Sesderma Azelac RU Liposomal Serum Review

Sesderma Azelac RU Liposomal Serum
5.1
/ 10
Moisturizing
10.0 Humectancy icon Humectancy
0.2 Occlusivity icon Occlusivity
2.5Anti-wrinkle icon/ 10
Anti-wrinkle
Rich
in Antioxidants
Review

Does Sesderma Azelac RU Liposomal Serum Work?

 
According to CreamScan AI's analysis of the ingredient list, here’s what Sesderma Azelac RU Liposomal Serum has to offer:
 
  • Strong humectant moisturizing. This lightweight, humectant-rich product, ideal for oily skin, has a moisturizing rating of 5.1 out of 10.
  • Modest anti-wrinkle efficacy: Sesderma Azelac RU Liposomal Serum has an anti-wrinkle rating of 2.5 out of 10 so you may expect some, although limited, effect on wrinkles.
  • Antioxidant protection.

Key Benefits of Sesderma Azelac RU Liposomal Serum

 
These are the key benefits you can expect from using Sesderma Azelac RU Liposomal Serum:
 

Lightweight Humectant Moisturizer Ideal for Oily Skin

According to CreamScan analysis, Sesderma Azelac RU Liposomal Serum is quite moisturizing, with a moisturizing rating of 5.1 out of 10.

Is it more humectant or occlusive? Significantly more humectant. It has a low occlusivity of 0.2 out of 10 and a maximum humectancy of 10 out of 10, primarily due to the high content of Propylene Glycol (est. ≈6.0%) and Lecithin (est. ≈4.0%).

This humectant-rich product, when used alone as a moisturizer, is ideal for oily skin, offering significant hydration in a lightweight, fast-absorbing formula with a minimal amount of occlusive ingredients.

It’s also a great choice for people with normal skin who prefer lightweight moisturizers.

A Humectant Boost for Any Skincare Routine

But it’s not limited to oily skin - such a humectant boost will also positively contribute to the moisturizing efficacy of any skincare routine when used as a step before applying the main moisturizer. This type of formulation is typically used in serums, where a light, fast-absorbing texture is key.

Please refer to the Ratings section below for details of the moisturizing rating calculation.

Modest Anti-Wrinkle Efficacy

According to CreamScan analysis, Sesderma Azelac RU Liposomal Serum has a modest level of anti-wrinkle efficacy, rated 2.5 out of 10.

It contains one ingredient with proven anti-wrinkle efficacy: Retinol (est. ≈0.1%), 
 the most effective non-prescription anti-wrinkle ingredient. Numerous clinical studies have shown its positive effects at concentrations as low as 0.1%. A study with 36 participants (Kafi et al.) confirmed that a lotion containing 0.4% retinol reduced wrinkle severity by 21% after 24 weeks of use, compared to the same formulation without retinol (vehicle).
 
Among others, Sesderma Azelac RU Liposomal Serum also contains Ascorbyl Glucoside, an ingredient often marketed as effective in reducing wrinkles. However, the studies supporting the anti-wrinkle claims of Ascorbyl Glucoside provide insufficient evidence of its efficacy according to CreamScan Research Evaluation Standards. Therefore, this ingredient does not contribute to the anti-wrinkle rating.
 
Moisturizers, when used regularly, are proven to prevent wrinkle formation and even reduce existing wrinkles. Therefore, this product, like any other moisturizer, can deliver some anti-wrinkle effects through its moisturizing action.
 

Please refer to the Ratings section below for details of the anti-wrinkle rating calculation.

Rich in Skin-Protecting Antioxidants

We estimate that Sesderma Azelac RU Liposomal Serum is rich (> 3%) in antioxidants, specifically 4-Butylresorcinol (est. ≈1.3%), Ascorbyl Glucoside (est. ≈1.0%), Morus Alba Root Extract (est. ≈0.3%), and others.

A key benefit of antioxidants is their ability to reduce oxidative stress caused by free radicals and therefore prevent accelerated skin aging. Studies also show that antioxidants can protect against environmental damage such as UV radiation and pollution, and help reduce inflammation and skin redness.

Please note that this is not a complete list of benefits. We are in the process of enhancing our AI model to incorporate anti-pigmentation, exfoliation and anti-acne ratings.

Pros & Cons of Sesderma Azelac RU Liposomal Serum

 
Here’s an overview of the pros and cons of Sesderma Azelac RU Liposomal Serum to help you decide if it’s the right choice for your skincare routine:
 

Pros:

  • Humectant-rich moisturizing ideal for oily skin
  • Lightweight texture
  • A humectant moisturizing boost for any skincare routine
  • Offers modest anti-wrinkle efficacy
  • Rich in antioxidants that combat oxidative stress associated with accelerated skin aging and defend against environmental damage such as UV radiation and pollution

Cons: 

Ingredients

Est. % Ingredient Origin Functions
75
6
4
3
2
1.5
1.3
1
0.1
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.15
0.3
0.3
0.3
0.03
Est. %
Water
Function:
Origin:
Propylene Glycol
Function:
Origin:
Lecithin
Function:
Origin:
Alcohol
Function:
Origin:
Polymethyl Methacrylate
Function:
Origin:
PEG-40 Hydrogenated Castor Oil
Function:
Origin:
4-Butylresorcinol
Function:
Origin:
Ascorbyl Glucoside
Function:
Origin:
Retinol
Function:
Origin:
Azelaic Acid
Function:
Origin:
Niacin
Function:
Origin:
Undecylenoyl Phenylalanine
Function:
Origin:
Glycyrrhetinic Acid
Function:
Origin:
Morus Alba Root Extract
Function:
Origin:
Diacetyl Boldine
Function:
Origin:
PEG/PPG-20/6 Dimethicone
Function:
Origin:
Sodium Cholate
Function:
Origin:
Polysorbate 80
Function:
Origin:
Xanthan Gum
Function:
Origin:
Carbomer
Function:
Origin:
Triethanolamine
Function:
Origin:
Tocopheryl Acetate
Function:
Origin:
Salicylic Acid
Function:
Origin:
Sodium Hydroxide
Function:
Origin:
Caprylic/Capric Triglyceride
Function:
Origin:
Sodium Chloride
Function:
Origin:
Hydroxypropyl Cyclodextrin
Function:
Origin:
Pentaerythrityl Tetra-di-t-butyl Hydroxyhydrocinnamate
Function:
Origin:
Triisopropanolamine
Function:
Origin:
Hydrochloric Acid
Function:
Origin:
Phenoxyethanol
Function:
Origin:
Ethylhexylglycerin
Function:
Origin:
Fragrance
Function:
Origin:
Citronellyl Methylcrotonate
Function:
Origin:
Citral
Function:
Origin:
Coumarin
Function:
Origin:
Eugenol
Function:
Origin:
Limonene
Function:
Origin:
Isoeugenol
Function:
Origin:

Ratings

All humectants
10.6
6
4
0.3
0.3
Benchmark
10
All occlusives
0.3
0.3
Benchmark
20
Moisturizing rating
5.1
Ingredient Est. % Benchmark Raiting
Humectancy All humectants 10.6 10
10.0
6
4
0.3
0.3
Occlusivity All occlusives 0.3 20
0.2
0.3
Moisturizing rating
5.1
Ingredient Est. % Benchmark Humectancy
6
4
0.3
0.3
All humectants 10.6 10
10
All humectants
10.6
6
4
0.3
0.3
Benchmark
10
Ingredient Est. % Benchmark Occlusivity
0.3
All occlusives 0.3 20
0.2
All occlusives
0.3
0.3
Benchmark
20
Ingredient
Ingredient anti-wrinkle power
when present at, %
in this formula est. %
Rating
10 /10 0.4 0.1 2.5
n/a
- 1 -
Total
2.5
Retinol
2.5
Ingredient anti-wrinkle power
10 /10
when present at, %
0.4
in this formula, est. %
0.1
Ascorbyl Glucoside
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
1
Anti-wrinkle rating
2.5
Ingredient Est. % Benchmark
Rich in Antioxidants
1.3
1
0.3
0.3
0.3
All antioxidants 3.2 3 Rich in antioxidants
All antioxidants
3.2
4-Butylresorcinol
1.3
Ascorbyl Glucoside
1
Morus Alba Root Extract
0.3
Tocopheryl Acetate
0.3
Pentaerythrityl Tetra-di-t-butyl Hydroxyhydrocinnamate
0.3
Benchmark
3
Ingredient Est. % Benchmark
Rich in Soothing
0.3
0.3
0.3
All soothing 0.9 5 No
All soothing
0.9
0.3
0.3
0.3
Benchmark
5

Ingredients explained

Water
Est. %75
Function
Origin
WaterThe most used ingredient in skincare. Its concentration defines the product texture: rich creams may have about 50% of water while a light jelly about 90%. Water doesn’t moisturize the skin by itself and is used in skincare as a solvent for other ingredients.
Propylene Glycol
Est. %6
Function
Origin
Propylene GlycolA clear, thick, odorless liquid of synthetic origin. Its main function is to stabilize cosmetic products exposed to varying temperatures. It is also a moderately strong humectant with similar properties to glycerin.
Lecithin
Est. %4
Function
Origin
LecithinA humectant, emollient, and emulsifier best suited for water-in-oil emulsions. Lecithin can come from sunflowers, soy, and eggs. The downside to lecithin is that it causes an extra burden on the formula’s preservative because it is nutritious.
Alcohol
Est. %3
Function
Origin
AlcoholAn effective antimicrobial ingredient that kills bacteria, fungi, and even some viruses. It is also an excellent solvent and astringent. Alcohol helps to create lighter and less viscous products. It can, however, be dehydrating and skin-sensitizing.
Polymethyl Methacrylate
Est. %2
Function
Origin
Polymethyl MethacrylateA powdered ingredient with an impressive sensory profile that gives off a creamy, sometimes velvety feeling on the skin. It is made up of tiny microspheres that roll smoothly across the skin and create slip and high spreadability.
PEG-40 Hydrogenated Castor Oil
Est. %1.5
Function
Origin
PEG-40 Hydrogenated Castor OilA castor oil-derived ingredient often used to incorporate small amounts of oil (such as a fragrance) into a water-based product. PEG-4 HCO is a gold-standard solubilizer and can be used in low amounts due to its ability to solubilize things so well.
4-Butylresorcinol
Est. %1.3
Function
Origin
4-Butylresorcinol
Ascorbyl Glucoside
Est. %1
Function
Origin
Ascorbyl GlucosideA derivative of vitamin C. It is more stable and less irritating than ascorbic acid. There are unfortunately no clinical studies on ascorbyl glucoside’s anti-pigment or anti-acne efficacy alone.
Retinol
Est. %0.1
Function
Origin
Retinol

One of the most famous and well-researched anti-aging ingredients with a maximum anti-wrinkle power of 10 out of 10. It is proven to decrease wrinkles and help the skin regain its thickness, firmness, and texture. Retinol is also effective in treating pigmentation issues such as dark spots and acne.

Azelaic Acid
Est. %0.3
Function
Origin
Azelaic AcidA powerful dermatological ingredient that helps to treat acne and various pigmentation issues. It appears both in medicated creams and regular skincare. It reduces redness and inflammation but can be irritating in high concentrations.
Niacin
Est. %0.3
Function
Origin
NiacinAn active form of vitamin B3 that is used to support and restore the healthy appearance of the skin, although it is less effective than Niacinamide.
Undecylenoyl Phenylalanine
Est. %0.3
Function
Origin
Undecylenoyl Phenylalanine
Glycyrrhetinic Acid
Est. %0.3
Function
Origin
Glycyrrhetinic AcidA compound derived from licorice root. It is a powerful anti-inflammatory ingredient with some anti-pigment properties.
Morus Alba Root Extract
Est. %0.3
Function
Origin
Morus Alba Root ExtractAn antioxidant, astringent, antimicrobial, and antifungal extract from white mulberry tree roots. It has been claimed to have anti-pigment potential.
Diacetyl Boldine
Est. %0.3
Function
Origin
Diacetyl Boldine
PEG/PPG-20/6 Dimethicone
Est. %0.3
Function
Origin
PEG/PPG-20/6 Dimethicone
Sodium Cholate
Est. %0.3
Function
Origin
Sodium Cholate
Polysorbate 80
Est. %0.3
Function
Origin
Polysorbate 80A non-ionic surfactant, which means that it contains no chemical charges. It can be used as a mild cleansing agent in skin cleansing products but is more commonly used for its emulsifying abilities.
Xanthan Gum
Est. %0.3
Function
Origin
Xanthan GumA natural multi-functional ingredient that originates from fermented sugars. Xanthan gum acts as a viscosity-building agent to thicken skincare products. It is also an excellent stabilizer and works well to hold other ingredients together.
Carbomer
Est. %0.3
Function
Origin
CarbomerA synthetic ingredient with the ability to gel water. When used in emulsions, such as lotions and creams, carbomer can also act as an emulsion stabilizer.
Triethanolamine
Est. %0.3
Function
Origin
TriethanolamineA clear, colorless, and highly viscous liquid, this ingredient is an excellent pH adjuster. When it is necessary to neutralize an acidic solution or to generally increase the pH of a product, triethanolamine is a common choice.
Tocopheryl Acetate
Est. %0.3
Function
Origin
Tocopheryl Acetate

An antioxidant derivative of tocopherol (vitamin E). It helps to protect cells from free radicals and UV damage through the conversion to active vitamin E in the skin. It is more stable than tocopherol.

Salicylic Acid
Est. %0.3
Function
Origin
Salicylic AcidThis effective peeling and anti-inflammatory BHA is used as an anti-acne agent and works by breaking down the junctions between dead skin cells. This results in the peeling of dead skin and the unclogging of pores.
Sodium Hydroxide
Est. %0.3
Function
Origin
Sodium Hydroxide

An ingredient that is able to bring the pH of a product up, thereby making it less harsh on the skin.

Caprylic/Capric Triglyceride
Est. %0.3
Function
Origin
Caprylic/Capric TriglycerideA natural occlusive moisturizing and emollient ingredient, it is a blend of glycerin and two fatty acids, caprylic and capric acid. It creates an oil-based protective layer on the skin, thereby preventing water loss.
Sodium Chloride
Est. %0.3
Function
Origin
Sodium Chloride

You’re definitely familiar with sodium chloride, even if you don’t think you are. It’s table salt! Salt works well with some cleansing ingredients (surfactants) to thicken them into gels. It also acts as a stabilizer for water-in-oil emulsions.

Hydroxypropyl Cyclodextrin
Est. %0.3
Function
Origin
Hydroxypropyl CyclodextrinA white crystalline powder that can reduce odors coming from other ingredients in a product.
Pentaerythrityl Tetra-di-t-butyl Hydroxyhydrocinnamate
Est. %0.3
Function
Origin
Pentaerythrityl Tetra-di-t-butyl HydroxyhydrocinnamateAn antioxidant that protects vulnerable ingredients from the damage caused by ultraviolet radiation, which can also lead to the generation of damaging free radical species.
Triisopropanolamine
Est. %0.3
Function
Origin
Triisopropanolamine
Hydrochloric Acid
Est. %0.3
Function
Origin
Hydrochloric Acid
Phenoxyethanol
Est. %0.3
Function
Origin
PhenoxyethanolThe most frequently used preservative in skincare. It is a clear, oil-like liquid synthetic substance that protects products from harmful bacteria and yeast, whilst still leaving skin microflora unharmed. It is confirmed by research to be harmless.
Ethylhexylglycerin
Est. %0.3
Function
Origin
EthylhexylglycerinA preservative booster derived from glycerin. It is commonly paired with other preservatives to improve their efficacy. Ethylhexylglycerin is also a humectant due to its chemical base of glycerin.
Fragrance
Est. %0.3
Function
Origin
FragranceUnder trade secret law, manufacturers have the right not to disclose what exactly went into the fragrance and use the unspecific word Fragrance or Parfum instead. Many fragrances are highly allergenic.
Citronellyl Methylcrotonate
Est. %0.3
Function
Origin
Citronellyl Methylcrotonate
Citral
Est. %0.15
Function
Origin
Citral

A fragrant compound found in many essential oils (especially lemon myrtle and lemongrass essential oil). It has a sweet, lemon-like scent. People with sensitive skin should try to avoid products with citral, or at least do a patch test before using.

Coumarin
Est. %0.3
Function
Origin
Coumarin

A plant-based fragrant compound that occurs in sweet-smelling grass, sweet woodruff, and sweet clover. It has a sweet and vanilla-like scent in high concentrations and a similar scent to freshly mowed grass in low concentrations.

Eugenol
Est. %0.3
Function
Origin
Eugenol

A fragrant liquid that can be found naturally in the essential oils derived from cloves, cinnamon, basil, and bay leaf. It has a spicy and warm scent. People with sensitive skin should consider doing a patch test first, as it is a potential irritant.

Limonene
Est. %0.3
Function
Origin
Limonene

One of the most used fragrances in skincare products. It is produced from the peels of citrus fruits and has a fresh, pleasant, citrusy smell. People who are sensitive to citrus should try to avoid it, or at least do a patch test before using it.

Isoeugenol
Est. %0.03
Function
Origin
Isoeugenol

A fragrant compound found in ylang-ylang essential oil that has a vanilla-like, creamy, and sweet aroma.