Perricone MD Essential Fx Acyl-Glutathione Rejuvenating Moisturizer

Perricone MD Essential Fx Acyl-Glutathione Rejuvenating Moisturizer
4.8
/ 10
Moisturizing
6.9 Humectancy icon Humectancy
2.7 Occlusivity icon Occlusivity
Rich
in Antioxidants

Review

Results you may expect from using Perricone MD Essential Fx Acyl-Glutathione Rejuvenating Moisturizer:

Based on the ingredient analysis by CreamScan, these are the key benefits you can expect from using Perricone MD Essential Fx Acyl-Glutathione Rejuvenating Moisturizer:

  • Moderate moisturizing. It has a moisturizing rating of 4.8 out of 10.
  • Antioxidant protection.

How moisturizing is it?

Quite moisturizing: Perricone MD Essential Fx Acyl-Glutathione Rejuvenating Moisturizer has a moisturizing rating of 4.8 out of 10.

Is it more humectant or occlusive? Significantly more humectant. It has a low occlusivity of 2.7 out of 10 and a high humectancy of 6.9 out of 10, primarily due to the high content of Glycerin (est. ≈6.0%).

Please refer to the Ratings section below for details of the moisturizing rating calculation.

Anti-wrinkle efficacy

According to CreamScan analysis, Perricone MD Essential Fx Acyl-Glutathione Rejuvenating Moisturizer has a zero anti-wrinkle rating.

It contains Tetrahexyldecyl Ascorbate, an ingredient marketed as effective in reducing wrinkles. However, the studies supporting the anti-wrinkle claims of Tetrahexyldecyl Ascorbate provide insufficient evidence of its efficacy according to CreamScan Research Evaluation Standards. Therefore, this ingredient does not generate the anti-wrinkle rating.

Moisturizers, when used regularly, are proven to prevent wrinkle formation and even reduce existing wrinkles. Therefore, this product, like any other moisturizer, could deliver some anti-wrinkle effects through its moisturizing action.

Please refer to the Ratings section below for details of the anti-wrinkle rating calculation.

Antioxidant benefits

We estimate that Perricone MD Essential Fx Acyl-Glutathione Rejuvenating Moisturizer is rich (> 3%) in antioxidants, specifically S-Palmitoylglutathione (est. ≈1.3%), Tetrahexyldecyl Ascorbate (est. ≈1.0%), Salvia Hispanica Seed Oil (est. ≈0.3%), and others.

A key benefit of antioxidants is their ability to reduce oxidative stress caused by free radicals and therefore prevent accelerated skin aging. Studies also show that antioxidants can protect against environmental damage such as UV radiation and pollution, and help reduce inflammation and skin redness.

Ingredients

Est. % Ingredient Origin Functions
60
Water
9
Ethylhexyl Palmitate
6
Glycerin
4
Dimethicone
3
Cetearyl Alcohol
2.5
Glyceryl Stearate
2
Polysorbate 60
1.5
Palmitoyl Glycine
1.3
S-Palmitoylglutathione
1
Tetrahexyldecyl Ascorbate
0.3
PEG-100 Stearate
0.3
Ribose
0.3
Lactic Acid
0.3
Linum Usitatissimum (Linseed) Seed Oil
0.3
Macadamia Ternifolia Seed Oil
0.3
Phospholipids
0.3
Polyglyceryl-10 Stearate
0.3
Ethylhexylglycerin
0.3
Salvia Hispanica Seed Oil
0.3
Tocopherol
0.3
Helianthus Annuus (Sunflower) Seed Oil
0.3
Rosmarinus Officinalis (Rosemary) Leaf Extract
0.3
Tetrasodium Glutamate Diacetate
0.3
Sodium Hydroxide
0.3
Polyacrylamide
0.3
Sodium Acrylates Copolymer
0.3
Polysilicone-11
0.3
Hydrogenated Polyisobutene
0.3
C13-14 Isoparaffin
0.3
Laureth-7
0.3
Phenoxyethanol
0.3
Fragrance
0.3
Citronellol
0.3
Hydroxycitronellal
0.3
Limonene
0.3
Linalool
Est. %
Water
Function:
Origin:
Ethylhexyl Palmitate
Function:
Origin:
Glycerin
Function:
Origin:
Dimethicone
Function:
Origin:
Cetearyl Alcohol
Function:
Origin:
Glyceryl Stearate
Function:
Origin:
Polysorbate 60
Function:
Origin:
Palmitoyl Glycine
Function:
Origin:
S-Palmitoylglutathione
Function:
Origin:
Tetrahexyldecyl Ascorbate
Function:
Origin:
PEG-100 Stearate
Function:
Origin:
Ribose
Function:
Origin:
Lactic Acid
Function:
Origin:
Linum Usitatissimum (Linseed) Seed Oil
Function:
Origin:
Macadamia Ternifolia Seed Oil
Function:
Origin:
Phospholipids
Function:
Origin:
Polyglyceryl-10 Stearate
Function:
Origin:
Ethylhexylglycerin
Function:
Origin:
Salvia Hispanica Seed Oil
Function:
Origin:
Tocopherol
Function:
Origin:
Helianthus Annuus (Sunflower) Seed Oil
Function:
Origin:
Rosmarinus Officinalis (Rosemary) Leaf Extract
Function:
Origin:
Tetrasodium Glutamate Diacetate
Function:
Origin:
Sodium Hydroxide
Function:
Origin:
Polyacrylamide
Function:
Origin:
Sodium Acrylates Copolymer
Function:
Origin:
Polysilicone-11
Function:
Origin:
Hydrogenated Polyisobutene
Function:
Origin:
C13-14 Isoparaffin
Function:
Origin:
Laureth-7
Function:
Origin:
Phenoxyethanol
Function:
Origin:
Fragrance
Function:
Origin:
Citronellol
Function:
Origin:
Hydroxycitronellal
Function:
Origin:
Limonene
Function:
Origin:
Linalool
Function:
Origin:

Ratings

All humectants
6.9
6
0.3
0.3
0.3
Benchmark
10
All occlusives
5.5
4.0
0.3
0.3
0.3
0.3
0.3
Benchmark
20
Moisturizing rating
4.8
Ingredient Est. % Benchmark Raiting
Humectancy All humectants 6.9 10
6.9
6
0.3
0.3
0.3
Occlusivity All occlusives 5.5 20
2.7
4.0
0.3
0.3
0.3
0.3
0.3
Moisturizing rating
4.8
Ingredient Est. % Benchmark Humectancy
6
0.3
0.3
0.3
All humectants 6.9 10
6.9
All humectants
6.9
6
0.3
0.3
0.3
Benchmark
10
Ingredient Est. % Benchmark Occlusivity
4
0.3
0.3
0.3
0.3
0.3
All occlusives 5.5 20
2.7
All occlusives
5.5
4.0
0.3
0.3
0.3
0.3
0.3
Benchmark
20
Ingredient
Ingredient anti-wrinkle power
when present at, %
in this formula est. %
Rating
n/a
- 1 -
Total
0
Tetrahexyldecyl Ascorbate
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
1
Anti-wrinkle rating
0
Ingredient Est. % Benchmark
Rich in Antioxidants
1.3
1
0.3
0.3
0.3
All antioxidants 3.2 3 Rich in antioxidants
All antioxidants
3.2
S-Palmitoylglutathione
1.3
Tetrahexyldecyl Ascorbate
1
Salvia Hispanica Seed Oil
0.3
Tocopherol
0.3
Rosmarinus Officinalis (Rosemary) Leaf Extract
0.3
Benchmark
3
Ingredient Est. % Benchmark
Rich in Soothing
0.3
All soothing 0.3 5 No
All soothing
0.3
0.3
Benchmark
5

Ingredients explained

Water
Est. %60
Function
Origin
WaterThe most used ingredient in skincare. Its concentration defines the product texture: rich creams may have about 50% of water while a light jelly about 90%. Water doesn’t moisturize the skin by itself and is used in skincare as a solvent for other ingredients.
Ethylhexyl Palmitate
Est. %9
Function
Origin
Ethylhexyl PalmitateA rich emollient without the oily after-feel, making it a popular replacement for mineral oil. It is derived from natural sources such as palm oil and palm kernel oil. Ethylhexyl palmitate is listed as a common comedogenic ingredient by acne.org.
Glycerin
Est. %6
Function
Origin
Glycerin

The most popular moisturizing ingredient in the world. It is a powerful humectant – cheap yet very effective.

Dimethicone
Est. %4
Function
Origin
DimethiconeThe most common silicone in skincare. It forms a silky, smooth film on the skin’s surface and can help to prevent water loss. It also aids in wound healing and can treat and soften scars. Dimethicone is considered to be very safe for use.
Cetearyl Alcohol
Est. %3
Function
Origin
Cetearyl AlcoholA blend of cetyl alcohol and stearyl alcohol, the fatty alcohols that are derived from palm oil. It helps to create emulsions that give off a soft and silky emollient feel and also increase product thickness.
Glyceryl Stearate
Est. %2.5
Function
Origin
Glyceryl StearateAn emollient and emulsifier typically derived from vegetable sources through a chemical reaction with glycerin. It provides stability, texture, and consistency to formulations. Its main function is to allow oil and water to mix.
Polysorbate 60
Est. %2
Function
Origin
Polysorbate 60An ester based on sorbitan. It is good for emulsifying water and oils together – specifically making oil-in-water emulsions. Polysorbate 60 is also said to give a product a notable fragrance.
Palmitoyl Glycine
Est. %1.5
Function
Origin
Palmitoyl GlycineDescription is coming soon
S-Palmitoylglutathione
Est. %1.3
Function
Origin
S-PalmitoylglutathioneDescription is coming soon
Tetrahexyldecyl Ascorbate
Est. %1
Function
Origin
Tetrahexyldecyl AscorbateA lipid-soluble form of vitamin C that is more stable and less irritating than ascorbic acid. According to a recent clinical study, THDA has all the capabilities of regular vitamin C, including anti-wrinkle and anti-pigment activity.
PEG-100 Stearate
Est. %0.3
Function
Origin
PEG-100 StearateThis surfactant is more specifically classified as an emulsifier that produces oil-in-water emulsions. PEG-100 stearate can also be used as a cleansing agent.
Ribose
Est. %0.3
Function
Origin
RiboseRibose is a simple sugar that is present in all living things. It has moderate humectant moisturizing properties in skincare, but is not used very often. It is manufactured from yeast or chemically derived from other sugars for use in cosmetic products.
Lactic Acid
Est. %0.3
Function
Origin
Lactic AcidThe most popular AHA in skincare and less irritating than glycolic acid. It can be naturally found in sour milk. It is a humectant moisturizing, pH stabilizing, and gently exfoliating ingredient, able to soften dry, cracked, and peeling skin.
Linum Usitatissimum (Linseed) Seed Oil
Est. %0.3
Function
Origin
Linum Usitatissimum (Linseed) Seed OilAn emollient and occlusive fatty oil pressed from flax seeds. It is the richest source of linolenic fatty acid (it contains up to 50% of it) among vegetable oils.
Macadamia Ternifolia Seed Oil
Est. %0.3
Function
Origin
Macadamia Ternifolia Seed OilAn occlusive moisturizing and emollient oil extracted from macadamia nuts. It is clear and pale yellow with a pleasant nutty aroma and contains oleic and palmitoleic fatty acids, tocopherols, phytosterols, squalene, and polyphenols.
Phospholipids
Est. %0.3
Function
Origin
PhospholipidsA large group of lipids that are an essential component of every single cell membrane in the body. They have excellent emollient properties. Phospholipids are also utilized in the manufacturing of ‘fancy’ formulations such as liposomes.
Polyglyceryl-10 Stearate
Est. %0.3
Function
Origin
Polyglyceryl-10 StearateA naturally-derived or synthetically produced mild emulsifier.
Ethylhexylglycerin
Est. %0.3
Function
Origin
EthylhexylglycerinA preservative booster derived from glycerin. It is commonly paired with other preservatives to improve their efficacy. Ethylhexylglycerin is also a humectant due to its chemical base of glycerin.
Salvia Hispanica Seed Oil
Est. %0.3
Function
Origin
Salvia Hispanica Seed OilAn oil extracted from Chia seeds. It has a unique ratio of omega-3 and omega-6 fatty acids, making it the richest source of polyunsaturated fatty acids. It also contains antioxidant phytosterols and tocopherols (vitamin E).
Tocopherol
Est. %0.3
Function
Origin
Tocopherol

Simply another name for vitamin E. Tocopherol is a fantastic ingredient and especially beneficial for dry and inflamed skin. It has occlusive moisturizing, emollient, antioxidant, and photoprotective properties.

Helianthus Annuus (Sunflower) Seed Oil
Est. %0.3
Function
Origin
Helianthus Annuus (Sunflower) Seed OilA fatty oil expressed from sunflower seeds and one of the most commonly used oils in skincare. It has great emollient and occlusive moisturizing properties. Sunflower oil is one of the richest sources of vitamin E – an important skin antioxidant.
Rosmarinus Officinalis (Rosemary) Leaf Extract
Est. %0.3
Function
Origin
Rosmarinus Officinalis (Rosemary) Leaf ExtractA soothing and astringent extract derived from the fragrant, spicy leaves of rosemary. It has strong antioxidant properties. Rosemary extract can reduce signs of inflammation and also acts as an emollient and antimicrobial agent.
Tetrasodium Glutamate Diacetate
Est. %0.3
Function
Origin
Tetrasodium Glutamate DiacetateA biodegradable chelating agent that chemically captures the heavy metal ions naturally present in water and disarms their harmful effects.
Sodium Hydroxide
Est. %0.3
Function
Origin
Sodium Hydroxide

An ingredient that is able to bring the pH of a product up, thereby making it less harsh on the skin.

Polyacrylamide
Est. %0.3
Function
Origin
PolyacrylamideA synthetic ingredient that can thicken products instantly while still keeping them light and often gel-like.
Sodium Acrylates Copolymer
Est. %0.3
Function
Origin
Sodium Acrylates CopolymerA synthetic polymer that can come in various forms and is often used to create light gel-like textures. Some versions can also create a light film on the skin.
Polysilicone-11
Est. %0.3
Function
Origin
Polysilicone-11A synthetic rubber-like substance of the silicone family that has no color or distinct scent. These are large molecules that cannot penetrate the skin but instead create a thin silky film on the skin's surface.
Hydrogenated Polyisobutene
Est. %0.3
Function
Origin
Hydrogenated PolyisobuteneA viscous liquid that makes a great oil base due to its smooth sensorial profile. It has emollient features, including good spreadability and little tack upon application. It also has the added benefit of being able to thicken products.
C13-14 Isoparaffin
Est. %0.3
Function
Origin
C13-14 IsoparaffinA lightweight petroleum derivative. It is a very thin liquid that functions as an emollient and a solvent for other liquids (such as thicker oils or silicones).
Laureth-7
Est. %0.3
Function
Origin
Laureth-7A mild but effective functional ingredient. It can emulsify (efficiently mix water and oil) without needing too much in a formula.
Phenoxyethanol
Est. %0.3
Function
Origin
PhenoxyethanolThe most frequently used preservative in skincare. It is a clear, oil-like liquid synthetic substance that protects products from harmful bacteria and yeast, whilst still leaving skin microflora unharmed. It is confirmed by research to be harmless.
Fragrance
Est. %0.3
Function
Origin
FragranceUnder trade secret law, manufacturers have the right not to disclose what exactly went into the fragrance and use the unspecific word Fragrance or Parfum instead. Many fragrances are highly allergenic.
Citronellol
Est. %0.3
Function
Origin
CitronellolA fragrant compound found naturally in many essential oils (mainly lemongrass). It can have a lemon or a rose scent. People with sensitive skin should try to avoid products with citronellol, or at least do a patch test before using it.
Hydroxycitronellal
Est. %0.3
Function
Origin
HydroxycitronellalA fragrant compound with a scent reminiscent of lilies and sweet tropical melon. It can be found in many different essential oils (such as palmarosa, ylang-ylang, and lemongrass essential oil) but is manufactured synthetically from citronellal.
Limonene
Est. %0.3
Function
Origin
LimoneneOne of the most used fragrances in skincare products. It is produced from the peels of citrus fruits and has a fresh, pleasant, citrusy smell. People who are sensitive to citrus should try to avoid it, or at least do a patch test before using it.
Linalool
Est. %0.3
Function
Origin
LinaloolA fragrant, volatile compound naturally present in many essential oils. It has a pleasant scent and is often used in skincare products as a fragrance. People with sensitive skin should try to avoid it, or at least do a patch test before using it.