Perricone MD Essential Fx Acyl-Glutathione Eyelid Lift Serum

Perricone MD Essential Fx Acyl-Glutathione Eyelid Lift Serum
5.2
/ 10
Moisturizing
9.9 Humectancy icon Humectancy
0.6 Occlusivity icon Occlusivity
2Anti-wrinkle icon/ 10
Anti-wrinkle
Rich
in Antioxidants

Review

Does Perricone MD Essential Fx Acyl-Glutathione Eyelid Lift Serum work?

Based on the ingredient list analysis by CreamScan AI, these are the key benefits you can expect from using Perricone MD Essential Fx Acyl-Glutathione Eyelid Lift Serum:

  • Moderate moisturizing. It has a moisturizing rating of 5.2 out of 10.
  • Some anti-wrinkle efficacy: Perricone MD Essential Fx Acyl-Glutathione Eyelid Lift Serum has an anti-wrinkle rating of 2.0 out of 10 so you may expect some, although limited, effect on wrinkles.
  • Antioxidant protection.

How moisturizing is it?

Quite moisturizing: Perricone MD Essential Fx Acyl-Glutathione Eyelid Lift Serum has a moisturizing rating of 5.2 out of 10.

Is it more humectant or occlusive? Significantly more humectant. It has a low occlusivity of 0.6 out of 10 and a very high humectancy of 9.9 out of 10, primarily due to the high content of Propanediol (est. ≈6.0%) and Glycerin (est. ≈3.0%).

Please refer to the Ratings section below for details of the moisturizing rating calculation.

Anti-wrinkle efficacy

According to CreamScan analysis, Perricone MD Essential Fx Acyl-Glutathione Eyelid Lift Serum has a slight anti-wrinkle rating of 2.0 out of 10. It contains one ingredient with proven anti-wrinkle efficacy: Ascorbyl Tetraisopalmitate (est. ≈2.0%), 
 the only derivative of Ascorbic acid with confirmed anti-wrinkle efficacy. This ingredient has below-average efficacy, proven by one study.
 
Among others, Perricone MD Essential Fx Acyl-Glutathione Eyelid Lift Serum also contains Palmitoyl Tripeptide-38, an ingredient marketed as effective in reducing wrinkles. However, the studies supporting the anti-wrinkle claims of Palmitoyl Tripeptide-38 provide insufficient evidence of its efficacy according to CreamScan Research Evaluation Standards. Therefore, this ingredient does not contribute to the anti-wrinkle rating.
 
Moisturizers, when used regularly, are proven to prevent wrinkle formation and even reduce existing wrinkles. Therefore, this product, like any other moisturizer, could deliver additional anti-wrinkle efficacy through its moisturizing action.
 

Please refer to the Ratings section below for details of the anti-wrinkle rating calculation.

Antioxidant benefits

We estimate that Perricone MD Essential Fx Acyl-Glutathione Eyelid Lift Serum is rich (> 3%) in antioxidants, specifically Ascorbyl Tetraisopalmitate (est. ≈2.0%).

A key benefit of antioxidants is their ability to reduce oxidative stress caused by free radicals and therefore prevent accelerated skin aging. Studies also show that antioxidants can protect against environmental damage such as UV radiation and pollution, and help reduce inflammation and skin redness.

Ingredients

Est. % Ingredient Origin Functions
75
6
4
3
2
1.5
1.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Est. %
Water
Function:
Origin:
Propanediol
Function:
Origin:
Pantethine
Function:
Origin:
Glycerin
Function:
Origin:
Ascorbyl Tetraisopalmitate
Function:
Origin:
S-Palmitoylglutathione
Function:
Origin:
Dimethyl MEA
Function:
Origin:
Palmitoyl Tripeptide-38
Function:
Origin:
Acetyl Tyrosine
Function:
Origin:
Avena Sativa (Oat) Kernel Extract
Function:
Origin:
Xanthan Gum
Function:
Origin:
Macadamia Ternifolia Seed Oil
Function:
Origin:
Linum Usitatissimum (Linseed) Seed Oil
Function:
Origin:
Salvia Hispanica Seed Oil
Function:
Origin:
Silica Cetyl Silylate
Function:
Origin:
Ethylhexylglycerin
Function:
Origin:
Sodium Hyaluronate
Function:
Origin:
Helianthus Annuus (Sunflower) Seed Oil
Function:
Origin:
Rosmarinus Officinalis (Rosemary) Leaf Extract
Function:
Origin:
Tetrasodium Glutamate Diacetate
Function:
Origin:
Acrylates/C10-30 Alkyl Acrylate Crosspolymer
Function:
Origin:
Caprylyl Glycol
Function:
Origin:
Hydroxypropyl Cyclodextrin
Function:
Origin:
Phenoxyethanol
Function:
Origin:
Silica
Function:
Origin:
Titanium Dioxide (CI 77891)
Function:
Origin:
Iron Oxides (CI 77491)
Function:
Origin:

Ratings

All humectants
9.9
6
3
0.3
0.3
0.3
Benchmark
10
All occlusives
1.2
0.3
0.3
0.3
0.3
Benchmark
20
Moisturizing rating
5.2
Ingredient Est. % Benchmark Raiting
Humectancy All humectants 9.9 10
9.9
6
3
0.3
0.3
0.3
Occlusivity All occlusives 1.2 20
0.6
0.3
0.3
0.3
0.3
Moisturizing rating
5.2
Ingredient Est. % Benchmark Humectancy
6
3
0.3
0.3
0.3
All humectants 9.9 10
9.9
All humectants
9.9
6
3
0.3
0.3
0.3
Benchmark
10
Ingredient Est. % Benchmark Occlusivity
0.3
0.3
0.3
0.3
All occlusives 1.2 20
0.6
All occlusives
1.2
0.3
0.3
0.3
0.3
Benchmark
20
Ingredient
Ingredient anti-wrinkle power
when present at, %
in this formula est. %
Rating
2 /10 1 2 2
n/a
- 0.3 -
Total
2
Ascorbyl Tetraisopalmitate
2
Ingredient anti-wrinkle power
2 /10
when present at, %
1
in this formula, est. %
2
Palmitoyl Tripeptide-38
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Anti-wrinkle rating
2
Ingredient Est. % Benchmark
Rich in Antioxidants
2
1.5
0.3
0.3
0.3
0.3
All antioxidants 4.7 3 Rich in antioxidants
All antioxidants
4.7
Ascorbyl Tetraisopalmitate
2
S-Palmitoylglutathione
1.5
Avena Sativa (Oat) Kernel Extract
0.3
Salvia Hispanica Seed Oil
0.3
Sodium Hyaluronate
0.3
Rosmarinus Officinalis (Rosemary) Leaf Extract
0.3
Benchmark
3
Ingredient Est. % Benchmark
Rich in Soothing
0.3
0.3
All soothing 0.6 5 No
All soothing
0.6
0.3
0.3
Benchmark
5

Ingredients explained

Water
Est. %75
Function
Origin
WaterThe most used ingredient in skincare. Its concentration defines the product texture: rich creams may have about 50% of water while a light jelly about 90%. Water doesn’t moisturize the skin by itself and is used in skincare as a solvent for other ingredients.
Propanediol
Est. %6
Function
Origin
PropanediolAn excellent solvent capable of mixing water with normally water-insoluble ingredients. It also functions as a humectant due to its water-loving alcohol groups. Propanediol can control the viscosity of a product by reducing its thickness.
Pantethine
Est. %4
Function
Origin
PantethineA synthetic emollient that provides a soft and smooth feeling to skin. Most emollients are oil-based, but pantethine dissolves in water.
Glycerin
Est. %3
Function
Origin
Glycerin

The most popular moisturizing ingredient in the world. It is a powerful humectant – cheap yet very effective.

Ascorbyl Tetraisopalmitate
Est. %2
Function
Origin
Ascorbyl Tetraisopalmitate

Ascorbyl Tetraisopalmitate (ATIP) is an oil-soluble derivative of ascorbic acid, or vitamin C. It is more stable than ascorbic acid, with studies supporting its collagen-boosting and anti-pigment effects.

S-Palmitoylglutathione
Est. %1.5
Function
Origin
S-Palmitoylglutathione
Dimethyl MEA
Est. %1.3
Function
Origin
Dimethyl MEADimethyl MEA is a chemical compound with many names - it can also be listed as DMAE, deanol or 2-dimethylaminoethanol. It is described as a colorless liquid with a fishy smell. DMAE is added to skincare products to regulate the pH balance, but can potentially be toxic.
Palmitoyl Tripeptide-38
Est. %0.3
Function
Origin
Palmitoyl Tripeptide-38

A small synthetic peptide that increases the production of collagen, fibronectin, and hyaluronic acid in the skin. It has also been shown to reduce wrinkles in combination with other anti-aging ingredients.

Acetyl Tyrosine
Est. %0.3
Function
Origin
Acetyl TyrosineAcetyl tyrosine is a derivative of the amino acid tyrosine. It is used as a tanning agent in skincare, helping pigment cells (melanosomes) to produce more dark skin pigment.
Avena Sativa (Oat) Kernel Extract
Est. %0.3
Function
Origin
Avena Sativa (Oat) Kernel ExtractA beneficial extract obtained from Oat groats popular in products aimed at eczema-prone skin. It contains skin healing beta-glucan, anti-inflammatory phenolic compounds, antioxidant flavonoids, various lipids, proteins, and moisturizing amino acids.
Xanthan Gum
Est. %0.3
Function
Origin
Xanthan GumA natural multi-functional ingredient that originates from fermented sugars. Xanthan gum acts as a viscosity-building agent to thicken skincare products. It is also an excellent stabilizer and works well to hold other ingredients together.
Macadamia Ternifolia Seed Oil
Est. %0.3
Function
Origin
Macadamia Ternifolia Seed OilAn occlusive moisturizing and emollient oil extracted from macadamia nuts. It is clear and pale yellow with a pleasant nutty aroma and contains oleic and palmitoleic fatty acids, tocopherols, phytosterols, squalene, and polyphenols.
Linum Usitatissimum (Linseed) Seed Oil
Est. %0.3
Function
Origin
Linum Usitatissimum (Linseed) Seed OilAn emollient and occlusive fatty oil pressed from flax seeds. It is the richest source of linolenic fatty acid (it contains up to 50% of it) among vegetable oils.
Salvia Hispanica Seed Oil
Est. %0.3
Function
Origin
Salvia Hispanica Seed OilAn oil extracted from Chia seeds. It has a unique ratio of omega-3 and omega-6 fatty acids, making it the richest source of polyunsaturated fatty acids. It also contains antioxidant phytosterols and tocopherols (vitamin E).
Silica Cetyl Silylate
Est. %0.3
Function
Origin
Silica Cetyl Silylate
Ethylhexylglycerin
Est. %0.3
Function
Origin
EthylhexylglycerinA preservative booster derived from glycerin. It is commonly paired with other preservatives to improve their efficacy. Ethylhexylglycerin is also a humectant due to its chemical base of glycerin.
Sodium Hyaluronate
Est. %0.3
Function
Origin
Sodium Hyaluronate

A sodium salt of famous hyaluronic acid. A potent humectant that hydrates the skin, supports collagen function, and fills out small wrinkles. Sodium hyaluronate also offers soothing and antioxidant properties.

Helianthus Annuus (Sunflower) Seed Oil
Est. %0.3
Function
Origin
Helianthus Annuus (Sunflower) Seed OilA fatty oil expressed from sunflower seeds and one of the most commonly used oils in skincare. It has great emollient and occlusive moisturizing properties. Sunflower oil is one of the richest sources of vitamin E – an important skin antioxidant.
Rosmarinus Officinalis (Rosemary) Leaf Extract
Est. %0.3
Function
Origin
Rosmarinus Officinalis (Rosemary) Leaf ExtractA soothing and astringent extract derived from the fragrant, spicy leaves of rosemary. It has strong antioxidant properties. Rosemary extract can reduce signs of inflammation and also acts as an emollient and antimicrobial agent.
Tetrasodium Glutamate Diacetate
Est. %0.3
Function
Origin
Tetrasodium Glutamate DiacetateA biodegradable chelating agent that chemically captures the heavy metal ions naturally present in water and disarms their harmful effects.
Acrylates/C10-30 Alkyl Acrylate Crosspolymer
Est. %0.3
Function
Origin
Acrylates/C10-30 Alkyl Acrylate CrosspolymerA synthetic ingredient that is used to thicken water and alcohol. It results in a more lightweight formula and is commonly found in gel products.
Caprylyl Glycol
Est. %0.3
Function
Origin
Caprylyl GlycolAn emollient that improves product spreadability and offers a silky feel on the skin. It also acts as a preservative booster that improves the efficacy of other preservatives. According to the manufacturer, it is also a humectant moisturizer.
Hydroxypropyl Cyclodextrin
Est. %0.3
Function
Origin
Hydroxypropyl CyclodextrinA white crystalline powder that can reduce odors coming from other ingredients in a product.
Phenoxyethanol
Est. %0.3
Function
Origin
PhenoxyethanolThe most frequently used preservative in skincare. It is a clear, oil-like liquid synthetic substance that protects products from harmful bacteria and yeast, whilst still leaving skin microflora unharmed. It is confirmed by research to be harmless.
Silica
Est. %0.3
Function
Origin
SilicaA widely used cosmetic ingredient with the same chemical composition as the sand found on beaches. A common function of silica is its ability to control viscosity. In certain chemical forms, it can effectively thicken cream-style products.
Titanium Dioxide (CI 77891)
Est. %0.3
Function
Origin
Titanium Dioxide (CI 77891)One of two the most commonly used mineral sunscreens. It can absorb UV light, including UVB – which causes burning, tanning, and even skin cancer. Also used as a colorant, titanium dioxide gives a product a bright white color.
Iron Oxides (CI 77491)
Est. %0.3
Function
Origin
Iron Oxides (CI 77491)A red colorant also known as red iron oxide. This is an EU-approved colorant used in a wide variety of products.