.5
Ingredient Est. % Benchmark Humectancy
4
1
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
All humectants 7.4 10
7.4
All humectants
7.4
4
1
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Benchmark
10
Ingredient Est. % Benchmark Occlusivity
2
0.3
0.3
0.3
0.3
All occlusives 3.2 20
1.6
All occlusives
3.2
2.0
0.3
0.3
0.3
0.3
Benchmark
20
Ingredient
Ingredient anti-wrinkle power
when present at, %
in this formula est. %
Rating
6 /10 4 1 1.5
n/a
- 0.3 -
n/a
- 0.3 -
Total
1.5
Niacinamide
1.5
Ingredient anti-wrinkle power
6 /10
when present at, %
4
in this formula, est. %
1
Adenosine
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Lactobacillus Ferment
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Anti-wrinkle rating
1.5
Ingredient Est. % Benchmark
Rich in Antioxidants
1
0.3
0.3
0.3
All antioxidants 1.9 3 No
All antioxidants
1.9
Niacinamide
1
Tocopheryl Acetate
0.3
Theobroma Cacao (Cocoa) Extract
0.3
Oryza Sativa (Rice) Seed Protein
0.3
Benchmark
3
Ingredient Est. % Benchmark
Rich in Soothing
1
0.3
0.3
0.3
0.3
All soothing 2.2 5 No
All soothing
2.2
1
0.3
0.3
0.3
0.3
Benchmark
5

Ingredients explained

Avena Sativa (Oat) Protein Extract
Est. %60
Function
Origin
Avena Sativa (Oat) Protein Extract
Water
Est. %9
Function
Origin
WaterThe most used ingredient in skincare. Its concentration defines the product texture: rich creams may have about 50% of water while a light jelly about 90%. Water doesn’t moisturize the skin by itself and is used in skincare as a solvent for other ingredients.
Cyclopentasiloxane
Est. %6
Function
Origin
CyclopentasiloxaneA lightweight, fast-spreading emollient that leaves a very soft and silky after-feel on the skin. Supplied as a clear and colorless liquid, cyclopentasiloxane is often used as a solvent to dissolve other silicones in.
Butylene Glycol
Est. %4
Function
Origin
Butylene Glycol

A clear, colorless liquid humectant that draws moisture to the skin. The humectancy of butylene glycol, owed to its two hydroxyl groups, is quite considerable, although not as powerful as glycerin, which contains three hydroxyl groups.

Cetearyl Ethylhexanoate
Est. %3
Function
Origin
Cetearyl EthylhexanoateAn emollient ester that is derived from palm and palm kernel oil and is known for its velvety soft skin feel and excellent spreading properties.
Cyclohexasiloxane
Est. %2.5
Function
Origin
CyclohexasiloxaneA clear silicone fluid with very low viscosity that is commonly used as a solvent and emollient. It has excellent spreadability, rubs in quickly, and leaves a silky smooth after-feel on the skin.
Phenyl Trimethicone
Est. %2
Function
Origin
Phenyl TrimethiconeA silicone fluid that is used as an occlusive moisturizer. It applies smoothly to the skin and reduces the tack associated with organic oils.
Cetyl PCA
Est. %1.5
Function
Origin
Cetyl PCA
Hydrogenated Polyisobutene
Est. %1.3
Function
Origin
Hydrogenated PolyisobuteneA viscous liquid that makes a great oil base due to its smooth sensorial profile. It has emollient features, including good spreadability and little tack upon application. It also has the added benefit of being able to thicken products.
Niacinamide
Est. %1
Function
Origin
Niacinamide

Also known as vitamin B3, this ingredient is a true superstar with confirmed moisturizing, anti-acne, hyperpigmentation, and antioxidant benefits. Two studies confirm its significant anti-wrinkle efficacy.

Panthenol
Est. %0.3
Function
Origin
PanthenolA popular soothing and moisturizing derivative of vitamin B5. Panthenol is particularly beneficial for dry, flaking, burned, or damaged skin. It is used to alleviate the symptoms of a rash, dermatitis, eczema, chapped lips, and sunburn.
1,2-Hexanediol
Est. %0.3
Function
Origin
1,2-HexanediolA multi-functional formula helper. It is a well-studied preservtive against bacteria and can help pigments and fragrances disperse evenly in a formula.
Glycerin
Est. %0.3
Function
Origin
Glycerin

The most popular moisturizing ingredient in the world. It is a powerful humectant – cheap yet very effective.

Erythritol
Est. %0.3
Function
Origin
ErythritolA naturally occurring sweetener that hydrates skin by drawing in water.
Limnanthes Alba (Meadowfoam) Seed Oil
Est. %0.3
Function
Origin
Limnanthes Alba (Meadowfoam) Seed OilA fatty oil expressed from the seeds of meadowfoam. It is used in skincare as an occlusive moisturizer and emollient that leaves the skin feeling soft and silky after application.
Sodium Chloride
Est. %0.3
Function
Origin
Sodium Chloride

You’re definitely familiar with sodium chloride, even if you don’t think you are. It’s table salt! Salt works well with some cleansing ingredients (surfactants) to thicken them into gels. It also acts as a stabilizer for water-in-oil emulsions.

Allantoin
Est. %0.3
Function
Origin
AllantoinA fluffy, white powder that acts as a humectant due to its water-loving chemistry and as an exfoliant that helps to remove dead skin cells. It has also been shown to be very soothing to irritated and inflamed skin.
Ethylhexylglycerin
Est. %0.3
Function
Origin
EthylhexylglycerinA preservative booster derived from glycerin. It is commonly paired with other preservatives to improve their efficacy. Ethylhexylglycerin is also a humectant due to its chemical base of glycerin.
Tocopheryl Acetate
Est. %0.3
Function
Origin
Tocopheryl Acetate

An antioxidant derivative of tocopherol (vitamin E). It helps to protect cells from free radicals and UV damage through the conversion to active vitamin E in the skin. It is more stable than tocopherol.

Adenosine
Est. %0.3
Function
Origin
Adenosine

A key molecule responsible for energy transportation, signaling, and enzyme activity. Adenosine is a popular anti-wrinkle ingredient, however, the key study about its anti-wrinkle efficacy (1) does not meet CreamScan Research Evaluation Standards as it is not double-blind.

Dextrin
Est. %0.3
Function
Origin
DextrinA partially hydrolyzed potato starch, most commonly used as a viscosity controlling and binding agent. When dispersed into water, it can create textures ranging from a thick paste to a soft gel.
Theobroma Cacao (Cocoa) Extract
Est. %0.3
Function
Origin
Theobroma Cacao (Cocoa) Extract

An extract from cocoa beans or cocoa powder with lots of beneficial compounds such as stimulant caffeine, antioxidant and astringent flavanols, and tannins – which are responsible for its bitter taste.

Pantolactone
Est. %0.3
Function
Origin
PantolactoneA vitamin B5 derivative. Similar to panthenol, it has several benefits as an antioxidant and humectant. However, it is less reactive and therefore products can stay stable longer.
Ceramide NP
Est. %0.3
Function
Origin
Ceramide NPAlso known as ceramide 3, it is the most common ceramide in our skin. It helps to restore the skin’s lipid barrier and alleviate the symptoms of dry and cracked skin. Research has shown that skin suffering from conditions such as AD lacks ceramides.
Cholesterol
Est. %0.3
Function
Origin
CholesterolAn emollient and important barrier repairing lipid, effective when combined with fatty acids and ceramides. Around 25% of the skin’s lipid layer is made up of cholesterol and it is found in the membrane of every single cell in our body.
Palmitic Acid
Est. %0.3
Function
Origin
Palmitic AcidA saturated fatty acid used in skincare as a strongly occlusive moisturizer and barrier repairing, emollient ingredient. It is a waxy-looking, white solid. Palmitic acid can be commonly found in animal and vegetable fats, notably palm oil.
Oryza Sativa (Rice) Seed Protein
Est. %0.3
Function
Origin
Oryza Sativa (Rice) Seed Protein
Stearic Acid
Est. %0.3
Function
Origin
Stearic AcidA saturated fatty acid found in vegetable butter and animal fats. It is an occlusive moisturizing and emollient ingredient and also helps to maintain the barrier function of the skin.
Hydrolyzed Milk Protein
Est. %0.3
Function
Origin
Hydrolyzed Milk Protein
Lactobacillus Ferment
Est. %0.3
Function
Origin
Lactobacillus FermentA biotechnological product – a mixture of metabolic products of Lactobacillus culture. Some Lactobacillus forms have been reported to have anti-wrinkle and barrier repairing effects, as well as able to improve skin hydration, elasticity, and gloss.
Glycine Soja (Soybean) Protein
Est. %0.3
Function
Origin
Glycine Soja (Soybean) ProteinAn emulsifying mixture of proteins extracted from soybeans. It has some soothing properties (e.g., it can help with the healing of sunburned skin) and contains various proteins, enzymes, and amino acids.
Hydrolyzed Lupine Protein
Est. %0.3
Function
Origin
Hydrolyzed Lupine Protein
Glucose
Est. %0.3
Function
Origin
GlucoseA simple sugar that is also one of two components of sucrose, or table sugar. It is used as a humectant in skincare products. Glucose is also used to flavor lip care cosmetics because of its mildly sweet taste.
Hydrolyzed Corn Protein
Est. %0.3
Function
Origin
Hydrolyzed Corn Protein
Hydrolyzed Rice Protein
Est. %0.3
Function
Origin
Hydrolyzed Rice ProteinA protein derived from rice bran with film-forming abilities. It can help increase moisturization in skin.
Hydrolyzed Soy Protein
Est. %0.3
Function
Origin
Hydrolyzed Soy ProteinA mixture of proteins obtained from soybeans. It can have many different functions depending on the manufacturer, although it is most commonly used in skincare products as a humectant moisturizing ingredient.
Hydrolyzed Sweet Almond Protein
Est. %0.3
Function
Origin
Hydrolyzed Sweet Almond Protein
Hydrolyzed Vegetable Protein
Est. %0.3
Function
Origin
Hydrolyzed Vegetable ProteinA blanket term used for plant-based proteins that have been processed into smaller chunks. They add to the skincare product's film-forming and water-binding properties.
Myristic Acid
Est. %0.3
Function
Origin
Myristic AcidA common fatty acid found in various vegetable oils, most notably palm and coconut oil. It is a strongly occlusive moisturizing, emollient, and emulsifying ingredient.
Hydrolyzed Pea Protein
Est. %0.3
Function
Origin
Hydrolyzed Pea Protein
Arachidic Acid
Est. %0.3
Function
Origin
Arachidic Acid
Lauric Acid
Est. %0.3
Function
Origin
Lauric AcidA fatty acid derived from various vegetable oils such as palm or coconut oil. It helps to maintain the barrier function of the skin and is also used as a cleansing or emulsifying agent. Lauric acid is listed among common comedogenic ingredients by acne.org.
Sodium Succinate
Est. %0.3
Function
Origin
Sodium Succinate
Disodium EDTA
Est. %0.3
Function
Origin
Disodium EDTAA synthetic chelator that helps to maintain the look and smell of a product by 'locking up' troublesome metal ions.
Fragrance
Est. %0.3
Function
Origin
FragranceUnder trade secret law, manufacturers have the right not to disclose what exactly went into the fragrance and use the unspecific word Fragrance or Parfum instead. Many fragrances are highly allergenic.