Avon Isa Knox Anew LX Ultimate Rejuvenating Serum Review

Avon Isa Knox Anew LX Ultimate Rejuvenating Serum
5.8
/ 10
Moisturizing
10.0 Humectancy icon Humectancy
1.6 Occlusivity icon Occlusivity
2Anti-wrinkle icon/ 10
Anti-wrinkle
Review

Does Avon Isa Knox Anew LX Ultimate Rejuvenating Serum Work?

 
According to CreamScan AI's analysis of the ingredient list, here’s what Avon Isa Knox Anew LX Ultimate Rejuvenating Serum has to offer:
 
✅ Strong humectant moisturizing. This lightweight, humectant-rich product, ideal for oily skin, has a moisturizing rating of 5.8 out of 10.
✅ Modest anti-wrinkle efficacy: Avon Isa Knox Anew LX Ultimate Rejuvenating Serum has an anti-wrinkle rating of 2.0 out of 10 so you may expect some, although limited, effect on wrinkles.

  

Key Benefits of Avon Isa Knox Anew LX Ultimate Rejuvenating Serum

 
These are the key benefits you can expect from using Avon Isa Knox Anew LX Ultimate Rejuvenating Serum:
 

🔵 Lightweight Humectant Moisturizer Ideal for Oily Skin

According to CreamScan analysis, Avon Isa Knox Anew LX Ultimate Rejuvenating Serum is quite moisturizing, with a moisturizing rating of 5.8 out of 10.

Is it more humectant or occlusive? Significantly more humectant. It has a low occlusivity of 1.6 out of 10 and a maximum humectancy of 10 out of 10, primarily due to the high content of Glycerin (est. ≈6.0%) and PEG/PPG/Polybutylene Glycol-8/5/3 Glycerin (est. ≈3.0%).

This humectant-rich product, when used alone as a moisturizer, is ideal for oily skin, offering significant hydration in a lightweight, fast-absorbing formula with a minimal amount of occlusive ingredients.

It’s also a great choice for people with normal skin who prefer lightweight moisturizers.

💧 A Humectant Boost for Any Skincare Routine

But it’s not limited to oily skin - such a humectant boost will also positively contribute to the moisturizing efficacy of any skincare routine when used as a step before applying the main moisturizer. This type of formulation is typically used in serums, where a light, fast-absorbing texture is key.

Please refer to the Ratings section below for details of the moisturizing rating calculation.

🟣 Modest Anti-Wrinkle Efficacy

According to CreamScan analysis, Avon Isa Knox Anew LX Ultimate Rejuvenating Serum has a modest level of anti-wrinkle efficacy, rated 2.0 out of 10.

It contains one ingredient with proven anti-wrinkle efficacy: Niacinamide (est. ≈1.3%),
 one of the most effective and well-researched anti-wrinkle ingredients. A clinical study involving 30 participants (Kawada et al.) confirmed that a cream with 4% niacinamide reduced the average depth of wrinkles around the eyes by 9% after 8 weeks of use, compared to a vehicle (the same formulation without niacinamide).
 
Among others, Avon Isa Knox Anew LX Ultimate Rejuvenating Serum also contains contains Adenosine and Beta-Glucan, two ingredients often marketed as effective in reducing wrinkles. However, the studies supporting the anti-wrinkle claims of these ingredients provide insufficient evidence of efficacy according to CreamScan Research Evaluation Standards.
 
While this does not categorically rule out the possibility that these ingredients may reduce wrinkles, their efficacy is not supported by convincing, vehicle-controlled, double-blind clinical studies - at least none that were available to the CreamScan team at the time of publication.
 
Therefore, these ingredients do not contribute to the anti-wrinkle rating.
 
📌 Moisturizers, when used regularly, are proven to prevent wrinkle formation and even reduce existing wrinkles. Therefore, this product, like any other moisturizer, can deliver some additional anti-wrinkle effects through its moisturizing action.
 

Please refer to the Ratings section below for details of the anti-wrinkle rating calculation.

📌 Please note that this is not a complete list of benefits. We are in the process of enhancing our AI model to incorporate anti-pigmentation, exfoliation and anti-acne ratings.

Pros & Cons of Avon Isa Knox Anew LX Ultimate Rejuvenating Serum

 
Here’s an overview of the pros and cons of Avon Isa Knox Anew LX Ultimate Rejuvenating Serum to help you decide if it’s the right choice for your skincare routine:
 

🟩 Pros:

✅ When used alone: Provides humectant-rich moisturizing ideal for oily skin
✅ As part of a routine: A humectant moisturizing boost, beneficial for any skin type
✅ Lightweight texture
Offers modest anti-wrinkle efficacy
 

⭕ Cons: 

✅ We couldn't find any
   

Summary: Avon Isa Knox Anew LX Ultimate Rejuvenating Serum

 
Based on the ingredient list analysis, CreamScan AI suggests that Avon Isa Knox Anew LX Ultimate Rejuvenating Serum
, when used alone, delivers lightweight, humectant-rich moisturizing, making it ideal for oily skin. As part of a moisturizing routine, it provides a humectant boost, beneficial for all skin types.
 
Avon Isa Knox Anew LX Ultimate Rejuvenating Serum contains ingredients with proven evidence of anti-wrinkle efficacy that may provide a modest anti-wrinkle effect. As a result, you can expect a positive, though not very significant, impact on wrinkles.
 
📌 Fact check. At CreamScan, we are committed to accuracy and fairness. If you spot any errors or something that doesn’t seem right, please click here to let us know. We regularly update the ingredient lists and monitor the latest research on ingredient efficacy to ensure that our information remains as complete and precise as possible. The information provided here is for informational purposes only and does not substitute professional advice. We do not guarantee the efficacy or safety of any product, as individual results may vary.

 

Ingredients

Est. % Ingredient Origin Functions
70
6
4
3
2
1.5
1.3
1
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Est. %
Water
Function:
Origin:
Glycerin
Function:
Origin:
Dipropylene Glycol
Function:
Origin:
PEG/PPG/Polybutylene Glycol-8/5/3 Glycerin
Function:
Origin:
Glyceryl Polymethacrylate
Function:
Origin:
Dimethicone
Function:
Origin:
Niacinamide
Function:
Origin:
1,2-Hexanediol
Function:
Origin:
PEG-150
Function:
Origin:
Methyl Trimethicone
Function:
Origin:
Panthenol
Function:
Origin:
Phenyl Trimethicone
Function:
Origin:
Cyclopentasiloxane
Function:
Origin:
Propylene Glycol
Function:
Origin:
Polymethylsilsesquioxane
Function:
Origin:
Hydrogenated Lecithin
Function:
Origin:
Serine
Function:
Origin:
C14-22 Alcohols
Function:
Origin:
Squalane
Function:
Origin:
PEG-60 Hydrogenated Castor Oil
Function:
Origin:
Macadamia Ternifolia Seed Oil
Function:
Origin:
Butyrospermum Parkii (Shea) Butter
Function:
Origin:
Ceramide NP
Function:
Origin:
Tromethamine
Function:
Origin:
Triethylhexanoin
Function:
Origin:
Carbomer
Function:
Origin:
Dimethiconol
Function:
Origin:
PEG-10 Rapeseed Sterol
Function:
Origin:
Arachidyl Glucoside
Function:
Origin:
Algin
Function:
Origin:
Sodium Polyacrylate
Function:
Origin:
Glyceryl Stearate
Function:
Origin:
Acrylates/C10-30 Alkyl Acrylate Crosspolymer
Function:
Origin:
Adenosine
Function:
Origin:
Stearic Acid
Function:
Origin:
Cholesterol
Function:
Origin:
PEG-100 Stearate
Function:
Origin:
Beta-Glucan
Function:
Origin:
Glycereth-20
Function:
Origin:
Trisodium EDTA
Function:
Origin:
Dextrin
Function:
Origin:
Theobroma Cacao (Cocoa) Seed Extract
Function:
Origin:
Ethylhexylglycerin
Function:
Origin:
Biosaccharide Gum-1
Function:
Origin:
Glycosphingolipids
Function:
Origin:
Phospholipids
Function:
Origin:
Paeonia Suffruticosa Branch/Flower/Leaf Extract
Function:
Origin:
Paeonol
Function:
Origin:
Yellow 6 (CI 15985)
Function:
Origin:
Yellow 5 (CI 19140)
Function:
Origin:
Fragrance
Function:
Origin:

Ratings

All humectants
12.7
6
3
1.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Benchmark
10
All occlusives
3.3
1.5
0.3
0.3
0.3
0.3
0.3
0.3
Benchmark
20
Moisturizing rating
5.8
Ingredient Est. % Benchmark Raiting
Humectancy All humectants 12.7 10
10.0
6
3
1.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Occlusivity All occlusives 3.3 20
1.6
1.5
0.3
0.3
0.3
0.3
0.3
0.3
Moisturizing rating
5.8
Ingredient Est. % Benchmark Humectancy
6
3
1.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
All humectants 12.7 10
10
All humectants
12.7
6
3
1.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Benchmark
10
Ingredient Est. % Benchmark Occlusivity
1.5
0.3
0.3
0.3
0.3
0.3
0.3
All occlusives 3.3 20
1.6
All occlusives
3.3
1.5
0.3
0.3
0.3
0.3
0.3
0.3
Benchmark
20
Ingredient
Ingredient anti-wrinkle power
when present at, %
in this formula est. %
Rating
6 /10 4 1.3 2
n/a
- 0.3 -
n/a
- 0.3 -
Total
2
Niacinamide
2
Ingredient anti-wrinkle power
6 /10
when present at, %
4
in this formula, est. %
1.3
Adenosine
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Beta-Glucan
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Anti-wrinkle rating
2
Ingredient Est. % Benchmark
Rich in Antioxidants
1.3
0.3
0.3
0.3
All antioxidants 2.2 3 No
All antioxidants
2.2
Niacinamide
1.3
Beta-Glucan
0.3
Theobroma Cacao (Cocoa) Seed Extract
0.3
Paeonol
0.3
Benchmark
3
Ingredient Est. % Benchmark
Rich in Soothing
1.3
0.3
0.3
0.3
All soothing 2.2 5 No
All soothing
2.2
1.3
0.3
0.3
0.3
Benchmark
5

Ingredients explained

Water
Est. %70
Function
Origin
WaterThe most used ingredient in skincare. Its concentration defines the product texture: rich creams may have about 50% of water while a light jelly about 90%. Water doesn’t moisturize the skin by itself and is used in skincare as a solvent for other ingredients.
Glycerin
Est. %6
Function
Origin
Glycerin

The most popular moisturizing ingredient in the world. It is a powerful humectant – cheap yet very effective.

Dipropylene Glycol
Est. %4
Function
Origin
Dipropylene GlycolA clear, colorless liquid that has several uses. One of its main functions is as a solvent. Dipropylene glycol is also used to reduce the thickness of skincare products.
PEG/PPG/Polybutylene Glycol-8/5/3 Glycerin
Est. %3
Function
Origin
PEG/PPG/Polybutylene Glycol-8/5/3 Glycerin
Glyceryl Polymethacrylate
Est. %2
Function
Origin
Glyceryl PolymethacrylateA synthetic polymer that is typically used as a viscosity modifier. Its benefits include a light after-feel on the skin and soft film, which is why it is frequently used in serums. It can form transparent gels and suspend some oils and particulates.
Dimethicone
Est. %1.5
Function
Origin
DimethiconeThe most common silicone in skincare. It forms a silky, smooth film on the skin’s surface and can help to prevent water loss. It also aids in wound healing and can treat and soften scars. Dimethicone is considered to be very safe for use.
Niacinamide
Est. %1.3
Function
Origin
Niacinamide

Also known as vitamin B3, this ingredient is a true superstar with confirmed moisturizing, anti-acne, hyperpigmentation, and antioxidant benefits. Two studies confirm its significant anti-wrinkle efficacy.

1,2-Hexanediol
Est. %1
Function
Origin
1,2-HexanediolA multi-functional formula helper. It is a well-studied preservtive against bacteria and can help pigments and fragrances disperse evenly in a formula.
PEG-150
Est. %0.3
Function
Origin
PEG-150
Methyl Trimethicone
Est. %0.3
Function
Origin
Methyl TrimethiconeA lightweight and volatile silicone known for its excellent solvency. This silicone has a silky, cushiony feel with excellent lubricity and is commonly used as an emollient in silicone-based skincare products.
Panthenol
Est. %0.3
Function
Origin
PanthenolA popular soothing and moisturizing derivative of vitamin B5. Panthenol is particularly beneficial for dry, flaking, burned, or damaged skin. It is used to alleviate the symptoms of a rash, dermatitis, eczema, chapped lips, and sunburn.
Phenyl Trimethicone
Est. %0.3
Function
Origin
Phenyl TrimethiconeA silicone fluid that is used as an occlusive moisturizer. It applies smoothly to the skin and reduces the tack associated with organic oils.
Cyclopentasiloxane
Est. %0.3
Function
Origin
CyclopentasiloxaneA lightweight, fast-spreading emollient that leaves a very soft and silky after-feel on the skin. Supplied as a clear and colorless liquid, cyclopentasiloxane is often used as a solvent to dissolve other silicones in.
Propylene Glycol
Est. %0.3
Function
Origin
Propylene GlycolA clear, thick, odorless liquid of synthetic origin. Its main function is to stabilize cosmetic products exposed to varying temperatures. It is also a moderately strong humectant with similar properties to glycerin.
Polymethylsilsesquioxane
Est. %0.3
Function
Origin
PolymethylsilsesquioxaneA type of spherical powder that functions on a ball-bearing effect in which the tiny microspheres roll around on the skin and create lubricity. Polymethylsilsesquioxane offers extra slip to skincare products and makes the skin feel soft and smooth.
Hydrogenated Lecithin
Est. %0.3
Function
Origin
Hydrogenated LecithinA version of plain lecithin that has been saturated with hydrogen atoms. This ingredient can be derived from plants, like soy or sunflower, from egg yolks, or made synthetically. Its major function is to emulsify water and oils.
Serine
Est. %0.3
Function
Origin
SerineA non-essential amino acid, meaning that our body can produce it. It is the largest constituent of the skin's Natural Moisturizing Factor and is used in skincare as a humectant moisturizing ingredient.
C14-22 Alcohols
Est. %0.3
Function
Origin
C14-22 AlcoholsA naturally-derived emulsion stabilizer that has a light feel. It is not a drying alcohol, in fact the emulsions it helps create can make the skin feel soft and cushioned.
Squalane
Est. %0.3
Function
Origin
SqualaneAn occlusive moisturizing and emollient compound that forms part of the skin’s sebum. The main source of squalane had always been shark liver. Now, however, it is manufactured synthetically or derived from plant oils, such as olive and peanut oil.
PEG-60 Hydrogenated Castor Oil
Est. %0.3
Function
Origin
PEG-60 Hydrogenated Castor OilA white paste-like substance derived from castor oil that belongs to a group of ingredients called PEGs (polyethylene glycols). It acts as a perfume solubilizer that helps fragrance agents dissolve in water and as a cleansing agent.
Macadamia Ternifolia Seed Oil
Est. %0.3
Function
Origin
Macadamia Ternifolia Seed OilAn occlusive moisturizing and emollient oil extracted from macadamia nuts. It is clear and pale yellow with a pleasant nutty aroma and contains oleic and palmitoleic fatty acids, tocopherols, phytosterols, squalene, and polyphenols.
Butyrospermum Parkii (Shea) Butter
Est. %0.3
Function
Origin
Butyrospermum Parkii (Shea) ButterA semi-solid, buttery fat extracted from the seeds of the Shea tree that is a wonderful occlusive and emollient ingredient mainly comprised of fatty acids. Shea butter contains a large amount of anti-inflammatory and antioxidant compounds.
Ceramide NP
Est. %0.3
Function
Origin
Ceramide NPAlso known as ceramide 3, it is the most common ceramide in our skin. It helps to restore the skin’s lipid barrier and alleviate the symptoms of dry and cracked skin. Research has shown that skin suffering from conditions such as AD lacks ceramides.
Tromethamine
Est. %0.3
Function
Origin
TromethamineAn ingredient based on amino acids that is commonly used as a pH adjuster. It has a high pH, which means that it is basic (alkaline), so adding tromethamine to a skincare product will increase its overall pH level.
Triethylhexanoin
Est. %0.3
Function
Origin
TriethylhexanoinAn occlusive and emollient ester of glycerin and a fatty acid. It is easily spreadable and does not leave a sticky after-feel.
Carbomer
Est. %0.3
Function
Origin
CarbomerA synthetic ingredient with the ability to gel water. When used in emulsions, such as lotions and creams, carbomer can also act as an emulsion stabilizer.
Dimethiconol
Est. %0.3
Function
Origin
DimethiconolA synthetic dimethicone with rich, non-tacky emolliency. It features the typical sensorial profile of silicones, with high spreadability and a luxurious, oil-free after-feel. Dimethiconol can also serve as an antifoaming agent.
PEG-10 Rapeseed Sterol
Est. %0.3
Function
Origin
PEG-10 Rapeseed SterolPEG-10 Rapeseed Sterol is a mixture of polyethylene glycol (a water-soluble bulking and lubricating synthetic compound) and fat-soluble phytosterols from rapeseed oil. This mixture is used in skincare products to assist with the solubility and the of oil and water (emulsification).
Arachidyl Glucoside
Est. %0.3
Function
Origin
Arachidyl GlucosideA mild cleanser and emulsifier that helps oil and water to mix and form emulsions.
Algin
Est. %0.3
Function
Origin
AlginA plant-based ingredient that can form gels when added to water, so it can thicken water-based products. Algin serves as a binding agent, where it helps hold the other ingredients in the product together and prevents them from separating.
Sodium Polyacrylate
Est. %0.3
Function
Origin
Sodium PolyacrylateThis white powder is primarily used as a viscosity controlling agent. It is added to the water phase, which then thickens to form a clear gel. Sodium polyacrylate can also serve as an emollient, absorbent, and emulsion stabilizer.
Glyceryl Stearate
Est. %0.3
Function
Origin
Glyceryl StearateAn emollient and emulsifier typically derived from vegetable sources through a chemical reaction with glycerin. It provides stability, texture, and consistency to formulations. Its main function is to allow oil and water to mix.
Acrylates/C10-30 Alkyl Acrylate Crosspolymer
Est. %0.3
Function
Origin
Acrylates/C10-30 Alkyl Acrylate CrosspolymerA synthetic ingredient that is used to thicken water and alcohol. It results in a more lightweight formula and is commonly found in gel products.
Adenosine
Est. %0.3
Function
Origin
Adenosine

A key molecule responsible for energy transportation, signaling, and enzyme activity. Adenosine is a popular anti-wrinkle ingredient, however, the key study about its anti-wrinkle efficacy (1) does not meet CreamScan Research Evaluation Standards as it is not double-blind.

Stearic Acid
Est. %0.3
Function
Origin
Stearic AcidA saturated fatty acid found in vegetable butter and animal fats. It is an occlusive moisturizing and emollient ingredient and also helps to maintain the barrier function of the skin.
Cholesterol
Est. %0.3
Function
Origin
CholesterolAn emollient and important barrier repairing lipid, effective when combined with fatty acids and ceramides. Around 25% of the skin’s lipid layer is made up of cholesterol and it is found in the membrane of every single cell in our body.
PEG-100 Stearate
Est. %0.3
Function
Origin
PEG-100 StearateThis surfactant is more specifically classified as an emulsifier that produces oil-in-water emulsions. PEG-100 stearate can also be used as a cleansing agent.
Beta-Glucan
Est. %0.3
Function
Origin
Beta-GlucanA special polysaccharide obtained from cereals, mushrooms, yeast, bacteria, and some species of seaweed. It is a promising anti-wrinkle, wound healing, antioxidant, and moisturizing ingredient.
Glycereth-20
Est. %0.3
Function
Origin
Glycereth-20
Trisodium EDTA
Est. %0.3
Function
Origin
Trisodium EDTAA chelating agent designed to encapsulate potentially harmful heavy metal ions that enter the formula through the water source. Once encapsulated, these heavy metal ions become inert.
Dextrin
Est. %0.3
Function
Origin
DextrinA partially hydrolyzed potato starch, most commonly used as a viscosity controlling and binding agent. When dispersed into water, it can create textures ranging from a thick paste to a soft gel.
Theobroma Cacao (Cocoa) Seed Extract
Est. %0.3
Function
Origin
Theobroma Cacao (Cocoa) Seed ExtractA cocoa beans extract that contains caffeine and astringent and antioxidant flavonols and tannins.
Ethylhexylglycerin
Est. %0.3
Function
Origin
EthylhexylglycerinA preservative booster derived from glycerin. It is commonly paired with other preservatives to improve their efficacy. Ethylhexylglycerin is also a humectant due to its chemical base of glycerin.
Biosaccharide Gum-1
Est. %0.3
Function
Origin
Biosaccharide Gum-1A polysaccharide with humectant moisturizing and soothing properties.
Glycosphingolipids
Est. %0.3
Function
Origin
GlycosphingolipidsGlycosphingolipids are body-natural compounds related to ceramides. Structurally, they are ceramide-like lipids with one or multiple sugar residues attached. They are used as emollients in skincare products, giving the skin a soft and smooth after-feel.
Phospholipids
Est. %0.3
Function
Origin
PhospholipidsA large group of lipids that are an essential component of every single cell membrane in the body. They have excellent emollient properties. Phospholipids are also utilized in the manufacturing of ‘fancy’ formulations such as liposomes.
Paeonia Suffruticosa Branch/Flower/Leaf Extract
Est. %0.3
Function
Origin
Paeonia Suffruticosa Branch/Flower/Leaf Extract
Paeonol
Est. %0.3
Function
Origin
Paeonol
Yellow 6 (CI 15985)
Est. %0.3
Function
Origin
Yellow 6 (CI 15985)A petroleum-derived reddish-yellow dye, also known as Sunset Yellow. It is the third most used pigment in food, cosmetics, and drugs.
Yellow 5 (CI 19140)
Est. %0.3
Function
Origin
Yellow 5 (CI 19140)A bright yellow colorant that is often also listed as FD&C Yellow 5.
Fragrance
Est. %0.3
Function
Origin
FragranceUnder trade secret law, manufacturers have the right not to disclose what exactly went into the fragrance and use the unspecific word Fragrance or Parfum instead. Many fragrances are highly allergenic.