Mediheal Derma Synergy Wrapping Mask Niacinamide X Glutathione

Mediheal Derma Synergy Wrapping Mask Niacinamide X Glutathione
5.1
/ 10
Moisturizing
10.0 Humectancy icon Humectancy
0.2 Occlusivity icon Occlusivity
6Anti-wrinkle icon/ 10
Anti-wrinkle
Rich
in Antioxidants
Rich Skin Soothing icon
in Skin Soothers

Review

Does Mediheal Derma Synergy Wrapping Mask Niacinamide X Glutathione work?

Based on the ingredient list analysis by CreamScan AI, these are the key benefits you can expect from using Mediheal Derma Synergy Wrapping Mask Niacinamide X Glutathione:

  • Strong humectant moisturizing. This lightweight, humectant-rich product, ideal for oily skin, has a moisturizing rating of 5.1 out of 10.
  • Significant anti-wrinkle efficacy. With an anti-wrinkle rating of 6.0 out of 10, Mediheal Derma Synergy Wrapping Mask Niacinamide X Glutathione is effective in minimizing wrinkles.
  • Soothing: Mediheal Derma Synergy Wrapping Mask Niacinamide X Glutathione contains a high concentration of soothing ingredients, which may help to reduce irritation and calm the skin.
  • Antioxidant protection.

Lightweight moisturizer ideal for oily skin and a humectant boost for any skincare routine

According to CreamScan analysis, Mediheal Derma Synergy Wrapping Mask Niacinamide X Glutathione is quite moisturizing, with a moisturizing rating of 5.1 out of 10.

Is it more humectant or occlusive? Significantly more humectant. It has a low occlusivity of 0.2 out of 10 and a maximum humectancy of 10 out of 10, primarily due to the high content of Niacinamide (est. ≈5.0%), Glycerin (est. ≈4.0%) and Propanediol (est. ≈3.0%).

This humectant-rich product, when used alone as a moisturizer, is ideal for oily skin, offering significant hydration in a lightweight, fast-absorbing formula with a minimal amount of occlusive ingredients. It’s also a great choice for people with normal skin who prefer lightweight moisturizers.

Such a humectant boost will also positively contribute to the moisturizing efficacy of any skincare routine when used as a step before applying the main moisturizer. This type of formulation is typically used in serums, where a light, fast-absorbing texture is key.

Please refer to the Ratings section below for details of the moisturizing rating calculation.

Significant anti-wrinkle efficacy

According to CreamScan analysis, Mediheal Derma Synergy Wrapping Mask Niacinamide X Glutathione has a high anti-wrinkle rating of 6.0 out of 10.

It contains one ingredient with proven anti-wrinkle efficacy: Niacinamide (est. ≈5.0%), 
 one of the most effective and well-researched anti-wrinkle ingredients. A clinical study involving 30 participants (Kawada et al.) confirmed that a cream with 4% niacinamide reduced the average depth of wrinkles around the eyes by 9% after 8 weeks of use, compared to a vehicle (the same formulation without niacinamide).
 
Among others, Mediheal Derma Synergy Wrapping Mask Niacinamide X Glutathione also contains some ingredients marketed often as effective in reducing wrinkles, specifically Adenosine, Gluconolactone, and Folic Acid. However, the studies supporting the anti-wrinkle claims of these ingredients provide insufficient evidence of efficacy according to CreamScan Research Evaluation Standards. Therefore, these ingredients do not contribute to the anti-wrinkle rating.
 

Please refer to the Ratings section below for details of the anti-wrinkle rating calculation.

Rich in skin-protecting antioxidants

We estimate that Mediheal Derma Synergy Wrapping Mask Niacinamide X Glutathione is rich (> 3%) in antioxidants, specifically Niacinamide (est. ≈5.0%).

A key benefit of antioxidants is their ability to reduce oxidative stress caused by free radicals and therefore prevent accelerated skin aging. Studies also show that antioxidants can protect against environmental damage such as UV radiation and pollution, and help reduce inflammation and skin redness.

Skin soothing and calming potential

Based on the ingredient list analysis, Mediheal Derma Synergy Wrapping Mask Niacinamide X Glutathione is rich (> 5%) in soothing ingredients, particularly Niacinamide (est. ≈5.0%).

When applied to the skin, compounds of soothing ingredients, such as triglycerides, phospholipids, fatty acids, phenolic compounds, and antioxidants, work together to soothe the skin through various mechanisms: reducing inflammation, promoting wound healing, repairing the skin barrier, and providing antimicrobial and antioxidant activities.

Ingredients

Est. % Ingredient Origin Functions
70
5
4
3
2
1.5
1.3
1
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Est. %
Water
Function:
Origin:
Niacinamide
Function:
Origin:
Glycerin
Function:
Origin:
Propanediol
Function:
Origin:
Dipropylene Glycol
Function:
Origin:
Butylene Glycol
Function:
Origin:
Glyceryl Glucoside
Function:
Origin:
1,2-Hexanediol
Function:
Origin:
Panthenol
Function:
Origin:
Hydroxyacetophenone
Function:
Origin:
Carbomer
Function:
Origin:
Arginine
Function:
Origin:
Polyglyceryl-10 Laurate
Function:
Origin:
Diglycerin
Function:
Origin:
Aminobutyric Acid
Function:
Origin:
Ethylhexylglycerin
Function:
Origin:
Pantolactone
Function:
Origin:
Galactomyces Ferment Filtrate
Function:
Origin:
Adenosine
Function:
Origin:
Xanthan Gum
Function:
Origin:
Saccharomyces Ferment Filtrate
Function:
Origin:
Disodium EDTA
Function:
Origin:
Glucose
Function:
Origin:
Paeonia Suffruticosa Branch/Flower/Leaf Extract
Function:
Origin:
Brassica Campestris (Rapeseed) Extract
Function:
Origin:
Citrus Aurantium Dulcis (Orange) Peel Extract
Function:
Origin:
Sodium Hyaluronate
Function:
Origin:
Rosa Damascena Flower Water
Function:
Origin:
Pelargonium Graveolens Water
Function:
Origin:
Rosa Rugosa Flower Extract
Function:
Origin:
Hydrogenated Lecithin
Function:
Origin:
Eucalyptus Globulus Leaf Water
Function:
Origin:
Tremella Fuciformis Polysaccharide
Function:
Origin:
Barosma Betulina Leaf Extract
Function:
Origin:
Pantothenic Acid
Function:
Origin:
Bambusa Vulgaris Leaf Extract
Function:
Origin:
Linum Usitatissimum (Linseed) Seed Extract
Function:
Origin:
Pentylene Glycol
Function:
Origin:
Ferula Galbaniflua (Galbanum) Resin Oil
Function:
Origin:
Gluconolactone
Function:
Origin:
Mangifera Indica (Mango) Fruit Extract
Function:
Origin:
Citrus Limon (Lemon) Seed Oil
Function:
Origin:
Glutathione
Function:
Origin:
Biotin
Function:
Origin:
Folic Acid
Function:
Origin:
Hesperidin
Function:
Origin:

Ratings

All humectants
19.0
5
4
3
1.5
1.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Benchmark
10
All occlusives
0.3
0.3
Benchmark
20
Moisturizing rating
5.1
Ingredient Est. % Benchmark Raiting
Humectancy All humectants 19.0 10
10.0
5
4
3
1.5
1.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Occlusivity All occlusives 0.3 20
0.2
0.3
Moisturizing rating
5.1
Ingredient Est. % Benchmark Humectancy
5
4
3
1.5
1.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
All humectants 19.0 10
10
All humectants
19.0
5
4
3
1.5
1.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Benchmark
10
Ingredient Est. % Benchmark Occlusivity
0.3
All occlusives 0.3 20
0.2
All occlusives
0.3
0.3
Benchmark
20
Ingredient
Ingredient anti-wrinkle power
when present at, %
in this formula est. %
Rating
6 /10 4 5 6
n/a
- 0.3 -
n/a
- 0.3 -
n/a
- 0.3 -
Total
6
Niacinamide
6
Ingredient anti-wrinkle power
6 /10
when present at, %
4
in this formula, est. %
5
Adenosine
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Gluconolactone
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Folic Acid
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Anti-wrinkle rating
6
Ingredient Est. % Benchmark
Rich in Antioxidants
5
0.3
0.3
0.3
0.3
All antioxidants 6.2 3 Rich in antioxidants
All antioxidants
6.2
Niacinamide
5
Hydroxyacetophenone
0.3
Sodium Hyaluronate
0.3
Mangifera Indica (Mango) Fruit Extract
0.3
Glutathione
0.3
Benchmark
3
Ingredient Est. % Benchmark
Rich in Soothing
5
0.3
0.3
All soothing 5.6 5 Rich in soothing
All soothing
5.6
5
0.3
0.3
Benchmark
5

Ingredients explained

Water
Est. %70
Function
Origin
WaterThe most used ingredient in skincare. Its concentration defines the product texture: rich creams may have about 50% of water while a light jelly about 90%. Water doesn’t moisturize the skin by itself and is used in skincare as a solvent for other ingredients.
Niacinamide
Est. %5
Function
Origin
Niacinamide

Also known as vitamin B3, this ingredient is a true superstar with confirmed moisturizing, anti-acne, hyperpigmentation, and antioxidant benefits. Two studies confirm its significant anti-wrinkle efficacy.

Glycerin
Est. %4
Function
Origin
Glycerin

The most popular moisturizing ingredient in the world. It is a powerful humectant – cheap yet very effective.

Propanediol
Est. %3
Function
Origin
PropanediolAn excellent solvent capable of mixing water with normally water-insoluble ingredients. It also functions as a humectant due to its water-loving alcohol groups. Propanediol can control the viscosity of a product by reducing its thickness.
Dipropylene Glycol
Est. %2
Function
Origin
Dipropylene GlycolA clear, colorless liquid that has several uses. One of its main functions is as a solvent. Dipropylene glycol is also used to reduce the thickness of skincare products.
Butylene Glycol
Est. %1.5
Function
Origin
Butylene Glycol

A clear, colorless liquid humectant that draws moisture to the skin. The humectancy of butylene glycol, owed to its two hydroxyl groups, is quite considerable, although not as powerful as glycerin, which contains three hydroxyl groups.

Glyceryl Glucoside
Est. %1.3
Function
Origin
Glyceryl Glucoside
1,2-Hexanediol
Est. %1
Function
Origin
1,2-HexanediolA multi-functional formula helper. It is a well-studied preservtive against bacteria and can help pigments and fragrances disperse evenly in a formula.
Panthenol
Est. %0.3
Function
Origin
PanthenolA popular soothing and moisturizing derivative of vitamin B5. Panthenol is particularly beneficial for dry, flaking, burned, or damaged skin. It is used to alleviate the symptoms of a rash, dermatitis, eczema, chapped lips, and sunburn.
Hydroxyacetophenone
Est. %0.3
Function
Origin
HydroxyacetophenoneAn antioxidant compound that can be found in many plants, although it is manufactured synthetically for skincare purposes. It can boost the preservative action of other conservants.
Carbomer
Est. %0.3
Function
Origin
CarbomerA synthetic ingredient with the ability to gel water. When used in emulsions, such as lotions and creams, carbomer can also act as an emulsion stabilizer.
Arginine
Est. %0.3
Function
Origin
ArginineA humectant amino acid used to attract water to the skin’s surface. It is a part of the skin's Natural Moisturizing Factor, a mixture of various compounds that keeps the skin’s surface well hydrated. Arginine can also be used as a pH adjuster.
Polyglyceryl-10 Laurate
Est. %0.3
Function
Origin
Polyglyceryl-10 LaurateA vegetable glycerin or synthetically produced emulsifier and gentle cleansing agent. It won't leave skin feeling tight or dry when used to cleanse.
Diglycerin
Est. %0.3
Function
Origin
DiglycerinA powerful humectant that collects moisture, making skin feel hydrated and supple. Diglycerin is less sticky and a stronger humectant, but slower absorbing than standard glycerin.
Aminobutyric Acid
Est. %0.3
Function
Origin
Aminobutyric AcidAlso called GABA, this amino acid is emollient and attracts water to the skin’s surface. It may also assist in speeding up the barrier repair process.
Ethylhexylglycerin
Est. %0.3
Function
Origin
EthylhexylglycerinA preservative booster derived from glycerin. It is commonly paired with other preservatives to improve their efficacy. Ethylhexylglycerin is also a humectant due to its chemical base of glycerin.
Pantolactone
Est. %0.3
Function
Origin
PantolactoneA vitamin B5 derivative. Similar to panthenol, it has several benefits as an antioxidant and humectant. However, it is less reactive and therefore products can stay stable longer.
Galactomyces Ferment Filtrate
Est. %0.3
Function
Origin
Galactomyces Ferment Filtrate
Adenosine
Est. %0.3
Function
Origin
Adenosine

A key molecule responsible for energy transportation, signaling, and enzyme activity. Adenosine is a popular anti-wrinkle ingredient, however, the key study about its anti-wrinkle efficacy (1) does not meet CreamScan Research Evaluation Standards as it is not double-blind.

Xanthan Gum
Est. %0.3
Function
Origin
Xanthan GumA natural multi-functional ingredient that originates from fermented sugars. Xanthan gum acts as a viscosity-building agent to thicken skincare products. It is also an excellent stabilizer and works well to hold other ingredients together.
Saccharomyces Ferment Filtrate
Est. %0.3
Function
Origin
Saccharomyces Ferment FiltrateA yeast mixture that contains humectant moisturizing amino acids, nucleic acids (building blocks of DNA), peptides, various minerals, and vitamins.
Disodium EDTA
Est. %0.3
Function
Origin
Disodium EDTAA synthetic chelator that helps to maintain the look and smell of a product by 'locking up' troublesome metal ions.
Glucose
Est. %0.3
Function
Origin
GlucoseA simple sugar that is also one of two components of sucrose, or table sugar. It is used as a humectant in skincare products. Glucose is also used to flavor lip care cosmetics because of its mildly sweet taste.
Paeonia Suffruticosa Branch/Flower/Leaf Extract
Est. %0.3
Function
Origin
Paeonia Suffruticosa Branch/Flower/Leaf Extract
Brassica Campestris (Rapeseed) Extract
Est. %0.3
Function
Origin
Brassica Campestris (Rapeseed) Extract
Citrus Aurantium Dulcis (Orange) Peel Extract
Est. %0.3
Function
Origin
Citrus Aurantium Dulcis (Orange) Peel Extract

Citrus aurantium dulcis peel extract is the same extract as Citrus aurantium dulcis (orange) fruit extract. It has antioxidant properties and gives a skincare product a fresh orange scent. It also works as a thickener due to its pectin content. Read more about the extract here: Citrus Aurantium Dulcis (Orange) Fruit Extract.

Sodium Hyaluronate
Est. %0.3
Function
Origin
Sodium Hyaluronate

A sodium salt of famous hyaluronic acid. A potent humectant that hydrates the skin, supports collagen function, and fills out small wrinkles. Sodium hyaluronate also offers soothing and antioxidant properties.

Rosa Damascena Flower Water
Est. %0.3
Function
Origin
Rosa Damascena Flower WaterA fragrant water that is leftover after the steam distillation of Damask rose petals. During this process, the essential oil floats to the surface of the water and is collected. The leftover water has a fresh, rosy scent.
Pelargonium Graveolens Water
Est. %0.3
Function
Origin
Pelargonium Graveolens Water
Rosa Rugosa Flower Extract
Est. %0.3
Function
Origin
Rosa Rugosa Flower Extract
Hydrogenated Lecithin
Est. %0.3
Function
Origin
Hydrogenated LecithinA version of plain lecithin that has been saturated with hydrogen atoms. This ingredient can be derived from plants, like soy or sunflower, from egg yolks, or made synthetically. Its major function is to emulsify water and oils.
Eucalyptus Globulus Leaf Water
Est. %0.3
Function
Origin
Eucalyptus Globulus Leaf Water
Tremella Fuciformis Polysaccharide
Est. %0.3
Function
Origin
Tremella Fuciformis Polysaccharide
Barosma Betulina Leaf Extract
Est. %0.3
Function
Origin
Barosma Betulina Leaf Extract
Pantothenic Acid
Est. %0.3
Function
Origin
Pantothenic AcidAlso known as vitamin B5, this ingredient helps to restore healthy moisturization of the skin and is essential for good skin health. Due to poor stability and skin penetration, panthenol is usually preferred over pantothenic acid.
Bambusa Vulgaris Leaf Extract
Est. %0.3
Function
Origin
Bambusa Vulgaris Leaf Extract
Linum Usitatissimum (Linseed) Seed Extract
Est. %0.3
Function
Origin
Linum Usitatissimum (Linseed) Seed ExtractAn extract obtained from flax seeds with emollient and moisturizing properties. It also contains antioxidant phenolics.
Pentylene Glycol
Est. %0.3
Function
Origin
Pentylene Glycol

A naturally or synthetically derived preservative that exhibits effective antifungal and antibacterial traits. It also acts as a booster for more traditional preservatives. Pentylene glycol can also serve as a moisturizing humectant and solvent.

Ferula Galbaniflua (Galbanum) Resin Oil
Est. %0.3
Function
Origin
Ferula Galbaniflua (Galbanum) Resin Oil
Gluconolactone
Est. %0.3
Function
Origin
GluconolactoneA PHA derived from glucose. It has exfoliating and humectant properties and acts as a penetration enhancer for other ingredients. It has also been shown to assist in the treatment of acne and the prevention of photoaging.
Mangifera Indica (Mango) Fruit Extract
Est. %0.3
Function
Origin
Mangifera Indica (Mango) Fruit ExtractAn extract derived from mango fruit that contains antioxidant flavonoids, carotenoids, and anthocyanins, as well as many astringent tannins. It gives a formula a nice, fruity scent.
Citrus Limon (Lemon) Seed Oil
Est. %0.3
Function
Origin
Citrus Limon (Lemon) Seed Oil
Glutathione
Est. %0.3
Function
Origin
GlutathioneA naturally occurring tripeptide that combats free radicals and acts as a reducing agent.
Biotin
Est. %0.3
Function
Origin
BiotinBiotin is an important nutrient that can cause weak hair and nails if deficient. Unfortunately, while biotin supplements have promising studies, topical biotin in creams and serums doesn’t have a large body of evidence to support its use.
Folic Acid
Est. %0.3
Function
Origin
Folic AcidA critical vitamin for the body that needs more research for topical applications.
Hesperidin
Est. %0.3
Function
Origin
Hesperidin