Quality First Derma Laser Azelaic Acid 100 Ulthera AZ Serum Review

Quality First Derma Laser Azelaic Acid 100 Ulthera AZ Serum
5.0
/ 10
Moisturizing
10.0 Humectancy icon Humectancy
0.0 Occlusivity icon Occlusivity
6Anti-wrinkle icon/ 10
Anti-wrinkle
Rich
in Antioxidants
Rich Skin Soothing icon
in Skin Soothers
Review

Does Quality First Derma Laser Azelaic Acid 100 Ulthera AZ Serum Work?

 
According to CreamScan AI's analysis of the ingredient list, here’s what Quality First Derma Laser Azelaic Acid 100 Ulthera AZ Serum has to offer:
 
✅ Strong humectant moisturizing. This lightweight, humectant-rich product, ideal for oily skin, has a moisturizing rating of 5.0 out of 10.
✅ Significant anti-wrinkle efficacy. With an anti-wrinkle rating of 6.0 out of 10, Quality First Derma Laser Azelaic Acid 100 Ulthera AZ Serum is effective in minimizing wrinkles.
✅ Soothing: Quality First Derma Laser Azelaic Acid 100 Ulthera AZ Serum contains a high concentration of soothing ingredients, which may help to reduce irritation and calm the skin.
✅ Antioxidant protection

  

Key Benefits of Quality First Derma Laser Azelaic Acid 100 Ulthera AZ Serum

 
These are the key benefits you can expect from using Quality First Derma Laser Azelaic Acid 100 Ulthera AZ Serum:
 

🔵 Lightweight Purely Humectant Moisturizing, Ideal for Oily Skin

According to CreamScan analysis, Quality First Derma Laser Azelaic Acid 100 Ulthera AZ Serum is quite moisturizing, with a moisturizing rating of 5.0 out of 10.

Is it more humectant or occlusive? It is purely humectant. It has zero occlusivity (we didn't find any occlusive ingredients on the ingredient list) and a maximum humectancy of 10 out of 10, primarily due to the high content of Galactomyces Ferment Filtrate (est. ≈55.0%), Butylene Glycol (est. ≈22.0%) and Niacinamide (est. ≈5.0%).

This humectant-rich product, when used alone as a moisturizer, is ideal for oily skin, providing significant hydration in a lightweight, fast-absorbing formula without any occlusive ingredients.

📌 Certain studies suggest that humectants alone may not effectively moisturize the skin. If you use this product as your only moisturizer, we recommend following it with one that contains at least some occlusive ingredients.

💧 A Humectant Boost for Any Skincare Routine

But it’s not limited to oily skin - such a humectant boost will also positively contribute to the moisturizing efficacy of any skincare routine when used as a step before applying the main moisturizer. This type of formulation is typically used in serums, where a light, fast-absorbing texture is key.

Please refer to the Ratings section below for details of the moisturizing rating calculation.

🟣🟣 Significant Anti-Wrinkle Efficacy

According to CreamScan analysis, Quality First Derma Laser Azelaic Acid 100 Ulthera AZ Serum has a high anti-wrinkle rating of 6.0 out of 10.

It contains one ingredient with proven anti-wrinkle efficacy: Niacinamide (est. ≈5.0%),
 one of the most effective and well-researched anti-wrinkle ingredients. A clinical study involving 30 participants (Kawada et al.) confirmed that a cream with 4% niacinamide reduced the average depth of wrinkles around the eyes by 9% after 8 weeks of use, compared to a vehicle (the same formulation without niacinamide).
 
Among others, Quality First Derma Laser Azelaic Acid 100 Ulthera AZ Serum also contains contains Centella Asiatica Extract and Camellia Sinensis Leaf Extract, two ingredients often marketed as effective in reducing wrinkles. However, the studies supporting the anti-wrinkle claims of these ingredients provide insufficient evidence of efficacy according to CreamScan Research Evaluation Standards.
 
While this does not categorically rule out the possibility that these ingredients may reduce wrinkles, their efficacy is not supported by convincing, vehicle-controlled, double-blind clinical studies - at least none that were available to the CreamScan team at the time of publication.
 
Therefore, these ingredients do not contribute to the anti-wrinkle rating.
 

Please refer to the Ratings section below for details of the anti-wrinkle rating calculation.

🍀 Rich in Skin-Protecting Antioxidants

We estimate that Quality First Derma Laser Azelaic Acid 100 Ulthera AZ Serum is rich (> 3%) in antioxidants, specifically Niacinamide (est. ≈5.0%).

A key benefit of antioxidants is their ability to reduce oxidative stress caused by free radicals and therefore prevent accelerated skin aging. Studies also show that antioxidants can protect against environmental damage such as UV radiation and pollution, and help reduce inflammation and skin redness.

🔴 Skin Soothing and Calming Potential

Based on the ingredient list analysis, Quality First Derma Laser Azelaic Acid 100 Ulthera AZ Serum is rich (> 5%) in soothing ingredients, particularly Niacinamide (est. ≈5.0%), Azelaic Acid (est. ≈4.0%) and Dipotassium Glycyrrhizate (est. ≈2.0%).

When applied to the skin, compounds of soothing ingredients, such as triglycerides, phospholipids, fatty acids, phenolic compounds, and antioxidants, work together to soothe the skin through various mechanisms: reducing inflammation, promoting wound healing, repairing the skin barrier, and providing antimicrobial and antioxidant activities.

📌 Please note that this is not a complete list of benefits. We are in the process of enhancing our AI model to incorporate anti-pigmentation, exfoliation and anti-acne ratings.

Things to Be Aware Of: Quality First Derma Laser Azelaic Acid 100 Ulthera AZ Serum

 
CreamScan AI identified a few things to consider before adding Quality First Derma Laser Azelaic Acid 100 Ulthera AZ Serum to your skincare routine:
 

⚠️ If It’s Your Only Moisturizer, It Needs to Be Paired with Some Occlusives

While humectants are highly effective at attracting water to the skin, studies (J. N. Kraft, C. W. Lynde) suggest they may not be efficient when used alone.

One major drawback of purely humectant moisturization is that the water attracted by humectants to the upper layers of the skin can evaporate completely into the environment through transepidermal water loss (TEWL). Adding occlusive ingredients helps seal this moisture into the skin and prevent further water loss.

If you’re using Quality First Derma Laser Azelaic Acid 100 Ulthera AZ Serum as your only moisturizer, consider pairing it with one that contains at least some occlusive ingredients, such as oils, butters, or silicones. These work alongside humectants to create a protective barrier, locking in hydration and ensuring longer-lasting moisturization. The amount of occlusive needed depends on your skin type - the drier the skin, the more occlusives it requires.

If this product is used not as a standalone moisturizer but as part of your skincare routine, such as a toner or serum, it should be applied before your main moisturizer (unless it's a sunscreen), which will provide the necessary occlusivity on top of it.

Pros & Cons of Quality First Derma Laser Azelaic Acid 100 Ulthera AZ Serum

 
Here’s an overview of the pros and cons of Quality First Derma Laser Azelaic Acid 100 Ulthera AZ Serum to help you decide if it’s the right choice for your skincare routine:
 

🟩 Pros:

✅ When used alone: Provides humectant-rich moisturizing ideal for oily skin
✅ As part of a routine: A humectant moisturizing boost, beneficial for any skin type
✅ Lightweight texture
Delivers signficant anti-wrinkle efficacy thanks to Niacinamide
✅ Rich in antioxidants that combat oxidative stress associated with accelerated skin aging and defend against environmental damage
✅ Potentially soothing, as it contains a high concentration of soothing ingredients like Niacinamide and Azelaic Acid
 

⭕ Cons: 

⚠️ Only if used as a standalone moisturizer - it needs to be paired with occlusives to seal in humectants
   

Summary: Quality First Derma Laser Azelaic Acid 100 Ulthera AZ Serum

 
Based on the ingredient list analysis, CreamScan AI suggests that Quality First Derma Laser Azelaic Acid 100 Ulthera AZ Serum
 is specifically effective in treating wrinkles, containing ingredients with solid, robust evidence of anti-wrinkle efficacy.
 

When used alone, it delivers lightweight, humectant-rich moisturizing, making it ideal for oily skin. As part of a moisturizing routine, it provides a humectant boost, beneficial for all skin types.

Rich in antioxidants, Quality First Derma Laser Azelaic Acid 100 Ulthera AZ Serum helps protect against free radical damage and offers multiple benefits for all skin types, including preventing premature aging, defending against environmental damage, and calming inflammation. This product is also formulated with a high concentration of soothing ingredients, offering the potential to calm and comfort irritated skin. Whether you’re experiencing redness, irritation, or general sensitivity, its soothing properties may help restore balance and provide relief.
 
That said, there are some things about Quality First Derma Laser Azelaic Acid 100 Ulthera AZ Serum worth noting.
 
Looking at its moisturizing profile, we found that it doesn’t contain any occlusive ingredients, potentially allowing the moisture attracted to the skin by humectants to evaporate. Therefore, if it’s used as the only moisturizer in a routine, it’s recommended to pair it with one that contains at least some occlusive ingredients, such as oils, butters, or silicones.
 
📌 Fact check. At CreamScan, we are committed to accuracy and fairness. If you spot any errors or something that doesn’t seem right, please click here to let us know. We regularly update the ingredient lists and monitor the latest research on ingredient efficacy to ensure that our information remains as complete and precise as possible. The information provided here is for informational purposes only and does not substitute professional advice. We do not guarantee the efficacy or safety of any product, as individual results may vary.

 

Ingredients

Est. % Ingredient Origin Functions
55
22
5
4.9
4
2
1.9
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Est. %
Galactomyces Ferment Filtrate
Function:
Origin:
Butylene Glycol
Function:
Origin:
Niacinamide
Function:
Origin:
Diglycerin
Function:
Origin:
Azelaic Acid
Function:
Origin:
Dipotassium Glycyrrhizate
Function:
Origin:
Melaleuca Alternifolia (Tea Tree) Leaf Oil
Function:
Origin:
Ceramide NP
Function:
Origin:
Centella Asiatica Extract
Function:
Origin:
Scutellaria Baicalensis Root Extract
Function:
Origin:
Polygonum Cuspidatum Root Extract
Function:
Origin:
Glycyrrhiza Glabra (Licorice) Root Extract
Function:
Origin:
Camellia Sinensis Leaf Extract
Function:
Origin:
Rosmarinus Officinalis (Rosemary) Leaf Extract
Function:
Origin:
Chamomilla Recutita (Matricaria) Flower
Function:
Origin:
Tripropylene Glycol
Function:
Origin:
Hydrogenated Lecithin
Function:
Origin:
Phytosterols
Function:
Origin:
PEG-60 Hydrogenated Castor Oil
Function:
Origin:
Ethylhexylglycerin
Function:
Origin:
1,2-Hexanediol
Function:
Origin:
Calcium Sulfate
Function:
Origin:
Silver Oxide
Function:
Origin:
Citric Acid
Function:
Origin:
Sodium Citrate
Function:
Origin:
Water
Function:
Origin:
Lavandula Angustifolia (Lavender) Oil
Function:
Origin:
Citrus Limon (Lemon) Peel Oil
Function:
Origin:
Citrus Aurantifolia (Lime) Oil
Function:
Origin:
Cymbopogon Schoenanthus Oil
Function:
Origin:
Salvia Officinalis (Sage) Oil
Function:
Origin:
Pelargonium Roseum Leaf Oil
Function:
Origin:

Ratings

All humectants
90.4
55
22
5
4.9
2
0.3
0.3
0.3
0.3
0.3
Benchmark
10
All occlusives
0.0
None
Benchmark
20
Moisturizing rating
5.0
Ingredient Est. % Benchmark Raiting
Humectancy All humectants 90.4 10
10.0
55
22
5
4.9
2
0.3
0.3
0.3
0.3
0.3
Occlusivity All occlusives 0.0 20
0.0
None
Moisturizing rating
5.0
Ingredient Est. % Benchmark Humectancy
55
22
5
4.9
2
0.3
0.3
0.3
0.3
0.3
All humectants 90.4 10
10
All humectants
90.4
55
22
5
4.9
2
0.3
0.3
0.3
0.3
0.3
Benchmark
10
Ingredient Est. % Benchmark Occlusivity
None
All occlusives 0.0 20
0.0
All occlusives
0.0
None
Benchmark
20
Ingredient
Ingredient anti-wrinkle power
when present at, %
in this formula est. %
Rating
6 /10 4 5 6
n/a
- 0.3 -
n/a
- 0.3 -
Total
6
Niacinamide
6
Ingredient anti-wrinkle power
6 /10
when present at, %
4
in this formula, est. %
5
Centella Asiatica Extract
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Camellia Sinensis Leaf Extract
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Anti-wrinkle rating
6
Ingredient Est. % Benchmark
Rich in Antioxidants
5
1.9
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
All antioxidants 9.3 3 Rich in antioxidants
All antioxidants
9.3
Niacinamide
5
Melaleuca Alternifolia (Tea Tree) Leaf Oil
1.9
Centella Asiatica Extract
0.3
Scutellaria Baicalensis Root Extract
0.3
Polygonum Cuspidatum Root Extract
0.3
Glycyrrhiza Glabra (Licorice) Root Extract
0.3
Camellia Sinensis Leaf Extract
0.3
Rosmarinus Officinalis (Rosemary) Leaf Extract
0.3
Tripropylene Glycol
0.3
Phytosterols
0.3
Benchmark
3
Ingredient Est. % Benchmark
Rich in Soothing
5
4
2
1.9
0.3
0.3
0.3
0.3
0.3
0.3
All soothing 14.7 5 Rich in soothing
All soothing
14.7
5
4
2
1.9
0.3
0.3
0.3
0.3
0.3
0.3
Benchmark
5

Ingredients explained

Galactomyces Ferment Filtrate
Est. %55
Function
Origin
Galactomyces Ferment Filtrate
Butylene Glycol
Est. %22
Function
Origin
Butylene Glycol

A clear, colorless liquid humectant that draws moisture to the skin. The humectancy of butylene glycol, owed to its two hydroxyl groups, is quite considerable, although not as powerful as glycerin, which contains three hydroxyl groups.

Niacinamide
Est. %5
Function
Origin
Niacinamide

Also known as vitamin B3, this ingredient is a true superstar with confirmed moisturizing, anti-acne, hyperpigmentation, and antioxidant benefits. Two studies confirm its significant anti-wrinkle efficacy.

Diglycerin
Est. %4.9
Function
Origin
DiglycerinA powerful humectant that collects moisture, making skin feel hydrated and supple. Diglycerin is less sticky and a stronger humectant, but slower absorbing than standard glycerin.
Azelaic Acid
Est. %4
Function
Origin
Azelaic AcidA powerful dermatological ingredient that helps to treat acne and various pigmentation issues. It appears both in medicated creams and regular skincare. It reduces redness and inflammation but can be irritating in high concentrations.
Dipotassium Glycyrrhizate
Est. %2
Function
Origin
Dipotassium GlycyrrhizateA licorice root derivative with powerful anti-inflammatory and soothing activities. It is often used as a flavoring agent in lip products.
Melaleuca Alternifolia (Tea Tree) Leaf Oil
Est. %1.9
Function
Origin
Melaleuca Alternifolia (Tea Tree) Leaf OilA fragrant and antioxidant essential tea tree oil praised for its antiseptic and antimicrobial properties. Tea tree oil helps to treat acne, inflamed skin, and small wounds. It might, however, cause allergies and skin irritations.
Ceramide NP
Est. %0.3
Function
Origin
Ceramide NPAlso known as ceramide 3, it is the most common ceramide in our skin. It helps to restore the skin’s lipid barrier and alleviate the symptoms of dry and cracked skin. Research has shown that skin suffering from conditions such as AD lacks ceramides.
Centella Asiatica Extract
Est. %0.3
Function
Origin
Centella Asiatica ExtractAn extract from the leaves of the Gotu kola. It is used in skincare for its antioxidant, wound healing, anti-inflammatory, and anti-aging properties. It increases the production of collagen and hyaluronic acid in the skin.
Scutellaria Baicalensis Root Extract
Est. %0.3
Function
Origin
Scutellaria Baicalensis Root ExtractA powerful antioxidant, soothing, and astringent extract derived from the roots of Baikal/Chinese skullcap. It contains various unique flavonoids that are believed to soothe irritated and inflamed skin and protect from UV-induced oxidative damage.
Polygonum Cuspidatum Root Extract
Est. %0.3
Function
Origin
Polygonum Cuspidatum Root ExtractAn extract from the roots of the Japanese knotweed, a plant from East Asia that has spread around the world as an invasive plant. It contains various antioxidant, anti-inflammatory, and potentially anti-pigment (more tests are necessary) phytochemicals.
Glycyrrhiza Glabra (Licorice) Root Extract
Est. %0.3
Function
Origin
Glycyrrhiza Glabra (Licorice) Root ExtractAn extract from the licorice root. It contains a well-researched anti-inflammatory compound called glycyrrhizin that can reduce inflammation. Licorice root extract is also used for its powerful antioxidant effects and ability to treat pigmentation.
Camellia Sinensis Leaf Extract
Est. %0.3
Function
Origin
Camellia Sinensis Leaf Extract

An antioxidant green tea extract. In the deeper layers, it slows down the destruction of collagen, elastin, and hyaluronic acid – thus delaying the signs of aging. It also acts as an anti-acne, soothing, moisturizing, and emollient ingredient.

Rosmarinus Officinalis (Rosemary) Leaf Extract
Est. %0.3
Function
Origin
Rosmarinus Officinalis (Rosemary) Leaf ExtractA soothing and astringent extract derived from the fragrant, spicy leaves of rosemary. It has strong antioxidant properties. Rosemary extract can reduce signs of inflammation and also acts as an emollient and antimicrobial agent.
Chamomilla Recutita (Matricaria) Flower
Est. %0.3
Function
Origin
Chamomilla Recutita (Matricaria) Flower
Tripropylene Glycol
Est. %0.3
Function
Origin
Tripropylene Glycol
Hydrogenated Lecithin
Est. %0.3
Function
Origin
Hydrogenated LecithinA version of plain lecithin that has been saturated with hydrogen atoms. This ingredient can be derived from plants, like soy or sunflower, from egg yolks, or made synthetically. Its major function is to emulsify water and oils.
Phytosterols
Est. %0.3
Function
Origin
PhytosterolsA plant-based version of cholesterol that is used for its emollient properties in skincare. The richest sources of phytosterols are corn, rapeseed, and wheat germ oil.
PEG-60 Hydrogenated Castor Oil
Est. %0.3
Function
Origin
PEG-60 Hydrogenated Castor OilA white paste-like substance derived from castor oil that belongs to a group of ingredients called PEGs (polyethylene glycols). It acts as a perfume solubilizer that helps fragrance agents dissolve in water and as a cleansing agent.
Ethylhexylglycerin
Est. %0.3
Function
Origin
EthylhexylglycerinA preservative booster derived from glycerin. It is commonly paired with other preservatives to improve their efficacy. Ethylhexylglycerin is also a humectant due to its chemical base of glycerin.
1,2-Hexanediol
Est. %0.3
Function
Origin
1,2-HexanediolA multi-functional formula helper. It is a well-studied preservtive against bacteria and can help pigments and fragrances disperse evenly in a formula.
Calcium Sulfate
Est. %0.3
Function
Origin
Calcium Sulfate
Silver Oxide
Est. %0.3
Function
Origin
Silver Oxide
Citric Acid
Est. %0.3
Function
Origin
Citric AcidA gently exfoliating AHA that helps to remove the top layer of dead skin cells. In comparison to other AHAs, citric acid has been shown to be one of the least effective. It is also very commonly used as a stabilizing and pH-controlling agent.
Sodium Citrate
Est. %0.3
Function
Origin
Sodium CitrateA salt of citric acid that has a salty and tart flavor and is used as a fragrance. It is mildly basic, meaning that its addition to a skincare product can adjust the pH upward.
Water
Est. %0.3
Function
Origin
WaterThe most used ingredient in skincare. Its concentration defines the product texture: rich creams may have about 50% of water while a light jelly about 90%. Water doesn’t moisturize the skin by itself and is used in skincare as a solvent for other ingredients.
Lavandula Angustifolia (Lavender) Oil
Est. %0.3
Function
Origin
Lavandula Angustifolia (Lavender) OilAn essential oil derived from common, or true, lavender. It is used in skincare for its lovely, calming scent. Like all essential oils, however, it may cause a contact skin allergy in more sensitive individuals.
Citrus Limon (Lemon) Peel Oil
Est. %0.3
Function
Origin
Citrus Limon (Lemon) Peel Oil

A fragrant essential oil extracted from the rind or peel of a lemon. It is mainly comprised of limonene (up to 70%) and has a fresh, citrusy scent. Lemon peel oil may cause a sun-induced skin rash in people with a sensitivity towards citrus fruits.

Citrus Aurantifolia (Lime) Oil
Est. %0.3
Function
Origin
Citrus Aurantifolia (Lime) Oil

A fragrant essential oil extracted from lime peels that is mostly comprised of limonene, pinene, terpinene, and terpineol - which give off a sweet citrusy scent.

Cymbopogon Schoenanthus Oil
Est. %0.3
Function
Origin
Cymbopogon Schoenanthus OilAn essential oil with a fresh, minty, and lemony scent. It is obtained from the West Indian lemongrass, also known as camel grass, and some studies suggest that it has an antibacterial effect.
Salvia Officinalis (Sage) Oil
Est. %0.3
Function
Origin
Salvia Officinalis (Sage) OilA fragrant essential oil derived from sage with a cooling, robust, and pine-like herbal scent.
Pelargonium Roseum Leaf Oil
Est. %0.3
Function
Origin
Pelargonium Roseum Leaf Oil