Physicians Formula 24-Karat Gold Collagen Serum Review

Physicians Formula 24-Karat Gold Collagen Serum
5.0
/ 10
Moisturizing
10.0 Humectancy icon Humectancy
0.0 Occlusivity icon Occlusivity
6Anti-wrinkle icon/ 10
Anti-wrinkle
Rich
in Antioxidants
Ingredients

Physicians Formula 24-Karat Gold Collagen Serum Ingredients

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Full Ingredient List (INCI):

Water, Glycerin, Niacinamide, Propanediol, Collagen, Gold (CI 77480), Caesalpinia Spinosa Fruit Extract, Kappaphycus Alvarezii Extract, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Butylene Glycol, Hydroxyethylcellulose, Carbomer, Disodium EDTA, Ethylhexylglycerin, Hexylene Glycol, Agar, Calcium Alginate, Gellan Gum, 1,2-Hexanediol, Sodium Hydroxide, Sodium Lactate, Polysorbate 20, Phenoxyethanol, Caprylyl Glycol, Leuconostoc/Radish Root Ferment Filtrate, Iron Oxides (CI 77491), Mica, Titanium Dioxide (CI 77891)
Review

Does Physicians Formula 24-Karat Gold Collagen Serum Work?

 
According to CreamScan's analysis of the ingredient list, here’s what Physicians Formula 24-Karat Gold Collagen Serum has to offer:
 
✅ Strong humectant moisturizing. This lightweight, humectant-rich product, ideal for oily skin, has a moisturizing rating of 5.0 out of 10.
✅ Significant anti-wrinkle efficacy. With an anti-wrinkle rating of 6.0 out of 10, Physicians Formula 24-Karat Gold Collagen Serum is effective in minimizing wrinkles.
✅ Antioxidant protection

  

Key Benefits of Physicians Formula 24-Karat Gold Collagen Serum

 
These are the key benefits you can expect from using Physicians Formula 24-Karat Gold Collagen Serum:
 

🔵 Lightweight Purely Humectant Moisturizing, Ideal for Oily Skin

According to CreamScan analysis, Physicians Formula 24-Karat Gold Collagen Serum is quite moisturizing, with a moisturizing rating of 5.0 out of 10.

Is it more humectant or occlusive? It is purely humectant. It has zero occlusivity (we didn't find any occlusive ingredients on the ingredient list) and a maximum humectancy of 10 out of 10, primarily due to the high content of Glycerin (est. ≈6.0%), Niacinamide (est. ≈4.0%) and Propanediol (est. ≈3.0%).

This humectant-rich product, when used alone as a moisturizer, is ideal for oily skin, providing significant hydration in a lightweight, fast-absorbing formula without any occlusive ingredients.

📌 Certain studies suggest that humectants alone may not effectively moisturize the skin. If you use this product as your only moisturizer, we recommend following it with one that contains at least some occlusive ingredients.

💧 A Humectant Boost for Any Skincare Routine

But it’s not limited to oily skin - such a humectant boost will also positively contribute to the moisturizing efficacy of any skincare routine when used as a step before applying the main moisturizer. This type of formulation is typically used in serums, where a light, fast-absorbing texture is key.

Please refer to the Ratings section below for details of the moisturizing rating calculation.

🟣🟣 Significant Anti-Wrinkle Efficacy

According to CreamScan analysis, Physicians Formula 24-Karat Gold Collagen Serum has a high anti-wrinkle rating of 6.0 out of 10.

It contains one ingredient with proven anti-wrinkle efficacy: Niacinamide (est. ≈4.0%),
 one of the most effective and well-researched anti-wrinkle ingredients. A clinical study involving 30 participants (Kawada et al.) confirmed that a cream with 4% niacinamide reduced the average depth of wrinkles around the eyes by 9% after 8 weeks of use, compared to a vehicle (the same formulation without niacinamide).
 
Among others, Physicians Formula 24-Karat Gold Collagen Serum also contains contains Palmitoyl Tripeptide-1 and Palmitoyl Tetrapeptide-7, two ingredients often marketed as effective in reducing wrinkles. However, the studies supporting the anti-wrinkle claims of these ingredients provide insufficient evidence of efficacy according to CreamScan Research Evaluation Standards.
 
While this does not categorically rule out the possibility that these ingredients may reduce wrinkles, their efficacy is not supported by convincing, vehicle-controlled, double-blind clinical studies - at least none that were available to the CreamScan team at the time of publication.
 
Therefore, these ingredients do not contribute to the anti-wrinkle rating.
 

Please refer to the Ratings section below for details of the anti-wrinkle rating calculation.

🍀 Rich in Skin-Protecting Antioxidants

We estimate that Physicians Formula 24-Karat Gold Collagen Serum is rich (> 3%) in antioxidants, specifically Niacinamide (est. ≈4.0%).

A key benefit of antioxidants is their ability to reduce oxidative stress caused by free radicals and therefore prevent accelerated skin aging. Studies also show that antioxidants can protect against environmental damage such as UV radiation and pollution, and help reduce inflammation and skin redness.

📌 Please note that this is not a complete list of benefits. We are in the process of enhancing our model to incorporate anti-pigmentation, exfoliation and anti-acne ratings.

Things to Be Aware Of: Physicians Formula 24-Karat Gold Collagen Serum

 
CreamScan identified a few things to consider before adding Physicians Formula 24-Karat Gold Collagen Serum to your skincare routine:
 

⚠️ If It’s Your Only Moisturizer, It Needs to Be Paired with Some Occlusives

While humectants are highly effective at attracting water to the skin, studies (J. N. Kraft, C. W. Lynde) suggest they may not be efficient when used alone.

One major drawback of purely humectant moisturization is that the water attracted by humectants to the upper layers of the skin can evaporate completely into the environment through transepidermal water loss (TEWL). Adding occlusive ingredients helps seal this moisture into the skin and prevent further water loss.

If you’re using Physicians Formula 24-Karat Gold Collagen Serum as your only moisturizer, consider pairing it with one that contains at least some occlusive ingredients, such as oils, butters, or silicones. These work alongside humectants to create a protective barrier, locking in hydration and ensuring longer-lasting moisturization. The amount of occlusive needed depends on your skin type - the drier the skin, the more occlusives it requires.

If this product is used not as a standalone moisturizer but as part of your skincare routine, such as a toner or serum, it should be applied before your main moisturizer (unless it's a sunscreen), which will provide the necessary occlusivity on top of it.

Pros & Cons of Physicians Formula 24-Karat Gold Collagen Serum

 
Here’s an overview of the pros and cons of Physicians Formula 24-Karat Gold Collagen Serum to help you decide if it’s the right choice for your skincare routine:
 

🟩 Pros:

✅ When used alone: Provides humectant-rich moisturizing ideal for oily skin
✅ As part of a routine: A humectant moisturizing boost, beneficial for any skin type
✅ Lightweight texture
Delivers signficant anti-wrinkle efficacy thanks to Niacinamide
✅ Rich in antioxidants that combat oxidative stress associated with accelerated skin aging and defend against environmental damage
 

⭕ Cons: 

⚠️ Only if used as a standalone moisturizer - it needs to be paired with occlusives to seal in humectants
   

Summary: Physicians Formula 24-Karat Gold Collagen Serum

 
Based on the ingredient list analysis, CreamScan AI suggests that Physicians Formula 24-Karat Gold Collagen Serum
 is specifically effective in treating wrinkles, containing ingredients with solid, robust evidence of anti-wrinkle efficacy.
 

When used alone, it delivers lightweight, humectant-rich moisturizing, making it ideal for oily skin. As part of a moisturizing routine, it provides a humectant boost, beneficial for all skin types.

With its high antioxidant content, Physicians Formula 24-Karat Gold Collagen Serum helps protect against free radical damage and offers multiple benefits for all skin types, including preventing premature aging, defending against environmental damage, and calming inflammation.
 
That said, there are some things about Physicians Formula 24-Karat Gold Collagen Serum worth noting.
 
Looking at its moisturizing profile, we found that it doesn’t contain any occlusive ingredients, potentially allowing the moisture attracted to the skin by humectants to evaporate. Therefore, if it’s used as the only moisturizer in a routine, it’s recommended to pair it with one that contains at least some occlusive ingredients, such as oils, butters, or silicones.
 
📌 Fact check. At CreamScan, we are committed to accuracy and fairness. If you spot any errors or something that doesn’t seem right, please click here to let us know. We regularly update the ingredient lists and monitor the latest research on ingredient efficacy to ensure that our information remains as complete and precise as possible. The information provided here is for informational purposes only and does not substitute professional advice. We do not guarantee the efficacy or safety of any product, as individual results may vary.

 

Ingredient Breakdown

Est. % Ingredient Origin Functions
75
6
4
3
2
1.5
1.3
1
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Est. %
Water
Function:
Origin:
Glycerin
Function:
Origin:
Niacinamide
Function:
Origin:
Propanediol
Function:
Origin:
Collagen
Function:
Origin:
Gold (CI 77480)
Function:
Origin:
Caesalpinia Spinosa Fruit Extract
Function:
Origin:
Kappaphycus Alvarezii Extract
Function:
Origin:
Palmitoyl Tripeptide-1
Function:
Origin:
Palmitoyl Tetrapeptide-7
Function:
Origin:
Butylene Glycol
Function:
Origin:
Hydroxyethylcellulose
Function:
Origin:
Carbomer
Function:
Origin:
Disodium EDTA
Function:
Origin:
Ethylhexylglycerin
Function:
Origin:
Hexylene Glycol
Function:
Origin:
Agar
Function:
Origin:
Calcium Alginate
Function:
Origin:
Gellan Gum
Function:
Origin:
1,2-Hexanediol
Function:
Origin:
Sodium Hydroxide
Function:
Origin:
Sodium Lactate
Function:
Origin:
Polysorbate 20
Function:
Origin:
Phenoxyethanol
Function:
Origin:
Caprylyl Glycol
Function:
Origin:
Leuconostoc/Radish Root Ferment Filtrate
Function:
Origin:
Iron Oxides (CI 77491)
Function:
Origin:
Mica
Function:
Origin:
Titanium Dioxide (CI 77891)
Function:
Origin:

Ratings

All humectants
17.2
6
4
3
2
1
0.3
0.3
0.3
0.3
Benchmark
10
All occlusives
0.0
None
Benchmark
20
Moisturizing rating
5.0
Ingredient Est. % Benchmark Raiting
Humectancy All humectants 17.2 10
10.0
6
4
3
2
1
0.3
0.3
0.3
0.3
Occlusivity All occlusives 0.0 20
0.0
None
Moisturizing rating
5.0
Ingredient Est. % Benchmark Humectancy
6
4
3
2
1
0.3
0.3
0.3
0.3
All humectants 17.2 10
10
All humectants
17.2
6
4
3
2
1
0.3
0.3
0.3
0.3
Benchmark
10
Ingredient Est. % Benchmark Occlusivity
None
All occlusives 0.0 20
0.0
All occlusives
0.0
None
Benchmark
20
Ingredient
Ingredient anti-wrinkle power
when present at, %
in this formula est. %
Rating
6 /10 4 4 6
n/a
- 0.3 -
n/a
- 0.3 -
Total
6
Niacinamide
6
Ingredient anti-wrinkle power
6 /10
when present at, %
4
in this formula, est. %
4
Palmitoyl Tripeptide-1
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Palmitoyl Tetrapeptide-7
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Anti-wrinkle rating
6
Ingredient Est. % Benchmark
Rich in Antioxidants
4
1.3
1
All antioxidants 6.3 3 Rich in antioxidants
All antioxidants
6.3
Niacinamide
4
Caesalpinia Spinosa Fruit Extract
1.3
Kappaphycus Alvarezii Extract
1
Benchmark
3
Ingredient Est. % Benchmark
Rich in Soothing
4
All soothing 4 5 No
All soothing
4
4
Benchmark
5

Ingredients explained

Water
Est. %75
Function
Origin
WaterThe most used ingredient in skincare. Its concentration defines the product texture: rich creams may have about 50% of water while a light jelly about 90%. Water doesn’t moisturize the skin by itself and is used in skincare as a solvent for other ingredients.
Glycerin
Est. %6
Function
Origin
Glycerin

The most popular moisturizing ingredient in the world. It is a powerful humectant – cheap yet very effective.

Niacinamide
Est. %4
Function
Origin
Niacinamide

Also known as vitamin B3, this ingredient is a true superstar with confirmed moisturizing, anti-acne, hyperpigmentation, and antioxidant benefits. Two studies confirm its significant anti-wrinkle efficacy.

Propanediol
Est. %3
Function
Origin
PropanediolAn excellent solvent capable of mixing water with normally water-insoluble ingredients. It also functions as a humectant due to its water-loving alcohol groups. Propanediol can control the viscosity of a product by reducing its thickness.
Collagen
Est. %2
Function
Origin
CollagenA protein that builds all human tissues, especially skin and joints. It is used as a moisturizing humectant ingredient in skincare.
Gold (CI 77480)
Est. %1.5
Function
Origin
Gold (CI 77480)

A colorant used in skincare, typically processed into fine particles for uniform dispersion. Its luxurious hue enhances product aesthetics, while its role as a slip and surface modifier improves texture and application. Despite touted anti-aging benefits, definitive scientific evidence is lacking.

Caesalpinia Spinosa Fruit Extract
Est. %1.3
Function
Origin
Caesalpinia Spinosa Fruit ExtractA powerful astringent ingredient extracted from Tara seed pods. It also has antioxidant benefits.
Kappaphycus Alvarezii Extract
Est. %1
Function
Origin
Kappaphycus Alvarezii ExtractAn emollient extract obtained from the red marine algae called elkhorn sea moss. It is a good source of moisturizing and antioxidant carrageenan, a seaweed polysaccharide.
Palmitoyl Tripeptide-1
Est. %0.3
Function
Origin
Palmitoyl Tripeptide-1

A small peptide consisting of three amino acids with anti-wrinkle effects. Together with Palmitoyl Tetrapeptide-7, it is a part of the popular anti-wrinkle complex called Matrixyl™ 3000.

Palmitoyl Tetrapeptide-7
Est. %0.3
Function
Origin
Palmitoyl Tetrapeptide-7

A synthetic peptide that mimics the activity of immunoglobulin G and signals to the skin to stop the inflammation. It has been shown in studies to reduce wrinkles and enhance collagen content.

Butylene Glycol
Est. %0.3
Function
Origin
Butylene Glycol

A clear, colorless liquid humectant that draws moisture to the skin. The humectancy of butylene glycol, owed to its two hydroxyl groups, is quite considerable, although not as powerful as glycerin, which contains three hydroxyl groups.

Hydroxyethylcellulose
Est. %0.3
Function
Origin
HydroxyethylcelluloseA naturally-derived thickener that can form clear gel textures without the slimy feeling, unlike some other natural gel-formers.
Carbomer
Est. %0.3
Function
Origin
CarbomerA synthetic ingredient with the ability to gel water. When used in emulsions, such as lotions and creams, carbomer can also act as an emulsion stabilizer.
Disodium EDTA
Est. %0.3
Function
Origin
Disodium EDTAA synthetic chelator that helps to maintain the look and smell of a product by 'locking up' troublesome metal ions.
Ethylhexylglycerin
Est. %0.3
Function
Origin
EthylhexylglycerinA preservative booster derived from glycerin. It is commonly paired with other preservatives to improve their efficacy. Ethylhexylglycerin is also a humectant due to its chemical base of glycerin.
Hexylene Glycol
Est. %0.3
Function
Origin
Hexylene GlycolA multifunctional ingredient that is best known for its use as a solvent. It can dissolve both water-based ingredients and oils. For this reason, it can also function as an emulsifier, allowing oil and water ingredients to mix and remain stable.
Agar
Est. %0.3
Function
Origin
AgarA multifunctional jelly derived from red algae that can thicken water-based products.
Calcium Alginate
Est. %0.3
Function
Origin
Calcium Alginate
Gellan Gum
Est. %0.3
Function
Origin
Gellan GumA polysaccharide gel created by a species of bacteria called Sphingomonas elodea. It is used to either create soft, viscous, elastic gels or hard, brittle gels.
1,2-Hexanediol
Est. %0.3
Function
Origin
1,2-HexanediolA multi-functional formula helper. It is a well-studied preservtive against bacteria and can help pigments and fragrances disperse evenly in a formula.
Sodium Hydroxide
Est. %0.3
Function
Origin
Sodium Hydroxide

An ingredient that is able to bring the pH of a product up, thereby making it less harsh on the skin.

Sodium Lactate
Est. %0.3
Function
Origin
Sodium LactateA sodium salt of lactic acid. Its main function is as a humectant but it can also serve as a pH adjuster. Additionally, sodium lactate can also be used as a chemical exfoliant due to its close chemical relation to lactic acid.
Polysorbate 20
Est. %0.3
Function
Origin
Polysorbate 20A viscous, amber-colored liquid that functions as a solubilizer to disperse small amounts of oil into a large water phase. Polysorbate 20 is frequently used to solubilize fragrance oils into water-based emulsions.
Phenoxyethanol
Est. %0.3
Function
Origin
PhenoxyethanolThe most frequently used preservative in skincare. It is a clear, oil-like liquid synthetic substance that protects products from harmful bacteria and yeast, whilst still leaving skin microflora unharmed. It is confirmed by research to be harmless.
Caprylyl Glycol
Est. %0.3
Function
Origin
Caprylyl GlycolAn emollient that improves product spreadability and offers a silky feel on the skin. It also acts as a preservative booster that improves the efficacy of other preservatives. According to the manufacturer, it is also a humectant moisturizer.
Leuconostoc/Radish Root Ferment Filtrate
Est. %0.3
Function
Origin
Leuconostoc/Radish Root Ferment FiltrateA biotechnological fermentation ingredient that is created by feeding radish root to Leuconostoc kimchii. It allegedly contains organic acids and a mixture of peptides known as bacteriocins – which have antimicrobial activity.
Iron Oxides (CI 77491)
Est. %0.3
Function
Origin
Iron Oxides (CI 77491)A red colorant also known as red iron oxide. This is an EU-approved colorant used in a wide variety of products.
Mica
Est. %0.3
Function
Origin
MicaA mineral powder made up of silicates with several functions (the main one being as a colorant). It has a shimmery appearance, making it highly desirable in certain cosmetic products. Mica also helps the product to apply more smoothly.
Titanium Dioxide (CI 77891)
Est. %0.3
Function
Origin
Titanium Dioxide (CI 77891)One of two the most commonly used mineral sunscreens. It can absorb UV light, including UVB – which causes burning, tanning, and even skin cancer. Also used as a colorant, titanium dioxide gives a product a bright white color.