Advanced Clinicals Complete 5-in-1 Eye Serum Review

Advanced Clinicals Complete 5-in-1 Eye Serum
5.1
/ 10
Moisturizing
9.7 Humectancy icon Humectancy
0.6 Occlusivity icon Occlusivity
2.5Anti-wrinkle icon/ 10
Anti-wrinkle
Rich
in Antioxidants
Review

Does Advanced Clinicals Complete 5-in-1 Eye Serum Work?

 
According to CreamScan AI's analysis of the ingredient list, here’s what Advanced Clinicals Complete 5-in-1 Eye Serum has to offer:
 
  • Strong humectant moisturizing. This lightweight, humectant-rich product, ideal for oily skin, has a moisturizing rating of 5.1 out of 10.
  • Modest anti-wrinkle efficacy: Advanced Clinicals Complete 5-in-1 Eye Serum has an anti-wrinkle rating of 2.5 out of 10 so you may expect some, although limited, effect on wrinkles.
  • Antioxidant protection.

Key Benefits of Advanced Clinicals Complete 5-in-1 Eye Serum

 
These are the key benefits you can expect from using Advanced Clinicals Complete 5-in-1 Eye Serum:
 

Lightweight Humectant Moisturizer Ideal for Oily Skin

According to CreamScan analysis, Advanced Clinicals Complete 5-in-1 Eye Serum is quite moisturizing, with a moisturizing rating of 5.1 out of 10.

Is it more humectant or occlusive? Significantly more humectant. It has a low occlusivity of 0.6 out of 10 and a very high humectancy of 9.7 out of 10, primarily due to the high content of Pyrus Malus (Apple) Fruit Extract (est. ≈4.0%) and Glycerin (est. ≈3.0%).

This humectant-rich product, when used alone as a moisturizer, is ideal for oily skin, offering significant hydration in a lightweight, fast-absorbing formula with a minimal amount of occlusive ingredients.

It’s also a great choice for people with normal skin who prefer lightweight moisturizers.

A Humectant Boost for Any Skincare Routine

But it’s not limited to oily skin - such a humectant boost will also positively contribute to the moisturizing efficacy of any skincare routine when used as a step before applying the main moisturizer. This type of formulation is typically used in serums, where a light, fast-absorbing texture is key.

Please refer to the Ratings section below for details of the moisturizing rating calculation.

Modest Anti-Wrinkle Efficacy

According to CreamScan analysis, Advanced Clinicals Complete 5-in-1 Eye Serum has a modest level of anti-wrinkle efficacy, rated 2.5 out of 10.

It contains one ingredient with proven anti-wrinkle efficacy: Retinol (est. ≈0.1%), 
 the most effective non-prescription anti-wrinkle ingredient. Numerous clinical studies have shown its positive effects at concentrations as low as 0.1%. A study with 36 participants (Kafi et al.) confirmed that a lotion containing 0.4% retinol reduced wrinkle severity by 21% after 24 weeks of use, compared to the same formulation without retinol (vehicle).
 
Among others, Advanced Clinicals Complete 5-in-1 Eye Serum also contains contains Acetyl Hexapeptide-8 and Aminopropyl Ascorbyl Phosphate, two ingredients often marketed as effective in reducing wrinkles. However, the studies supporting the anti-wrinkle claims of these ingredients provide insufficient evidence of efficacy according to CreamScan Research Evaluation Standards. Therefore, these ingredients do not contribute to the anti-wrinkle rating.
 
Moisturizers, when used regularly, are proven to prevent wrinkle formation and even reduce existing wrinkles. Therefore, this product, like any other moisturizer, can deliver some anti-wrinkle effects through its moisturizing action.
 

Please refer to the Ratings section below for details of the anti-wrinkle rating calculation.

Rich in Skin-Protecting Antioxidants

We estimate that Advanced Clinicals Complete 5-in-1 Eye Serum is rich (> 3%) in antioxidants, specifically Pyrus Malus (Apple) Fruit Extract (est. ≈4.0%).

A key benefit of antioxidants is their ability to reduce oxidative stress caused by free radicals and therefore prevent accelerated skin aging. Studies also show that antioxidants can protect against environmental damage such as UV radiation and pollution, and help reduce inflammation and skin redness.

Please note that this is not a complete list of benefits. We are in the process of enhancing our AI model to incorporate anti-pigmentation, exfoliation and anti-acne ratings.

Pros & Cons of Advanced Clinicals Complete 5-in-1 Eye Serum

 
Here’s an overview of the pros and cons of Advanced Clinicals Complete 5-in-1 Eye Serum to help you decide if it’s the right choice for your skincare routine:
 

Pros:

  • Humectant-rich moisturizing ideal for oily skin
  • Lightweight texture
  • A humectant moisturizing boost for any skincare routine
  • Offers modest anti-wrinkle efficacy
  • Rich in antioxidants that combat oxidative stress associated with accelerated skin aging and defend against environmental damage such as UV radiation and pollution

Cons: 

Ingredients

Est. % Ingredient Origin Functions
70
6
4
3
2
1.5
0.1
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Est. %
Water
Function:
Origin:
Isopropyl Myristate
Function:
Origin:
Pyrus Malus (Apple) Fruit Extract
Function:
Origin:
Glycerin
Function:
Origin:
Hydrogenated Ethylhexyl Olivate
Function:
Origin:
Cetearyl Alcohol
Function:
Origin:
Retinol
Function:
Origin:
Aloe Barbadensis Leaf Juice
Function:
Origin:
Sodium Hyaluronate
Function:
Origin:
Dipotassium Glycyrrhizate
Function:
Origin:
Tocopherol
Function:
Origin:
Chlorella Vulgaris Extract
Function:
Origin:
Acetyl Hexapeptide-8
Function:
Origin:
Ferulic Acid
Function:
Origin:
Colloidal Gold
Function:
Origin:
Caulerpa Lentillifera Extract
Function:
Origin:
Chenopodium Quinoa Seed Extract
Function:
Origin:
Oryza Sativa (Rice) Bran Extract
Function:
Origin:
Hydrogenated Olive Oil Unsaponifiables
Function:
Origin:
Daucus Carota Sativa (Carrot) Root Extract
Function:
Origin:
Glycine Max (Soybean) Seed Extract
Function:
Origin:
Oryza Sativa (Rice) Extract
Function:
Origin:
Panax Ginseng Root Extract
Function:
Origin:
Citrus Aurantium Dulcis (Orange) Peel Extract
Function:
Origin:
Helianthus Annuus (Sunflower) Extract
Function:
Origin:
Rosmarinus Officinalis (Rosemary) Leaf Extract
Function:
Origin:
Tocopheryl Acetate
Function:
Origin:
Aminopropyl Ascorbyl Phosphate
Function:
Origin:
Argania Spinosa Kernel Oil
Function:
Origin:
Cocos Nucifera (Coconut) Oil
Function:
Origin:
Glycine Soja (Soybean) Oil
Function:
Origin:
Honey Extract
Function:
Origin:
Cyamopsis Tetragonoloba (Guar) Gum
Function:
Origin:
Avena Sativa (Oat) Bran Extract
Function:
Origin:
Pentylene Glycol
Function:
Origin:
Polyurethane Crosspolymer-1
Function:
Origin:
Ammonium Acryloyldimethyltaurate/VP Copolymer
Function:
Origin:
Butylene Glycol
Function:
Origin:
Sodium Benzoate
Function:
Origin:
Tetrasodium Glutamate Diacetate
Function:
Origin:
Sodium Hydroxide
Function:
Origin:
Phenoxyethanol
Function:
Origin:
Caprylyl Glycol
Function:
Origin:
Ethylhexylglycerin
Function:
Origin:
Hexylene Glycol
Function:
Origin:

Ratings

All humectants
9.7
4
3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Benchmark
10
All occlusives
1.2
0.3
0.3
0.3
0.3
Benchmark
20
Moisturizing rating
5.1
Ingredient Est. % Benchmark Raiting
Humectancy All humectants 9.7 10
9.7
4
3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Occlusivity All occlusives 1.2 20
0.6
0.3
0.3
0.3
0.3
Moisturizing rating
5.1
Ingredient Est. % Benchmark Humectancy
4
3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
All humectants 9.7 10
9.7
All humectants
9.7
4
3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Benchmark
10
Ingredient Est. % Benchmark Occlusivity
0.3
0.3
0.3
0.3
All occlusives 1.2 20
0.6
All occlusives
1.2
0.3
0.3
0.3
0.3
Benchmark
20
Ingredient
Ingredient anti-wrinkle power
when present at, %
in this formula est. %
Rating
10 /10 0.4 0.1 2.5
n/a
- 0.3 -
n/a
- 0.3 -
Total
2.5
Retinol
2.5
Ingredient anti-wrinkle power
10 /10
when present at, %
0.4
in this formula, est. %
0.1
Acetyl Hexapeptide-8
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Aminopropyl Ascorbyl Phosphate
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Anti-wrinkle rating
2.5
Ingredient Est. % Benchmark
Rich in Antioxidants
4
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
All antioxidants 7.6 3 Rich in antioxidants
All antioxidants
7.6
Pyrus Malus (Apple) Fruit Extract
4
Aloe Barbadensis Leaf Juice
0.3
Sodium Hyaluronate
0.3
Tocopherol
0.3
Chlorella Vulgaris Extract
0.3
Ferulic Acid
0.3
Daucus Carota Sativa (Carrot) Root Extract
0.3
Panax Ginseng Root Extract
0.3
Rosmarinus Officinalis (Rosemary) Leaf Extract
0.3
Tocopheryl Acetate
0.3
Aminopropyl Ascorbyl Phosphate
0.3
Argania Spinosa Kernel Oil
0.3
Glycine Soja (Soybean) Oil
0.3
Benchmark
3
Ingredient Est. % Benchmark
Rich in Soothing
0.3
0.3
0.3
0.3
0.3
0.3
0.3
All soothing 2.1 5 No
All soothing
2.1
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Benchmark
5

Ingredients explained

Water
Est. %70
Function
Origin
WaterThe most used ingredient in skincare. Its concentration defines the product texture: rich creams may have about 50% of water while a light jelly about 90%. Water doesn’t moisturize the skin by itself and is used in skincare as a solvent for other ingredients.
Isopropyl Myristate
Est. %6
Function
Origin
Isopropyl MyristateA fast-spreading, cost-effective, non-greasy emollient that is typically used for lubrication, spreadability, or to remove “tackiness” from a product. Isopropyl Myristate is listed as a common comedogenic ingredient by acne.org.
Pyrus Malus (Apple) Fruit Extract
Est. %4
Function
Origin
Pyrus Malus (Apple) Fruit ExtractAn extract derived from apple fruit that has humectant moisturizing and antioxidant properties, as well as gentle anti-pigment effects. It contains humectant sugars, anti-pigment organic acids, and flavonoids.
Glycerin
Est. %3
Function
Origin
Glycerin

The most popular moisturizing ingredient in the world. It is a powerful humectant – cheap yet very effective.

Hydrogenated Ethylhexyl Olivate
Est. %2
Function
Origin
Hydrogenated Ethylhexyl Olivate
Cetearyl Alcohol
Est. %1.5
Function
Origin
Cetearyl AlcoholA blend of cetyl alcohol and stearyl alcohol, the fatty alcohols that are derived from palm oil. It helps to create emulsions that give off a soft and silky emollient feel and also increase product thickness.
Retinol
Est. %0.1
Function
Origin
Retinol

One of the most famous and well-researched anti-aging ingredients with a maximum anti-wrinkle power of 10 out of 10. It is proven to decrease wrinkles and help the skin regain its thickness, firmness, and texture. Retinol is also effective in treating pigmentation issues such as dark spots and acne.

Aloe Barbadensis Leaf Juice
Est. %0.3
Function
Origin
Aloe Barbadensis Leaf JuiceA gelatinous juice from Aloe vera leaves that acts as a powerful humectant, emollient, and antioxidant. It contains enzymes, amino acids, vitamins, and minerals that soothe irritated skin and have wound-healing and anti-inflammatory properties.
Sodium Hyaluronate
Est. %0.3
Function
Origin
Sodium Hyaluronate

A sodium salt of famous hyaluronic acid. A potent humectant that hydrates the skin, supports collagen function, and fills out small wrinkles. Sodium hyaluronate also offers soothing and antioxidant properties.

Dipotassium Glycyrrhizate
Est. %0.3
Function
Origin
Dipotassium GlycyrrhizateA licorice root derivative with powerful anti-inflammatory and soothing activities. It is often used as a flavoring agent in lip products.
Tocopherol
Est. %0.3
Function
Origin
Tocopherol

Simply another name for vitamin E. Tocopherol is a fantastic ingredient and especially beneficial for dry and inflamed skin. It has occlusive moisturizing, emollient, antioxidant, and photoprotective properties.

Chlorella Vulgaris Extract
Est. %0.3
Function
Origin
Chlorella Vulgaris ExtractA dried mass of tiny, single-cell green algae. It is widely used as a food source or dietary supplement since it is rich in proteins, amino acids, minerals, and vitamins. This dark green extract is used as an antioxidant agent in skincare.
Acetyl Hexapeptide-8
Est. %0.3
Function
Origin
Acetyl Hexapeptide-8

A small synthetic peptide that is thought to act similarly to Botox by calming contractions of the facial muscles and reducing expression wrinkles. The effect is only temporary and it does not improve the skin structure in any way.

Ferulic Acid
Est. %0.3
Function
Origin
Ferulic AcidA plant-based phenolic acid with powerful and scientifically proven antioxidant properties. It enhances the effects of vitamins C and E, as well as the UV protective effects of sunscreens.
Colloidal Gold
Est. %0.3
Function
Origin
Colloidal Gold
Caulerpa Lentillifera Extract
Est. %0.3
Function
Origin
Caulerpa Lentillifera Extract
Chenopodium Quinoa Seed Extract
Est. %0.3
Function
Origin
Chenopodium Quinoa Seed ExtractDerived from quinoa seeds, the extract contains various emollient phytochemicals such as phytosterols, saponins, proteins, and amino acids.
Oryza Sativa (Rice) Bran Extract
Est. %0.3
Function
Origin
Oryza Sativa (Rice) Bran ExtractAn extract from rice bran, the brown outer part of the rice kernel. It contains emollient fatty acids and antioxidants such as tocopherols (vitamin E) and γ-oryzanol.
Hydrogenated Olive Oil Unsaponifiables
Est. %0.3
Function
Origin
Hydrogenated Olive Oil UnsaponifiablesA strongly emollient fraction of olive oil. It contains sterols and fatty alcohols along with various antioxidant compounds and squalane - which replenishes skin sebum.
Daucus Carota Sativa (Carrot) Root Extract
Est. %0.3
Function
Origin
Daucus Carota Sativa (Carrot) Root ExtractAn antioxidant extract derived from carrots. It is a rich source of the orange-colored beta-carotene (pro-vitamin A). Carrot root extract is often added to skincare products that are aimed at providing a better suntan.
Glycine Max (Soybean) Seed Extract
Est. %0.3
Function
Origin
Glycine Max (Soybean) Seed Extract
Oryza Sativa (Rice) Extract
Est. %0.3
Function
Origin
Oryza Sativa (Rice) ExtractAn abrasive rice extract rich in various emollient fatty acids, amino acids, and vitamin E.
Panax Ginseng Root Extract
Est. %0.3
Function
Origin
Panax Ginseng Root ExtractDerived from the roots of the Korean Ginseng, this extract contains a mixture of antioxidant and soothing ginsenosides which are proven to reduce inflammation and treat eczema. The root is a major part of Chinese traditional medicine.
Citrus Aurantium Dulcis (Orange) Peel Extract
Est. %0.3
Function
Origin
Citrus Aurantium Dulcis (Orange) Peel Extract

Citrus aurantium dulcis peel extract is the same extract as Citrus aurantium dulcis (orange) fruit extract. It has antioxidant properties and gives a skincare product a fresh orange scent. It also works as a thickener due to its pectin content. Read more about the extract here: Citrus Aurantium Dulcis (Orange) Fruit Extract.

Helianthus Annuus (Sunflower) Extract
Est. %0.3
Function
Origin
Helianthus Annuus (Sunflower) ExtractAn emollient extract derived from sunflower seeds that is packed with skin-benefiting ingredients such as squalene, phytosterols, phospholipids, amino acids, and antioxidant vitamin E.
Rosmarinus Officinalis (Rosemary) Leaf Extract
Est. %0.3
Function
Origin
Rosmarinus Officinalis (Rosemary) Leaf ExtractA soothing and astringent extract derived from the fragrant, spicy leaves of rosemary. It has strong antioxidant properties. Rosemary extract can reduce signs of inflammation and also acts as an emollient and antimicrobial agent.
Tocopheryl Acetate
Est. %0.3
Function
Origin
Tocopheryl Acetate

An antioxidant derivative of tocopherol (vitamin E). It helps to protect cells from free radicals and UV damage through the conversion to active vitamin E in the skin. It is more stable than tocopherol.

Aminopropyl Ascorbyl Phosphate
Est. %0.3
Function
Origin
Aminopropyl Ascorbyl PhosphateOne of the most recent vitamin C derivatives. Although the manufacturer claims it has all the powers of ascorbic acid (e.g., it is collagen-boosting and able to treat hyperpigmentation), this has not been proven in scientific studies.
Argania Spinosa Kernel Oil
Est. %0.3
Function
Origin
Argania Spinosa Kernel OilA fatty oil from Moroccan argan tree kernels commonly used as an occlusive moisturizer and emollient. Its uniqueness comes from its compounds: vitamin E, phospholipids, phenolic compounds, and rare phytosterols with antioxidant and emollient effects.
Cocos Nucifera (Coconut) Oil
Est. %0.3
Function
Origin
Cocos Nucifera (Coconut) OilA famous occlusive moisturizing and emollient oil. It is derived from coconuts and may give a product a lovely coconut scent. Coconut oil is listed as a common comedogenic ingredient by acne.org.
Glycine Soja (Soybean) Oil
Est. %0.3
Function
Origin
Glycine Soja (Soybean) OilAn occlusive moisturizing oil expressed from soybeans. It does not leave an oily feeling on the skin due to its low content of saturated fatty acids. Glycine soja oil contains emollient fatty acids and a significant amount of antioxidants.
Honey Extract
Est. %0.3
Function
Origin
Honey ExtractAn extract obtained from honey that is comprised of proteins, minerals, and various bioactive compounds with antimicrobial, emollient, moisturizing humectant, and soothing properties.
Cyamopsis Tetragonoloba (Guar) Gum
Est. %0.3
Function
Origin
Cyamopsis Tetragonoloba (Guar) GumA plant-based gum extracted from the seeds of guar or cluster bean. It is comprised of various polysaccharides and is used as a thickening and gelling agent.
Avena Sativa (Oat) Bran Extract
Est. %0.3
Function
Origin
Avena Sativa (Oat) Bran Extract
Pentylene Glycol
Est. %0.3
Function
Origin
Pentylene Glycol

A naturally or synthetically derived preservative that exhibits effective antifungal and antibacterial traits. It also acts as a booster for more traditional preservatives. Pentylene glycol can also serve as a moisturizing humectant and solvent.

Polyurethane Crosspolymer-1
Est. %0.3
Function
Origin
Polyurethane Crosspolymer-1
Ammonium Acryloyldimethyltaurate/VP Copolymer
Est. %0.3
Function
Origin
Ammonium Acryloyldimethyltaurate/VP CopolymerA polymeric ingredient that creates lightweight and refreshing gel textures. It also works as a viscosity controlling agent.
Butylene Glycol
Est. %0.3
Function
Origin
Butylene Glycol

A clear, colorless liquid humectant that draws moisture to the skin. The humectancy of butylene glycol, owed to its two hydroxyl groups, is quite considerable, although not as powerful as glycerin, which contains three hydroxyl groups.

Sodium Benzoate
Est. %0.3
Function
Origin
Sodium BenzoateA preservative that usually works in combination with other preservatives. It has to be at low pH (<5.5) to be effective.
Tetrasodium Glutamate Diacetate
Est. %0.3
Function
Origin
Tetrasodium Glutamate DiacetateA biodegradable chelating agent that chemically captures the heavy metal ions naturally present in water and disarms their harmful effects.
Sodium Hydroxide
Est. %0.3
Function
Origin
Sodium Hydroxide

An ingredient that is able to bring the pH of a product up, thereby making it less harsh on the skin.

Phenoxyethanol
Est. %0.3
Function
Origin
PhenoxyethanolThe most frequently used preservative in skincare. It is a clear, oil-like liquid synthetic substance that protects products from harmful bacteria and yeast, whilst still leaving skin microflora unharmed. It is confirmed by research to be harmless.
Caprylyl Glycol
Est. %0.3
Function
Origin
Caprylyl GlycolAn emollient that improves product spreadability and offers a silky feel on the skin. It also acts as a preservative booster that improves the efficacy of other preservatives. According to the manufacturer, it is also a humectant moisturizer.
Ethylhexylglycerin
Est. %0.3
Function
Origin
EthylhexylglycerinA preservative booster derived from glycerin. It is commonly paired with other preservatives to improve their efficacy. Ethylhexylglycerin is also a humectant due to its chemical base of glycerin.
Hexylene Glycol
Est. %0.3
Function
Origin
Hexylene GlycolA multifunctional ingredient that is best known for its use as a solvent. It can dissolve both water-based ingredients and oils. For this reason, it can also function as an emulsifier, allowing oil and water ingredients to mix and remain stable.