DefenAge 8 in 1 Bioserum Review

DefenAge 8 in 1 Bioserum
4.9
/ 10
Moisturizing
8.8 Humectancy icon Humectancy
0.9 Occlusivity icon Occlusivity
4.5Anti-wrinkle icon/ 10
Anti-wrinkle
Rich
in Antioxidants
Review

Does DefenAge 8 in 1 Bioserum Work?

 
According to CreamScan AI's analysis of the ingredient list, here’s what DefenAge 8 in 1 Bioserum has to offer:
 
Moderate moisturizing. It has a moisturizing rating of 4.9 out of 10.
✅ Considerable anti-wrinkle efficacy: DefenAge 8 in 1 Bioserum has an anti-wrinkle rating of 4.5 out of 10, indicating a moderate ability to reduce wrinkles.
✅ Antioxidant protection

  

Key Benefits of DefenAge 8 in 1 Bioserum

 
These are the key benefits you can expect from using DefenAge 8 in 1 Bioserum:
 

🔵 Lightweight Humectant Moisturizer Ideal for Oily Skin

According to CreamScan analysis, DefenAge 8 in 1 Bioserum is quite moisturizing, with a moisturizing rating of 4.9 out of 10.

Is it more humectant or occlusive? Significantly more humectant. It has a low occlusivity of 0.9 out of 10 and a very high humectancy of 8.8 out of 10, primarily due to the high content of Glycerin (est. ≈4.0%) and Niacinamide (est. ≈3.0%).

This humectant-rich product, when used alone as a moisturizer, is ideal for oily skin, offering significant hydration in a lightweight, fast-absorbing formula with a minimal amount of occlusive ingredients.

It’s also a great choice for people with normal skin who prefer lightweight moisturizers.

💧 A Humectant Boost for Any Skincare Routine

But it’s not limited to oily skin - such a humectant boost will also positively contribute to the moisturizing efficacy of any skincare routine when used as a step before applying the main moisturizer. This type of formulation is typically used in serums, where a light, fast-absorbing texture is key.

Please refer to the Ratings section below for details of the moisturizing rating calculation.

🟣🟣 Considerable Anti-Wrinkle Efficacy

According to CreamScan analysis, DefenAge 8 in 1 Bioserum has a moderate anti-wrinkle rating of 4.5 out of 10.

It contains one ingredient with proven anti-wrinkle efficacy: Niacinamide (est. ≈3.0%),
 one of the most effective and well-researched anti-wrinkle ingredients. A clinical study involving 30 participants (Kawada et al.) confirmed that a cream with 4% niacinamide reduced the average depth of wrinkles around the eyes by 9% after 8 weeks of use, compared to a vehicle (the same formulation without niacinamide).
 
Among others, DefenAge 8 in 1 Bioserum also contains contains Palmitoyl Tripeptide-38 and Ubiquinone, two ingredients often marketed as effective in reducing wrinkles. However, the studies supporting the anti-wrinkle claims of these ingredients provide insufficient evidence of efficacy according to CreamScan Research Evaluation Standards.
 
While this does not categorically rule out the possibility that these ingredients may reduce wrinkles, their efficacy is not supported by convincing, vehicle-controlled, double-blind clinical studies - at least none that were available to the CreamScan team at the time of publication.
 
Therefore, these ingredients do not contribute to the anti-wrinkle rating.
 
📌 Moisturizers, when used regularly, are proven to prevent wrinkle formation and even reduce existing wrinkles. Therefore, this product, like any other moisturizer, can deliver some additional anti-wrinkle effects through its moisturizing action.
 

Please refer to the Ratings section below for details of the anti-wrinkle rating calculation.

🍀 Rich in Skin-Protecting Antioxidants

We estimate that DefenAge 8 in 1 Bioserum is rich (> 3%) in antioxidants, specifically Niacinamide (est. ≈3.0%).

A key benefit of antioxidants is their ability to reduce oxidative stress caused by free radicals and therefore prevent accelerated skin aging. Studies also show that antioxidants can protect against environmental damage such as UV radiation and pollution, and help reduce inflammation and skin redness.

📌 Please note that this is not a complete list of benefits. We are in the process of enhancing our AI model to incorporate anti-pigmentation, exfoliation and anti-acne ratings.

Pros & Cons of DefenAge 8 in 1 Bioserum

 
Here’s an overview of the pros and cons of DefenAge 8 in 1 Bioserum to help you decide if it’s the right choice for your skincare routine:
 

🟩 Pros:

✅ When used alone: Provides humectant-rich moisturizing ideal for oily skin
✅ As part of a routine: A humectant moisturizing boost, beneficial for any skin type
✅ Lightweight texture
Provides considerable anti-wrinkle efficacy thanks to Niacinamide
✅ Rich in antioxidants that combat oxidative stress associated with accelerated skin aging and defend against environmental damage
 

⭕ Cons: 

✅ We couldn't find any
   

Summary: DefenAge 8 in 1 Bioserum

 
Based on the ingredient list analysis, CreamScan AI suggests that DefenAge 8 in 1 Bioserum
, when used alone, delivers lightweight, humectant-rich moisturizing, making it ideal for oily skin. As part of a moisturizing routine, it provides a humectant boost, beneficial for all skin types.
 
DefenAge 8 in 1 Bioserum contains ingredients with solid, robust evidence of anti-wrinkle efficacy, in concentrations that may deliver a noticeable anti-wrinkle effect.
 
With its high antioxidant content, DefenAge 8 in 1 Bioserum helps protect against free radical damage and offers multiple benefits for all skin types, including preventing premature aging, defending against environmental damage, and calming inflammation.
 
📌 Fact check. At CreamScan, we are committed to accuracy and fairness. If you spot any errors or something that doesn’t seem right, please click here to let us know. We regularly update the ingredient lists and monitor the latest research on ingredient efficacy to ensure that our information remains as complete and precise as possible. The information provided here is for informational purposes only and does not substitute professional advice. We do not guarantee the efficacy or safety of any product, as individual results may vary.

 

Ingredients

Est. % Ingredient Origin Functions
75
6
4
3
2
1.5
1.3
1
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Est. %
Water
Function:
Origin:
Cyclopentasiloxane
Function:
Origin:
Glycerin
Function:
Origin:
Niacinamide
Function:
Origin:
Sinorhizobium Meliloti Ferment Filtrate
Function:
Origin:
Dimethicone
Function:
Origin:
Polysorbate 20
Function:
Origin:
Dimethicone/Vinyl Dimethicone Crosspolymer
Function:
Origin:
Lauryl PEG-9 Polydimethylsiloxyethyl Dimethicone
Function:
Origin:
Ammonium Acryloyldimethyltaurate Crosspolymer
Function:
Origin:
Phospholipids
Function:
Origin:
Alpha-Arbutin
Function:
Origin:
Palmitoyl Tripeptide-38
Function:
Origin:
Sodium Hyaluronate
Function:
Origin:
Arabidopsis Thaliana Extract
Function:
Origin:
Sea Silt Extract
Function:
Origin:
Ergothioneine
Function:
Origin:
Helianthus Annuus (Sunflower) Seed Oil
Function:
Origin:
Rosmarinus Officinalis (Rosemary) Leaf Extract
Function:
Origin:
Tocopheryl Acetate
Function:
Origin:
Ubiquinone
Function:
Origin:
Leuconostoc Ferment Filtrate
Function:
Origin:
Serum Albumin
Function:
Origin:
Alanyl Glutamine
Function:
Origin:
Caprylic Acid
Function:
Origin:
Hydroxypropyl Methylcellulose
Function:
Origin:
Lecithin
Function:
Origin:
Hydroxypropyl Cyclodextrin
Function:
Origin:
Phytic Acid
Function:
Origin:
Phenoxyethanol
Function:
Origin:
Caprylyl Glycol
Function:
Origin:
Ethylhexylglycerin
Function:
Origin:
Hexylene Glycol
Function:
Origin:
Sodium Chloride
Function:
Origin:

Ratings

All humectants
8.8
4
3
0.3
0.3
0.3
0.3
0.3
0.3
Benchmark
10
All occlusives
1.8
1.5
0.3
Benchmark
20
Moisturizing rating
4.9
Ingredient Est. % Benchmark Raiting
Humectancy All humectants 8.8 10
8.8
4
3
0.3
0.3
0.3
0.3
0.3
0.3
Occlusivity All occlusives 1.8 20
0.9
1.5
0.3
Moisturizing rating
4.9
Ingredient Est. % Benchmark Humectancy
4
3
0.3
0.3
0.3
0.3
0.3
0.3
All humectants 8.8 10
8.8
All humectants
8.8
4
3
0.3
0.3
0.3
0.3
0.3
0.3
Benchmark
10
Ingredient Est. % Benchmark Occlusivity
1.5
0.3
All occlusives 1.8 20
0.9
All occlusives
1.8
1.5
0.3
Benchmark
20
Ingredient
Ingredient anti-wrinkle power
when present at, %
in this formula est. %
Rating
6 /10 4 3 4.5
n/a
- 0.3 -
n/a
- 0.3 -
Total
4.5
Niacinamide
4.5
Ingredient anti-wrinkle power
6 /10
when present at, %
4
in this formula, est. %
3
Palmitoyl Tripeptide-38
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Ubiquinone
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Anti-wrinkle rating
4.5
Ingredient Est. % Benchmark
Rich in Antioxidants
3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
All antioxidants 5.1 3 Rich in antioxidants
All antioxidants
5.1
Niacinamide
3
Alpha-Arbutin
0.3
Sodium Hyaluronate
0.3
Arabidopsis Thaliana Extract
0.3
Ergothioneine
0.3
Rosmarinus Officinalis (Rosemary) Leaf Extract
0.3
Tocopheryl Acetate
0.3
Ubiquinone
0.3
Benchmark
3
Ingredient Est. % Benchmark
Rich in Soothing
3
0.3
All soothing 3.3 5 No
All soothing
3.3
3
0.3
Benchmark
5

Ingredients explained

Water
Est. %75
Function
Origin
WaterThe most used ingredient in skincare. Its concentration defines the product texture: rich creams may have about 50% of water while a light jelly about 90%. Water doesn’t moisturize the skin by itself and is used in skincare as a solvent for other ingredients.
Cyclopentasiloxane
Est. %6
Function
Origin
CyclopentasiloxaneA lightweight, fast-spreading emollient that leaves a very soft and silky after-feel on the skin. Supplied as a clear and colorless liquid, cyclopentasiloxane is often used as a solvent to dissolve other silicones in.
Glycerin
Est. %4
Function
Origin
Glycerin

The most popular moisturizing ingredient in the world. It is a powerful humectant – cheap yet very effective.

Niacinamide
Est. %3
Function
Origin
Niacinamide

Also known as vitamin B3, this ingredient is a true superstar with confirmed moisturizing, anti-acne, hyperpigmentation, and antioxidant benefits. Two studies confirm its significant anti-wrinkle efficacy.

Sinorhizobium Meliloti Ferment Filtrate
Est. %2
Function
Origin
Sinorhizobium Meliloti Ferment Filtrate
Dimethicone
Est. %1.5
Function
Origin
DimethiconeThe most common silicone in skincare. It forms a silky, smooth film on the skin’s surface and can help to prevent water loss. It also aids in wound healing and can treat and soften scars. Dimethicone is considered to be very safe for use.
Polysorbate 20
Est. %1.3
Function
Origin
Polysorbate 20A viscous, amber-colored liquid that functions as a solubilizer to disperse small amounts of oil into a large water phase. Polysorbate 20 is frequently used to solubilize fragrance oils into water-based emulsions.
Dimethicone/Vinyl Dimethicone Crosspolymer
Est. %1
Function
Origin
Dimethicone/Vinyl Dimethicone CrosspolymerThis ingredient can refer to several kinds of dimethicone crosspolymers. Like other silicones, it makes products feel slippery and non-greasy but can also increase the thickness or improve the water-resistance of a formula.
Lauryl PEG-9 Polydimethylsiloxyethyl Dimethicone
Est. %0.3
Function
Origin
Lauryl PEG-9 Polydimethylsiloxyethyl DimethiconeA powerful emulsifier with the unique trait of being able to work in both oil- and silicone-based formulas. It can also function as a thickener in low concentrations.
Ammonium Acryloyldimethyltaurate Crosspolymer
Est. %0.3
Function
Origin
Ammonium Acryloyldimethyltaurate Crosspolymer
Phospholipids
Est. %0.3
Function
Origin
PhospholipidsA large group of lipids that are an essential component of every single cell membrane in the body. They have excellent emollient properties. Phospholipids are also utilized in the manufacturing of ‘fancy’ formulations such as liposomes.
Alpha-Arbutin
Est. %0.3
Function
Origin
Alpha-Arbutin
Palmitoyl Tripeptide-38
Est. %0.3
Function
Origin
Palmitoyl Tripeptide-38

A small synthetic peptide that increases the production of collagen, fibronectin, and hyaluronic acid in the skin. It has also been shown to reduce wrinkles in combination with other anti-aging ingredients.

Sodium Hyaluronate
Est. %0.3
Function
Origin
Sodium Hyaluronate

A sodium salt of famous hyaluronic acid. A potent humectant that hydrates the skin, supports collagen function, and fills out small wrinkles. Sodium hyaluronate also offers soothing and antioxidant properties.

Arabidopsis Thaliana Extract
Est. %0.3
Function
Origin
Arabidopsis Thaliana ExtractAn extract from a small, flowering plant called thale cress. It contains antioxidant flavonoids and organic acids and is claimed to be able to repair UV-induced DNA damage.
Sea Silt Extract
Est. %0.3
Function
Origin
Sea Silt Extract
Ergothioneine
Est. %0.3
Function
Origin
ErgothioneineA naturally-occurring amino acid that functions as a powerful and versatile antioxidant.
Helianthus Annuus (Sunflower) Seed Oil
Est. %0.3
Function
Origin
Helianthus Annuus (Sunflower) Seed OilA fatty oil expressed from sunflower seeds and one of the most commonly used oils in skincare. It has great emollient and occlusive moisturizing properties. Sunflower oil is one of the richest sources of vitamin E – an important skin antioxidant.
Rosmarinus Officinalis (Rosemary) Leaf Extract
Est. %0.3
Function
Origin
Rosmarinus Officinalis (Rosemary) Leaf ExtractA soothing and astringent extract derived from the fragrant, spicy leaves of rosemary. It has strong antioxidant properties. Rosemary extract can reduce signs of inflammation and also acts as an emollient and antimicrobial agent.
Tocopheryl Acetate
Est. %0.3
Function
Origin
Tocopheryl Acetate

An antioxidant derivative of tocopherol (vitamin E). It helps to protect cells from free radicals and UV damage through the conversion to active vitamin E in the skin. It is more stable than tocopherol.

Ubiquinone
Est. %0.3
Function
Origin
UbiquinoneAlso known as Coenzyme Q10, this bright orange antioxidant supports the skin's energy metabolism. It also offers some anti-pigment action. Dietary supplementation of Ubiquinone improves the appearance of wrinkles.
Leuconostoc Ferment Filtrate
Est. %0.3
Function
Origin
Leuconostoc Ferment Filtrate
Serum Albumin
Est. %0.3
Function
Origin
Serum Albumin
Alanyl Glutamine
Est. %0.3
Function
Origin
Alanyl Glutamine
Caprylic Acid
Est. %0.3
Function
Origin
Caprylic Acid
Hydroxypropyl Methylcellulose
Est. %0.3
Function
Origin
Hydroxypropyl MethylcelluloseA natural viscosity controlling agent that is commonly used in skin cleansing products to thicken the consistency. It also functions as an emulsion stabilizing agent and binding agent.
Lecithin
Est. %0.3
Function
Origin
LecithinA humectant, emollient, and emulsifier best suited for water-in-oil emulsions. Lecithin can come from sunflowers, soy, and eggs. The downside to lecithin is that it causes an extra burden on the formula’s preservative because it is nutritious.
Hydroxypropyl Cyclodextrin
Est. %0.3
Function
Origin
Hydroxypropyl CyclodextrinA white crystalline powder that can reduce odors coming from other ingredients in a product.
Phytic Acid
Est. %0.3
Function
Origin
Phytic AcidPhytic acid is found in rice and is seen as a cousin of alpha-hydroxy acids. As a chelator, it can bind to certain metals that may cause discoloration in products or reduce the efficacy of other ingredients.
Phenoxyethanol
Est. %0.3
Function
Origin
PhenoxyethanolThe most frequently used preservative in skincare. It is a clear, oil-like liquid synthetic substance that protects products from harmful bacteria and yeast, whilst still leaving skin microflora unharmed. It is confirmed by research to be harmless.
Caprylyl Glycol
Est. %0.3
Function
Origin
Caprylyl GlycolAn emollient that improves product spreadability and offers a silky feel on the skin. It also acts as a preservative booster that improves the efficacy of other preservatives. According to the manufacturer, it is also a humectant moisturizer.
Ethylhexylglycerin
Est. %0.3
Function
Origin
EthylhexylglycerinA preservative booster derived from glycerin. It is commonly paired with other preservatives to improve their efficacy. Ethylhexylglycerin is also a humectant due to its chemical base of glycerin.
Hexylene Glycol
Est. %0.3
Function
Origin
Hexylene GlycolA multifunctional ingredient that is best known for its use as a solvent. It can dissolve both water-based ingredients and oils. For this reason, it can also function as an emulsifier, allowing oil and water ingredients to mix and remain stable.
Sodium Chloride
Est. %0.3
Function
Origin
Sodium Chloride

You’re definitely familiar with sodium chloride, even if you don’t think you are. It’s table salt! Salt works well with some cleansing ingredients (surfactants) to thicken them into gels. It also acts as a stabilizer for water-in-oil emulsions.