Sesderma Sesretinal Liposomal Serum Review

Sesderma Sesretinal Liposomal Serum
5.3
/ 10
Moisturizing
10.0 Humectancy icon Humectancy
0.6 Occlusivity icon Occlusivity
5.1Anti-wrinkle icon/ 10
Anti-wrinkle
Review

Does Sesderma Sesretinal Liposomal Serum Work?

 
According to CreamScan AI's analysis of the ingredient list, here’s what Sesderma Sesretinal Liposomal Serum has to offer:
 
  • Strong humectant moisturizing. This lightweight, humectant-rich product, ideal for oily skin, has a moisturizing rating of 5.3 out of 10.
  • Considerable anti-wrinkle efficacy: Sesderma Sesretinal Liposomal Serum has an anti-wrinkle rating of 5.1 out of 10, indicating a moderate ability to reduce wrinkles.

Key Benefits of Sesderma Sesretinal Liposomal Serum

 
These are the key benefits you can expect from using Sesderma Sesretinal Liposomal Serum:
 

Lightweight Humectant Moisturizer Ideal for Oily Skin

According to CreamScan analysis, Sesderma Sesretinal Liposomal Serum is quite moisturizing, with a moisturizing rating of 5.3 out of 10.

Is it more humectant or occlusive? Significantly more humectant. It has a low occlusivity of 0.6 out of 10 and a maximum humectancy of 10 out of 10, primarily due to the high content of Bis-PEG-18 Methyl Ether Dimethyl Silane (est. ≈6.0%) and Propanediol (est. ≈2.0%).

This humectant-rich product, when used alone as a moisturizer, is ideal for oily skin, offering significant hydration in a lightweight, fast-absorbing formula with a minimal amount of occlusive ingredients.

It’s also a great choice for people with normal skin who prefer lightweight moisturizers.

A Humectant Boost for Any Skincare Routine

But it’s not limited to oily skin - such a humectant boost will also positively contribute to the moisturizing efficacy of any skincare routine when used as a step before applying the main moisturizer. This type of formulation is typically used in serums, where a light, fast-absorbing texture is key.

Please refer to the Ratings section below for details of the moisturizing rating calculation.

Considerable Anti-Wrinkle Efficacy

According to CreamScan analysis, Sesderma Sesretinal Liposomal Serum has a moderate anti-wrinkle rating of 5.1 out of 10.

It contains 2 active ingredients with proven anti-wrinkle efficacy:

  • Retinal (est. ≈0.05%),
     also known as retinaldehyde, is a potent retinoid with anti-wrinkle efficacy confirmed by a single clinical study involving 125 participants (Creidi et al.). This study demonstrated that a cream containing 0.05% retinal reduced the average wrinkle depth by 8% after 18 weeks of use, compared to a vehicle (the same formulation without retinal).
  • Glycolic Acid (est. ≈0.3%),
     a highly effective ingredient in peelings but with moderate anti-wrinkle efficacy in leave-on skincare products, as supported by a single clinical study. This study, involving 72 participants (Thibault et al.), demonstrated that a lotion with 5% GA reduced the fine wrinkling score by 6% after 34 days of use, compared to a vehicle (the same formulation without GA).
Among others, Sesderma Sesretinal Liposomal Serum also contains some ingredients marketed often as effective in reducing wrinkles, specifically Gluconolactone, Bakuchiol, and Retinyl Palmitate. However, the studies supporting the anti-wrinkle claims of these ingredients provide insufficient evidence of efficacy according to CreamScan Research Evaluation Standards. Therefore, these ingredients do not contribute to the anti-wrinkle rating.
 
Moisturizers, when used regularly, are proven to prevent wrinkle formation and even reduce existing wrinkles. Therefore, this product, like any other moisturizer, can deliver some anti-wrinkle effects through its moisturizing action.
 

Please refer to the Ratings section below for details of the anti-wrinkle rating calculation.

Please note that this is not a complete list of benefits. We are in the process of enhancing our AI model to incorporate anti-pigmentation, exfoliation and anti-acne ratings.

Pros & Cons of Sesderma Sesretinal Liposomal Serum

 
Here’s an overview of the pros and cons of Sesderma Sesretinal Liposomal Serum to help you decide if it’s the right choice for your skincare routine:
 

Pros:

  • Humectant-rich moisturizing ideal for oily skin
  • Lightweight texture
  • A humectant moisturizing boost for any skincare routine
  • Provides considerable anti-wrinkle efficacy

Cons: 

Ingredients

Est. % Ingredient Origin Functions
65
6
4
3
2
1.5
1.3
1
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.05
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Est. %
Water
Function:
Origin:
Bis-PEG-18 Methyl Ether Dimethyl Silane
Function:
Origin:
Hydrogenated Polydecene
Function:
Origin:
Ceteth-20
Function:
Origin:
Propanediol
Function:
Origin:
C12-15 Alkyl Benzoate
Function:
Origin:
Cyclopentasiloxane
Function:
Origin:
Glyceryl Stearate
Function:
Origin:
Gluconolactone
Function:
Origin:
Ammonium Acryloyldimethyltaurate Crosspolymer
Function:
Origin:
Nicotiana Benthamiana Hexapeptide-40 sh-Oligopeptide-1
Function:
Origin:
Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-5
Function:
Origin:
Nicotiana Benthamiana sh-Polypeptide-15 Hexapeptide-40
Function:
Origin:
Alcohol
Function:
Origin:
Bakuchiol
Function:
Origin:
BHT
Function:
Origin:
Bidens Pilosa Extract
Function:
Origin:
Carbomer
Function:
Origin:
Ceramide AP
Function:
Origin:
Ceramide EOP
Function:
Origin:
Ceramide NP
Function:
Origin:
Cetearyl Alcohol
Function:
Origin:
Cholesterol
Function:
Origin:
Copper Sulfate
Function:
Origin:
Dipotassium Phosphate
Function:
Origin:
Disodium EDTA
Function:
Origin:
Elaeis Guineensis (Palm) Oil
Function:
Origin:
Ethylhexylglycerin
Function:
Origin:
Glucosamine HCl
Function:
Origin:
Glycerin
Function:
Origin:
Glycolic Acid
Function:
Origin:
Glycyrrhetinic Acid
Function:
Origin:
Gossypium Herbaceum (Cotton) Seed Oil
Function:
Origin:
Hydrochloric Acid
Function:
Origin:
Lactic Acid
Function:
Origin:
Linum Usitatissimum (Linseed) Seed Oil
Function:
Origin:
Lycium Barbarum Fruit Extract
Function:
Origin:
Mandelic Acid
Function:
Origin:
Niacin
Function:
Origin:
Nicotiana Benthamiana Sh-Polypedtide-7
Function:
Origin:
Fragrance
Function:
Origin:
Phenoxyethanol
Function:
Origin:
Phosphatidylcholine
Function:
Origin:
Phytosphingosine
Function:
Origin:
Polysorbate 20
Function:
Origin:
Potassium Phosphate
Function:
Origin:
Potassium Sorbate
Function:
Origin:
Retinal
Function:
Origin:
Retinyl Palmitate
Function:
Origin:
Sodium Benzoate
Function:
Origin:
Sodium Chloride
Function:
Origin:
Sodium Cholate
Function:
Origin:
Sodium Hyaluronate
Function:
Origin:
Sodium Hydroxide
Function:
Origin:
Sodium Lauroyl Lactylate
Function:
Origin:
Tocopherol
Function:
Origin:
Tocopheryl Acetate
Function:
Origin:
Triethanolamine
Function:
Origin:
Tromethamine
Function:
Origin:
Xanthan Gum
Function:
Origin:
Zinc Chloride
Function:
Origin:

Ratings

All humectants
10.1
6
2
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Benchmark
10
All occlusives
1.2
0.3
0.3
0.3
0.3
Benchmark
20
Moisturizing rating
5.3
Ingredient Est. % Benchmark Raiting
Humectancy All humectants 10.1 10
10.0
6
2
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Occlusivity All occlusives 1.2 20
0.6
0.3
0.3
0.3
0.3
Moisturizing rating
5.3
Ingredient Est. % Benchmark Humectancy
6
2
0.3
0.3
0.3
0.3
0.3
0.3
0.3
All humectants 10.1 10
10
All humectants
10.1
6
2
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Benchmark
10
Ingredient Est. % Benchmark Occlusivity
0.3
0.3
0.3
0.3
All occlusives 1.2 20
0.6
All occlusives
1.2
0.3
0.3
0.3
0.3
Benchmark
20
Ingredient
Ingredient anti-wrinkle power
when present at, %
in this formula est. %
Rating
5 /10 0.05 0.05 5
1.5 /10 5 0.3 0.1
n/a
- 0.3 -
n/a
- 0.3 -
n/a
- 0.3 -
Total
5.1
Retinal
5
Ingredient anti-wrinkle power
5 /10
when present at, %
0.05
in this formula, est. %
0.05
Glycolic Acid
0.1
Ingredient anti-wrinkle power
1.5 /10
when present at, %
5
in this formula, est. %
0.3
Gluconolactone
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Bakuchiol
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Retinyl Palmitate
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Anti-wrinkle rating
5.1
Ingredient Est. % Benchmark
Rich in Antioxidants
0.3
0.3
0.3
0.3
0.3
0.3
All antioxidants 1.8 3 No
All antioxidants
1.8
Bakuchiol
0.3
BHT
0.3
Lycium Barbarum Fruit Extract
0.3
Sodium Hyaluronate
0.3
Tocopherol
0.3
Tocopheryl Acetate
0.3
Benchmark
3
Ingredient Est. % Benchmark
Rich in Soothing
0.3
0.3
0.3
All soothing 0.9 5 No
All soothing
0.9
0.3
0.3
0.3
Benchmark
5

Ingredients explained

Water
Est. %65
Function
Origin
WaterThe most used ingredient in skincare. Its concentration defines the product texture: rich creams may have about 50% of water while a light jelly about 90%. Water doesn’t moisturize the skin by itself and is used in skincare as a solvent for other ingredients.
Bis-PEG-18 Methyl Ether Dimethyl Silane
Est. %6
Function
Origin
Bis-PEG-18 Methyl Ether Dimethyl SilaneA silicone with the unusual trait of being able to disperse in water. It moisturizes the skin as a humectant and leaves a soft and smooth after-feel. This ingredient also has foam-boosting properties.
Hydrogenated Polydecene
Est. %4
Function
Origin
Hydrogenated PolydeceneA clear, colorless, highly viscous liquid that commonly serves as an emollient. This rich emollient is on the heavier side but provides a smooth sensorial profile upon application.
Ceteth-20
Est. %3
Function
Origin
Ceteth-20A very mild but effective polyethylene-based cleanser and emulsifier.
Propanediol
Est. %2
Function
Origin
PropanediolAn excellent solvent capable of mixing water with normally water-insoluble ingredients. It also functions as a humectant due to its water-loving alcohol groups. Propanediol can control the viscosity of a product by reducing its thickness.
C12-15 Alkyl Benzoate
Est. %1.5
Function
Origin
C12-15 Alkyl BenzoateA synthetic emollient ester. It works to improve the appearance of the skin by filling in the microcracks on the surface, thereby making the skin appear softer and smoother. It imparts a lightweight, velvety feel.
Cyclopentasiloxane
Est. %1.3
Function
Origin
CyclopentasiloxaneA lightweight, fast-spreading emollient that leaves a very soft and silky after-feel on the skin. Supplied as a clear and colorless liquid, cyclopentasiloxane is often used as a solvent to dissolve other silicones in.
Glyceryl Stearate
Est. %1
Function
Origin
Glyceryl StearateAn emollient and emulsifier typically derived from vegetable sources through a chemical reaction with glycerin. It provides stability, texture, and consistency to formulations. Its main function is to allow oil and water to mix.
Gluconolactone
Est. %0.3
Function
Origin
GluconolactoneA PHA derived from glucose. It has exfoliating and humectant properties and acts as a penetration enhancer for other ingredients. It has also been shown to assist in the treatment of acne and the prevention of photoaging.
Ammonium Acryloyldimethyltaurate Crosspolymer
Est. %0.3
Function
Origin
Ammonium Acryloyldimethyltaurate Crosspolymer
Nicotiana Benthamiana Hexapeptide-40 sh-Oligopeptide-1
Est. %0.3
Function
Origin
Nicotiana Benthamiana Hexapeptide-40 sh-Oligopeptide-1
Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-5
Est. %0.3
Function
Origin
Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-5
Nicotiana Benthamiana sh-Polypeptide-15 Hexapeptide-40
Est. %0.3
Function
Origin
Nicotiana Benthamiana sh-Polypeptide-15 Hexapeptide-40
Alcohol
Est. %0.3
Function
Origin
AlcoholAn effective antimicrobial ingredient that kills bacteria, fungi, and even some viruses. It is also an excellent solvent and astringent. Alcohol helps to create lighter and less viscous products. It can, however, be dehydrating and skin-sensitizing.
Bakuchiol
Est. %0.3
Function
Origin
BakuchiolA newly discovered bioactive obtained from the seeds of Babchi. It boosts collagen production like retinol, but with fewer side effects. Its effects include reduced wrinkles and faded pigmentation.
BHT
Est. %0.3
Function
Origin
BHTAn antioxidant ingredient that naturally occurs in green algae and some bacteria or fungi but, for commercial use, is created synthetically. BHT is also used occasionally as a fragrance, where it presents a sweet, camphor-like odor.
Bidens Pilosa Extract
Est. %0.3
Function
Origin
Bidens Pilosa Extract
Carbomer
Est. %0.3
Function
Origin
CarbomerA synthetic ingredient with the ability to gel water. When used in emulsions, such as lotions and creams, carbomer can also act as an emulsion stabilizer.
Ceramide AP
Est. %0.3
Function
Origin
Ceramide APPreviously called Ceramide 6 II, Ceramide AP is one of the most common ceramides in the skin. Research has shown that dry, flaky skin has significantly less Ceramide AP. Its application helps to treat dry skin by restoring balance in the skin lipids.
Ceramide EOP
Est. %0.3
Function
Origin
Ceramide EOP

Formerly called Ceramide 1, this ingredient is a skin-identical wax-like lipid with an ultra-long fatty acid chain. It restores and stabilizes the skin’s lipid matrix and helps to treat dry and flaky skin, especially when combined with other ceramides.

Ceramide NP
Est. %0.3
Function
Origin
Ceramide NPAlso known as ceramide 3, it is the most common ceramide in our skin. It helps to restore the skin’s lipid barrier and alleviate the symptoms of dry and cracked skin. Research has shown that skin suffering from conditions such as AD lacks ceramides.
Cetearyl Alcohol
Est. %0.3
Function
Origin
Cetearyl AlcoholA blend of cetyl alcohol and stearyl alcohol, the fatty alcohols that are derived from palm oil. It helps to create emulsions that give off a soft and silky emollient feel and also increase product thickness.
Cholesterol
Est. %0.3
Function
Origin
CholesterolAn emollient and important barrier repairing lipid, effective when combined with fatty acids and ceramides. Around 25% of the skin’s lipid layer is made up of cholesterol and it is found in the membrane of every single cell in our body.
Copper Sulfate
Est. %0.3
Function
Origin
Copper Sulfate
Dipotassium Phosphate
Est. %0.3
Function
Origin
Dipotassium Phosphate
Disodium EDTA
Est. %0.3
Function
Origin
Disodium EDTAA synthetic chelator that helps to maintain the look and smell of a product by 'locking up' troublesome metal ions.
Elaeis Guineensis (Palm) Oil
Est. %0.3
Function
Origin
Elaeis Guineensis (Palm) OilA fatty oil expressed from the pulp of the oil palm fruits. It is mostly composed of occlusive and emollient saturated fatty acids. The unrefined oil has a large amount of antioxidant carotenoids.
Ethylhexylglycerin
Est. %0.3
Function
Origin
EthylhexylglycerinA preservative booster derived from glycerin. It is commonly paired with other preservatives to improve their efficacy. Ethylhexylglycerin is also a humectant due to its chemical base of glycerin.
Glucosamine HCl
Est. %0.3
Function
Origin
Glucosamine HClA naturally occurring compound that reduces static and lowers the pH of skincare products.
Glycerin
Est. %0.3
Function
Origin
Glycerin

The most popular moisturizing ingredient in the world. It is a powerful humectant – cheap yet very effective.

Glycolic Acid
Est. %0.3
Function
Origin
Glycolic Acid

The second most used AHA (after lactic acid) known for its potent exfoliating and smoothing effects. It increases skin cell turnover, which is beneficial for treating acne. When used in peels, glycolic acid has confirmed anti-wrinkle efficacy, though it is less effective in leave-on products like creams and serums.

Glycyrrhetinic Acid
Est. %0.3
Function
Origin
Glycyrrhetinic AcidA compound derived from licorice root. It is a powerful anti-inflammatory ingredient with some anti-pigment properties.
Gossypium Herbaceum (Cotton) Seed Oil
Est. %0.3
Function
Origin
Gossypium Herbaceum (Cotton) Seed OilDerived from the seeds of the cotton plant, this emollient and occlusive fatty oil is mainly comprised of linoleic and palmitic acids. It also contains large amounts of phospholipids - key components of all cell membranes.
Hydrochloric Acid
Est. %0.3
Function
Origin
Hydrochloric Acid
Lactic Acid
Est. %0.3
Function
Origin
Lactic AcidThe most popular AHA in skincare and less irritating than glycolic acid. It can be naturally found in sour milk. It is a humectant moisturizing, pH stabilizing, and gently exfoliating ingredient, able to soften dry, cracked, and peeling skin.
Linum Usitatissimum (Linseed) Seed Oil
Est. %0.3
Function
Origin
Linum Usitatissimum (Linseed) Seed OilAn emollient and occlusive fatty oil pressed from flax seeds. It is the richest source of linolenic fatty acid (it contains up to 50% of it) among vegetable oils.
Lycium Barbarum Fruit Extract
Est. %0.3
Function
Origin
Lycium Barbarum Fruit ExtractAn extract obtained from Goji berries with moisturizing and antioxidant polysaccharides and glycoproteins. It is also rich in other antioxidants such as vitamins B and C, carotenoids, flavonoids, and phytosterols.
Mandelic Acid
Est. %0.3
Function
Origin
Mandelic AcidDerived from almonds, this ingredient is one of the gentlest AHAs and is used for its exfoliating and antimicrobial properties. It is particularly beneficial for acne but also helps to treat post-inflammatory hyperpigmentation.
Niacin
Est. %0.3
Function
Origin
NiacinAn active form of vitamin B3 that is used to support and restore the healthy appearance of the skin, although it is less effective than Niacinamide.
Nicotiana Benthamiana Sh-Polypedtide-7
Est. %0.3
Function
Origin
Nicotiana Benthamiana Sh-Polypedtide-7
Fragrance
Est. %0.3
Function
Origin
FragranceUnder trade secret law, manufacturers have the right not to disclose what exactly went into the fragrance and use the unspecific word Fragrance or Parfum instead. Many fragrances are highly allergenic.
Phenoxyethanol
Est. %0.3
Function
Origin
PhenoxyethanolThe most frequently used preservative in skincare. It is a clear, oil-like liquid synthetic substance that protects products from harmful bacteria and yeast, whilst still leaving skin microflora unharmed. It is confirmed by research to be harmless.
Phosphatidylcholine
Est. %0.3
Function
Origin
PhosphatidylcholineA special emulsifying lipid used to create delivery spheres called liposomes.
Phytosphingosine
Est. %0.3
Function
Origin
PhytosphingosineA key component of ceramides NP, AP, and EOP. It has barrier repair properties and stimulates the production of the skin’s Natural Moisturizing Factor. Phytosphingosine has strong antimicrobial and anti-inflammatory activity, which can be used to treat acne.
Polysorbate 20
Est. %0.3
Function
Origin
Polysorbate 20A viscous, amber-colored liquid that functions as a solubilizer to disperse small amounts of oil into a large water phase. Polysorbate 20 is frequently used to solubilize fragrance oils into water-based emulsions.
Potassium Phosphate
Est. %0.3
Function
Origin
Potassium PhosphateA salt of phosphoric acid that normally acts as a weak base.
Potassium Sorbate
Est. %0.3
Function
Origin
Potassium SorbateA preservative widely used in food and personal care products, available from natural sources or synthetically produced. Potassium sorbate works by inhibiting the growth of yeasts, molds, and some bacteria.
Retinal
Est. %0.05
Function
Origin
Retinal

A potent ingredient of the retinoid group with confirmed anti-wrinkle capabilities.

Retinyl Palmitate
Est. %0.3
Function
Origin
Retinyl PalmitateAn esterified form of retinol – it combines retinol and palmitic acid into one molecule. Retinyl palmitate is less irritating than retinol but also much less effective in its anti-aging and acne-reducing effects.
Sodium Benzoate
Est. %0.3
Function
Origin
Sodium BenzoateA preservative that usually works in combination with other preservatives. It has to be at low pH (<5.5) to be effective.
Sodium Chloride
Est. %0.3
Function
Origin
Sodium Chloride

You’re definitely familiar with sodium chloride, even if you don’t think you are. It’s table salt! Salt works well with some cleansing ingredients (surfactants) to thicken them into gels. It also acts as a stabilizer for water-in-oil emulsions.

Sodium Cholate
Est. %0.3
Function
Origin
Sodium Cholate
Sodium Hyaluronate
Est. %0.3
Function
Origin
Sodium Hyaluronate

A sodium salt of famous hyaluronic acid. A potent humectant that hydrates the skin, supports collagen function, and fills out small wrinkles. Sodium hyaluronate also offers soothing and antioxidant properties.

Sodium Hydroxide
Est. %0.3
Function
Origin
Sodium Hydroxide

An ingredient that is able to bring the pH of a product up, thereby making it less harsh on the skin.

Sodium Lauroyl Lactylate
Est. %0.3
Function
Origin
Sodium Lauroyl LactylateA multifunctional ingredient that produces foamy cleansers and allows oil and water to mix.
Tocopherol
Est. %0.3
Function
Origin
Tocopherol

Simply another name for vitamin E. Tocopherol is a fantastic ingredient and especially beneficial for dry and inflamed skin. It has occlusive moisturizing, emollient, antioxidant, and photoprotective properties.

Tocopheryl Acetate
Est. %0.3
Function
Origin
Tocopheryl Acetate

An antioxidant derivative of tocopherol (vitamin E). It helps to protect cells from free radicals and UV damage through the conversion to active vitamin E in the skin. It is more stable than tocopherol.

Triethanolamine
Est. %0.3
Function
Origin
TriethanolamineA clear, colorless, and highly viscous liquid, this ingredient is an excellent pH adjuster. When it is necessary to neutralize an acidic solution or to generally increase the pH of a product, triethanolamine is a common choice.
Tromethamine
Est. %0.3
Function
Origin
TromethamineAn ingredient based on amino acids that is commonly used as a pH adjuster. It has a high pH, which means that it is basic (alkaline), so adding tromethamine to a skincare product will increase its overall pH level.
Xanthan Gum
Est. %0.3
Function
Origin
Xanthan GumA natural multi-functional ingredient that originates from fermented sugars. Xanthan gum acts as a viscosity-building agent to thicken skincare products. It is also an excellent stabilizer and works well to hold other ingredients together.
Zinc Chloride
Est. %0.3
Function
Origin
Zinc Chloride