Perricone MD Essential Fx Acyl-Glutathione Eyelid Lift Serum Review

Perricone MD Essential Fx Acyl-Glutathione Eyelid Lift Serum
5.2
/ 10
Moisturizing
9.9 Humectancy icon Humectancy
0.6 Occlusivity icon Occlusivity
2Anti-wrinkle icon/ 10
Anti-wrinkle
Rich
in Antioxidants
Review

Does Perricone MD Essential Fx Acyl-Glutathione Eyelid Lift Serum Work?

 
According to CreamScan AI's analysis of the ingredient list, here’s what Perricone MD Essential Fx Acyl-Glutathione Eyelid Lift Serum has to offer:
 
✅ Strong humectant moisturizing. This lightweight, humectant-rich product, ideal for oily skin, has a moisturizing rating of 5.2 out of 10.
✅ Modest anti-wrinkle efficacy: Perricone MD Essential Fx Acyl-Glutathione Eyelid Lift Serum has an anti-wrinkle rating of 2.0 out of 10 so you may expect some, although limited, effect on wrinkles.
✅ Antioxidant protection

  

Key Benefits of Perricone MD Essential Fx Acyl-Glutathione Eyelid Lift Serum

 
These are the key benefits you can expect from using Perricone MD Essential Fx Acyl-Glutathione Eyelid Lift Serum:
 

🔵 Lightweight Humectant Moisturizer Ideal for Oily Skin

According to CreamScan analysis, Perricone MD Essential Fx Acyl-Glutathione Eyelid Lift Serum is quite moisturizing, with a moisturizing rating of 5.2 out of 10.

Is it more humectant or occlusive? Significantly more humectant. It has a low occlusivity of 0.6 out of 10 and a very high humectancy of 9.9 out of 10, primarily due to the high content of Propanediol (est. ≈6.0%) and Glycerin (est. ≈3.0%).

This humectant-rich product, when used alone as a moisturizer, is ideal for oily skin, offering significant hydration in a lightweight, fast-absorbing formula with a minimal amount of occlusive ingredients.

It’s also a great choice for people with normal skin who prefer lightweight moisturizers.

💧 A Humectant Boost for Any Skincare Routine

But it’s not limited to oily skin - such a humectant boost will also positively contribute to the moisturizing efficacy of any skincare routine when used as a step before applying the main moisturizer. This type of formulation is typically used in serums, where a light, fast-absorbing texture is key.

Please refer to the Ratings section below for details of the moisturizing rating calculation.

🟣 Modest Anti-Wrinkle Efficacy

According to CreamScan analysis, Perricone MD Essential Fx Acyl-Glutathione Eyelid Lift Serum has a modest level of anti-wrinkle efficacy, rated 2.0 out of 10.

It contains one ingredient with proven anti-wrinkle efficacy: Ascorbyl Tetraisopalmitate (est. ≈2.0%),
 the only derivative of ascorbic acid with solid evidence of anti-wrinkle efficacy. A single clinical study involving 23 participants (Mariko et al.) demonstrated that a cream with 1% ATIP reduced the average depth of periorbital wrinkles by 6% after 8 weeks of use, compared to a vehicle (the same formulation without ATIP).
 
Among others, Perricone MD Essential Fx Acyl-Glutathione Eyelid Lift Serum also contains contains Dimethyl MEA and Palmitoyl Tripeptide-38, two ingredients often marketed as effective in reducing wrinkles. However, the studies supporting the anti-wrinkle claims of these ingredients provide insufficient evidence of efficacy according to CreamScan Research Evaluation Standards.
 
While this does not categorically rule out the possibility that these ingredients may reduce wrinkles, their efficacy is not supported by convincing, vehicle-controlled, double-blind clinical studies - at least none that were available to the CreamScan team at the time of publication.
 
Therefore, these ingredients do not contribute to the anti-wrinkle rating.
 
📌 Moisturizers, when used regularly, are proven to prevent wrinkle formation and even reduce existing wrinkles. Therefore, this product, like any other moisturizer, can deliver some additional anti-wrinkle effects through its moisturizing action.
 

Please refer to the Ratings section below for details of the anti-wrinkle rating calculation.

🍀 Rich in Skin-Protecting Antioxidants

We estimate that Perricone MD Essential Fx Acyl-Glutathione Eyelid Lift Serum is rich (> 3%) in antioxidants, specifically Ascorbyl Tetraisopalmitate (est. ≈2.0%).

A key benefit of antioxidants is their ability to reduce oxidative stress caused by free radicals and therefore prevent accelerated skin aging. Studies also show that antioxidants can protect against environmental damage such as UV radiation and pollution, and help reduce inflammation and skin redness.

📌 Please note that this is not a complete list of benefits. We are in the process of enhancing our AI model to incorporate anti-pigmentation, exfoliation and anti-acne ratings.

Pros & Cons of Perricone MD Essential Fx Acyl-Glutathione Eyelid Lift Serum

 
Here’s an overview of the pros and cons of Perricone MD Essential Fx Acyl-Glutathione Eyelid Lift Serum to help you decide if it’s the right choice for your skincare routine:
 

🟩 Pros:

✅ When used alone: Provides humectant-rich moisturizing ideal for oily skin
✅ As part of a routine: A humectant moisturizing boost, beneficial for any skin type
✅ Lightweight texture
Offers modest anti-wrinkle efficacy
✅ Rich in antioxidants that combat oxidative stress associated with accelerated skin aging and defend against environmental damage
 

⭕ Cons: 

✅ We couldn't find any
   

Summary: Perricone MD Essential Fx Acyl-Glutathione Eyelid Lift Serum

 
Based on the ingredient list analysis, CreamScan AI suggests that Perricone MD Essential Fx Acyl-Glutathione Eyelid Lift Serum
, when used alone, delivers lightweight, humectant-rich moisturizing, making it ideal for oily skin. As part of a moisturizing routine, it provides a humectant boost, beneficial for all skin types.
 
Perricone MD Essential Fx Acyl-Glutathione Eyelid Lift Serum contains ingredients with proven evidence of anti-wrinkle efficacy that may provide a modest anti-wrinkle effect. As a result, you can expect a positive, though not very significant, impact on wrinkles.
 
With its high antioxidant content, Perricone MD Essential Fx Acyl-Glutathione Eyelid Lift Serum helps protect against free radical damage and offers multiple benefits for all skin types, including preventing premature aging, defending against environmental damage, and calming inflammation.
 
📌 Fact check. At CreamScan, we are committed to accuracy and fairness. If you spot any errors or something that doesn’t seem right, please click here to let us know. We regularly update the ingredient lists and monitor the latest research on ingredient efficacy to ensure that our information remains as complete and precise as possible. The information provided here is for informational purposes only and does not substitute professional advice. We do not guarantee the efficacy or safety of any product, as individual results may vary.

 

Ingredients

Est. % Ingredient Origin Functions
75
6
4
3
2
1.5
1.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Est. %
Water
Function:
Origin:
Propanediol
Function:
Origin:
Pantethine
Function:
Origin:
Glycerin
Function:
Origin:
Ascorbyl Tetraisopalmitate
Function:
Origin:
S-Palmitoylglutathione
Function:
Origin:
Dimethyl MEA
Function:
Origin:
Palmitoyl Tripeptide-38
Function:
Origin:
Acetyl Tyrosine
Function:
Origin:
Avena Sativa (Oat) Kernel Extract
Function:
Origin:
Xanthan Gum
Function:
Origin:
Macadamia Ternifolia Seed Oil
Function:
Origin:
Linum Usitatissimum (Linseed) Seed Oil
Function:
Origin:
Salvia Hispanica Seed Oil
Function:
Origin:
Silica Cetyl Silylate
Function:
Origin:
Ethylhexylglycerin
Function:
Origin:
Sodium Hyaluronate
Function:
Origin:
Helianthus Annuus (Sunflower) Seed Oil
Function:
Origin:
Rosmarinus Officinalis (Rosemary) Leaf Extract
Function:
Origin:
Tetrasodium Glutamate Diacetate
Function:
Origin:
Acrylates/C10-30 Alkyl Acrylate Crosspolymer
Function:
Origin:
Caprylyl Glycol
Function:
Origin:
Hydroxypropyl Cyclodextrin
Function:
Origin:
Phenoxyethanol
Function:
Origin:
Silica
Function:
Origin:
Titanium Dioxide (CI 77891)
Function:
Origin:
Iron Oxides (CI 77491)
Function:
Origin:

Ratings

All humectants
9.9
6
3
0.3
0.3
0.3
Benchmark
10
All occlusives
1.2
0.3
0.3
0.3
0.3
Benchmark
20
Moisturizing rating
5.2
Ingredient Est. % Benchmark Raiting
Humectancy All humectants 9.9 10
9.9
6
3
0.3
0.3
0.3
Occlusivity All occlusives 1.2 20
0.6
0.3
0.3
0.3
0.3
Moisturizing rating
5.2
Ingredient Est. % Benchmark Humectancy
6
3
0.3
0.3
0.3
All humectants 9.9 10
9.9
All humectants
9.9
6
3
0.3
0.3
0.3
Benchmark
10
Ingredient Est. % Benchmark Occlusivity
0.3
0.3
0.3
0.3
All occlusives 1.2 20
0.6
All occlusives
1.2
0.3
0.3
0.3
0.3
Benchmark
20
Ingredient
Ingredient anti-wrinkle power
when present at, %
in this formula est. %
Rating
2 /10 1 2 2
n/a
- 1.3 -
n/a
- 0.3 -
Total
2
Ascorbyl Tetraisopalmitate
2
Ingredient anti-wrinkle power
2 /10
when present at, %
1
in this formula, est. %
2
Dimethyl MEA
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
1.3
Palmitoyl Tripeptide-38
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Anti-wrinkle rating
2
Ingredient Est. % Benchmark
Rich in Antioxidants
2
1.5
0.3
0.3
0.3
0.3
All antioxidants 4.7 3 Rich in antioxidants
All antioxidants
4.7
Ascorbyl Tetraisopalmitate
2
S-Palmitoylglutathione
1.5
Avena Sativa (Oat) Kernel Extract
0.3
Salvia Hispanica Seed Oil
0.3
Sodium Hyaluronate
0.3
Rosmarinus Officinalis (Rosemary) Leaf Extract
0.3
Benchmark
3
Ingredient Est. % Benchmark
Rich in Soothing
0.3
0.3
All soothing 0.6 5 No
All soothing
0.6
0.3
0.3
Benchmark
5

Ingredients explained

Water
Est. %75
Function
Origin
WaterThe most used ingredient in skincare. Its concentration defines the product texture: rich creams may have about 50% of water while a light jelly about 90%. Water doesn’t moisturize the skin by itself and is used in skincare as a solvent for other ingredients.
Propanediol
Est. %6
Function
Origin
PropanediolAn excellent solvent capable of mixing water with normally water-insoluble ingredients. It also functions as a humectant due to its water-loving alcohol groups. Propanediol can control the viscosity of a product by reducing its thickness.
Pantethine
Est. %4
Function
Origin
PantethineA synthetic emollient that provides a soft and smooth feeling to skin. Most emollients are oil-based, but pantethine dissolves in water.
Glycerin
Est. %3
Function
Origin
Glycerin

The most popular moisturizing ingredient in the world. It is a powerful humectant – cheap yet very effective.

Ascorbyl Tetraisopalmitate
Est. %2
Function
Origin
Ascorbyl Tetraisopalmitate

Ascorbyl Tetraisopalmitate (ATIP) is an oil-soluble derivative of ascorbic acid, or vitamin C. It is more stable than ascorbic acid, with studies supporting its collagen-boosting and anti-pigment effects.

S-Palmitoylglutathione
Est. %1.5
Function
Origin
S-Palmitoylglutathione
Dimethyl MEA
Est. %1.3
Function
Origin
Dimethyl MEA

Dimethyl MEA, also known as DMAE, or deanol, is a colorless liquid with a fishy smell. It can also be supplied as a crystalline white powder. Some studies suggest it may have some effects on skin firmness. Additionally, DMAE is used to regulate pH balance. It has the potential to be toxic.

Palmitoyl Tripeptide-38
Est. %0.3
Function
Origin
Palmitoyl Tripeptide-38

A small synthetic peptide that increases the production of collagen, fibronectin, and hyaluronic acid in the skin. It has also been shown to reduce wrinkles in combination with other anti-aging ingredients.

Acetyl Tyrosine
Est. %0.3
Function
Origin
Acetyl TyrosineAcetyl tyrosine is a derivative of the amino acid tyrosine. It is used as a tanning agent in skincare, helping pigment cells (melanosomes) to produce more dark skin pigment.
Avena Sativa (Oat) Kernel Extract
Est. %0.3
Function
Origin
Avena Sativa (Oat) Kernel ExtractA beneficial extract obtained from Oat groats popular in products aimed at eczema-prone skin. It contains skin healing beta-glucan, anti-inflammatory phenolic compounds, antioxidant flavonoids, various lipids, proteins, and moisturizing amino acids.
Xanthan Gum
Est. %0.3
Function
Origin
Xanthan GumA natural multi-functional ingredient that originates from fermented sugars. Xanthan gum acts as a viscosity-building agent to thicken skincare products. It is also an excellent stabilizer and works well to hold other ingredients together.
Macadamia Ternifolia Seed Oil
Est. %0.3
Function
Origin
Macadamia Ternifolia Seed OilAn occlusive moisturizing and emollient oil extracted from macadamia nuts. It is clear and pale yellow with a pleasant nutty aroma and contains oleic and palmitoleic fatty acids, tocopherols, phytosterols, squalene, and polyphenols.
Linum Usitatissimum (Linseed) Seed Oil
Est. %0.3
Function
Origin
Linum Usitatissimum (Linseed) Seed OilAn emollient and occlusive fatty oil pressed from flax seeds. It is the richest source of linolenic fatty acid (it contains up to 50% of it) among vegetable oils.
Salvia Hispanica Seed Oil
Est. %0.3
Function
Origin
Salvia Hispanica Seed OilAn oil extracted from Chia seeds. It has a unique ratio of omega-3 and omega-6 fatty acids, making it the richest source of polyunsaturated fatty acids. It also contains antioxidant phytosterols and tocopherols (vitamin E).
Silica Cetyl Silylate
Est. %0.3
Function
Origin
Silica Cetyl Silylate
Ethylhexylglycerin
Est. %0.3
Function
Origin
EthylhexylglycerinA preservative booster derived from glycerin. It is commonly paired with other preservatives to improve their efficacy. Ethylhexylglycerin is also a humectant due to its chemical base of glycerin.
Sodium Hyaluronate
Est. %0.3
Function
Origin
Sodium Hyaluronate

A sodium salt of famous hyaluronic acid. A potent humectant that hydrates the skin, supports collagen function, and fills out small wrinkles. Sodium hyaluronate also offers soothing and antioxidant properties.

Helianthus Annuus (Sunflower) Seed Oil
Est. %0.3
Function
Origin
Helianthus Annuus (Sunflower) Seed OilA fatty oil expressed from sunflower seeds and one of the most commonly used oils in skincare. It has great emollient and occlusive moisturizing properties. Sunflower oil is one of the richest sources of vitamin E – an important skin antioxidant.
Rosmarinus Officinalis (Rosemary) Leaf Extract
Est. %0.3
Function
Origin
Rosmarinus Officinalis (Rosemary) Leaf ExtractA soothing and astringent extract derived from the fragrant, spicy leaves of rosemary. It has strong antioxidant properties. Rosemary extract can reduce signs of inflammation and also acts as an emollient and antimicrobial agent.
Tetrasodium Glutamate Diacetate
Est. %0.3
Function
Origin
Tetrasodium Glutamate DiacetateA biodegradable chelating agent that chemically captures the heavy metal ions naturally present in water and disarms their harmful effects.
Acrylates/C10-30 Alkyl Acrylate Crosspolymer
Est. %0.3
Function
Origin
Acrylates/C10-30 Alkyl Acrylate CrosspolymerA synthetic ingredient that is used to thicken water and alcohol. It results in a more lightweight formula and is commonly found in gel products.
Caprylyl Glycol
Est. %0.3
Function
Origin
Caprylyl GlycolAn emollient that improves product spreadability and offers a silky feel on the skin. It also acts as a preservative booster that improves the efficacy of other preservatives. According to the manufacturer, it is also a humectant moisturizer.
Hydroxypropyl Cyclodextrin
Est. %0.3
Function
Origin
Hydroxypropyl CyclodextrinA white crystalline powder that can reduce odors coming from other ingredients in a product.
Phenoxyethanol
Est. %0.3
Function
Origin
PhenoxyethanolThe most frequently used preservative in skincare. It is a clear, oil-like liquid synthetic substance that protects products from harmful bacteria and yeast, whilst still leaving skin microflora unharmed. It is confirmed by research to be harmless.
Silica
Est. %0.3
Function
Origin
SilicaA widely used cosmetic ingredient with the same chemical composition as the sand found on beaches. A common function of silica is its ability to control viscosity. In certain chemical forms, it can effectively thicken cream-style products.
Titanium Dioxide (CI 77891)
Est. %0.3
Function
Origin
Titanium Dioxide (CI 77891)One of two the most commonly used mineral sunscreens. It can absorb UV light, including UVB – which causes burning, tanning, and even skin cancer. Also used as a colorant, titanium dioxide gives a product a bright white color.
Iron Oxides (CI 77491)
Est. %0.3
Function
Origin
Iron Oxides (CI 77491)A red colorant also known as red iron oxide. This is an EU-approved colorant used in a wide variety of products.