Natio Skin Renewal Ceramide Line & Wrinkle Cream Review

Natio Skin Renewal Ceramide Line & Wrinkle Cream
8.4
/ 10
Moisturizing
8.6 Humectancy icon Humectancy
8.2 Occlusivity icon Occlusivity
2Anti-wrinkle icon/ 10
Anti-wrinkle
Rich
in Antioxidants
Ingredients

Natio Skin Renewal Ceramide Line & Wrinkle Cream Ingredients

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Full Ingredient List (INCI):

Water, Caprylic/Capric Triglyceride, Glycerin, Cetearyl Alcohol, Olea Europaea (Olive) Fruit Oil, Helianthus Annuus (Sunflower) Seed Oil, Argania Spinosa Kernel Oil, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Niacinamide, Sodium Hyaluronate, Ceramide NP, Ceramide NS, Ceramide EOS, Ceramide EOP, Ceramide AP, Cholesterol, Caprooyl Phytosphingosine, Caprooyl Sphingosine, Ceteareth-25, Cetyl Alcohol, Behenic Acid, Sodium Ascorbyl Phosphate, Citrus Aurantium Dulcis (Orange) Peel Oil, Aniba Rosaeodora Wood Oil, Fragrance, Lavandula Angustifolia (Lavender) Oil, Citrus Limon (Lemon) Peel Oil, Rosa Damascena Flower Extract, Arctostaphylos Uva-Ursi Leaf Extract, Disodium EDTA, Phenoxyethanol, Caprylyl Glycol, Salicylic Acid
Review

Does Natio Skin Renewal Ceramide Line & Wrinkle Cream Work?

 
According to CreamScan's analysis of the ingredient list, here’s what Natio Skin Renewal Ceramide Line & Wrinkle Cream has to offer:
 
✅ Intense moisturizing. It has a moisturizing rating of 8.4 out of 10.
✅ Modest anti-wrinkle efficacy: Natio Skin Renewal Ceramide Line & Wrinkle Cream has an anti-wrinkle rating of 2.0 out of 10 so you may expect some, although limited, effect on wrinkles.
✅ Antioxidant protection

  

Key Benefits of Natio Skin Renewal Ceramide Line & Wrinkle Cream

 
These are the key benefits you can expect from using Natio Skin Renewal Ceramide Line & Wrinkle Cream:
 

🔵🔵🔵 Rich Moisturizer Perfect for Dry Skin

According to CreamScan analysis, Natio Skin Renewal Ceramide Line & Wrinkle Cream is intensely moisturizing, with a moisturizing rating of 8.4 out of 10.

Is it more humectant or occlusive? This product has relatively comparable levels of humectancy and occlusivity: a very high humectancy of 8.6 out of 10, primarily due to the substantial concentration of Glycerin (est. ≈6.0%), and a very high occlusivity of 8.2 out of 10, mainly due to the significant content of Caprylic/Capric Triglyceride (est. ≈9.0%) and Olea Europaea (Olive) Fruit Oil (est. ≈3.0%).

This type of moisturizer is ideal for people with dry skin who want intense hydration. It combines a high concentration of humectants and occlusive ingredients to provide effective dual-action moisturizing specifically for dry skin.

The occlusive profile of Natio Skin Renewal Ceramide Line & Wrinkle Cream suggests a rich, thick texture, making it perfectly suited for dry skin.

Please refer to the Ratings section below for details of the moisturizing rating calculation.

🟣 Modest Anti-Wrinkle Efficacy

According to CreamScan analysis, Natio Skin Renewal Ceramide Line & Wrinkle Cream has a modest level of anti-wrinkle efficacy, rated 2.0 out of 10.

It contains one ingredient with proven anti-wrinkle efficacy: Niacinamide (est. ≈1.3%),
 one of the most effective and well-researched anti-wrinkle ingredients. A clinical study involving 30 participants (Kawada et al.) confirmed that a cream with 4% niacinamide reduced the average depth of wrinkles around the eyes by 9% after 8 weeks of use, compared to a vehicle (the same formulation without niacinamide).
 
Among others, Natio Skin Renewal Ceramide Line & Wrinkle Cream also contains Sodium Ascorbyl Phosphate, an ingredient often marketed as effective in reducing wrinkles. However, the studies supporting the anti-wrinkle claims of Sodium Ascorbyl Phosphate provide insufficient evidence of its efficacy according to CreamScan Research Evaluation Standards.
 
While this does not categorically rule out the possibility that Sodium Ascorbyl Phosphate may reduce wrinkles, its efficacy is not supported by convincing, vehicle-controlled, double-blind clinical studies - at least none that were available to the CreamScan team at the time of publication.
 
Therefore, this ingredient does not contribute to the anti-wrinkle rating.
 
📌 Moisturizers, when used regularly, are proven to prevent wrinkle formation and even reduce existing wrinkles. Therefore, this product, like any other moisturizer, can deliver some additional anti-wrinkle effects through its moisturizing action.
 

Please refer to the Ratings section below for details of the anti-wrinkle rating calculation.

🍀 Rich in Skin-Protecting Antioxidants

We estimate that Natio Skin Renewal Ceramide Line & Wrinkle Cream is rich (> 3%) in antioxidants, specifically Olea Europaea (Olive) Fruit Oil (est. ≈3.0%) and Argania Spinosa Kernel Oil (est. ≈2.0%).

A key benefit of antioxidants is their ability to reduce oxidative stress caused by free radicals and therefore prevent accelerated skin aging. Studies also show that antioxidants can protect against environmental damage such as UV radiation and pollution, and help reduce inflammation and skin redness.

📌 Please note that this is not a complete list of benefits. We are in the process of enhancing our model to incorporate anti-pigmentation, exfoliation and anti-acne ratings.

Things to Be Aware Of: Natio Skin Renewal Ceramide Line & Wrinkle Cream

 
CreamScan identified a few things to consider before adding Natio Skin Renewal Ceramide Line & Wrinkle Cream to your skincare routine:
 

⚠️ Best for Dry Skin - May Be Too Thick for Other Skin Types

With high occlusivity, this product is optimal for dry skin but may be too thick for combination and especially oily skin. Even on normal skin, it can feel too rich depending on the quantity applied, the environment, and individual preferences.

If you have oily, combination, or normal skin and are considering purchasing this product for the first time, it might be a good idea to try a sample before buying.

Pros & Cons of Natio Skin Renewal Ceramide Line & Wrinkle Cream

 
Here’s an overview of the pros and cons of Natio Skin Renewal Ceramide Line & Wrinkle Cream to help you decide if it’s the right choice for your skincare routine:
 

🟩 Pros:

✅ Rich moisturizer perfect for dry skin: highly occlusive and humectant-rich
Offers modest anti-wrinkle efficacy
✅ Rich in antioxidants that combat oxidative stress associated with accelerated skin aging and defend against environmental damage
 

⭕ Cons: 

⚠️ May feel too rich and thick on skin types other than dry
✅ We couldn't find any
   

Summary: Natio Skin Renewal Ceramide Line & Wrinkle Cream

 
Based on the ingredient list analysis, CreamScan AI suggests that Natio Skin Renewal Ceramide Line & Wrinkle Cream
 is an ideal moisturizer for dry skin, combining a very high concentration of humectants and occlusive ingredients in a rich, thick texture.
 
Natio Skin Renewal Ceramide Line & Wrinkle Cream contains ingredients with proven evidence of anti-wrinkle efficacy that may provide a modest anti-wrinkle effect. As a result, you can expect a positive, though not very significant, impact on wrinkles.
 
With its high antioxidant content, Natio Skin Renewal Ceramide Line & Wrinkle Cream helps protect against free radical damage and offers multiple benefits for all skin types, including preventing premature aging, defending against environmental damage, and calming inflammation.
 
That said, there are some things about Natio Skin Renewal Ceramide Line & Wrinkle Cream worth noting.
 
With its high occlusivity, Natio Skin Renewal Ceramide Line & Wrinkle Cream is ideal for dry skin but may feel too thick on other skin types. If you have oily, combination, or normal skin, it’s a good idea to try a sample before purchasing.
 
📌 Fact check. At CreamScan, we are committed to accuracy and fairness. If you spot any errors or something that doesn’t seem right, please click here to let us know. We regularly update the ingredient lists and monitor the latest research on ingredient efficacy to ensure that our information remains as complete and precise as possible. The information provided here is for informational purposes only and does not substitute professional advice. We do not guarantee the efficacy or safety of any product, as individual results may vary.

 

Ingredient Breakdown

Est. % Ingredient Origin Functions
65
9
6
4
3
2.5
2
1.5
1.3
1
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Est. %
Water
Function:
Origin:
Caprylic/Capric Triglyceride
Function:
Origin:
Glycerin
Function:
Origin:
Cetearyl Alcohol
Function:
Origin:
Olea Europaea (Olive) Fruit Oil
Function:
Origin:
Helianthus Annuus (Sunflower) Seed Oil
Function:
Origin:
Argania Spinosa Kernel Oil
Function:
Origin:
Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer
Function:
Origin:
Niacinamide
Function:
Origin:
Sodium Hyaluronate
Function:
Origin:
Ceramide NP
Function:
Origin:
Ceramide NS
Function:
Origin:
Ceramide EOS
Function:
Origin:
Ceramide EOP
Function:
Origin:
Ceramide AP
Function:
Origin:
Cholesterol
Function:
Origin:
Caprooyl Phytosphingosine
Function:
Origin:
Caprooyl Sphingosine
Function:
Origin:
Ceteareth-25
Function:
Origin:
Cetyl Alcohol
Function:
Origin:
Behenic Acid
Function:
Origin:
Sodium Ascorbyl Phosphate
Function:
Origin:
Citrus Aurantium Dulcis (Orange) Peel Oil
Function:
Origin:
Aniba Rosaeodora Wood Oil
Function:
Origin:
Fragrance
Function:
Origin:
Lavandula Angustifolia (Lavender) Oil
Function:
Origin:
Citrus Limon (Lemon) Peel Oil
Function:
Origin:
Rosa Damascena Flower Extract
Function:
Origin:
Arctostaphylos Uva-Ursi Leaf Extract
Function:
Origin:
Disodium EDTA
Function:
Origin:
Phenoxyethanol
Function:
Origin:
Caprylyl Glycol
Function:
Origin:
Salicylic Acid
Function:
Origin:

Ratings

All humectants
8.6
6
1.3
1
0.3
Benchmark
10
All occlusives
16.5
9.0
3.0
2.5
2.0
Benchmark
20
Moisturizing rating
8.4
Ingredient Est. % Benchmark Raiting
Humectancy All humectants 8.6 10
8.6
6
1.3
1
0.3
Occlusivity All occlusives 16.5 20
8.2
9.0
3.0
2.5
2.0
Moisturizing rating
8.4
Ingredient Est. % Benchmark Humectancy
6
1.3
1
0.3
All humectants 8.6 10
8.6
All humectants
8.6
6
1.3
1
0.3
Benchmark
10
Ingredient Est. % Benchmark Occlusivity
9
3
2.5
2
All occlusives 16.5 20
8.2
All occlusives
16.5
9.0
3.0
2.5
2.0
Benchmark
20
Ingredient
Ingredient anti-wrinkle power
when present at, %
in this formula est. %
Rating
6 /10 4 1.3 2
n/a
- 0.3 -
Total
2
Niacinamide
2
Ingredient anti-wrinkle power
6 /10
when present at, %
4
in this formula, est. %
1.3
Sodium Ascorbyl Phosphate
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Anti-wrinkle rating
2
Ingredient Est. % Benchmark
Rich in Antioxidants
3
2
1.3
1
0.3
All antioxidants 7.6 3 Rich in antioxidants
All antioxidants
7.6
Olea Europaea (Olive) Fruit Oil
3
Argania Spinosa Kernel Oil
2
Niacinamide
1.3
Sodium Hyaluronate
1
Sodium Ascorbyl Phosphate
0.3
Benchmark
3
Ingredient Est. % Benchmark
Rich in Soothing
1.3
0.3
All soothing 1.6 5 No
All soothing
1.6
1.3
0.3
Benchmark
5

Ingredients explained

Water
Est. %65
Function
Origin
WaterThe most used ingredient in skincare. Its concentration defines the product texture: rich creams may have about 50% of water while a light jelly about 90%. Water doesn’t moisturize the skin by itself and is used in skincare as a solvent for other ingredients.
Caprylic/Capric Triglyceride
Est. %9
Function
Origin
Caprylic/Capric TriglycerideA natural occlusive moisturizing and emollient ingredient, it is a blend of glycerin and two fatty acids, caprylic and capric acid. It creates an oil-based protective layer on the skin, thereby preventing water loss.
Glycerin
Est. %6
Function
Origin
Glycerin

The most popular moisturizing ingredient in the world. It is a powerful humectant – cheap yet very effective.

Cetearyl Alcohol
Est. %4
Function
Origin
Cetearyl AlcoholA blend of cetyl alcohol and stearyl alcohol, the fatty alcohols that are derived from palm oil. It helps to create emulsions that give off a soft and silky emollient feel and also increase product thickness.
Olea Europaea (Olive) Fruit Oil
Est. %3
Function
Origin
Olea Europaea (Olive) Fruit Oil

A famous olive oil widely used in skincare as an emollient and occlusive moisturizer. It contains mainly unsaturated fatty acids, antioxidant flavonoids, and oleuropeins. Olive oil is listed as a common comedogenic ingredient by acne.org.

Helianthus Annuus (Sunflower) Seed Oil
Est. %2.5
Function
Origin
Helianthus Annuus (Sunflower) Seed OilA fatty oil expressed from sunflower seeds and one of the most commonly used oils in skincare. It has great emollient and occlusive moisturizing properties. Sunflower oil is one of the richest sources of vitamin E – an important skin antioxidant.
Argania Spinosa Kernel Oil
Est. %2
Function
Origin
Argania Spinosa Kernel OilA fatty oil from Moroccan argan tree kernels commonly used as an occlusive moisturizer and emollient. Its uniqueness comes from its compounds: vitamin E, phospholipids, phenolic compounds, and rare phytosterols with antioxidant and emollient effects.
Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer
Est. %1.5
Function
Origin
Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate CopolymerAn emulsion stabilizer and thickener that helps to create a pleasant, satiny, and light formula texture. It works by forming a gel-like network within water or oil, which both stabilizes other ingredients and produces a thickening effect.
Niacinamide
Est. %1.3
Function
Origin
Niacinamide

Also known as vitamin B3, this ingredient is a true superstar with confirmed moisturizing, anti-acne, hyperpigmentation, and antioxidant benefits. Two studies confirm its significant anti-wrinkle efficacy.

Sodium Hyaluronate
Est. %1
Function
Origin
Sodium Hyaluronate

A sodium salt of famous hyaluronic acid. A potent humectant that hydrates the skin, supports collagen function, and fills out small wrinkles. Sodium hyaluronate also offers soothing and antioxidant properties.

Ceramide NP
Est. %0.3
Function
Origin
Ceramide NPAlso known as ceramide 3, it is the most common ceramide in our skin. It helps to restore the skin’s lipid barrier and alleviate the symptoms of dry and cracked skin. Research has shown that skin suffering from conditions such as AD lacks ceramides.
Ceramide NS
Est. %0.3
Function
Origin
Ceramide NSA wax-like lipid natural to the skin’s lipid matrix. It is less frequently used but, in combination with other ceramides, can help to restore balance in the skin’s lipid barrier.
Ceramide EOS
Est. %0.3
Function
Origin
Ceramide EOS

A skin-identical lipid that is an essential part of the skin barrier. Aging or exposed-to-cold skin lacks it and applying a ceramide-rich cream can replenish the lipid barrier. It may replenish linoleic acid levels in acne-prone skin.

Ceramide EOP
Est. %0.3
Function
Origin
Ceramide EOP

Formerly called Ceramide 1, this ingredient is a skin-identical wax-like lipid with an ultra-long fatty acid chain. It restores and stabilizes the skin’s lipid matrix and helps to treat dry and flaky skin, especially when combined with other ceramides.

Ceramide AP
Est. %0.3
Function
Origin
Ceramide APPreviously called Ceramide 6 II, Ceramide AP is one of the most common ceramides in the skin. Research has shown that dry, flaky skin has significantly less Ceramide AP. Its application helps to treat dry skin by restoring balance in the skin lipids.
Cholesterol
Est. %0.3
Function
Origin
CholesterolAn emollient and important barrier repairing lipid, effective when combined with fatty acids and ceramides. Around 25% of the skin’s lipid layer is made up of cholesterol and it is found in the membrane of every single cell in our body.
Caprooyl Phytosphingosine
Est. %0.3
Function
Origin
Caprooyl PhytosphingosineA synthetic emollient that is similar to skin-identical ceramides. It helps to replenish the building blocks of the skin’s lipid barrier and helps with the formation and stability of emulsions.
Caprooyl Sphingosine
Est. %0.3
Function
Origin
Caprooyl SphingosineA synthetic emollient similar to skin-identical ceramides. It helps to replenish the building blocks of the skin’s lipid barrier and aids in the formation and stability of emulsions.
Ceteareth-25
Est. %0.3
Function
Origin
Ceteareth-25A natural or synthetically produced emulsifier often used to help form stable emulsions.
Cetyl Alcohol
Est. %0.3
Function
Origin
Cetyl AlcoholA waxy solid fatty alcohol derived from palm oil. It is most commonly used as a co-emulsifier and affects the final aesthetic of the product, leaving a soft and silky feeling on the skin. Cetyl alcohol is also used as a viscosity controlling agent.
Behenic Acid
Est. %0.3
Function
Origin
Behenic AcidA naturally-occuring ingredient from certain plant oils, behenic acid acts as an emulsifier and surfactant and provides a soft cushiony feeling.
Sodium Ascorbyl Phosphate
Est. %0.3
Function
Origin
Sodium Ascorbyl PhosphateThe most researched derivative of vitamin C. It boosts collagen synthesis, thereby improving skin structure and elasticity. SAP is effective in the treatment of inflamed acne lesions and has a weak but positive effect on pigmentation issues.
Citrus Aurantium Dulcis (Orange) Peel Oil
Est. %0.3
Function
Origin
Citrus Aurantium Dulcis (Orange) Peel Oil

An essential oil derived from the peels of the sweet orange. It is commonly used as a fragrance because of its pleasant, citrusy scent. The main constituent of the essential oil is limonene (up to 96%).

Aniba Rosaeodora Wood Oil
Est. %0.3
Function
Origin
Aniba Rosaeodora Wood OilA rare and expensive fragrant essential oil obtained from the Brazilian rosewood.
Fragrance
Est. %0.3
Function
Origin
FragranceUnder trade secret law, manufacturers have the right not to disclose what exactly went into the fragrance and use the unspecific word Fragrance or Parfum instead. Many fragrances are highly allergenic.
Lavandula Angustifolia (Lavender) Oil
Est. %0.3
Function
Origin
Lavandula Angustifolia (Lavender) OilAn essential oil derived from common, or true, lavender. It is used in skincare for its lovely, calming scent. Like all essential oils, however, it may cause a contact skin allergy in more sensitive individuals.
Citrus Limon (Lemon) Peel Oil
Est. %0.3
Function
Origin
Citrus Limon (Lemon) Peel Oil

A fragrant essential oil extracted from the rind or peel of a lemon. It is mainly comprised of limonene (up to 70%) and has a fresh, citrusy scent. Lemon peel oil may cause a sun-induced skin rash in people with a sensitivity towards citrus fruits.

Rosa Damascena Flower Extract
Est. %0.3
Function
Origin
Rosa Damascena Flower ExtractDerived from the flowers of the Damask rose, this extract contains the luxurious fragrant rose essential oil and astringent tannins.
Arctostaphylos Uva-Ursi Leaf Extract
Est. %0.3
Function
Origin
Arctostaphylos Uva-Ursi Leaf Extract
Disodium EDTA
Est. %0.3
Function
Origin
Disodium EDTAA synthetic chelator that helps to maintain the look and smell of a product by 'locking up' troublesome metal ions.
Phenoxyethanol
Est. %0.3
Function
Origin
PhenoxyethanolThe most frequently used preservative in skincare. It is a clear, oil-like liquid synthetic substance that protects products from harmful bacteria and yeast, whilst still leaving skin microflora unharmed. It is confirmed by research to be harmless.
Caprylyl Glycol
Est. %0.3
Function
Origin
Caprylyl GlycolAn emollient that improves product spreadability and offers a silky feel on the skin. It also acts as a preservative booster that improves the efficacy of other preservatives. According to the manufacturer, it is also a humectant moisturizer.
Salicylic Acid
Est. %0.3
Function
Origin
Salicylic AcidThis effective peeling and anti-inflammatory BHA is used as an anti-acne agent and works by breaking down the junctions between dead skin cells. This results in the peeling of dead skin and the unclogging of pores.