Replenix Restorative Nighttime Bio-Therapy Review

Replenix Restorative Nighttime Bio-Therapy
6.2
/ 10
Moisturizing
10.0 Humectancy icon Humectancy
2.3 Occlusivity icon Occlusivity
Ingredients

Replenix Restorative Nighttime Bio-Therapy Ingredients

Hover to see details. On mobile? Tap for ingredient stories!

Full Ingredient List (INCI):

Water, Cyclopentasiloxane, Sodium PCA, Glycerin, Caprylic/Capric Triglyceride, Polysorbate 60, Cetearyl Alcohol, Yucca Glauca Root Extract, Dimethicone, Cetearyl Glucoside, Polyacrylamide, C13-14 Isoparaffin, Laureth-7, Ceramide NP, Ceramide AP, Ceramide EOP, Sodium Hyaluronate, Phytosphingosine, Cholesterol, Sodium Lauroyl Lactylate, Camellia Sinensis Polyphenols, Malus Domestica Fruit Cell Culture Extract, Squalane, Ceramide NS, Tetrapeptide-21, Resveratrol, Bisabolol, Caffeine, Lecithin, Glyceryl Stearate, PEG-100 Stearate, Dimethicone Crosspolymer, Carbomer, Xanthan Gum, Phenoxyethanol, Sorbic Acid, Caprylyl Glycol, Disodium EDTA, Fragrance
Review

Does Replenix Restorative Nighttime Bio-Therapy Work?

 
According to CreamScan's analysis of the ingredient list, here’s what Replenix Restorative Nighttime Bio-Therapy has to offer:
 
✅ Significant moisturizing. It has a moisturizing rating of 6.2 out of 10.

  

Key Benefits of Replenix Restorative Nighttime Bio-Therapy

 
These are the key benefits you can expect from using Replenix Restorative Nighttime Bio-Therapy:
 

🔵 Lightweight Moisturizer Perfect for Combination and Oily Skin

According to CreamScan analysis, Replenix Restorative Nighttime Bio-Therapy is highly moisturizing, with a moisturizing rating of 6.2 out of 10.

Is it more humectant or occlusive? Significantly more humectant. It has a low occlusivity of 2.3 out of 10 and a maximum humectancy of 10 out of 10, primarily due to the high content of Sodium PCA (est. ≈6.0%) and Glycerin (est. ≈4.0%).

This type of moisturizer is ideal for people with combination and oily skin who want maximum hydration in a relatively lightweight, non-greasy formula. It combines a significant amount of humectants with a limited amount of occlusive ingredients to boost moisturizing efficacy without feeling too heavy.

This product may also be a good choice for people with normal skin who prefer fast-absorbing textures, as it balances significant moisturizing potential with a relatively lightweight texture.

💧 A Humectant Boost for Any Skincare Routine

But it’s not limited to combination and oily skin - such a humectant boost will also positively contribute to the moisturizing efficacy of any skincare routine when used as a step before applying the main moisturizer. This type of formulation is typically used in serums, where a light, fast-absorbing texture is key.

Please refer to the Ratings section below for details of the moisturizing rating calculation.

📌 Please note that this is not a complete list of benefits. We are in the process of enhancing our model to incorporate anti-pigmentation, exfoliation and anti-acne ratings.

Things to Be Aware Of: Replenix Restorative Nighttime Bio-Therapy

 
CreamScan identified a few things to consider before adding Replenix Restorative Nighttime Bio-Therapy to your skincare routine:
 

⚠️ Questionable anti-wrinkle efficacy

If one of your main reasons for choosing Replenix Restorative Nighttime Bio-Therapy is its potential anti-aging effects, please note that, according to CreamScan analysis, it currently has a zero anti-wrinkle rating.

It contains some ingredients often marketed as effective in reducing wrinkles, specifically Malus Domestica Fruit Cell Culture Extract, Tetrapeptide-21, and Caffeine. However, the studies supporting the anti-wrinkle claims of these ingredients provide insufficient evidence of efficacy according to CreamScan Research Evaluation Standards. 

While this does not categorically rule out the possibility that these ingredients may reduce wrinkles, their efficacy is not supported by convincing, vehicle-controlled, double-blind clinical studies - at least none that were available to the CreamScan team at the time of publication.

Therefore, these ingredients do not generate the anti-wrinkle rating.

📌 Moisturizers, when used regularly, are proven to prevent wrinkle formation and even reduce existing wrinkles. Therefore, this product, like any other moisturizer, can deliver some anti-wrinkle effects through its moisturizing action.

Please refer to the Ratings section below for details of the anti-wrinkle rating calculation.

Pros & Cons of Replenix Restorative Nighttime Bio-Therapy

 
Here’s an overview of the pros and cons of Replenix Restorative Nighttime Bio-Therapy to help you decide if it’s the right choice for your skincare routine:
 

🟩 Pros:

✅ When used alone: Provides humectant-rich moisturizing perfect for combination and oily skin
✅ Also a good choice for people with normal skin who prefer fast-absorbing textures
✅ As part of a routine: A humectant moisturizing boost, beneficial for any skin type
✅ Lightweight texture
 

⭕ Cons: 

⚠️ Questionable anti-wrinkle efficacy
   

Summary: Replenix Restorative Nighttime Bio-Therapy

 
Based on the ingredient list analysis, CreamScan AI suggests that Replenix Restorative Nighttime Bio-Therapy
, when used alone, delivers lightweight, humectant-rich moisturizing, perfect for combination and oily skin. It's also a great option for those with normal skin who prefer fast-absorbing textures. As part of a moisturizing routine, it provides a humectant boost, beneficial for all skin types.
 
That said, there are some things about Replenix Restorative Nighttime Bio-Therapy worth noting.
 
If one of your main reasons for considering Replenix Restorative Nighttime Bio-Therapy is its potential anti-aging effects, please note that, according to CreamScan analysis, its anti-wrinkle efficacy is questionable. None of the ingredients in this product provide substantial evidence of their anti-wrinkle efficacy according to CreamScan Research Evaluation Standards.
 
📌 Fact check. At CreamScan, we are committed to accuracy and fairness. If you spot any errors or something that doesn’t seem right, please click here to let us know. We regularly update the ingredient lists and monitor the latest research on ingredient efficacy to ensure that our information remains as complete and precise as possible. The information provided here is for informational purposes only and does not substitute professional advice. We do not guarantee the efficacy or safety of any product, as individual results may vary.

 

Ingredient Breakdown

Est. % Ingredient Origin Functions
60
9
6
4
3
2.5
2
1.5
1.3
1
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Est. %
Water
Function:
Origin:
Cyclopentasiloxane
Function:
Origin:
Sodium PCA
Function:
Origin:
Glycerin
Function:
Origin:
Caprylic/Capric Triglyceride
Function:
Origin:
Polysorbate 60
Function:
Origin:
Cetearyl Alcohol
Function:
Origin:
Yucca Glauca Root Extract
Function:
Origin:
Dimethicone
Function:
Origin:
Cetearyl Glucoside
Function:
Origin:
Polyacrylamide
Function:
Origin:
C13-14 Isoparaffin
Function:
Origin:
Laureth-7
Function:
Origin:
Ceramide NP
Function:
Origin:
Ceramide AP
Function:
Origin:
Ceramide EOP
Function:
Origin:
Sodium Hyaluronate
Function:
Origin:
Phytosphingosine
Function:
Origin:
Cholesterol
Function:
Origin:
Sodium Lauroyl Lactylate
Function:
Origin:
Camellia Sinensis Polyphenols
Function:
Origin:
Malus Domestica Fruit Cell Culture Extract
Function:
Origin:
Squalane
Function:
Origin:
Ceramide NS
Function:
Origin:
Tetrapeptide-21
Function:
Origin:
Resveratrol
Function:
Origin:
Bisabolol
Function:
Origin:
Caffeine
Function:
Origin:
Lecithin
Function:
Origin:
Glyceryl Stearate
Function:
Origin:
PEG-100 Stearate
Function:
Origin:
Dimethicone Crosspolymer
Function:
Origin:
Carbomer
Function:
Origin:
Xanthan Gum
Function:
Origin:
Phenoxyethanol
Function:
Origin:
Sorbic Acid
Function:
Origin:
Caprylyl Glycol
Function:
Origin:
Disodium EDTA
Function:
Origin:
Fragrance
Function:
Origin:

Ratings

All humectants
10.9
6
4
0.3
0.3
0.3
Benchmark
10
All occlusives
4.6
3.0
1.3
0.3
Benchmark
20
Moisturizing rating
6.2
Ingredient Est. % Benchmark Raiting
Humectancy All humectants 10.9 10
10.0
6
4
0.3
0.3
0.3
Occlusivity All occlusives 4.6 20
2.3
3.0
1.3
0.3
Moisturizing rating
6.2
Ingredient Est. % Benchmark Humectancy
6
4
0.3
0.3
0.3
All humectants 10.9 10
10
All humectants
10.9
6
4
0.3
0.3
0.3
Benchmark
10
Ingredient Est. % Benchmark Occlusivity
3
1.3
0.3
All occlusives 4.6 20
2.3
All occlusives
4.6
3.0
1.3
0.3
Benchmark
20
Ingredient
Ingredient anti-wrinkle power
when present at, %
in this formula est. %
Rating
n/a
- 0.3 -
n/a
- 0.3 -
n/a
- 0.3 -
Total
0
Malus Domestica Fruit Cell Culture Extract
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Tetrapeptide-21
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Caffeine
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Anti-wrinkle rating
0
Ingredient Est. % Benchmark
Rich in Antioxidants
0.3
0.3
0.3
0.3
0.3
All antioxidants 1.5 3 No
All antioxidants
1.5
Sodium Hyaluronate
0.3
Camellia Sinensis Polyphenols
0.3
Malus Domestica Fruit Cell Culture Extract
0.3
Resveratrol
0.3
Caffeine
0.3
Benchmark
3
Ingredient Est. % Benchmark
Rich in Soothing
0.3
0.3
All soothing 0.6 5 No
All soothing
0.6
0.3
0.3
Benchmark
5

Ingredients explained

Water
Est. %60
Function
Origin
WaterThe most used ingredient in skincare. Its concentration defines the product texture: rich creams may have about 50% of water while a light jelly about 90%. Water doesn’t moisturize the skin by itself and is used in skincare as a solvent for other ingredients.
Cyclopentasiloxane
Est. %9
Function
Origin
CyclopentasiloxaneA lightweight, fast-spreading emollient that leaves a very soft and silky after-feel on the skin. Supplied as a clear and colorless liquid, cyclopentasiloxane is often used as a solvent to dissolve other silicones in.
Sodium PCA
Est. %6
Function
Origin
Sodium PCAOne of the most important parts of the skin's Natural Moisturizing Factor, a mixture of various compounds that keeps the skin’s surface well hydrated. Sodium PCA is used in skincare for its fantastic humectant properties.
Glycerin
Est. %4
Function
Origin
Glycerin

The most popular moisturizing ingredient in the world. It is a powerful humectant – cheap yet very effective.

Caprylic/Capric Triglyceride
Est. %3
Function
Origin
Caprylic/Capric TriglycerideA natural occlusive moisturizing and emollient ingredient, it is a blend of glycerin and two fatty acids, caprylic and capric acid. It creates an oil-based protective layer on the skin, thereby preventing water loss.
Polysorbate 60
Est. %2.5
Function
Origin
Polysorbate 60An ester based on sorbitan. It is good for emulsifying water and oils together – specifically making oil-in-water emulsions. Polysorbate 60 is also said to give a product a notable fragrance.
Cetearyl Alcohol
Est. %2
Function
Origin
Cetearyl AlcoholA blend of cetyl alcohol and stearyl alcohol, the fatty alcohols that are derived from palm oil. It helps to create emulsions that give off a soft and silky emollient feel and also increase product thickness.
Yucca Glauca Root Extract
Est. %1.5
Function
Origin
Yucca Glauca Root Extract
Dimethicone
Est. %1.3
Function
Origin
DimethiconeThe most common silicone in skincare. It forms a silky, smooth film on the skin’s surface and can help to prevent water loss. It also aids in wound healing and can treat and soften scars. Dimethicone is considered to be very safe for use.
Cetearyl Glucoside
Est. %1
Function
Origin
Cetearyl GlucosideAn emulsifier that creates stable mixtures of oil in water that feel soft and spread easily. Cetearyl glucoside is sold with cetearyl alcohol as an emulsifier blend and also provides some body to the formula.
Polyacrylamide
Est. %0.3
Function
Origin
PolyacrylamideA synthetic ingredient that can thicken products instantly while still keeping them light and often gel-like.
C13-14 Isoparaffin
Est. %0.3
Function
Origin
C13-14 IsoparaffinA lightweight petroleum derivative. It is a very thin liquid that functions as an emollient and a solvent for other liquids (such as thicker oils or silicones).
Laureth-7
Est. %0.3
Function
Origin
Laureth-7A mild but effective functional ingredient. It can emulsify (efficiently mix water and oil) without needing too much in a formula.
Ceramide NP
Est. %0.3
Function
Origin
Ceramide NPAlso known as ceramide 3, it is the most common ceramide in our skin. It helps to restore the skin’s lipid barrier and alleviate the symptoms of dry and cracked skin. Research has shown that skin suffering from conditions such as AD lacks ceramides.
Ceramide AP
Est. %0.3
Function
Origin
Ceramide APPreviously called Ceramide 6 II, Ceramide AP is one of the most common ceramides in the skin. Research has shown that dry, flaky skin has significantly less Ceramide AP. Its application helps to treat dry skin by restoring balance in the skin lipids.
Ceramide EOP
Est. %0.3
Function
Origin
Ceramide EOP

Formerly called Ceramide 1, this ingredient is a skin-identical wax-like lipid with an ultra-long fatty acid chain. It restores and stabilizes the skin’s lipid matrix and helps to treat dry and flaky skin, especially when combined with other ceramides.

Sodium Hyaluronate
Est. %0.3
Function
Origin
Sodium Hyaluronate

A sodium salt of famous hyaluronic acid. A potent humectant that hydrates the skin, supports collagen function, and fills out small wrinkles. Sodium hyaluronate also offers soothing and antioxidant properties.

Phytosphingosine
Est. %0.3
Function
Origin
PhytosphingosineA key component of ceramides NP, AP, and EOP. It has barrier repair properties and stimulates the production of the skin’s Natural Moisturizing Factor. Phytosphingosine has strong antimicrobial and anti-inflammatory activity, which can be used to treat acne.
Cholesterol
Est. %0.3
Function
Origin
CholesterolAn emollient and important barrier repairing lipid, effective when combined with fatty acids and ceramides. Around 25% of the skin’s lipid layer is made up of cholesterol and it is found in the membrane of every single cell in our body.
Sodium Lauroyl Lactylate
Est. %0.3
Function
Origin
Sodium Lauroyl LactylateA multifunctional ingredient that produces foamy cleansers and allows oil and water to mix.
Camellia Sinensis Polyphenols
Est. %0.3
Function
Origin
Camellia Sinensis Polyphenols
Malus Domestica Fruit Cell Culture Extract
Est. %0.3
Function
Origin
Malus Domestica Fruit Cell Culture ExtractAn extract that comes from a certain apple cultivar. It is claimed to have superior properties over any other apple extracts and the patent holder claims that it has anti-wrinkle activity.
Squalane
Est. %0.3
Function
Origin
SqualaneAn occlusive moisturizing and emollient compound that forms part of the skin’s sebum. The main source of squalane had always been shark liver. Now, however, it is manufactured synthetically or derived from plant oils, such as olive and peanut oil.
Ceramide NS
Est. %0.3
Function
Origin
Ceramide NSA wax-like lipid natural to the skin’s lipid matrix. It is less frequently used but, in combination with other ceramides, can help to restore balance in the skin’s lipid barrier.
Tetrapeptide-21
Est. %0.3
Function
Origin
Tetrapeptide-21

A synthetically made peptide (similar to skin proteins) designed to increase the synthesis of collagen, HA, and fibronectin. It has been clinically proven to improve skin quality and elasticity, as well as the appearance of wrinkles.

Resveratrol
Est. %0.3
Function
Origin
ResveratrolA famous plant-based polyphenol found mainly in red grapes. It is a potent antioxidant, soothing, and wound healing ingredient.
Bisabolol
Est. %0.3
Function
Origin
Bisabolol

An anti-inflammatory compound found naturally in German chamomile essential oil. It has a pleasant, sweet, and floral scent. Bisabolol also has soothing and anti-inflammatory properties but can cause an allergic reaction in more sensitive individuals.

Caffeine
Est. %0.3
Function
Origin
CaffeineAn antioxidant compound that is obtained from coffee and tea leaves. It increases the microcirculation of blood in the skin and is claimed to be able to reduce the appearance of orange peel skin (although the research is lacking).
Lecithin
Est. %0.3
Function
Origin
LecithinA humectant, emollient, and emulsifier best suited for water-in-oil emulsions. Lecithin can come from sunflowers, soy, and eggs. The downside to lecithin is that it causes an extra burden on the formula’s preservative because it is nutritious.
Glyceryl Stearate
Est. %0.3
Function
Origin
Glyceryl StearateAn emollient and emulsifier typically derived from vegetable sources through a chemical reaction with glycerin. It provides stability, texture, and consistency to formulations. Its main function is to allow oil and water to mix.
PEG-100 Stearate
Est. %0.3
Function
Origin
PEG-100 StearateThis surfactant is more specifically classified as an emulsifier that produces oil-in-water emulsions. PEG-100 stearate can also be used as a cleansing agent.
Dimethicone Crosspolymer
Est. %0.3
Function
Origin
Dimethicone CrosspolymerA group of ingredients that are typically added to skincare products to adjust the formula. Dimethicone Crosspolymers stabilize a formula, regulate its thickness and consistency and give the product a velvety feel.
Carbomer
Est. %0.3
Function
Origin
CarbomerA synthetic ingredient with the ability to gel water. When used in emulsions, such as lotions and creams, carbomer can also act as an emulsion stabilizer.
Xanthan Gum
Est. %0.3
Function
Origin
Xanthan GumA natural multi-functional ingredient that originates from fermented sugars. Xanthan gum acts as a viscosity-building agent to thicken skincare products. It is also an excellent stabilizer and works well to hold other ingredients together.
Phenoxyethanol
Est. %0.3
Function
Origin
PhenoxyethanolThe most frequently used preservative in skincare. It is a clear, oil-like liquid synthetic substance that protects products from harmful bacteria and yeast, whilst still leaving skin microflora unharmed. It is confirmed by research to be harmless.
Sorbic Acid
Est. %0.3
Function
Origin
Sorbic AcidAn organic acid that can be naturally found in the berries of the Mountain ash, although it is manufactured synthetically for skincare purposes. It is used as a preservative and antimicrobial agent, protecting a skincare product from spoiling.
Caprylyl Glycol
Est. %0.3
Function
Origin
Caprylyl GlycolAn emollient that improves product spreadability and offers a silky feel on the skin. It also acts as a preservative booster that improves the efficacy of other preservatives. According to the manufacturer, it is also a humectant moisturizer.
Disodium EDTA
Est. %0.3
Function
Origin
Disodium EDTAA synthetic chelator that helps to maintain the look and smell of a product by 'locking up' troublesome metal ions.
Fragrance
Est. %0.3
Function
Origin
FragranceUnder trade secret law, manufacturers have the right not to disclose what exactly went into the fragrance and use the unspecific word Fragrance or Parfum instead. Many fragrances are highly allergenic.