Perricone MD High Potency Hyaluronic Intensive Hydrating Serum

Perricone MD High Potency Hyaluronic Intensive Hydrating Serum
6.8
/ 10
Moisturizing
9.7 Humectancy icon Humectancy
3.8 Occlusivity icon Occlusivity
4.5Anti-wrinkle icon/ 10
Anti-wrinkle
Rich
in Antioxidants

Review

Results you may expect from using Perricone MD High Potency Hyaluronic Intensive Hydrating Serum:

Based on the ingredient analysis by CreamScan, these are the key benefits you can expect from using Perricone MD High Potency Hyaluronic Intensive Hydrating Serum:

  • Significant moisturizing. It has a moisturizing rating of 6.8 out of 10.
  • Considerable anti-wrinkle efficacy: Perricone MD High Potency Hyaluronic Intensive Hydrating Serum has an anti-wrinkle rating of 4.5 out of 10, indicating a moderate ability to reduce wrinkles.
  • Antioxidant protection.

How moisturizing is it?

Highly moisturizing: Perricone MD High Potency Hyaluronic Intensive Hydrating Serum has a moisturizing rating of 6.8 out of 10.

Is it more humectant or occlusive? Significantly more humectant. It has a very high humectancy of 9.7 out of 10, primarily due to the substantial concentration of Butylene Glycol (est. ≈4.0%) and Niacinamide (est. ≈3.0%), and a moderate occlusivity of 3.8 out of 10, mainly due to the significant content of Dimethicone (est. ≈6.0%).

Please refer to the Ratings section below for details of the moisturizing rating calculation.

Anti-wrinkle efficacy

According to CreamScan analysis, Perricone MD High Potency Hyaluronic Intensive Hydrating Serum has a moderate anti-wrinkle rating of 4.5 out of 10. It contains one ingredient with proven anti-wrinkle efficacy: Niacinamide (est. ≈3.0%),
 one of the most effective and well-researched anti-wrinkle ingredients.
 
Among others, Perricone MD High Potency Hyaluronic Intensive Hydrating Serum also contains contains Acetyl Glucosamine and Acetyl Tetrapeptide-9, two ingredients marketed as effective in reducing wrinkles. However, the studies supporting the anti-wrinkle claims of these ingredients provide insufficient evidence of efficacy according to CreamScan Research Evaluation Standards. Therefore, these ingredients do not contribute to the anti-wrinkle rating.
 
Moisturizers, when used regularly, are proven to prevent wrinkle formation and even reduce existing wrinkles. Therefore, this product, like any other moisturizer, could deliver additional anti-wrinkle efficacy through its moisturizing action.
 

Please refer to the Ratings section below for details of the anti-wrinkle rating calculation.

Antioxidant benefits

We estimate that Perricone MD High Potency Hyaluronic Intensive Hydrating Serum is rich (> 3%) in antioxidants, specifically Niacinamide (est. ≈3.0%).

A key benefit of antioxidants is their ability to reduce oxidative stress caused by free radicals and therefore prevent accelerated skin aging. Studies also show that antioxidants can protect against environmental damage such as UV radiation and pollution, and help reduce inflammation and skin redness.

Ingredients

Est. % Ingredient Origin Functions
70
Water
6
Dimethicone
4
Butylene Glycol
3
Niacinamide
2
Acetyl Glucosamine
1.5
Squalane
1.3
Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer
1
Polysilicone-11
0.3
Cetearyl Olivate
0.3
HDI/Trimethylol Hexyllactone Crosspolymer
0.3
Polyisobutene
0.3
Sorbitan Olivate
0.3
Dimethyl Isosorbide
0.3
Polysorbate 20
0.3
1,2-Hexanediol
0.3
Caprylyl Glycol
0.3
Dimethyl MEA
0.3
Hydroxyacetophenone
0.3
Citric Acid
0.3
Ceramide NP
0.3
Caprylyl/Capryl Glucoside
0.3
Sorbitan Oleate
0.3
Sodium Gluconate
0.3
Spermidine
0.3
Silica
0.3
Sodium Acetylated Hyaluronate
0.3
Sodium Hyaluronate
0.3
Phenoxyethanol
0.3
Phytosphingosine
0.3
Sodium Hyaluronate Crosspolymer
0.3
Hyaluronic Acid
0.3
Ethylhexylglycerin
0.3
Acetyl Tetrapeptide-11
0.3
Acetyl Tetrapeptide-9
0.3
Glycerin
0.3
Disodium Acetyl Glucosamine Phosphate
0.3
Sodium Glucuronate
0.3
Magnesium Sulfate
Est. %
Water
Function:
Origin:
Dimethicone
Function:
Origin:
Butylene Glycol
Function:
Origin:
Niacinamide
Function:
Origin:
Acetyl Glucosamine
Function:
Origin:
Squalane
Function:
Origin:
Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer
Function:
Origin:
Polysilicone-11
Function:
Origin:
Cetearyl Olivate
Function:
Origin:
HDI/Trimethylol Hexyllactone Crosspolymer
Function:
Origin:
Polyisobutene
Function:
Origin:
Sorbitan Olivate
Function:
Origin:
Dimethyl Isosorbide
Function:
Origin:
Polysorbate 20
Function:
Origin:
1,2-Hexanediol
Function:
Origin:
Caprylyl Glycol
Function:
Origin:
Dimethyl MEA
Function:
Origin:
Hydroxyacetophenone
Function:
Origin:
Citric Acid
Function:
Origin:
Ceramide NP
Function:
Origin:
Caprylyl/Capryl Glucoside
Function:
Origin:
Sorbitan Oleate
Function:
Origin:
Sodium Gluconate
Function:
Origin:
Spermidine
Function:
Origin:
Silica
Function:
Origin:
Sodium Acetylated Hyaluronate
Function:
Origin:
Sodium Hyaluronate
Function:
Origin:
Phenoxyethanol
Function:
Origin:
Phytosphingosine
Function:
Origin:
Sodium Hyaluronate Crosspolymer
Function:
Origin:
Hyaluronic Acid
Function:
Origin:
Ethylhexylglycerin
Function:
Origin:
Acetyl Tetrapeptide-11
Function:
Origin:
Acetyl Tetrapeptide-9
Function:
Origin:
Glycerin
Function:
Origin:
Disodium Acetyl Glucosamine Phosphate
Function:
Origin:
Sodium Glucuronate
Function:
Origin:
Magnesium Sulfate
Function:
Origin:

Ratings

All humectants
9.7
4
3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Benchmark
10
All occlusives
7.5
6.0
1.5
Benchmark
20
Moisturizing rating
6.8
Ingredient Est. % Benchmark Raiting
Humectancy All humectants 9.7 10
9.7
4
3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Occlusivity All occlusives 7.5 20
3.8
6.0
1.5
Moisturizing rating
6.8
Ingredient Est. % Benchmark Humectancy
4
3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
All humectants 9.7 10
9.7
All humectants
9.7
4
3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Benchmark
10
Ingredient Est. % Benchmark Occlusivity
6
1.5
All occlusives 7.5 20
3.8
All occlusives
7.5
6.0
1.5
Benchmark
20
Ingredient
Ingredient anti-wrinkle power
when present at, %
in this formula est. %
Rating
6 /10 4 3 4.5
n/a
- 2 -
n/a
- 0.3 -
Total
4.5
Niacinamide
4.5
Ingredient anti-wrinkle power
6 /10
when present at, %
4
in this formula, est. %
3
Acetyl Glucosamine
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
2
Acetyl Tetrapeptide-9
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Anti-wrinkle rating
4.5
Ingredient Est. % Benchmark
Rich in Antioxidants
3
0.3
0.3
0.3
0.3
All antioxidants 4.2 3 Rich in antioxidants
All antioxidants
4.2
Niacinamide
3
Hydroxyacetophenone
0.3
Spermidine
0.3
Sodium Hyaluronate
0.3
Hyaluronic Acid
0.3
Benchmark
3
Ingredient Est. % Benchmark
Rich in Soothing
3
0.3
All soothing 3.3 5 No
All soothing
3.3
3
0.3
Benchmark
5

Ingredients explained

Water
Est. %70
Function
Origin
WaterThe most used ingredient in skincare. Its concentration defines the product texture: rich creams may have about 50% of water while a light jelly about 90%. Water doesn’t moisturize the skin by itself and is used in skincare as a solvent for other ingredients.
Dimethicone
Est. %6
Function
Origin
DimethiconeThe most common silicone in skincare. It forms a silky, smooth film on the skin’s surface and can help to prevent water loss. It also aids in wound healing and can treat and soften scars. Dimethicone is considered to be very safe for use.
Butylene Glycol
Est. %4
Function
Origin
Butylene GlycolA clear, colorless liquid humectant that draws moisture to the skin. The humectancy of butylene glycol, owed to its two hydroxyl groups, is quite considerable, although not as powerful as glycerin, which contains three hydroxyl groups.
Niacinamide
Est. %3
Function
Origin
Niacinamide

Also known as vitamin B3, this ingredient is a true superstar with confirmed moisturizing, anti-acne, hyperpigmentation, and antioxidant benefits. Two studies confirm its significant anti-wrinkle efficacy.

Acetyl Glucosamine
Est. %2
Function
Origin
Acetyl GlucosamineA body-natural amino-saccharide used in skincare as an anti-pigment ingredient. Some other benefits of acetyl glucosamine include decreased skin flakiness, improved wound healing, and even a slight reduction in facial wrinkles.
Squalane
Est. %1.5
Function
Origin
SqualaneAn occlusive moisturizing and emollient compound that forms part of the skin’s sebum. The main source of squalane had always been shark liver. Now, however, it is manufactured synthetically or derived from plant oils, such as olive and peanut oil.
Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer
Est. %1.3
Function
Origin
Sodium Acrylate/Sodium Acryloyldimethyl Taurate CopolymerA multi-functional ingredient that forms a polymeric network, thereby thickening the formula and preventing other ingredients from shifting around.
Polysilicone-11
Est. %1
Function
Origin
Polysilicone-11A synthetic rubber-like substance of the silicone family that has no color or distinct scent. These are large molecules that cannot penetrate the skin but instead create a thin silky film on the skin's surface.
Cetearyl Olivate
Est. %0.3
Function
Origin
Cetearyl Olivate

A multifunctional ingredient derived from plants that primarily serves as an emulsifier. Supplied as a waxy ivory-colored flake, it can also be used as an emollient and slip modifier that gives a product an overall light, silky finish.

HDI/Trimethylol Hexyllactone Crosspolymer
Est. %0.3
Function
Origin
HDI/Trimethylol Hexyllactone CrosspolymerAn anticaking agent that prevents a product from forming lumps. It also increases slip and produces an elegant finish in skincare formulations.
Polyisobutene
Est. %0.3
Function
Origin
PolyisobuteneA highly viscous liquid that is used in lip gloss formulations to prolong wear time and add shimmer. Polyisobutene dramatically increases the thickness of skincare products it is added to.
Sorbitan Olivate
Est. %0.3
Function
Origin
Sorbitan OlivateAn ester of sorbitol (a type of sugar alcohol) and olive oil fatty acids. It is used as an emulsifying agent to stabilize oil droplets in water (or vice versa).
Dimethyl Isosorbide
Est. %0.3
Function
Origin
Dimethyl IsosorbideA solvent for active ingredients that is claimed to help them better penetrate the outer layer of skin. It also helps to reduce the thickness of a product.
Polysorbate 20
Est. %0.3
Function
Origin
Polysorbate 20A viscous, amber-colored liquid that functions as a solubilizer to disperse small amounts of oil into a large water phase. Polysorbate 20 is frequently used to solubilize fragrance oils into water-based emulsions.
1,2-Hexanediol
Est. %0.3
Function
Origin
1,2-HexanediolA multi-functional formula helper. It is a well-studied preservtive against bacteria and can help pigments and fragrances disperse evenly in a formula.
Caprylyl Glycol
Est. %0.3
Function
Origin
Caprylyl GlycolAn emollient that improves product spreadability and offers a silky feel on the skin. It also acts as a preservative booster that improves the efficacy of other preservatives. According to the manufacturer, it is also a humectant moisturizer.
Dimethyl MEA
Est. %0.3
Function
Origin
Dimethyl MEADimethyl MEA is a chemical compound with many names - it can also be listed as DMAE, deanol or 2-dimethylaminoethanol. It is described as a colorless liquid with a fishy smell. DMAE is added to skincare products to regulate the pH balance, but can potentially be toxic.
Hydroxyacetophenone
Est. %0.3
Function
Origin
HydroxyacetophenoneAn antioxidant compound that can be found in many plants, although it is manufactured synthetically for skincare purposes. It can boost the preservative action of other conservants.
Citric Acid
Est. %0.3
Function
Origin
Citric AcidA gently exfoliating AHA that helps to remove the top layer of dead skin cells. In comparison to other AHAs, citric acid has been shown to be one of the least effective. It is also very commonly used as a stabilizing and pH-controlling agent.
Ceramide NP
Est. %0.3
Function
Origin
Ceramide NPAlso known as ceramide 3, it is the most common ceramide in our skin. It helps to restore the skin’s lipid barrier and alleviate the symptoms of dry and cracked skin. Research has shown that skin suffering from conditions such as AD lacks ceramides.
Caprylyl/Capryl Glucoside
Est. %0.3
Function
Origin
Caprylyl/Capryl GlucosideA naturally-derived surfactant used for gentle cleansing and foam-boosting when combined with other surfactants.
Sorbitan Oleate
Est. %0.3
Function
Origin
Sorbitan OleateA vegetable-based ingredient that stabilizes mixtures of oil and water. Sorbitan oleate serves primarily as an emulsifier that produces water-in-oil emulsions.
Sodium Gluconate
Est. %0.3
Function
Origin
Sodium GluconateA chelating ingredient that ensures that the harmful metal ions in a formula are unreactive. It also protects other ingredients from degrading.
Spermidine
Est. %0.3
Function
Origin
SpermidineDescription is coming soon
Silica
Est. %0.3
Function
Origin
SilicaA widely used cosmetic ingredient with the same chemical composition as the sand found on beaches. A common function of silica is its ability to control viscosity. In certain chemical forms, it can effectively thicken cream-style products.
Sodium Acetylated Hyaluronate
Est. %0.3
Function
Origin
Sodium Acetylated HyaluronateA chemically modified version of hyaluronic acid. It is more stable and less sticky than regular HA, while still providing the same humectant moisturizing properties (according to the manufacturer). There have been no clinical studies to confirm this.
Sodium Hyaluronate
Est. %0.3
Function
Origin
Sodium Hyaluronate

A sodium salt of famous hyaluronic acid. A potent humectant that hydrates the skin, supports collagen function, and fills out small wrinkles. Sodium hyaluronate also offers soothing and antioxidant properties.

Phenoxyethanol
Est. %0.3
Function
Origin
PhenoxyethanolThe most frequently used preservative in skincare. It is a clear, oil-like liquid synthetic substance that protects products from harmful bacteria and yeast, whilst still leaving skin microflora unharmed. It is confirmed by research to be harmless.
Phytosphingosine
Est. %0.3
Function
Origin
PhytosphingosineA key component of ceramides NP, AP, and EOP. It has barrier repair properties and stimulates the production of the skin’s Natural Moisturizing Factor. Phytosphingosine has strong antimicrobial and anti-inflammatory activity, which can be used to treat acne.
Sodium Hyaluronate Crosspolymer
Est. %0.3
Function
Origin
Sodium Hyaluronate CrosspolymerA modified version of regular hyaluronic acid. It attracts large volumes of water, thereby making it an effective humectant moisturizing ingredient.
Hyaluronic Acid
Est. %0.3
Function
Origin
Hyaluronic Acid

A potent, skin-identical humectant moisturizing ingredient that is able to bind water 1000 times its own weight. The anti-aging benefits of hyaluronic acid are due to its ability to stimulate the synthesis of collagen in the skin.

Ethylhexylglycerin
Est. %0.3
Function
Origin
EthylhexylglycerinA preservative booster derived from glycerin. It is commonly paired with other preservatives to improve their efficacy. Ethylhexylglycerin is also a humectant due to its chemical base of glycerin.
Acetyl Tetrapeptide-11
Est. %0.3
Function
Origin
Acetyl Tetrapeptide-11Description is coming soon
Acetyl Tetrapeptide-9
Est. %0.3
Function
Origin
Acetyl Tetrapeptide-9

A synthetically made peptide that works as a signal peptide, increasing the production of collagen in the skin.

Glycerin
Est. %0.3
Function
Origin
Glycerin

The most popular moisturizing ingredient in the world. It is a powerful humectant – cheap yet very effective.

Disodium Acetyl Glucosamine Phosphate
Est. %0.3
Function
Origin
Disodium Acetyl Glucosamine PhosphateDescription is coming soon
Sodium Glucuronate
Est. %0.3
Function
Origin
Sodium GlucuronateDescription is coming soon
Magnesium Sulfate
Est. %0.3
Function
Origin
Magnesium SulfateA naturally occurring mineral that is commonly used in skincare products as a bulking agent. It helps to control the viscosity of products by making them thicker.