AMPLE:N Acne Shot Ampoule Review

AMPLE:N Acne Shot Ampoule
5.0
/ 10
Moisturizing
10.0 Humectancy icon Humectancy
0.0 Occlusivity icon Occlusivity
Rich
in Antioxidants
Rich Skin Soothing icon
in Skin Soothers
Review

Does AMPLE:N Acne Shot Ampoule Work?

 
According to CreamScan AI's analysis of the ingredient list, here’s what AMPLE:N Acne Shot Ampoule has to offer:
 
  • Strong humectant moisturizing. This lightweight, humectant-rich product, ideal for oily skin, has a moisturizing rating of 5.0 out of 10.
  • Soothing: AMPLE:N Acne Shot Ampoule contains a high concentration of soothing ingredients, which may help to reduce irritation and calm the skin.
  • Antioxidant protection.

Key Benefits of AMPLE:N Acne Shot Ampoule

 
These are the key benefits you can expect from using AMPLE:N Acne Shot Ampoule:
 

Lightweight Purely Humectant Moisturizing, Ideal for Oily Skin

According to CreamScan analysis, AMPLE:N Acne Shot Ampoule is quite moisturizing, with a moisturizing rating of 5.0 out of 10.

Is it more humectant or occlusive? It is purely humectant. It has zero occlusivity (we didn't find any occlusive ingredients on the ingredient list) and a maximum humectancy of 10 out of 10, primarily due to the high content of Butylene Glycol (est. ≈11.0%) and Propanediol (est. ≈8.2%).

This humectant-rich product, when used alone as a moisturizer, is ideal for oily skin, providing significant hydration in a lightweight, fast-absorbing formula without any occlusive ingredients.

Tip: Certain studies suggest that humectants alone may not effectively moisturize the skin. If you use this product as your only moisturizer, we recommend following it with one that contains at least some occlusive ingredients.

A Humectant Boost for Any Skincare Routine

But it’s not limited to oily skin - such a humectant boost will also positively contribute to the moisturizing efficacy of any skincare routine when used as a step before applying the main moisturizer. This type of formulation is typically used in serums, where a light, fast-absorbing texture is key.

Please refer to the Ratings section below for details of the moisturizing rating calculation.

Rich in Skin-Protecting Antioxidants

We estimate that AMPLE:N Acne Shot Ampoule is rich (> 3%) in antioxidants, specifically Propolis Extract (est. ≈45.0%) and Chamomilla Recutita (Matricaria) Flower Extract (est. ≈3.6%).

A key benefit of antioxidants is their ability to reduce oxidative stress caused by free radicals and therefore prevent accelerated skin aging. Studies also show that antioxidants can protect against environmental damage such as UV radiation and pollution, and help reduce inflammation and skin redness.

Skin Soothing and Calming Potential

Based on the ingredient list analysis, AMPLE:N Acne Shot Ampoule is rich (> 5%) in soothing ingredients, particularly Propolis Extract (est. ≈45.0%) and Chamomilla Recutita (Matricaria) Flower Extract (est. ≈3.6%).

When applied to the skin, compounds of soothing ingredients, such as triglycerides, phospholipids, fatty acids, phenolic compounds, and antioxidants, work together to soothe the skin through various mechanisms: reducing inflammation, promoting wound healing, repairing the skin barrier, and providing antimicrobial and antioxidant activities.

Please note that this is not a complete list of benefits. We are in the process of enhancing our AI model to incorporate anti-pigmentation, exfoliation and anti-acne ratings.

Things to Be Aware Of: AMPLE:N Acne Shot Ampoule

 
CreamScan AI identified a few things to consider before adding AMPLE:N Acne Shot Ampoule to your skincare routine:
 

If It’s Your Only Moisturizer, It Needs to Be Paired with Some Occlusives

While humectants are highly effective at attracting water to the skin, studies (J. N. Kraft, C. W. Lynde) suggest they may not be efficient when used alone.

One major drawback of purely humectant moisturization is that the water attracted by humectants to the upper layers of the skin can evaporate completely into the environment through transepidermal water loss (TEWL). Adding occlusive ingredients helps seal this moisture into the skin and prevent further water loss.

If you’re using AMPLE:N Acne Shot Ampoule as your only moisturizer, consider pairing it with one that contains at least some occlusive ingredients, such as oils, butters, or silicones. These work alongside humectants to create a protective barrier, locking in hydration and ensuring longer-lasting moisturization. The amount of occlusive needed depends on your skin type - the drier the skin, the more occlusives it requires.

If this product is used not as a standalone moisturizer but as part of your skincare routine, such as a toner or serum, it should be applied before your main moisturizer (unless it's a sunscreen), which will provide the necessary occlusivity on top of it.

Questionable anti-wrinkle efficacy

If one of your main reasons for choosing AMPLE:N Acne Shot Ampoule is its potential anti-aging effects, please note that, according to CreamScan analysis, it currently has a zero anti-wrinkle rating.

It contains some ingredients often marketed as effective in reducing wrinkles, specifically Centella Asiatica Extract, Adenosine, and Melia Azadirachta Leaf Extract. However, the studies supporting the anti-wrinkle claims of these ingredients provide insufficient evidence of efficacy according to CreamScan Research Evaluation Standards. 

While this does not categorically exclude the possibility that these ingredients may reduce wrinkles, their efficacy is not supported by convincing, vehicle-controlled, double-blind clinical studies - at least none that were accessible to the CreamScan team at the time of publication.

Therefore, these ingredients do not generate the anti-wrinkle rating.

Moisturizers, when used regularly, are proven to prevent wrinkle formation and even reduce existing wrinkles. Therefore, this product, like any other moisturizer, can deliver some anti-wrinkle effects through its moisturizing action.

Please refer to the Ratings section below for details of the anti-wrinkle rating calculation.

Pros & Cons of AMPLE:N Acne Shot Ampoule

 
Here’s an overview of the pros and cons of AMPLE:N Acne Shot Ampoule to help you decide if it’s the right choice for your skincare routine:
 

Pros:

  • When used alone: Provides humectant-rich moisturizing ideal for oily skin
  • As part of a routine: A humectant moisturizing boost, beneficial for any skin type
  • Lightweight texture
  • Rich in antioxidants that combat oxidative stress associated with accelerated skin aging and defend against environmental damage
  • Potentially soothing, as it contains a high concentration of soothing ingredients like Propolis Extract and Chamomilla Recutita (Matricaria) Flower Extract

Cons: 

  • Only if used as a standalone moisturizer - it needs to be paired with occlusives to seal in humectants
  • Questionable anti-wrinkle efficacy

Ingredients

Est. % Ingredient Origin Functions
45
16.5
11
8.2
5.5
4.1
3.6
1
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Est. %
Propolis Extract
Function:
Origin:
Water
Function:
Origin:
Butylene Glycol
Function:
Origin:
Propanediol
Function:
Origin:
Octyldodeceth-16
Function:
Origin:
1,2-Hexanediol
Function:
Origin:
Chamomilla Recutita (Matricaria) Flower Extract
Function:
Origin:
Glycyrrhiza Glabra (Licorice) Root Extract
Function:
Origin:
Centella Asiatica Extract
Function:
Origin:
Arginine
Function:
Origin:
Gaultheria Procumbens (Wintergreen) Leaf Extract
Function:
Origin:
Glycine Soja (Soybean) Sprout Extract
Function:
Origin:
Dipotassium Glycyrrhizate
Function:
Origin:
Madecassoside
Function:
Origin:
Capryloyl Salicylic Acid
Function:
Origin:
Adenosine
Function:
Origin:
Melia Azadirachta Leaf Extract
Function:
Origin:
Melia Azadirachta Flower Extract
Function:
Origin:
Curcuma Longa (Turmeric) Root Extract
Function:
Origin:
Disodium EDTA
Function:
Origin:
Sodium Metaphosphate
Function:
Origin:
Melaleuca Alternifolia (Tea Tree) Leaf Oil
Function:
Origin:
Ocimum Sanctum Leaf Extract
Function:
Origin:
Corallina Officinalis Extract
Function:
Origin:
Hydrolyzed Chitosan
Function:
Origin:

Ratings

All humectants
20.8
11
8.2
1
0.3
0.3
Benchmark
10
All occlusives
0.0
None
Benchmark
20
Moisturizing rating
5.0
Ingredient Est. % Benchmark Raiting
Humectancy All humectants 20.8 10
10.0
11
8.2
1
0.3
0.3
Occlusivity All occlusives 0.0 20
0.0
None
Moisturizing rating
5.0
Ingredient Est. % Benchmark Humectancy
11
8.2
1
0.3
0.3
All humectants 20.8 10
10
All humectants
20.8
11
8.2
1
0.3
0.3
Benchmark
10
Ingredient Est. % Benchmark Occlusivity
None
All occlusives 0.0 20
0.0
All occlusives
0.0
None
Benchmark
20
Ingredient
Ingredient anti-wrinkle power
when present at, %
in this formula est. %
Rating
n/a
- 0.3 -
n/a
- 0.3 -
n/a
- 0.3 -
Total
0
Centella Asiatica Extract
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Adenosine
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Melia Azadirachta Leaf Extract
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Anti-wrinkle rating
0
Ingredient Est. % Benchmark
Rich in Antioxidants
45
3.6
1
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
All antioxidants 52 3 Rich in antioxidants
All antioxidants
52
Propolis Extract
45
Chamomilla Recutita (Matricaria) Flower Extract
3.6
Glycyrrhiza Glabra (Licorice) Root Extract
1
Centella Asiatica Extract
0.3
Madecassoside
0.3
Melia Azadirachta Leaf Extract
0.3
Melia Azadirachta Flower Extract
0.3
Curcuma Longa (Turmeric) Root Extract
0.3
Melaleuca Alternifolia (Tea Tree) Leaf Oil
0.3
Ocimum Sanctum Leaf Extract
0.3
Corallina Officinalis Extract
0.3
Benchmark
3
Ingredient Est. % Benchmark
Rich in Soothing
45
3.6
1
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
All soothing 52 5 Rich in soothing
All soothing
52
45
3.6
1
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Benchmark
5

Ingredients explained

Propolis Extract
Est. %45
Function
Origin
Propolis ExtractA famous bee product that has traditionally been used to treat inflammation and wounds. The extract is soothing and promotes skin healing.
Water
Est. %16.5
Function
Origin
WaterThe most used ingredient in skincare. Its concentration defines the product texture: rich creams may have about 50% of water while a light jelly about 90%. Water doesn’t moisturize the skin by itself and is used in skincare as a solvent for other ingredients.
Butylene Glycol
Est. %11
Function
Origin
Butylene Glycol

A clear, colorless liquid humectant that draws moisture to the skin. The humectancy of butylene glycol, owed to its two hydroxyl groups, is quite considerable, although not as powerful as glycerin, which contains three hydroxyl groups.

Propanediol
Est. %8.2
Function
Origin
PropanediolAn excellent solvent capable of mixing water with normally water-insoluble ingredients. It also functions as a humectant due to its water-loving alcohol groups. Propanediol can control the viscosity of a product by reducing its thickness.
Octyldodeceth-16
Est. %5.5
Function
Origin
Octyldodeceth-16
1,2-Hexanediol
Est. %4.1
Function
Origin
1,2-HexanediolA multi-functional formula helper. It is a well-studied preservtive against bacteria and can help pigments and fragrances disperse evenly in a formula.
Chamomilla Recutita (Matricaria) Flower Extract
Est. %3.6
Function
Origin
Chamomilla Recutita (Matricaria) Flower ExtractDerived from German chamomile flowers, this extract is especially known for its anti-inflammatory and soothing benefits. It contains two soothing compounds called chamazulene and bisabolol, as well as antioxidant flavonoids.
Glycyrrhiza Glabra (Licorice) Root Extract
Est. %1
Function
Origin
Glycyrrhiza Glabra (Licorice) Root ExtractAn extract from the licorice root. It contains a well-researched anti-inflammatory compound called glycyrrhizin that can reduce inflammation. Licorice root extract is also used for its powerful antioxidant effects and ability to treat pigmentation.
Centella Asiatica Extract
Est. %0.3
Function
Origin
Centella Asiatica ExtractAn extract from the leaves of the Gotu kola. It is used in skincare for its antioxidant, wound healing, anti-inflammatory, and anti-aging properties. It increases the production of collagen and hyaluronic acid in the skin.
Arginine
Est. %0.3
Function
Origin
ArginineA humectant amino acid used to attract water to the skin’s surface. It is a part of the skin's Natural Moisturizing Factor, a mixture of various compounds that keeps the skin’s surface well hydrated. Arginine can also be used as a pH adjuster.
Gaultheria Procumbens (Wintergreen) Leaf Extract
Est. %0.3
Function
Origin
Gaultheria Procumbens (Wintergreen) Leaf Extract
Glycine Soja (Soybean) Sprout Extract
Est. %0.3
Function
Origin
Glycine Soja (Soybean) Sprout Extract
Dipotassium Glycyrrhizate
Est. %0.3
Function
Origin
Dipotassium GlycyrrhizateA licorice root derivative with powerful anti-inflammatory and soothing activities. It is often used as a flavoring agent in lip products.
Madecassoside
Est. %0.3
Function
Origin
MadecassosideAn isolated Gotu Kola compound. It helps to increase collagen and hyaluronic acid production in the skin and assists in wound healing.
Capryloyl Salicylic Acid
Est. %0.3
Function
Origin
Capryloyl Salicylic AcidA derivative of salicylic acid, with bigger and more lipid-soluble molecules. This makes it more powerful and safer than salicylic acid. It is used as an exfoliating and peeling agent.
Adenosine
Est. %0.3
Function
Origin
Adenosine

A key molecule responsible for energy transportation, signaling, and enzyme activity. Adenosine is a popular anti-wrinkle ingredient, however, the key study about its anti-wrinkle efficacy (1) does not meet CreamScan Research Evaluation Standards as it is not double-blind.

Melia Azadirachta Leaf Extract
Est. %0.3
Function
Origin
Melia Azadirachta Leaf ExtractAn antimicrobial and antioxidant extract derived from Neem leaves – an Indian traditional medicine. Neem leaves have been found to possess antibacterial and antifungal activity. It is also a prospective anti-wrinkle ingredient.
Melia Azadirachta Flower Extract
Est. %0.3
Function
Origin
Melia Azadirachta Flower ExtractAn antioxidant extract derived from the flowers of the Indian lilac, also known as Neem. It is often used in traditional medicine in India. The Neem flower extracts contain limonoids, which are currently under research for their anti-pigment activity.
Curcuma Longa (Turmeric) Root Extract
Est. %0.3
Function
Origin
Curcuma Longa (Turmeric) Root ExtractAn extract derived from the thick roots of curcuma (turmeric), a famous yellow spice and a major ingredient in curry powder. It is used in skincare for its proven antioxidant and anti-inflammatory properties.
Disodium EDTA
Est. %0.3
Function
Origin
Disodium EDTAA synthetic chelator that helps to maintain the look and smell of a product by 'locking up' troublesome metal ions.
Sodium Metaphosphate
Est. %0.3
Function
Origin
Sodium MetaphosphateA sodium salt that captures heavy metal ions and raises the pH.
Melaleuca Alternifolia (Tea Tree) Leaf Oil
Est. %0.3
Function
Origin
Melaleuca Alternifolia (Tea Tree) Leaf OilA fragrant and antioxidant essential tea tree oil praised for its antiseptic and antimicrobial properties. Tea tree oil helps to treat acne, inflamed skin, and small wounds. It might, however, cause allergies and skin irritations.
Ocimum Sanctum Leaf Extract
Est. %0.3
Function
Origin
Ocimum Sanctum Leaf ExtractAn extract derived from the leaves of Holy Basil, also known as Tulsi, a traditional herb used in Ayurveda medicine. It contains antioxidant and anti-inflammatory rosmarinic acid, galic acid, flavonoids, and a sweet-scented essential oil.
Corallina Officinalis Extract
Est. %0.3
Function
Origin
Corallina Officinalis ExtractAn extract from red marine alga, Corallina officinalis is used in skincare for its antioxidant properties. It also contains an immense amount of calcium and special, sulfur-containing polysaccharides.
Hydrolyzed Chitosan
Est. %0.3
Function
Origin
Hydrolyzed Chitosan