ma:nyo Bifida Biome Concentrate Serum Review

ma:nyo Bifida Biome Concentrate Serum
5.4
/ 10
Moisturizing
10.0 Humectancy icon Humectancy
0.8 Occlusivity icon Occlusivity
2.2Anti-wrinkle icon/ 10
Anti-wrinkle
Rich
in Antioxidants
Rich Skin Soothing icon
in Skin Soothers
Review

Does ma:nyo Bifida Biome Concentrate Serum Work?

 
According to CreamScan AI's analysis of the ingredient list, here’s what ma:nyo Bifida Biome Concentrate Serum has to offer:
 
  • Strong humectant moisturizing. This lightweight, humectant-rich product, ideal for oily skin, has a moisturizing rating of 5.4 out of 10.
  • Modest anti-wrinkle efficacy: ma:nyo Bifida Biome Concentrate Serum has an anti-wrinkle rating of 2.2 out of 10 so you may expect some, although limited, effect on wrinkles.
  • Soothing: ma:nyo Bifida Biome Concentrate Serum contains a high concentration of soothing ingredients, which may help to reduce irritation and calm the skin.
  • Antioxidant protection.

Key Benefits of ma:nyo Bifida Biome Concentrate Serum

 
These are the key benefits you can expect from using ma:nyo Bifida Biome Concentrate Serum:
 

Lightweight Humectant Moisturizer Ideal for Oily Skin

According to CreamScan analysis, ma:nyo Bifida Biome Concentrate Serum is quite moisturizing, with a moisturizing rating of 5.4 out of 10.

Is it more humectant or occlusive? Significantly more humectant. It has a low occlusivity of 0.8 out of 10 and a maximum humectancy of 10 out of 10, primarily due to the high content of Glycerin (est. ≈22.0%), Propanediol (est. ≈6.0%) and Butylene Glycol (est. ≈2.0%).

This humectant-rich product, when used alone as a moisturizer, is ideal for oily skin, offering significant hydration in a lightweight, fast-absorbing formula with a minimal amount of occlusive ingredients.

It’s also a great choice for people with normal skin who prefer lightweight moisturizers.

A Humectant Boost for Any Skincare Routine

But it’s not limited to oily skin - such a humectant boost will also positively contribute to the moisturizing efficacy of any skincare routine when used as a step before applying the main moisturizer. This type of formulation is typically used in serums, where a light, fast-absorbing texture is key.

Please refer to the Ratings section below for details of the moisturizing rating calculation.

Modest Anti-Wrinkle Efficacy

According to CreamScan analysis, ma:nyo Bifida Biome Concentrate Serum has a modest level of anti-wrinkle efficacy, rated 2.2 out of 10.

It contains one ingredient with proven anti-wrinkle efficacy: Niacinamide (est. ≈1.5%), 
 one of the most effective and well-researched anti-wrinkle ingredients. A clinical study involving 30 participants (Kawada et al.) confirmed that a cream with 4% niacinamide reduced the average depth of wrinkles around the eyes by 9% after 8 weeks of use, compared to a vehicle (the same formulation without niacinamide).
 
Among others, ma:nyo Bifida Biome Concentrate Serum also contains contains Adenosine and Camellia Sinensis Leaf Extract, two ingredients often marketed as effective in reducing wrinkles. However, the studies supporting the anti-wrinkle claims of these ingredients provide insufficient evidence of efficacy according to CreamScan Research Evaluation Standards. Therefore, these ingredients do not contribute to the anti-wrinkle rating.
 
Moisturizers, when used regularly, are proven to prevent wrinkle formation and even reduce existing wrinkles. Therefore, this product, like any other moisturizer, can deliver some anti-wrinkle effects through its moisturizing action.
 

Please refer to the Ratings section below for details of the anti-wrinkle rating calculation.

Rich in Skin-Protecting Antioxidants

We estimate that ma:nyo Bifida Biome Concentrate Serum is rich (> 3%) in antioxidants, specifically Niacinamide (est. ≈1.5%), Sodium Hyaluronate (est. ≈0.3%), Hydrolyzed Hyaluronic Acid (est. ≈0.3%), and others.

A key benefit of antioxidants is their ability to reduce oxidative stress caused by free radicals and therefore prevent accelerated skin aging. Studies also show that antioxidants can protect against environmental damage such as UV radiation and pollution, and help reduce inflammation and skin redness.

Skin Soothing and Calming Potential

Based on the ingredient list analysis, ma:nyo Bifida Biome Concentrate Serum is rich (> 5%) in soothing ingredients, particularly Bifida Ferment Lysate (est. ≈40.0%).

When applied to the skin, compounds of soothing ingredients, such as triglycerides, phospholipids, fatty acids, phenolic compounds, and antioxidants, work together to soothe the skin through various mechanisms: reducing inflammation, promoting wound healing, repairing the skin barrier, and providing antimicrobial and antioxidant activities.

Please note that this is not a complete list of benefits. We are in the process of enhancing our AI model to incorporate anti-pigmentation, exfoliation and anti-acne ratings.

Pros & Cons of ma:nyo Bifida Biome Concentrate Serum

 
Here’s an overview of the pros and cons of ma:nyo Bifida Biome Concentrate Serum to help you decide if it’s the right choice for your skincare routine:
 

Pros:

  • When used alone: Provides humectant-rich moisturizing ideal for oily skin
  • As part of a routine: A humectant moisturizing boost, beneficial for any skin type
  • Lightweight texture
  • Offers modest anti-wrinkle efficacy
  • Rich in antioxidants that combat oxidative stress associated with accelerated skin aging and defend against environmental damage
  • Potentially soothing, as it contains a high concentration of soothing ingredients, specifically Bifida Ferment Lysate

Cons: 

  • We couldn't find any

Ingredients

Est. % Ingredient Origin Functions
40
22
11
6
4
3
2
1.5
1
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Est. %
Bifida Ferment Lysate
Function:
Origin:
Glycerin
Function:
Origin:
Dipropylene Glycol
Function:
Origin:
Propanediol
Function:
Origin:
1,2-Hexanediol
Function:
Origin:
Water
Function:
Origin:
Butylene Glycol
Function:
Origin:
Niacinamide
Function:
Origin:
Rosa Damascena Flower Water
Function:
Origin:
Panthenol
Function:
Origin:
Cutibacterium Granulosum Ferment Extract Filtrate
Function:
Origin:
Phytosphingosine
Function:
Origin:
Acetylphytosphingosine
Function:
Origin:
Sodium Hyaluronate
Function:
Origin:
Hydroxypropyltrimonium Hyaluronate
Function:
Origin:
Hydrolyzed Hyaluronic Acid
Function:
Origin:
Sodium Acetylated Hyaluronate
Function:
Origin:
Sodium Hyaluronate Crosspolymer
Function:
Origin:
Hydrolyzed Sodium Hyaluronate
Function:
Origin:
Hyaluronic Acid
Function:
Origin:
Potassium Hyaluronate
Function:
Origin:
Caprylic/Capric Triglyceride
Function:
Origin:
Glyceryl Acrylate/Acrylic Acid Copolymer
Function:
Origin:
C10-30 Alkyl Acrylate
Function:
Origin:
PEG-Crosspolymer
Function:
Origin:
Adenosine
Function:
Origin:
Squalane
Function:
Origin:
Polyglyceryl-10 Laurate
Function:
Origin:
Polyglyceryl-10 Myristate
Function:
Origin:
Ceramide NP
Function:
Origin:
Ceramide NS
Function:
Origin:
Ceramide AP
Function:
Origin:
Ceramide EOP
Function:
Origin:
Cholesterol
Function:
Origin:
Centella Asiatica Leaf Water
Function:
Origin:
Camellia Sinensis Leaf Extract
Function:
Origin:
Olea Europaea (Olive) Fruit Oil
Function:
Origin:
Butyrospermum Parkii (Shea) Butter
Function:
Origin:
Hydrogenated Lecithin
Function:
Origin:
Polyglyceryl-4 Oleate
Function:
Origin:
Ethylhexyl Olivate
Function:
Origin:
Ethylhexylglycerin
Function:
Origin:
Disodium EDTA
Function:
Origin:
Arginine
Function:
Origin:
Carbomer
Function:
Origin:
Portulaca Oleracea Extract
Function:
Origin:
Linalool
Function:
Origin:
Benzyl Salicylate
Function:
Origin:
Fragrance
Function:
Origin:

Ratings

All humectants
35.1
22
6
2
1.5
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Benchmark
10
All occlusives
1.5
0.3
0.3
0.3
0.3
0.3
Benchmark
20
Moisturizing rating
5.4
Ingredient Est. % Benchmark Raiting
Humectancy All humectants 35.1 10
10.0
22
6
2
1.5
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Occlusivity All occlusives 1.5 20
0.8
0.3
0.3
0.3
0.3
0.3
Moisturizing rating
5.4
Ingredient Est. % Benchmark Humectancy
22
6
2
1.5
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
All humectants 35.1 10
10
All humectants
35.1
22
6
2
1.5
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Benchmark
10
Ingredient Est. % Benchmark Occlusivity
0.3
0.3
0.3
0.3
0.3
All occlusives 1.5 20
0.8
All occlusives
1.5
0.3
0.3
0.3
0.3
0.3
Benchmark
20
Ingredient
Ingredient anti-wrinkle power
when present at, %
in this formula est. %
Rating
6 /10 4 1.5 2.2
n/a
- 0.3 -
n/a
- 0.3 -
Total
2.2
Niacinamide
2.2
Ingredient anti-wrinkle power
6 /10
when present at, %
4
in this formula, est. %
1.5
Adenosine
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Camellia Sinensis Leaf Extract
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Anti-wrinkle rating
2.2
Ingredient Est. % Benchmark
Rich in Antioxidants
1.5
0.3
0.3
0.3
0.3
0.3
0.3
0.3
All antioxidants 3.6 3 Rich in antioxidants
All antioxidants
3.6
Niacinamide
1.5
Sodium Hyaluronate
0.3
Hydrolyzed Hyaluronic Acid
0.3
Hydrolyzed Sodium Hyaluronate
0.3
Hyaluronic Acid
0.3
Camellia Sinensis Leaf Extract
0.3
Olea Europaea (Olive) Fruit Oil
0.3
Portulaca Oleracea Extract
0.3
Benchmark
3
Ingredient Est. % Benchmark
Rich in Soothing
40
1.5
0.3
0.3
0.3
0.3
All soothing 42.7 5 Rich in soothing
All soothing
42.7
40
1.5
0.3
0.3
0.3
0.3
Benchmark
5

Ingredients explained

Bifida Ferment Lysate
Est. %40
Function
Origin
Bifida Ferment LysateA mixture of probiotic bacteria. According to the patent holder, it contains enzymes that are able to repair damaged DNA in skin cells. A single study confirms that it is able to reduce skin sensitivity.
Glycerin
Est. %22
Function
Origin
Glycerin

The most popular moisturizing ingredient in the world. It is a powerful humectant – cheap yet very effective.

Dipropylene Glycol
Est. %11
Function
Origin
Dipropylene GlycolA clear, colorless liquid that has several uses. One of its main functions is as a solvent. Dipropylene glycol is also used to reduce the thickness of skincare products.
Propanediol
Est. %6
Function
Origin
PropanediolAn excellent solvent capable of mixing water with normally water-insoluble ingredients. It also functions as a humectant due to its water-loving alcohol groups. Propanediol can control the viscosity of a product by reducing its thickness.
1,2-Hexanediol
Est. %4
Function
Origin
1,2-HexanediolA multi-functional formula helper. It is a well-studied preservtive against bacteria and can help pigments and fragrances disperse evenly in a formula.
Water
Est. %3
Function
Origin
WaterThe most used ingredient in skincare. Its concentration defines the product texture: rich creams may have about 50% of water while a light jelly about 90%. Water doesn’t moisturize the skin by itself and is used in skincare as a solvent for other ingredients.
Butylene Glycol
Est. %2
Function
Origin
Butylene Glycol

A clear, colorless liquid humectant that draws moisture to the skin. The humectancy of butylene glycol, owed to its two hydroxyl groups, is quite considerable, although not as powerful as glycerin, which contains three hydroxyl groups.

Niacinamide
Est. %1.5
Function
Origin
Niacinamide

Also known as vitamin B3, this ingredient is a true superstar with confirmed moisturizing, anti-acne, hyperpigmentation, and antioxidant benefits. Two studies confirm its significant anti-wrinkle efficacy.

Rosa Damascena Flower Water
Est. %1
Function
Origin
Rosa Damascena Flower WaterA fragrant water that is leftover after the steam distillation of Damask rose petals. During this process, the essential oil floats to the surface of the water and is collected. The leftover water has a fresh, rosy scent.
Panthenol
Est. %0.3
Function
Origin
PanthenolA popular soothing and moisturizing derivative of vitamin B5. Panthenol is particularly beneficial for dry, flaking, burned, or damaged skin. It is used to alleviate the symptoms of a rash, dermatitis, eczema, chapped lips, and sunburn.
Cutibacterium Granulosum Ferment Extract Filtrate
Est. %0.3
Function
Origin
Cutibacterium Granulosum Ferment Extract Filtrate
Phytosphingosine
Est. %0.3
Function
Origin
PhytosphingosineA key component of ceramides NP, AP, and EOP. It has barrier repair properties and stimulates the production of the skin’s Natural Moisturizing Factor. Phytosphingosine has strong antimicrobial and anti-inflammatory activity, which can be used to treat acne.
Acetylphytosphingosine
Est. %0.3
Function
Origin
Acetylphytosphingosine
Sodium Hyaluronate
Est. %0.3
Function
Origin
Sodium Hyaluronate

A sodium salt of famous hyaluronic acid. A potent humectant that hydrates the skin, supports collagen function, and fills out small wrinkles. Sodium hyaluronate also offers soothing and antioxidant properties.

Hydroxypropyltrimonium Hyaluronate
Est. %0.3
Function
Origin
Hydroxypropyltrimonium Hyaluronate
Hydrolyzed Hyaluronic Acid
Est. %0.3
Function
Origin
Hydrolyzed Hyaluronic AcidA smaller-molecule version of the regular hyaluronic acid. It is a powerful humectant that absorbs into the skin and offers moisturizing, smoothing, and anti-wrinkle effects. It is also slightly anti-inflammatory and displays subtle antioxidant properties.
Sodium Acetylated Hyaluronate
Est. %0.3
Function
Origin
Sodium Acetylated HyaluronateA chemically modified version of hyaluronic acid. It is more stable and less sticky than regular HA, while still providing the same humectant moisturizing properties (according to the manufacturer). There have been no clinical studies to confirm this.
Sodium Hyaluronate Crosspolymer
Est. %0.3
Function
Origin
Sodium Hyaluronate CrosspolymerA modified version of regular hyaluronic acid. It attracts large volumes of water, thereby making it an effective humectant moisturizing ingredient.
Hydrolyzed Sodium Hyaluronate
Est. %0.3
Function
Origin
Hydrolyzed Sodium HyaluronateA very small-molecule version of regular sodium hyaluronate. It is a powerful humectant skin-identical ingredient that absorbs into the skin and offers plumping, smoothing, and anti-wrinkle effects.
Hyaluronic Acid
Est. %0.3
Function
Origin
Hyaluronic Acid

A potent, skin-identical humectant moisturizing ingredient that is able to bind water 1000 times its own weight. The anti-aging benefits of hyaluronic acid are due to its ability to stimulate the synthesis of collagen in the skin.

Potassium Hyaluronate
Est. %0.3
Function
Origin
Potassium Hyaluronate
Caprylic/Capric Triglyceride
Est. %0.3
Function
Origin
Caprylic/Capric TriglycerideA natural occlusive moisturizing and emollient ingredient, it is a blend of glycerin and two fatty acids, caprylic and capric acid. It creates an oil-based protective layer on the skin, thereby preventing water loss.
Glyceryl Acrylate/Acrylic Acid Copolymer
Est. %0.3
Function
Origin
Glyceryl Acrylate/Acrylic Acid CopolymerA synthetic humectant moisturizer often paired with glycerin. It also functions as a viscosity-controlling agent that creates gel-like formulas with thicker textures.
C10-30 Alkyl Acrylate
Est. %0.3
Function
Origin
C10-30 Alkyl Acrylate
PEG-Crosspolymer
Est. %0.3
Function
Origin
PEG-Crosspolymer
Adenosine
Est. %0.3
Function
Origin
Adenosine

A key molecule responsible for energy transportation, signaling, and enzyme activity. Adenosine is a popular anti-wrinkle ingredient, however, the key study about its anti-wrinkle efficacy (1) does not meet CreamScan Research Evaluation Standards as it is not double-blind.

Squalane
Est. %0.3
Function
Origin
SqualaneAn occlusive moisturizing and emollient compound that forms part of the skin’s sebum. The main source of squalane had always been shark liver. Now, however, it is manufactured synthetically or derived from plant oils, such as olive and peanut oil.
Polyglyceryl-10 Laurate
Est. %0.3
Function
Origin
Polyglyceryl-10 LaurateA vegetable glycerin or synthetically produced emulsifier and gentle cleansing agent. It won't leave skin feeling tight or dry when used to cleanse.
Polyglyceryl-10 Myristate
Est. %0.3
Function
Origin
Polyglyceryl-10 MyristateA solubilizer that can help incorporate small amounts of oil to an otherwise watery product while providing lightweight skin feel.
Ceramide NP
Est. %0.3
Function
Origin
Ceramide NPAlso known as ceramide 3, it is the most common ceramide in our skin. It helps to restore the skin’s lipid barrier and alleviate the symptoms of dry and cracked skin. Research has shown that skin suffering from conditions such as AD lacks ceramides.
Ceramide NS
Est. %0.3
Function
Origin
Ceramide NSA wax-like lipid natural to the skin’s lipid matrix. It is less frequently used but, in combination with other ceramides, can help to restore balance in the skin’s lipid barrier.
Ceramide AP
Est. %0.3
Function
Origin
Ceramide APPreviously called Ceramide 6 II, Ceramide AP is one of the most common ceramides in the skin. Research has shown that dry, flaky skin has significantly less Ceramide AP. Its application helps to treat dry skin by restoring balance in the skin lipids.
Ceramide EOP
Est. %0.3
Function
Origin
Ceramide EOP

Formerly called Ceramide 1, this ingredient is a skin-identical wax-like lipid with an ultra-long fatty acid chain. It restores and stabilizes the skin’s lipid matrix and helps to treat dry and flaky skin, especially when combined with other ceramides.

Cholesterol
Est. %0.3
Function
Origin
CholesterolAn emollient and important barrier repairing lipid, effective when combined with fatty acids and ceramides. Around 25% of the skin’s lipid layer is made up of cholesterol and it is found in the membrane of every single cell in our body.
Centella Asiatica Leaf Water
Est. %0.3
Function
Origin
Centella Asiatica Leaf Water
Camellia Sinensis Leaf Extract
Est. %0.3
Function
Origin
Camellia Sinensis Leaf Extract

An antioxidant green tea extract. In the deeper layers, it slows down the destruction of collagen, elastin, and hyaluronic acid – thus delaying the signs of aging. It also acts as an anti-acne, soothing, moisturizing, and emollient ingredient.

Olea Europaea (Olive) Fruit Oil
Est. %0.3
Function
Origin
Olea Europaea (Olive) Fruit Oil

A famous olive oil widely used in skincare as an emollient and occlusive moisturizer. It contains mainly unsaturated fatty acids, antioxidant flavonoids, and oleuropeins. Olive oil is listed as a common comedogenic ingredient by acne.org.

Butyrospermum Parkii (Shea) Butter
Est. %0.3
Function
Origin
Butyrospermum Parkii (Shea) ButterA semi-solid, buttery fat extracted from the seeds of the Shea tree that is a wonderful occlusive and emollient ingredient mainly comprised of fatty acids. Shea butter contains a large amount of anti-inflammatory and antioxidant compounds.
Hydrogenated Lecithin
Est. %0.3
Function
Origin
Hydrogenated LecithinA version of plain lecithin that has been saturated with hydrogen atoms. This ingredient can be derived from plants, like soy or sunflower, from egg yolks, or made synthetically. Its major function is to emulsify water and oils.
Polyglyceryl-4 Oleate
Est. %0.3
Function
Origin
Polyglyceryl-4 Oleate
Ethylhexyl Olivate
Est. %0.3
Function
Origin
Ethylhexyl Olivate
Ethylhexylglycerin
Est. %0.3
Function
Origin
EthylhexylglycerinA preservative booster derived from glycerin. It is commonly paired with other preservatives to improve their efficacy. Ethylhexylglycerin is also a humectant due to its chemical base of glycerin.
Disodium EDTA
Est. %0.3
Function
Origin
Disodium EDTAA synthetic chelator that helps to maintain the look and smell of a product by 'locking up' troublesome metal ions.
Arginine
Est. %0.3
Function
Origin
ArginineA humectant amino acid used to attract water to the skin’s surface. It is a part of the skin's Natural Moisturizing Factor, a mixture of various compounds that keeps the skin’s surface well hydrated. Arginine can also be used as a pH adjuster.
Carbomer
Est. %0.3
Function
Origin
CarbomerA synthetic ingredient with the ability to gel water. When used in emulsions, such as lotions and creams, carbomer can also act as an emulsion stabilizer.
Portulaca Oleracea Extract
Est. %0.3
Function
Origin
Portulaca Oleracea ExtractDerived from green or common purslane, this moisturizing extract is particularly rich in alpha-linolenic acid, an omega-3 fatty acid, and contains antioxidant glutathione and vitamin E. As a herbal medicine, it is believed to treat headaches and inflammation.
Linalool
Est. %0.3
Function
Origin
LinaloolA fragrant, volatile compound naturally present in many essential oils. It has a pleasant scent and is often used in skincare products as a fragrance. People with sensitive skin should try to avoid it, or at least do a patch test before using it.
Benzyl Salicylate
Est. %0.3
Function
Origin
Benzyl Salicylate

A fragrance ingredient with a sweet, floral, and slightly balsamic scent. It is one of the twenty-six fragrances that are considered allergens according to the International Fragrance Association (IFRA), and so its use is restricted.

Fragrance
Est. %0.3
Function
Origin
FragranceUnder trade secret law, manufacturers have the right not to disclose what exactly went into the fragrance and use the unspecific word Fragrance or Parfum instead. Many fragrances are highly allergenic.