Perricone MD Hypoallergenic Nourishing Moisturizer Review

Perricone MD Hypoallergenic Nourishing Moisturizer
7.0
/ 10
Moisturizing
5.5 Humectancy icon Humectancy
8.4 Occlusivity icon Occlusivity
0.4Anti-wrinkle icon/ 10
Anti-wrinkle
Review

Does Perricone MD Hypoallergenic Nourishing Moisturizer Work?

 
According to CreamScan AI's analysis of the ingredient list, here’s what Perricone MD Hypoallergenic Nourishing Moisturizer has to offer:
 
  • Significant moisturizing. It has a moisturizing rating of 7.0 out of 10.
  • Slight anti-wrinkle effect: Perricone MD Hypoallergenic Nourishing Moisturizer has an anti-wrinkle rating of 0.4 out of 10, so you may expect a positive, although insignificant, effect on wrinkles.

Key Benefits of Perricone MD Hypoallergenic Nourishing Moisturizer

 
These are the key benefits you can expect from using Perricone MD Hypoallergenic Nourishing Moisturizer:
 

Rich Moisturizer with the Right Occlusivity for Dry Skin

According to CreamScan analysis, Perricone MD Hypoallergenic Nourishing Moisturizer is highly moisturizing, with a moisturizing rating of 7.0 out of 10.

Is it more humectant or occlusive? Significantly more occlusive. It has a moderate humectancy of 5.5 out of 10, primarily due to the substantial concentration of Glycerin (est. ≈4.0%), and a very high occlusivity of 8.4 out of 10, mainly due to the significant content of Caprylic/Capric Triglyceride (est. ≈9.0%) and Dimethicone (est. ≈3.0%).

This type of product, when used as a standalone moisturizer, can deliver a substantial level of occlusive hydration that is adequate for dry skin. The occlusive profile of Perricone MD Hypoallergenic Nourishing Moisturizer suggests a rich, thick texture, making it perfectly suited for dry skin.

Please refer to the Ratings section below for details of the moisturizing rating calculation.

Slight Anti-Wrinkle Efficacy

According to CreamScan analysis, Perricone MD Hypoallergenic Nourishing Moisturizer has a slight anti-wrinkle rating of 0.4 out of 10.

It contains one ingredient with proven anti-wrinkle efficacy: Ectoin (est. ≈0.3%), 
 an amino acid-derived ingredient with moderate but proven anti-wrinkle efficacy.  A single clinical study involving 104 participants (Heinrich et al.) confirmed that a cream containing 2% ectoin reduced the average wrinkle width by 7% after 4 weeks of use, compared to the same formulation without ectoin (vehicle).
 
Among others, Perricone MD Hypoallergenic Nourishing Moisturizer also contains contains Palmitoyl Hexapeptide-12 and Olea Europaea (Olive) Leaf Extract, two ingredients often marketed as effective in reducing wrinkles. However, the studies supporting the anti-wrinkle claims of these ingredients provide insufficient evidence of efficacy according to CreamScan Research Evaluation Standards. Therefore, these ingredients do not contribute to the anti-wrinkle rating.
 
Moisturizers, when used regularly, are proven to prevent wrinkle formation and even reduce existing wrinkles. Therefore, this product, like any other moisturizer, can deliver some anti-wrinkle effects through its moisturizing action.
 

Please refer to the Ratings section below for details of the anti-wrinkle rating calculation.

Please note that this is not a complete list of benefits. We are in the process of enhancing our AI model to incorporate anti-pigmentation, exfoliation and anti-acne ratings.

Things to Be Aware Of: Perricone MD Hypoallergenic Nourishing Moisturizer

 
CreamScan AI identified a few things to consider before adding Perricone MD Hypoallergenic Nourishing Moisturizer to your skincare routine:
 

Best for Dry Skin - May Be Too Thick for Other Skin Types

With high occlusivity, this product is optimal for dry skin but may be too thick for combination and especially oily skin. Even on normal skin, it can feel too rich depending on the quantity applied, the environment, and individual preferences.

If you have oily, combination, or normal skin and are considering purchasing this product for the first time, it might be a good idea to try a sample before buying.

If It’s Your Only Moisturizer, It’s Better When Paired with Some Humectants

An ideal moisturizer for any skin type should balance the right level of occlusivity (depending on skin type) with a significant amount of humectants, while Perricone MD Hypoallergenic Nourishing Moisturizer contains a moderate level of humectants.

People with dry skin would definitely benefit from adding more humectants to their moisturizing routine beyond what this product offers. If this is your only moisturizer, it may be worth including a humectant-rich product, such as a serum, in your skincare routine.

Pros & Cons of Perricone MD Hypoallergenic Nourishing Moisturizer

 
Here’s an overview of the pros and cons of Perricone MD Hypoallergenic Nourishing Moisturizer to help you decide if it’s the right choice for your skincare routine:
 

Pros:

  • Provides the right level of occlusivity to moisturize dry skin
  • Rich texture well-suited for dry skin
  • Provides slight anti-wrinkle efficacy

Cons: 

  • Ideally needs to be paired with extra humectants for optimal moisturizing efficacy

Ingredients

Est. % Ingredient Origin Functions
60
9
6
4
3
2.5
2
1.5
1.3
1
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Est. %
Water
Function:
Origin:
Caprylic/Capric Triglyceride
Function:
Origin:
PEG-8 Dimethicone
Function:
Origin:
Glycerin
Function:
Origin:
Dimethicone
Function:
Origin:
Simmondsia Chinensis (Jojoba) Seed Oil
Function:
Origin:
Cetyl Alcohol
Function:
Origin:
Glyceryl Stearate
Function:
Origin:
C12-15 Alkyl Benzoate
Function:
Origin:
Butyrospermum Parkii (Shea) Butter
Function:
Origin:
Ethoxydiglycol
Function:
Origin:
Squalane
Function:
Origin:
Palmitoyl Hexapeptide-12
Function:
Origin:
Panthenol
Function:
Origin:
Ectoin
Function:
Origin:
Phospholipids
Function:
Origin:
Hydrolyzed Sericin
Function:
Origin:
Allantoin
Function:
Origin:
Xanthan Gum
Function:
Origin:
Olea Europaea (Olive) Leaf Extract
Function:
Origin:
Aloe Barbadensis Leaf Juice
Function:
Origin:
Stearyl Glycyrrhetinate
Function:
Origin:
Ceramide NG
Function:
Origin:
Tocotrienols
Function:
Origin:
Tocopherol
Function:
Origin:
Ammonium Acryloyldimethyltaurate/VP Copolymer
Function:
Origin:
PEG-75 Stearate
Function:
Origin:
Benzyl Alcohol
Function:
Origin:
Tribehenin
Function:
Origin:
Ceteth-20
Function:
Origin:
Steareth-20
Function:
Origin:
Butylene Glycol
Function:
Origin:
PEG-10 Rapeseed Sterol
Function:
Origin:
Elaeis Guineensis (Palm) Oil
Function:
Origin:
Dehydroacetic Acid
Function:
Origin:

Ratings

All humectants
5.5
4
0.3
0.3
0.3
0.3
0.3
Benchmark
10
All occlusives
16.7
9.0
3.0
2.5
1.0
0.3
0.3
0.3
0.3
Benchmark
20
Moisturizing rating
7.0
Ingredient Est. % Benchmark Raiting
Humectancy All humectants 5.5 10
5.5
4
0.3
0.3
0.3
0.3
0.3
Occlusivity All occlusives 16.7 20
8.4
9.0
3.0
2.5
1.0
0.3
0.3
0.3
0.3
Moisturizing rating
7.0
Ingredient Est. % Benchmark Humectancy
4
0.3
0.3
0.3
0.3
0.3
All humectants 5.5 10
5.5
All humectants
5.5
4
0.3
0.3
0.3
0.3
0.3
Benchmark
10
Ingredient Est. % Benchmark Occlusivity
9
3
2.5
1
0.3
0.3
0.3
0.3
All occlusives 16.7 20
8.4
All occlusives
16.7
9.0
3.0
2.5
1.0
0.3
0.3
0.3
0.3
Benchmark
20
Ingredient
Ingredient anti-wrinkle power
when present at, %
in this formula est. %
Rating
2.5 /10 2 0.3 0.4
n/a
- 0.3 -
n/a
- 0.3 -
Total
0.4
Ectoin
0.4
Ingredient anti-wrinkle power
2.5 /10
when present at, %
2
in this formula, est. %
0.3
Palmitoyl Hexapeptide-12
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Olea Europaea (Olive) Leaf Extract
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Anti-wrinkle rating
0.4
Ingredient Est. % Benchmark
Rich in Antioxidants
0.3
0.3
0.3
0.3
All antioxidants 1.2 3 No
All antioxidants
1.2
Palmitoyl Hexapeptide-12
0.3
Olea Europaea (Olive) Leaf Extract
0.3
Aloe Barbadensis Leaf Juice
0.3
Tocopherol
0.3
Benchmark
3
Ingredient Est. % Benchmark
Rich in Soothing
0.3
0.3
0.3
0.3
0.3
All soothing 1.5 5 No
All soothing
1.5
0.3
0.3
0.3
0.3
0.3
Benchmark
5

Ingredients explained

Water
Est. %60
Function
Origin
WaterThe most used ingredient in skincare. Its concentration defines the product texture: rich creams may have about 50% of water while a light jelly about 90%. Water doesn’t moisturize the skin by itself and is used in skincare as a solvent for other ingredients.
Caprylic/Capric Triglyceride
Est. %9
Function
Origin
Caprylic/Capric TriglycerideA natural occlusive moisturizing and emollient ingredient, it is a blend of glycerin and two fatty acids, caprylic and capric acid. It creates an oil-based protective layer on the skin, thereby preventing water loss.
PEG-8 Dimethicone
Est. %6
Function
Origin
PEG-8 Dimethicone
Glycerin
Est. %4
Function
Origin
Glycerin

The most popular moisturizing ingredient in the world. It is a powerful humectant – cheap yet very effective.

Dimethicone
Est. %3
Function
Origin
DimethiconeThe most common silicone in skincare. It forms a silky, smooth film on the skin’s surface and can help to prevent water loss. It also aids in wound healing and can treat and soften scars. Dimethicone is considered to be very safe for use.
Simmondsia Chinensis (Jojoba) Seed Oil
Est. %2.5
Function
Origin
Simmondsia Chinensis (Jojoba) Seed OilA liquid plant wax, also known as Jojoba oil, pressed from the seeds of Simmondsia chinensis. These seeds can contain up to 50% of liquid wax. It is used as an occlusive moisturizer, emollient, and emulsifier.
Cetyl Alcohol
Est. %2
Function
Origin
Cetyl AlcoholA waxy solid fatty alcohol derived from palm oil. It is most commonly used as a co-emulsifier and affects the final aesthetic of the product, leaving a soft and silky feeling on the skin. Cetyl alcohol is also used as a viscosity controlling agent.
Glyceryl Stearate
Est. %1.5
Function
Origin
Glyceryl StearateAn emollient and emulsifier typically derived from vegetable sources through a chemical reaction with glycerin. It provides stability, texture, and consistency to formulations. Its main function is to allow oil and water to mix.
C12-15 Alkyl Benzoate
Est. %1.3
Function
Origin
C12-15 Alkyl BenzoateA synthetic emollient ester. It works to improve the appearance of the skin by filling in the microcracks on the surface, thereby making the skin appear softer and smoother. It imparts a lightweight, velvety feel.
Butyrospermum Parkii (Shea) Butter
Est. %1
Function
Origin
Butyrospermum Parkii (Shea) ButterA semi-solid, buttery fat extracted from the seeds of the Shea tree that is a wonderful occlusive and emollient ingredient mainly comprised of fatty acids. Shea butter contains a large amount of anti-inflammatory and antioxidant compounds.
Ethoxydiglycol
Est. %0.3
Function
Origin
EthoxydiglycolA type of alcohol with humectant moisturizing properties. It also acts as a solvent, since it mixes well with a variety of other compounds, including water and even some oils.
Squalane
Est. %0.3
Function
Origin
SqualaneAn occlusive moisturizing and emollient compound that forms part of the skin’s sebum. The main source of squalane had always been shark liver. Now, however, it is manufactured synthetically or derived from plant oils, such as olive and peanut oil.
Palmitoyl Hexapeptide-12
Est. %0.3
Function
Origin
Palmitoyl Hexapeptide-12

A short, synthetically made peptide similar to elastin fragments. It works as a signal peptide, stimulating the growth of skin cells and facilitating skin repair. It has been tested mostly in test-tube experiments so far.

Panthenol
Est. %0.3
Function
Origin
PanthenolA popular soothing and moisturizing derivative of vitamin B5. Panthenol is particularly beneficial for dry, flaking, burned, or damaged skin. It is used to alleviate the symptoms of a rash, dermatitis, eczema, chapped lips, and sunburn.
Ectoin
Est. %0.3
Function
Origin
Ectoin

An amino acid-derived ingredient with average, yet proven by one study, anti-wrinkle efficacy.

Phospholipids
Est. %0.3
Function
Origin
PhospholipidsA large group of lipids that are an essential component of every single cell membrane in the body. They have excellent emollient properties. Phospholipids are also utilized in the manufacturing of ‘fancy’ formulations such as liposomes.
Hydrolyzed Sericin
Est. %0.3
Function
Origin
Hydrolyzed Sericin
Allantoin
Est. %0.3
Function
Origin
AllantoinA fluffy, white powder that acts as a humectant due to its water-loving chemistry and as an exfoliant that helps to remove dead skin cells. It has also been shown to be very soothing to irritated and inflamed skin.
Xanthan Gum
Est. %0.3
Function
Origin
Xanthan GumA natural multi-functional ingredient that originates from fermented sugars. Xanthan gum acts as a viscosity-building agent to thicken skincare products. It is also an excellent stabilizer and works well to hold other ingredients together.
Olea Europaea (Olive) Leaf Extract
Est. %0.3
Function
Origin
Olea Europaea (Olive) Leaf ExtractAn antioxidant and fragrant extract from the leaves of the olive tree. It contains a promising anti-aging compound called Oleuropein, and a prospective anti-pigment compound called Cornoside.
Aloe Barbadensis Leaf Juice
Est. %0.3
Function
Origin
Aloe Barbadensis Leaf JuiceA gelatinous juice from Aloe vera leaves that acts as a powerful humectant, emollient, and antioxidant. It contains enzymes, amino acids, vitamins, and minerals that soothe irritated skin and have wound-healing and anti-inflammatory properties.
Stearyl Glycyrrhetinate
Est. %0.3
Function
Origin
Stearyl GlycyrrhetinateA plant compound obtained from licorice root. It is a powerful soothing ingredient that acts similar to steroid hormones and helps to treat inflamed and irritated skin.
Ceramide NG
Est. %0.3
Function
Origin
Ceramide NGA lipid that is mainly found on scalp skin and that helps with the barrier repair. It is one of the less popular ceramides and is usually used in combination with other ceramides for better barrier repair properties.
Tocotrienols
Est. %0.3
Function
Origin
Tocotrienols
Tocopherol
Est. %0.3
Function
Origin
Tocopherol

Simply another name for vitamin E. Tocopherol is a fantastic ingredient and especially beneficial for dry and inflamed skin. It has occlusive moisturizing, emollient, antioxidant, and photoprotective properties.

Ammonium Acryloyldimethyltaurate/VP Copolymer
Est. %0.3
Function
Origin
Ammonium Acryloyldimethyltaurate/VP CopolymerA polymeric ingredient that creates lightweight and refreshing gel textures. It also works as a viscosity controlling agent.
PEG-75 Stearate
Est. %0.3
Function
Origin
PEG-75 Stearate
Benzyl Alcohol
Est. %0.3
Function
Origin
Benzyl Alcohol

A multifunctional ingredient that is supplied as a clear, colorless liquid. Its main function is as a flavoring agent and fragrance. It also acts as a broad-spectrum preservative, solvent, and viscosity-controlling agent that thins the product.

Tribehenin
Est. %0.3
Function
Origin
TribeheninA soft, pliable wax that serves as an occlusive moisturizer and emollient. It improves the spreadability of skincare products, including the increased payoff of stick products, and imparts a pleasant, smooth feel upon application.
Ceteth-20
Est. %0.3
Function
Origin
Ceteth-20A very mild but effective polyethylene-based cleanser and emulsifier.
Steareth-20
Est. %0.3
Function
Origin
Steareth-20A white to light brown reaction product of a clear gas and stearyl alcohol. Like the other steareth ingredients, steareth-20 is a waxy emulsifier that can help to form a stable emulsion, even in extreme conditions.
Butylene Glycol
Est. %0.3
Function
Origin
Butylene Glycol

A clear, colorless liquid humectant that draws moisture to the skin. The humectancy of butylene glycol, owed to its two hydroxyl groups, is quite considerable, although not as powerful as glycerin, which contains three hydroxyl groups.

PEG-10 Rapeseed Sterol
Est. %0.3
Function
Origin
PEG-10 Rapeseed SterolPEG-10 Rapeseed Sterol is a mixture of polyethylene glycol (a water-soluble bulking and lubricating synthetic compound) and fat-soluble phytosterols from rapeseed oil. This mixture is used in skincare products to assist with the solubility and the of oil and water (emulsification).
Elaeis Guineensis (Palm) Oil
Est. %0.3
Function
Origin
Elaeis Guineensis (Palm) OilA fatty oil expressed from the pulp of the oil palm fruits. It is mostly composed of occlusive and emollient saturated fatty acids. The unrefined oil has a large amount of antioxidant carotenoids.
Dehydroacetic Acid
Est. %0.3
Function
Origin
Dehydroacetic AcidA globally approved preservative ingredient. It is a powerful fungicide and a moderate bactericide, which makes it a broad-spectrum preservative. Because it is mildly effective against bacteria, it is often paired with stronger bactericides.