Hylamide SubQ Skin Review

Hylamide SubQ Skin
5.0
/ 10
Moisturizing
10.0 Humectancy icon Humectancy
0.0 Occlusivity icon Occlusivity
Review

Does Hylamide SubQ Skin Work?

 
According to CreamScan AI's analysis of the ingredient list, here’s what Hylamide SubQ Skin has to offer:
 
  • Strong humectant moisturizing. This lightweight, humectant-rich product, ideal for oily skin, has a moisturizing rating of 5.0 out of 10.

Key Benefits of Hylamide SubQ Skin

 
These are the key benefits you can expect from using Hylamide SubQ Skin:
 

Lightweight Purely Humectant Moisturizing, Ideal for Oily Skin

According to CreamScan analysis, Hylamide SubQ Skin is quite moisturizing, with a moisturizing rating of 5.0 out of 10.

Is it more humectant or occlusive? It is purely humectant. It has zero occlusivity (we didn't find any occlusive ingredients on the ingredient list) and a maximum humectancy of 10 out of 10, primarily due to the high content of Glycerin (est. ≈6.0%), Pentylene Glycol (est. ≈3.0%) and Tamarindus Indica Seed Gum (est. ≈2.0%).

This humectant-rich product, when used alone as a moisturizer, is ideal for oily skin, providing significant hydration in a lightweight, fast-absorbing formula without any occlusive ingredients.

Tip: Certain studies suggest that humectants alone may not effectively moisturize the skin. If you use this product as your only moisturizer, we recommend following it with one that contains at least some occlusive ingredients.

A Humectant Boost for Any Skincare Routine

But it’s not limited to oily skin - such a humectant boost will also positively contribute to the moisturizing efficacy of any skincare routine when used as a step before applying the main moisturizer. This type of formulation is typically used in serums, where a light, fast-absorbing texture is key.

Please refer to the Ratings section below for details of the moisturizing rating calculation.

Please note that this is not a complete list of benefits. We are in the process of enhancing our AI model to incorporate anti-pigmentation, exfoliation and anti-acne ratings.

Things to Be Aware Of: Hylamide SubQ Skin

 
CreamScan AI identified a few things to consider before adding Hylamide SubQ Skin to your skincare routine:
 

If It’s Your Only Moisturizer, It Needs to Be Paired with Some Occlusives

While humectants are highly effective at attracting water to the skin, studies (J. N. Kraft, C. W. Lynde) suggest they may not be efficient when used alone.

One major drawback of purely humectant moisturization is that the water attracted by humectants to the upper layers of the skin can evaporate completely into the environment through transepidermal water loss (TEWL). Adding occlusive ingredients helps seal this moisture into the skin and prevent further water loss.

If you’re using Hylamide SubQ Skin as your only moisturizer, consider pairing it with one that contains at least some occlusive ingredients, such as oils, butters, or silicones. These work alongside humectants to create a protective barrier, locking in hydration and ensuring longer-lasting moisturization. The amount of occlusive needed depends on your skin type - the drier the skin, the more occlusives it requires.

If this product is used not as a standalone moisturizer but as part of your skincare routine, such as a toner or serum, it should be applied before your main moisturizer (unless it's a sunscreen), which will provide the necessary occlusivity on top of it.

Questionable anti-wrinkle efficacy

If one of your main reasons for choosing Hylamide SubQ Skin is its potential anti-aging effects, please note that, according to CreamScan analysis, it currently has a zero anti-wrinkle rating.

It contains some ingredients often marketed as effective in reducing wrinkles, specifically Palmitoyl Tripeptide-38, Copper Lysinate/Prolinate, and Pseudoalteromonas Ferment Extract. However, the studies supporting the anti-wrinkle claims of these ingredients provide insufficient evidence of efficacy according to CreamScan Research Evaluation Standards. 

While this does not categorically exclude the possibility that these ingredients may reduce wrinkles, their efficacy is not supported by convincing, vehicle-controlled, double-blind clinical studies - at least none that were accessible to the CreamScan team at the time of publication.

Therefore, these ingredients do not generate the anti-wrinkle rating.

Moisturizers, when used regularly, are proven to prevent wrinkle formation and even reduce existing wrinkles. Therefore, this product, like any other moisturizer, can deliver some anti-wrinkle effects through its moisturizing action.

Please refer to the Ratings section below for details of the anti-wrinkle rating calculation.

Pros & Cons of Hylamide SubQ Skin

 
Here’s an overview of the pros and cons of Hylamide SubQ Skin to help you decide if it’s the right choice for your skincare routine:
 

Pros:

  • Humectant-rich moisturizing ideal for oily skin
  • Lightweight texture
  • A humectant moisturizing boost for any skincare routine

Cons: 

  • Needs occlusives to seal in humectants if used as a standalone moisturizer
  • Questionable anti-wrinkle efficacy

Ingredients

Est. % Ingredient Origin Functions
75
6
4
3
2
1.5
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Est. %
Water
Function:
Origin:
Glycerin
Function:
Origin:
Hydrolyzed Yeast Extract
Function:
Origin:
Pentylene Glycol
Function:
Origin:
Tamarindus Indica Seed Gum
Function:
Origin:
Sodium Hyaluronate Crosspolymer
Function:
Origin:
Palmitoyl Tripeptide-38
Function:
Origin:
Myristoyl Nonapeptide-3
Function:
Origin:
Copper Lysinate/Prolinate
Function:
Origin:
Methylglucoside Phosphate
Function:
Origin:
Hydrolyzed Sodium Hyaluronate
Function:
Origin:
Sodium Hyaluronate
Function:
Origin:
Ahnfeltiopsis Concinna Extract
Function:
Origin:
Saccharide Isomerate
Function:
Origin:
Polyglucuronic Acid
Function:
Origin:
Lactobacillus/Eriodictyon Californicum Ferment Extract
Function:
Origin:
Pseudoalteromonas Ferment Extract
Function:
Origin:
Phospholipids
Function:
Origin:
Lecithin
Function:
Origin:
Hydroxypropyl Cyclodextrin
Function:
Origin:
Cetyl Hydroxyethylcellulose
Function:
Origin:
Polyacrylate Crosspolymer-6
Function:
Origin:
Hexylene Glycol
Function:
Origin:
Salicylic Acid
Function:
Origin:
Citric Acid
Function:
Origin:
Sodium Citrate
Function:
Origin:
Sodium Hydroxide
Function:
Origin:
Trisodium Ethylenediamine Disuccinate
Function:
Origin:
Ethoxydiglycol
Function:
Origin:
Leuconostoc/Radish Root Ferment Filtrate
Function:
Origin:
Sodium Benzoate
Function:
Origin:
Potassium Sorbate
Function:
Origin:
Ethylhexylglycerin
Function:
Origin:
Caprylyl Glycol
Function:
Origin:
Phenoxyethanol
Function:
Origin:
Chlorphenesin
Function:
Origin:

Ratings

All humectants
15.2
6
3
2
1.5
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Benchmark
10
All occlusives
0.0
None
Benchmark
20
Moisturizing rating
5.0
Ingredient Est. % Benchmark Raiting
Humectancy All humectants 15.2 10
10.0
6
3
2
1.5
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Occlusivity All occlusives 0.0 20
0.0
None
Moisturizing rating
5.0
Ingredient Est. % Benchmark Humectancy
6
3
2
1.5
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
All humectants 15.2 10
10
All humectants
15.2
6
3
2
1.5
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Benchmark
10
Ingredient Est. % Benchmark Occlusivity
None
All occlusives 0.0 20
0.0
All occlusives
0.0
None
Benchmark
20
Ingredient
Ingredient anti-wrinkle power
when present at, %
in this formula est. %
Rating
n/a
- 0.3 -
n/a
- 0.3 -
n/a
- 0.3 -
Total
0
Palmitoyl Tripeptide-38
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Copper Lysinate/Prolinate
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Pseudoalteromonas Ferment Extract
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Anti-wrinkle rating
0
Ingredient Est. % Benchmark
Rich in Antioxidants
0.3
0.3
All antioxidants 0.6 3 No
All antioxidants
0.6
Hydrolyzed Sodium Hyaluronate
0.3
Sodium Hyaluronate
0.3
Benchmark
3
Ingredient Est. % Benchmark
Rich in Soothing
0.3
0.3
All soothing 0.6 5 No
All soothing
0.6
0.3
0.3
Benchmark
5

Ingredients explained

Water
Est. %75
Function
Origin
WaterThe most used ingredient in skincare. Its concentration defines the product texture: rich creams may have about 50% of water while a light jelly about 90%. Water doesn’t moisturize the skin by itself and is used in skincare as a solvent for other ingredients.
Glycerin
Est. %6
Function
Origin
Glycerin

The most popular moisturizing ingredient in the world. It is a powerful humectant – cheap yet very effective.

Hydrolyzed Yeast Extract
Est. %4
Function
Origin
Hydrolyzed Yeast Extract
Pentylene Glycol
Est. %3
Function
Origin
Pentylene Glycol

A naturally or synthetically derived preservative that exhibits effective antifungal and antibacterial traits. It also acts as a booster for more traditional preservatives. Pentylene glycol can also serve as a moisturizing humectant and solvent.

Tamarindus Indica Seed Gum
Est. %2
Function
Origin
Tamarindus Indica Seed Gum
Sodium Hyaluronate Crosspolymer
Est. %1.5
Function
Origin
Sodium Hyaluronate CrosspolymerA modified version of regular hyaluronic acid. It attracts large volumes of water, thereby making it an effective humectant moisturizing ingredient.
Palmitoyl Tripeptide-38
Est. %0.3
Function
Origin
Palmitoyl Tripeptide-38

A small synthetic peptide that increases the production of collagen, fibronectin, and hyaluronic acid in the skin. It has also been shown to reduce wrinkles in combination with other anti-aging ingredients.

Myristoyl Nonapeptide-3
Est. %0.3
Function
Origin
Myristoyl Nonapeptide-3

Description is coming soon

Copper Lysinate/Prolinate
Est. %0.3
Function
Origin
Copper Lysinate/ProlinateA complex of copper and two amino acids. It may stimulate the production of collagen in the skin because of the supply of copper, thus resulting in anti-wrinkle effects. This, however, has not been confirmed by studies.
Methylglucoside Phosphate
Est. %0.3
Function
Origin
Methylglucoside PhosphateA derivative of glucose. It is allegedly an activated form of glucose that may be able to serve as an energy source to the skin, although this claim has not been supported by any research.
Hydrolyzed Sodium Hyaluronate
Est. %0.3
Function
Origin
Hydrolyzed Sodium HyaluronateA very small-molecule version of regular sodium hyaluronate. It is a powerful humectant skin-identical ingredient that absorbs into the skin and offers plumping, smoothing, and anti-wrinkle effects.
Sodium Hyaluronate
Est. %0.3
Function
Origin
Sodium Hyaluronate

A sodium salt of famous hyaluronic acid. A potent humectant that hydrates the skin, supports collagen function, and fills out small wrinkles. Sodium hyaluronate also offers soothing and antioxidant properties.

Ahnfeltiopsis Concinna Extract
Est. %0.3
Function
Origin
Ahnfeltiopsis Concinna Extract
Saccharide Isomerate
Est. %0.3
Function
Origin
Saccharide IsomerateA naturally-derived humectant that provides moisturization at low levels and is less sticky than other humectants like glycerin.
Polyglucuronic Acid
Est. %0.3
Function
Origin
Polyglucuronic Acid
Lactobacillus/Eriodictyon Californicum Ferment Extract
Est. %0.3
Function
Origin
Lactobacillus/Eriodictyon Californicum Ferment Extract
Pseudoalteromonas Ferment Extract
Est. %0.3
Function
Origin
Pseudoalteromonas Ferment ExtractAn ingredient obtained from a bacterial culture. According to the patent holder, it produces a special glycoprotein that promotes collagen and elastin synthesis and moisturizes the skin by drawing water to it.
Phospholipids
Est. %0.3
Function
Origin
PhospholipidsA large group of lipids that are an essential component of every single cell membrane in the body. They have excellent emollient properties. Phospholipids are also utilized in the manufacturing of ‘fancy’ formulations such as liposomes.
Lecithin
Est. %0.3
Function
Origin
LecithinA humectant, emollient, and emulsifier best suited for water-in-oil emulsions. Lecithin can come from sunflowers, soy, and eggs. The downside to lecithin is that it causes an extra burden on the formula’s preservative because it is nutritious.
Hydroxypropyl Cyclodextrin
Est. %0.3
Function
Origin
Hydroxypropyl CyclodextrinA white crystalline powder that can reduce odors coming from other ingredients in a product.
Cetyl Hydroxyethylcellulose
Est. %0.3
Function
Origin
Cetyl HydroxyethylcelluloseA naturally-derived polymer that helps products feel buttery and bouncy and can reduce stringiness in a formula.
Polyacrylate Crosspolymer-6
Est. %0.3
Function
Origin
Polyacrylate Crosspolymer-6A polymeric ingredient that works best in water-based formulas to create gel textures. It helps to stabilize emulsions and control viscosity.
Hexylene Glycol
Est. %0.3
Function
Origin
Hexylene GlycolA multifunctional ingredient that is best known for its use as a solvent. It can dissolve both water-based ingredients and oils. For this reason, it can also function as an emulsifier, allowing oil and water ingredients to mix and remain stable.
Salicylic Acid
Est. %0.3
Function
Origin
Salicylic AcidThis effective peeling and anti-inflammatory BHA is used as an anti-acne agent and works by breaking down the junctions between dead skin cells. This results in the peeling of dead skin and the unclogging of pores.
Citric Acid
Est. %0.3
Function
Origin
Citric AcidA gently exfoliating AHA that helps to remove the top layer of dead skin cells. In comparison to other AHAs, citric acid has been shown to be one of the least effective. It is also very commonly used as a stabilizing and pH-controlling agent.
Sodium Citrate
Est. %0.3
Function
Origin
Sodium CitrateA salt of citric acid that has a salty and tart flavor and is used as a fragrance. It is mildly basic, meaning that its addition to a skincare product can adjust the pH upward.
Sodium Hydroxide
Est. %0.3
Function
Origin
Sodium Hydroxide

An ingredient that is able to bring the pH of a product up, thereby making it less harsh on the skin.

Trisodium Ethylenediamine Disuccinate
Est. %0.3
Function
Origin
Trisodium Ethylenediamine DisuccinateA chelating agent that disables harmful heavy metal ions present in skincare.
Ethoxydiglycol
Est. %0.3
Function
Origin
EthoxydiglycolA type of alcohol with humectant moisturizing properties. It also acts as a solvent, since it mixes well with a variety of other compounds, including water and even some oils.
Leuconostoc/Radish Root Ferment Filtrate
Est. %0.3
Function
Origin
Leuconostoc/Radish Root Ferment FiltrateA biotechnological fermentation ingredient that is created by feeding radish root to Leuconostoc kimchii. It allegedly contains organic acids and a mixture of peptides known as bacteriocins – which have antimicrobial activity.
Sodium Benzoate
Est. %0.3
Function
Origin
Sodium BenzoateA preservative that usually works in combination with other preservatives. It has to be at low pH (<5.5) to be effective.
Potassium Sorbate
Est. %0.3
Function
Origin
Potassium SorbateA preservative widely used in food and personal care products, available from natural sources or synthetically produced. Potassium sorbate works by inhibiting the growth of yeasts, molds, and some bacteria.
Ethylhexylglycerin
Est. %0.3
Function
Origin
EthylhexylglycerinA preservative booster derived from glycerin. It is commonly paired with other preservatives to improve their efficacy. Ethylhexylglycerin is also a humectant due to its chemical base of glycerin.
Caprylyl Glycol
Est. %0.3
Function
Origin
Caprylyl GlycolAn emollient that improves product spreadability and offers a silky feel on the skin. It also acts as a preservative booster that improves the efficacy of other preservatives. According to the manufacturer, it is also a humectant moisturizer.
Phenoxyethanol
Est. %0.3
Function
Origin
PhenoxyethanolThe most frequently used preservative in skincare. It is a clear, oil-like liquid synthetic substance that protects products from harmful bacteria and yeast, whilst still leaving skin microflora unharmed. It is confirmed by research to be harmless.
Chlorphenesin
Est. %0.3
Function
Origin
ChlorphenesinA preservative and broad-spectrum antimicrobial agent that protects products from a wide range of bacteria and fungi.