ma:nyo Bifida Biome Deep Sleeping Mask Review

ma:nyo Bifida Biome Deep Sleeping Mask
5.0
/ 10
Moisturizing
10.0 Humectancy icon Humectancy
0.0 Occlusivity icon Occlusivity
2.2Anti-wrinkle icon/ 10
Anti-wrinkle
Rich
in Antioxidants
Rich Skin Soothing icon
in Skin Soothers
Review

Does ma:nyo Bifida Biome Deep Sleeping Mask Work?

 
According to CreamScan AI's analysis of the ingredient list, here’s what ma:nyo Bifida Biome Deep Sleeping Mask has to offer:
 
  • Strong humectant moisturizing. This lightweight, humectant-rich product, ideal for oily skin, has a moisturizing rating of 5.0 out of 10.
  • Modest anti-wrinkle efficacy: ma:nyo Bifida Biome Deep Sleeping Mask has an anti-wrinkle rating of 2.2 out of 10 so you may expect some, although limited, effect on wrinkles.
  • Soothing: ma:nyo Bifida Biome Deep Sleeping Mask contains a high concentration of soothing ingredients, which may help to reduce irritation and calm the skin.
  • Antioxidant protection.

Key Benefits of ma:nyo Bifida Biome Deep Sleeping Mask

 
These are the key benefits you can expect from using ma:nyo Bifida Biome Deep Sleeping Mask:
 

Lightweight Purely Humectant Moisturizing, Ideal for Oily Skin

According to CreamScan analysis, ma:nyo Bifida Biome Deep Sleeping Mask is quite moisturizing, with a moisturizing rating of 5.0 out of 10.

Is it more humectant or occlusive? It is purely humectant. It has zero occlusivity (we didn't find any occlusive ingredients on the ingredient list) and a maximum humectancy of 10 out of 10, primarily due to the high content of Glycerin (est. ≈6.0%), Butylene Glycol (est. ≈4.0%) and Methylpropanediol (est. ≈2.0%).

This humectant-rich product, when used alone as a moisturizer, is ideal for oily skin, providing significant hydration in a lightweight, fast-absorbing formula without any occlusive ingredients.

Tip: Certain studies suggest that humectants alone may not effectively moisturize the skin. If you use this product as your only moisturizer, we recommend following it with one that contains at least some occlusive ingredients.

A Humectant Boost for Any Skincare Routine

But it’s not limited to oily skin - such a humectant boost will also positively contribute to the moisturizing efficacy of any skincare routine when used as a step before applying the main moisturizer. This type of formulation is typically used in serums, where a light, fast-absorbing texture is key.

Please refer to the Ratings section below for details of the moisturizing rating calculation.

Modest Anti-Wrinkle Efficacy

According to CreamScan analysis, ma:nyo Bifida Biome Deep Sleeping Mask has a modest level of anti-wrinkle efficacy, rated 2.2 out of 10.

It contains one ingredient with proven anti-wrinkle efficacy: Niacinamide (est. ≈1.5%), 
 one of the most effective and well-researched anti-wrinkle ingredients. A clinical study involving 30 participants (Kawada et al.) confirmed that a cream with 4% niacinamide reduced the average depth of wrinkles around the eyes by 9% after 8 weeks of use, compared to a vehicle (the same formulation without niacinamide).
 
Among others, ma:nyo Bifida Biome Deep Sleeping Mask also contains some ingredients often marketed as effective in reducing wrinkles, specifically Centella Asiatica Extract, Gluconolactone, Adenosine, and Lactobacillus Ferment. However, the studies supporting the anti-wrinkle claims of these ingredients provide insufficient evidence of efficacy according to CreamScan Research Evaluation Standards. Therefore, these ingredients do not contribute to the anti-wrinkle rating.
 
Moisturizers, when used regularly, are proven to prevent wrinkle formation and even reduce existing wrinkles. Therefore, this product, like any other moisturizer, can deliver some anti-wrinkle effects through its moisturizing action.
 

Please refer to the Ratings section below for details of the anti-wrinkle rating calculation.

Rich in Skin-Protecting Antioxidants

We estimate that ma:nyo Bifida Biome Deep Sleeping Mask is rich (> 3%) in antioxidants, specifically Niacinamide (est. ≈1.5%), Centella Asiatica Extract (est. ≈1.0%), Chamomilla Recutita (Matricaria) Flower Extract (est. ≈0.3%), and others.

A key benefit of antioxidants is their ability to reduce oxidative stress caused by free radicals and therefore prevent accelerated skin aging. Studies also show that antioxidants can protect against environmental damage such as UV radiation and pollution, and help reduce inflammation and skin redness.

Skin Soothing and Calming Potential

Based on the ingredient list analysis, ma:nyo Bifida Biome Deep Sleeping Mask is rich (> 5%) in soothing ingredients, particularly Bifida Ferment Lysate (est. ≈10.0%).

When applied to the skin, compounds of soothing ingredients, such as triglycerides, phospholipids, fatty acids, phenolic compounds, and antioxidants, work together to soothe the skin through various mechanisms: reducing inflammation, promoting wound healing, repairing the skin barrier, and providing antimicrobial and antioxidant activities.

Please note that this is not a complete list of benefits. We are in the process of enhancing our AI model to incorporate anti-pigmentation, exfoliation and anti-acne ratings.

Things to Be Aware Of: ma:nyo Bifida Biome Deep Sleeping Mask

 
CreamScan AI identified a few things to consider before adding ma:nyo Bifida Biome Deep Sleeping Mask to your skincare routine:
 

If It’s Your Only Moisturizer, It Needs to Be Paired with Some Occlusives

While humectants are highly effective at attracting water to the skin, studies (J. N. Kraft, C. W. Lynde) suggest they may not be efficient when used alone.

One major drawback of purely humectant moisturization is that the water attracted by humectants to the upper layers of the skin can evaporate completely into the environment through transepidermal water loss (TEWL). Adding occlusive ingredients helps seal this moisture into the skin and prevent further water loss.

If you’re using ma:nyo Bifida Biome Deep Sleeping Mask as your only moisturizer, consider pairing it with one that contains at least some occlusive ingredients, such as oils, butters, or silicones. These work alongside humectants to create a protective barrier, locking in hydration and ensuring longer-lasting moisturization. The amount of occlusive needed depends on your skin type - the drier the skin, the more occlusives it requires.

If this product is used not as a standalone moisturizer but as part of your skincare routine, such as a toner or serum, it should be applied before your main moisturizer (unless it's a sunscreen), which will provide the necessary occlusivity on top of it.

Pros & Cons of ma:nyo Bifida Biome Deep Sleeping Mask

 
Here’s an overview of the pros and cons of ma:nyo Bifida Biome Deep Sleeping Mask to help you decide if it’s the right choice for your skincare routine:
 

Pros:

  • Humectant-rich moisturizing ideal for oily skin
  • Lightweight texture
  • A humectant moisturizing boost for any skincare routine
  • Offers modest anti-wrinkle efficacy
  • Rich in antioxidants that combat oxidative stress associated with accelerated skin aging and defend against environmental damage such as UV radiation and pollution
  • Contains a high concentration of soothing ingredients, which may help reduce irritation and soothe the skin

Cons: 

  • Needs occlusives to seal in humectants if used as a standalone moisturizer

Ingredients

Est. % Ingredient Origin Functions
55
10
6
4
3
2.5
2
1.5
1.3
1
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Est. %
Water
Function:
Origin:
Bifida Ferment Lysate
Function:
Origin:
Glycerin
Function:
Origin:
Butylene Glycol
Function:
Origin:
Capric Acid
Function:
Origin:
Cetyl Ethylhexanoate
Function:
Origin:
Methylpropanediol
Function:
Origin:
Niacinamide
Function:
Origin:
1,2-Hexanediol
Function:
Origin:
Centella Asiatica Extract
Function:
Origin:
Oenothera Biennis (Evening Primrose) Leaf Extract
Function:
Origin:
Chamomilla Recutita (Matricaria) Flower Extract
Function:
Origin:
Hamamelis Virginiana (Witch Hazel) Water
Function:
Origin:
Borago Officinalis Extract
Function:
Origin:
Centaurea Cyanus Flower Extract
Function:
Origin:
Lavandula Angustifolia (Lavender) Flower Extract
Function:
Origin:
Salvia Sclarea (Clary) Oil
Function:
Origin:
Dextrin
Function:
Origin:
Hydrogenated Lecithin
Function:
Origin:
Dipropylene Glycol
Function:
Origin:
Ceramide NP
Function:
Origin:
Cholesterol
Function:
Origin:
Capryloyl Salicylic Acid
Function:
Origin:
Gluconolactone
Function:
Origin:
Theobroma Cacao (Cocoa) Extract
Function:
Origin:
Inulin
Function:
Origin:
Xanthan Gum
Function:
Origin:
Cellulose
Function:
Origin:
Fructose
Function:
Origin:
Glucose
Function:
Origin:
Polyglyceryl-3 Methylglucose Distearate
Function:
Origin:
Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer
Function:
Origin:
Polyisobutene
Function:
Origin:
Carbomer
Function:
Origin:
Polyglyceryl-3 Diisostearate
Function:
Origin:
2-Hydroxyethyl Acrylate
Function:
Origin:
Sorbitan Isostearate
Function:
Origin:
Adenosine
Function:
Origin:
Lactobacillus Ferment
Function:
Origin:
Lactobacillus
Function:
Origin:
Streptococcus Oralis
Function:
Origin:
Arginine
Function:
Origin:
Glyceryl Stearate SE
Function:
Origin:
Stearyl Alcohol
Function:
Origin:
Ethylhexylglycerin
Function:
Origin:
Betaine
Function:
Origin:
Caprylyl/Capryl Glucoside
Function:
Origin:
Sorbitan Oleate
Function:
Origin:
Cellulose Gum
Function:
Origin:
Disodium EDTA
Function:
Origin:

Ratings

All humectants
15.9
6
4
2
1.5
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Benchmark
10
All occlusives
0.0
None
Benchmark
20
Moisturizing rating
5.0
Ingredient Est. % Benchmark Raiting
Humectancy All humectants 15.9 10
10.0
6
4
2
1.5
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Occlusivity All occlusives 0.0 20
0.0
None
Moisturizing rating
5.0
Ingredient Est. % Benchmark Humectancy
6
4
2
1.5
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
All humectants 15.9 10
10
All humectants
15.9
6
4
2
1.5
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Benchmark
10
Ingredient Est. % Benchmark Occlusivity
None
All occlusives 0.0 20
0.0
All occlusives
0.0
None
Benchmark
20
Ingredient
Ingredient anti-wrinkle power
when present at, %
in this formula est. %
Rating
6 /10 4 1.5 2.2
n/a
- 1 -
n/a
- 0.3 -
n/a
- 0.3 -
n/a
- 0.3 -
Total
2.2
Niacinamide
2.2
Ingredient anti-wrinkle power
6 /10
when present at, %
4
in this formula, est. %
1.5
Centella Asiatica Extract
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
1
Gluconolactone
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Adenosine
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Lactobacillus Ferment
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Anti-wrinkle rating
2.2
Ingredient Est. % Benchmark
Rich in Antioxidants
1.5
1
0.3
0.3
0.3
0.3
0.3
All antioxidants 4 3 Rich in antioxidants
All antioxidants
4
Niacinamide
1.5
Centella Asiatica Extract
1
Chamomilla Recutita (Matricaria) Flower Extract
0.3
Borago Officinalis Extract
0.3
Centaurea Cyanus Flower Extract
0.3
Theobroma Cacao (Cocoa) Extract
0.3
Lactobacillus
0.3
Benchmark
3
Ingredient Est. % Benchmark
Rich in Soothing
10
1.5
1
0.3
0.3
0.3
0.3
All soothing 13.7 5 Rich in soothing
All soothing
13.7
10
1.5
1
0.3
0.3
0.3
0.3
Benchmark
5

Ingredients explained

Water
Est. %55
Function
Origin
WaterThe most used ingredient in skincare. Its concentration defines the product texture: rich creams may have about 50% of water while a light jelly about 90%. Water doesn’t moisturize the skin by itself and is used in skincare as a solvent for other ingredients.
Bifida Ferment Lysate
Est. %10
Function
Origin
Bifida Ferment LysateA mixture of probiotic bacteria. According to the patent holder, it contains enzymes that are able to repair damaged DNA in skin cells. A single study confirms that it is able to reduce skin sensitivity.
Glycerin
Est. %6
Function
Origin
Glycerin

The most popular moisturizing ingredient in the world. It is a powerful humectant – cheap yet very effective.

Butylene Glycol
Est. %4
Function
Origin
Butylene Glycol

A clear, colorless liquid humectant that draws moisture to the skin. The humectancy of butylene glycol, owed to its two hydroxyl groups, is quite considerable, although not as powerful as glycerin, which contains three hydroxyl groups.

Capric Acid
Est. %3
Function
Origin
Capric Acid
Cetyl Ethylhexanoate
Est. %2.5
Function
Origin
Cetyl EthylhexanoateA clear, pale yellow liquid, that functions as an emollient and a solvent, meaning that it is useful for dissolving oil-soluble ingredients.
Methylpropanediol
Est. %2
Function
Origin
MethylpropanediolMethylpropanediol is a unique glycol that contains two primary hydroxyl groups. That makes methylpropanediol a powerful humectant and an excellent solvent.
Niacinamide
Est. %1.5
Function
Origin
Niacinamide

Also known as vitamin B3, this ingredient is a true superstar with confirmed moisturizing, anti-acne, hyperpigmentation, and antioxidant benefits. Two studies confirm its significant anti-wrinkle efficacy.

1,2-Hexanediol
Est. %1.3
Function
Origin
1,2-HexanediolA multi-functional formula helper. It is a well-studied preservtive against bacteria and can help pigments and fragrances disperse evenly in a formula.
Centella Asiatica Extract
Est. %1
Function
Origin
Centella Asiatica ExtractAn extract from the leaves of the Gotu kola. It is used in skincare for its antioxidant, wound healing, anti-inflammatory, and anti-aging properties. It increases the production of collagen and hyaluronic acid in the skin.
Oenothera Biennis (Evening Primrose) Leaf Extract
Est. %0.3
Function
Origin
Oenothera Biennis (Evening Primrose) Leaf Extract
Chamomilla Recutita (Matricaria) Flower Extract
Est. %0.3
Function
Origin
Chamomilla Recutita (Matricaria) Flower ExtractDerived from German chamomile flowers, this extract is especially known for its anti-inflammatory and soothing benefits. It contains two soothing compounds called chamazulene and bisabolol, as well as antioxidant flavonoids.
Hamamelis Virginiana (Witch Hazel) Water
Est. %0.3
Function
Origin
Hamamelis Virginiana (Witch Hazel) WaterA fragrant, astringent essential water obtained by steeping and distilling the twigs and leaves of the witch hazel plant. It leaves the skin feeling tight and refreshed after application and helps with the healing of small cuts on the skin.
Borago Officinalis Extract
Est. %0.3
Function
Origin
Borago Officinalis Extract
Centaurea Cyanus Flower Extract
Est. %0.3
Function
Origin
Centaurea Cyanus Flower ExtractObtained from the cornflower, this extract contains antioxidant and astringent protocyanin, anthocyanins, flavonoids, and organic acids.
Lavandula Angustifolia (Lavender) Flower Extract
Est. %0.3
Function
Origin
Lavandula Angustifolia (Lavender) Flower ExtractObtained from lavender flowers, this extract contains a fragrant essential oil along with various antioxidant and astringent flavonoids, terpenes, and phenolic acids. It is used in skincare for its refreshing, calming scent, or as a cleansing ingredient.
Salvia Sclarea (Clary) Oil
Est. %0.3
Function
Origin
Salvia Sclarea (Clary) OilA fragrant essential oil obtained from the clary sage that has a sweet, herbal, soft, and woody aroma, with some hints of lavender.
Dextrin
Est. %0.3
Function
Origin
DextrinA partially hydrolyzed potato starch, most commonly used as a viscosity controlling and binding agent. When dispersed into water, it can create textures ranging from a thick paste to a soft gel.
Hydrogenated Lecithin
Est. %0.3
Function
Origin
Hydrogenated LecithinA version of plain lecithin that has been saturated with hydrogen atoms. This ingredient can be derived from plants, like soy or sunflower, from egg yolks, or made synthetically. Its major function is to emulsify water and oils.
Dipropylene Glycol
Est. %0.3
Function
Origin
Dipropylene GlycolA clear, colorless liquid that has several uses. One of its main functions is as a solvent. Dipropylene glycol is also used to reduce the thickness of skincare products.
Ceramide NP
Est. %0.3
Function
Origin
Ceramide NPAlso known as ceramide 3, it is the most common ceramide in our skin. It helps to restore the skin’s lipid barrier and alleviate the symptoms of dry and cracked skin. Research has shown that skin suffering from conditions such as AD lacks ceramides.
Cholesterol
Est. %0.3
Function
Origin
CholesterolAn emollient and important barrier repairing lipid, effective when combined with fatty acids and ceramides. Around 25% of the skin’s lipid layer is made up of cholesterol and it is found in the membrane of every single cell in our body.
Capryloyl Salicylic Acid
Est. %0.3
Function
Origin
Capryloyl Salicylic AcidA derivative of salicylic acid, with bigger and more lipid-soluble molecules. This makes it more powerful and safer than salicylic acid. It is used as an exfoliating and peeling agent.
Gluconolactone
Est. %0.3
Function
Origin
GluconolactoneA PHA derived from glucose. It has exfoliating and humectant properties and acts as a penetration enhancer for other ingredients. It has also been shown to assist in the treatment of acne and the prevention of photoaging.
Theobroma Cacao (Cocoa) Extract
Est. %0.3
Function
Origin
Theobroma Cacao (Cocoa) Extract

An extract from cocoa beans or cocoa powder with lots of beneficial compounds such as stimulant caffeine, antioxidant and astringent flavanols, and tannins – which are responsible for its bitter taste.

Inulin
Est. %0.3
Function
Origin
InulinA naturally occurring polysaccharide that works as a humectant moisturizing ingredient.
Xanthan Gum
Est. %0.3
Function
Origin
Xanthan GumA natural multi-functional ingredient that originates from fermented sugars. Xanthan gum acts as a viscosity-building agent to thicken skincare products. It is also an excellent stabilizer and works well to hold other ingredients together.
Cellulose
Est. %0.3
Function
Origin
CelluloseA natural ingredient that can create water-based gels, absorb oils, and exfoliate the skin. One of the main functions of cellulose is as a bulking and viscosity controlling agent. Cellulose can also modify the slip aesthetics and act as an opacifying agent.
Fructose
Est. %0.3
Function
Origin
FructoseA natural sugar that moisturizes the skin by drawing water to the surface.
Glucose
Est. %0.3
Function
Origin
GlucoseA simple sugar that is also one of two components of sucrose, or table sugar. It is used as a humectant in skincare products. Glucose is also used to flavor lip care cosmetics because of its mildly sweet taste.
Polyglyceryl-3 Methylglucose Distearate
Est. %0.3
Function
Origin
Polyglyceryl-3 Methylglucose DistearateA natural ingredient that produces oil and water mixtures with soft skin feel.
Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer
Est. %0.3
Function
Origin
Sodium Acrylate/Sodium Acryloyldimethyl Taurate CopolymerA multi-functional ingredient that forms a polymeric network, thereby thickening the formula and preventing other ingredients from shifting around.
Polyisobutene
Est. %0.3
Function
Origin
PolyisobuteneA highly viscous liquid that is used in lip gloss formulations to prolong wear time and add shimmer. Polyisobutene dramatically increases the thickness of skincare products it is added to.
Carbomer
Est. %0.3
Function
Origin
CarbomerA synthetic ingredient with the ability to gel water. When used in emulsions, such as lotions and creams, carbomer can also act as an emulsion stabilizer.
Polyglyceryl-3 Diisostearate
Est. %0.3
Function
Origin
Polyglyceryl-3 DiisostearateA vegetable-based ingredient that stabilizes mixtures of oil and water.
2-Hydroxyethyl Acrylate
Est. %0.3
Function
Origin
2-Hydroxyethyl Acrylate
Sorbitan Isostearate
Est. %0.3
Function
Origin
Sorbitan IsostearateA mild yet powerful emulsifier primarily utilized to produce water-in-oil emulsions. It helps to create a particularly rich and substantial emulsion.
Adenosine
Est. %0.3
Function
Origin
Adenosine

A key molecule responsible for energy transportation, signaling, and enzyme activity. Adenosine is a popular anti-wrinkle ingredient, however, the key study about its anti-wrinkle efficacy (1) does not meet CreamScan Research Evaluation Standards as it is not double-blind.

Lactobacillus Ferment
Est. %0.3
Function
Origin
Lactobacillus FermentA biotechnological product – a mixture of metabolic products of Lactobacillus culture. Some Lactobacillus forms have been reported to have anti-wrinkle and barrier repairing effects, as well as able to improve skin hydration, elasticity, and gloss.
Lactobacillus
Est. %0.3
Function
Origin
LactobacillusA genus of probiotic bacteria. Lactobacillus bacteria are part of the human microflora and their ferment products contain antioxidants.
Streptococcus Oralis
Est. %0.3
Function
Origin
Streptococcus Oralis
Arginine
Est. %0.3
Function
Origin
ArginineA humectant amino acid used to attract water to the skin’s surface. It is a part of the skin's Natural Moisturizing Factor, a mixture of various compounds that keeps the skin’s surface well hydrated. Arginine can also be used as a pH adjuster.
Glyceryl Stearate SE
Est. %0.3
Function
Origin
Glyceryl Stearate SEAn emulsifier, where the SE stands for self-emulsifying. Emulsions containing glyceryl stearate SE often impart a smooth, velvety feel upon the skin.
Stearyl Alcohol
Est. %0.3
Function
Origin
Stearyl AlcoholA natural fatty alcohol that thickens, stabilizes, and keeps emulsions a bright white color. It has many uses, the main one being as an emulsifier. It also acts as an opacifying agent and emollient.
Ethylhexylglycerin
Est. %0.3
Function
Origin
EthylhexylglycerinA preservative booster derived from glycerin. It is commonly paired with other preservatives to improve their efficacy. Ethylhexylglycerin is also a humectant due to its chemical base of glycerin.
Betaine
Est. %0.3
Function
Origin
BetaineAn ingredient derived from the sucrose in sugar beets. It has a negative chemical charge and a positive chemical charge on the same molecule. This allows betaine to be hygroscopic or humectant and thus provide moisturization by drawing water to the skin.
Caprylyl/Capryl Glucoside
Est. %0.3
Function
Origin
Caprylyl/Capryl GlucosideA naturally-derived surfactant used for gentle cleansing and foam-boosting when combined with other surfactants.
Sorbitan Oleate
Est. %0.3
Function
Origin
Sorbitan OleateA vegetable-based ingredient that stabilizes mixtures of oil and water. Sorbitan oleate serves primarily as an emulsifier that produces water-in-oil emulsions.
Cellulose Gum
Est. %0.3
Function
Origin
Cellulose GumA polymer that is derived from its namesake, cellulose, which is plant-based. It has many formula-helper benefits, including thickening and product stabilization.
Disodium EDTA
Est. %0.3
Function
Origin
Disodium EDTAA synthetic chelator that helps to maintain the look and smell of a product by 'locking up' troublesome metal ions.