Isntree C-Niacin Toning Ampoule

Isntree C-Niacin Toning Ampoule
5.1
/ 10
Moisturizing
10.0 Humectancy icon Humectancy
0.2 Occlusivity icon Occlusivity
2Anti-wrinkle icon/ 10
Anti-wrinkle
Rich
in Antioxidants

Review

Does Isntree C-Niacin Toning Ampoule work?

Based on the ingredient list analysis by CreamScan AI, these are the key benefits you can expect from using Isntree C-Niacin Toning Ampoule:

  • Strong humectant moisturizing. This lightweight, humectant-rich product, ideal for oily skin, has a moisturizing rating of 5.1 out of 10.
  • Some anti-wrinkle efficacy: Isntree C-Niacin Toning Ampoule has an anti-wrinkle rating of 2.0 out of 10 so you may expect some, although limited, effect on wrinkles.
  • Antioxidant protection.

Lightweight moisturizer ideal for oily skin and a humectant boost for any skincare routine

According to CreamScan analysis, Isntree C-Niacin Toning Ampoule is quite moisturizing, with a moisturizing rating of 5.1 out of 10.

Is it more humectant or occlusive? Significantly more humectant. It has a low occlusivity of 0.2 out of 10 and a maximum humectancy of 10 out of 10, primarily due to the high content of Butylene Glycol (est. ≈6.0%), Pentylene Glycol (est. ≈4.0%) and Glycerin (est. ≈3.0%).

This humectant-rich product, when used alone as a moisturizer, is ideal for oily skin, offering significant hydration in a lightweight, fast-absorbing formula with a minimal amount of occlusive ingredients. It’s also a great choice for people with normal skin who prefer lightweight moisturizers.

Such a humectant boost will also positively contribute to the moisturizing efficacy of any skincare routine when used as a step before applying the main moisturizer. This type of formulation is typically used in serums, where a light, fast-absorbing texture is key.

Please refer to the Ratings section below for details of the moisturizing rating calculation.

Some anti-wrinkle efficacy

According to CreamScan analysis, Isntree C-Niacin Toning Ampoule has a slight anti-wrinkle rating of 2.0 out of 10.

It contains one ingredient with proven anti-wrinkle efficacy: Niacinamide (est. ≈1.3%), 
 one of the most effective and well-researched anti-wrinkle ingredients. A clinical study involving 30 participants (Kawada et al.) confirmed that a cream with 4% niacinamide reduced the average depth of wrinkles around the eyes by 9% after 8 weeks of use, compared to a vehicle (the same formulation without niacinamide).
 
Among others, Isntree C-Niacin Toning Ampoule also contains some ingredients marketed often as effective in reducing wrinkles, specifically Melia Azadirachta Leaf Extract, Beta-Glucan, and 3-O-Ethyl Ascorbic Acid. However, the studies supporting the anti-wrinkle claims of these ingredients provide insufficient evidence of efficacy according to CreamScan Research Evaluation Standards. Therefore, these ingredients do not contribute to the anti-wrinkle rating.
 
Moisturizers, when used regularly, are proven to prevent wrinkle formation and even reduce existing wrinkles. Therefore, this product, like any other moisturizer, can deliver some anti-wrinkle effects through its moisturizing action.
 

Please refer to the Ratings section below for details of the anti-wrinkle rating calculation.

Rich in skin-protecting antioxidants

We estimate that Isntree C-Niacin Toning Ampoule is rich (> 3%) in antioxidants, specifically Niacinamide (est. ≈1.3%), Aloe Barbadensis Leaf Extract (est. ≈0.3%), Melia Azadirachta Flower Extract (est. ≈0.3%), and others.

A key benefit of antioxidants is their ability to reduce oxidative stress caused by free radicals and therefore prevent accelerated skin aging. Studies also show that antioxidants can protect against environmental damage such as UV radiation and pollution, and help reduce inflammation and skin redness.

Ingredients

Est. % Ingredient Origin Functions
75
6
4
3
2
1.5
1.3
1
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Est. %
Hippophae Rhamnoides Fruit Extract
Function:
Origin:
Butylene Glycol
Function:
Origin:
Pentylene Glycol
Function:
Origin:
Glycerin
Function:
Origin:
Betaine
Function:
Origin:
Water
Function:
Origin:
Niacinamide
Function:
Origin:
Propanediol
Function:
Origin:
Aloe Barbadensis Leaf Extract
Function:
Origin:
Melia Azadirachta Flower Extract
Function:
Origin:
Melia Azadirachta Leaf Extract
Function:
Origin:
Cucurbita Pepo (Pumpkin) Fruit Extract
Function:
Origin:
Physalis Alkekengi Fruit Extract
Function:
Origin:
Sodium Hyaluronate
Function:
Origin:
Dipotassium Glycyrrhizate
Function:
Origin:
Ocimum Sanctum Leaf Extract
Function:
Origin:
Beta-Glucan
Function:
Origin:
Curcuma Longa (Turmeric) Root Extract
Function:
Origin:
Corallina Officinalis Extract
Function:
Origin:
Brassica Oleracea Italica (Broccoli) Extract
Function:
Origin:
Coccinia Indica Fruit Extract
Function:
Origin:
Moringa Oleifera Seed Oil
Function:
Origin:
Boswellia Serrata Resin Extract
Function:
Origin:
Bioflavonoids
Function:
Origin:
Panthenol
Function:
Origin:
Allantoin
Function:
Origin:
Sodium Polyacrylate
Function:
Origin:
Ammonium Acryloyldimethyltaurate/VP Copolymer
Function:
Origin:
3-O-Ethyl Ascorbic Acid
Function:
Origin:
Ethyl Hexanediol
Function:
Origin:
Polysorbate 80
Function:
Origin:
1,2-Hexanediol
Function:
Origin:

Ratings

All humectants
19.1
6
4
3
2
1.3
1
0.3
0.3
0.3
0.3
0.3
0.3
Benchmark
10
All occlusives
0.3
0.3
Benchmark
20
Moisturizing rating
5.1
Ingredient Est. % Benchmark Raiting
Humectancy All humectants 19.1 10
10.0
6
4
3
2
1.3
1
0.3
0.3
0.3
0.3
0.3
0.3
Occlusivity All occlusives 0.3 20
0.2
0.3
Moisturizing rating
5.1
Ingredient Est. % Benchmark Humectancy
6
4
3
2
1.3
1
0.3
0.3
0.3
0.3
0.3
0.3
All humectants 19.1 10
10
All humectants
19.1
6
4
3
2
1.3
1
0.3
0.3
0.3
0.3
0.3
0.3
Benchmark
10
Ingredient Est. % Benchmark Occlusivity
0.3
All occlusives 0.3 20
0.2
All occlusives
0.3
0.3
Benchmark
20
Ingredient
Ingredient anti-wrinkle power
when present at, %
in this formula est. %
Rating
6 /10 4 1.3 2
n/a
- 0.3 -
n/a
- 0.3 -
n/a
- 0.3 -
Total
2
Niacinamide
2
Ingredient anti-wrinkle power
6 /10
when present at, %
4
in this formula, est. %
1.3
Melia Azadirachta Leaf Extract
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Beta-Glucan
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
3-O-Ethyl Ascorbic Acid
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Anti-wrinkle rating
2
Ingredient Est. % Benchmark
Rich in Antioxidants
1.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
All antioxidants 5.2 3 Rich in antioxidants
All antioxidants
5.2
Niacinamide
1.3
Aloe Barbadensis Leaf Extract
0.3
Melia Azadirachta Flower Extract
0.3
Melia Azadirachta Leaf Extract
0.3
Sodium Hyaluronate
0.3
Ocimum Sanctum Leaf Extract
0.3
Beta-Glucan
0.3
Curcuma Longa (Turmeric) Root Extract
0.3
Corallina Officinalis Extract
0.3
Brassica Oleracea Italica (Broccoli) Extract
0.3
Coccinia Indica Fruit Extract
0.3
Moringa Oleifera Seed Oil
0.3
Bioflavonoids
0.3
3-O-Ethyl Ascorbic Acid
0.3
Benchmark
3
Ingredient Est. % Benchmark
Rich in Soothing
1.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
All soothing 4.6 5 No
All soothing
4.6
1.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Benchmark
5

Ingredients explained

Hippophae Rhamnoides Fruit Extract
Est. %75
Function
Origin
Hippophae Rhamnoides Fruit Extract
Butylene Glycol
Est. %6
Function
Origin
Butylene Glycol

A clear, colorless liquid humectant that draws moisture to the skin. The humectancy of butylene glycol, owed to its two hydroxyl groups, is quite considerable, although not as powerful as glycerin, which contains three hydroxyl groups.

Pentylene Glycol
Est. %4
Function
Origin
Pentylene Glycol

A naturally or synthetically derived preservative that exhibits effective antifungal and antibacterial traits. It also acts as a booster for more traditional preservatives. Pentylene glycol can also serve as a moisturizing humectant and solvent.

Glycerin
Est. %3
Function
Origin
Glycerin

The most popular moisturizing ingredient in the world. It is a powerful humectant – cheap yet very effective.

Betaine
Est. %2
Function
Origin
BetaineAn ingredient derived from the sucrose in sugar beets. It has a negative chemical charge and a positive chemical charge on the same molecule. This allows betaine to be hygroscopic or humectant and thus provide moisturization by drawing water to the skin.
Water
Est. %1.5
Function
Origin
WaterThe most used ingredient in skincare. Its concentration defines the product texture: rich creams may have about 50% of water while a light jelly about 90%. Water doesn’t moisturize the skin by itself and is used in skincare as a solvent for other ingredients.
Niacinamide
Est. %1.3
Function
Origin
Niacinamide

Also known as vitamin B3, this ingredient is a true superstar with confirmed moisturizing, anti-acne, hyperpigmentation, and antioxidant benefits. Two studies confirm its significant anti-wrinkle efficacy.

Propanediol
Est. %1
Function
Origin
PropanediolAn excellent solvent capable of mixing water with normally water-insoluble ingredients. It also functions as a humectant due to its water-loving alcohol groups. Propanediol can control the viscosity of a product by reducing its thickness.
Aloe Barbadensis Leaf Extract
Est. %0.3
Function
Origin
Aloe Barbadensis Leaf ExtractDerived from Aloe vera leaves, this moisturizing humectant, soothing, and antioxidant extract is commonly used in products targeting eczema, sunburn, or dermatitis. It soothes the skin and reduces the signs of inflammation and sensitivity.
Melia Azadirachta Flower Extract
Est. %0.3
Function
Origin
Melia Azadirachta Flower ExtractAn antioxidant extract derived from the flowers of the Indian lilac, also known as Neem. It is often used in traditional medicine in India. The Neem flower extracts contain limonoids, which are currently under research for their anti-pigment activity.
Melia Azadirachta Leaf Extract
Est. %0.3
Function
Origin
Melia Azadirachta Leaf ExtractAn antimicrobial and antioxidant extract derived from Neem leaves – an Indian traditional medicine. Neem leaves have been found to possess antibacterial and antifungal activity. It is also a prospective anti-wrinkle ingredient.
Cucurbita Pepo (Pumpkin) Fruit Extract
Est. %0.3
Function
Origin
Cucurbita Pepo (Pumpkin) Fruit Extract
Physalis Alkekengi Fruit Extract
Est. %0.3
Function
Origin
Physalis Alkekengi Fruit Extract
Sodium Hyaluronate
Est. %0.3
Function
Origin
Sodium Hyaluronate

A sodium salt of famous hyaluronic acid. A potent humectant that hydrates the skin, supports collagen function, and fills out small wrinkles. Sodium hyaluronate also offers soothing and antioxidant properties.

Dipotassium Glycyrrhizate
Est. %0.3
Function
Origin
Dipotassium GlycyrrhizateA licorice root derivative with powerful anti-inflammatory and soothing activities. It is often used as a flavoring agent in lip products.
Ocimum Sanctum Leaf Extract
Est. %0.3
Function
Origin
Ocimum Sanctum Leaf ExtractAn extract derived from the leaves of Holy Basil, also known as Tulsi, a traditional herb used in Ayurveda medicine. It contains antioxidant and anti-inflammatory rosmarinic acid, galic acid, flavonoids, and a sweet-scented essential oil.
Beta-Glucan
Est. %0.3
Function
Origin
Beta-GlucanA special polysaccharide obtained from cereals, mushrooms, yeast, bacteria, and some species of seaweed. It is a promising anti-wrinkle, wound healing, antioxidant, and moisturizing ingredient.
Curcuma Longa (Turmeric) Root Extract
Est. %0.3
Function
Origin
Curcuma Longa (Turmeric) Root ExtractAn extract derived from the thick roots of curcuma (turmeric), a famous yellow spice and a major ingredient in curry powder. It is used in skincare for its proven antioxidant and anti-inflammatory properties.
Corallina Officinalis Extract
Est. %0.3
Function
Origin
Corallina Officinalis ExtractAn extract from red marine alga, Corallina officinalis is used in skincare for its antioxidant properties. It also contains an immense amount of calcium and special, sulfur-containing polysaccharides.
Brassica Oleracea Italica (Broccoli) Extract
Est. %0.3
Function
Origin
Brassica Oleracea Italica (Broccoli) ExtractAn extract obtained from broccoli that contains antimicrobial sulfur compounds and various antioxidant vitamins, flavonoids, and phenolic acids.
Coccinia Indica Fruit Extract
Est. %0.3
Function
Origin
Coccinia Indica Fruit ExtractAn extract derived from the cucumber-like fruits of ivy gourd. It contains a large amount of soothing mucilage as well as some antioxidant carotenoids. It has also been shown that the extract may have some anti-allergy properties.
Moringa Oleifera Seed Oil
Est. %0.3
Function
Origin
Moringa Oleifera Seed OilAn oil obtained from the seeds of Moringa oleifera, a fast-growing bush native to Northern India and the sub-Himalayan regions. It contains mainly oleic acid, as well as many additional anti-inflammatory compounds and high levels of vitamin E.
Boswellia Serrata Resin Extract
Est. %0.3
Function
Origin
Boswellia Serrata Resin Extract
Bioflavonoids
Est. %0.3
Function
Origin
BioflavonoidsA mixture of plant-based compounds commonly referred to as flavonoids. Each flavonoid has slightly different properties, but overall they are potent antioxidant and anti-inflammatory compounds.
Panthenol
Est. %0.3
Function
Origin
PanthenolA popular soothing and moisturizing derivative of vitamin B5. Panthenol is particularly beneficial for dry, flaking, burned, or damaged skin. It is used to alleviate the symptoms of a rash, dermatitis, eczema, chapped lips, and sunburn.
Allantoin
Est. %0.3
Function
Origin
AllantoinA fluffy, white powder that acts as a humectant due to its water-loving chemistry and as an exfoliant that helps to remove dead skin cells. It has also been shown to be very soothing to irritated and inflamed skin.
Sodium Polyacrylate
Est. %0.3
Function
Origin
Sodium PolyacrylateThis white powder is primarily used as a viscosity controlling agent. It is added to the water phase, which then thickens to form a clear gel. Sodium polyacrylate can also serve as an emollient, absorbent, and emulsion stabilizer.
Ammonium Acryloyldimethyltaurate/VP Copolymer
Est. %0.3
Function
Origin
Ammonium Acryloyldimethyltaurate/VP CopolymerA polymeric ingredient that creates lightweight and refreshing gel textures. It also works as a viscosity controlling agent.
3-O-Ethyl Ascorbic Acid
Est. %0.3
Function
Origin
3-O-Ethyl Ascorbic AcidA derivative of vitamin C. Its stability in skincare formulations is better than ascorbic acid’s, although clinical studies are yet to indicate whether it has the same collagen-boosting benefits.
Ethyl Hexanediol
Est. %0.3
Function
Origin
Ethyl HexanediolA synthetic solvent used to dissolve difficult ingredients. It also has a pleasant scent and could be used to contribute to product fragrance.
Polysorbate 80
Est. %0.3
Function
Origin
Polysorbate 80A non-ionic surfactant, which means that it contains no chemical charges. It can be used as a mild cleansing agent in skin cleansing products but is more commonly used for its emulsifying abilities.
1,2-Hexanediol
Est. %0.3
Function
Origin
1,2-HexanediolA multi-functional formula helper. It is a well-studied preservtive against bacteria and can help pigments and fragrances disperse evenly in a formula.