iS Clinical Youth Serum Review

iS Clinical Youth Serum
3.0
/ 10
Moisturizing
6.0 Humectancy icon Humectancy
0.0 Occlusivity icon Occlusivity
3Anti-wrinkle icon/ 10
Anti-wrinkle
Rich
in Antioxidants
Ingredients

iS Clinical Youth Serum Ingredients

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Full Ingredient List (INCI):

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Water, PVP, Caffeine, Glycerin, Disodium EDTA, Hydroxyethylcellulose, Ceratonia Siliqua (Carob) Gum, Hydrolyzed Casein, Pseudoalteromonas Ferment Extract, Hydrolyzed Wheat Protein, Hydrolyzed Soy Protein, Tripeptide-10 Citrulline, Tripeptide-1, Lecithin, Butylene Glycol, Xanthan Gum, Carbomer, Triethanolamine, Caprylyl Glycol, Phenoxyethanol, Ahnfeltiopsis Concinna Extract, Beta Vulgaris (Beet) Root Extract, Haberlea Rhodopensis Leaf Extract, Yeast Extract, Acetyl Tyrosine, Proline, Hydrolyzed Vegetable Protein, Adenosine Triphosphate, Ergothioneine, Saccharide Isomerate, Hydrolyzed Wheat Protein/PVP Crosspolymer, VP/Dimethylaminoethylmethacrylate Copolymer, Phospholipids, Tocopheryl Acetate, Retinyl Palmitate, Ascorbyl Palmitate, Asiaticoside, Asiatic Acid, Madecassic Acid, 1,2-Hexanediol
Review

Does iS Clinical Youth Serum Work?

 
According to CreamScan's analysis of the ingredient list, here’s what iS Clinical Youth Serum has to offer:
 
✅ Light moisturizing. It has a moisturizing rating of 3.0 out of 10.
✅ Modest anti-wrinkle efficacy: iS Clinical Youth Serum has an anti-wrinkle rating of 3.0 out of 10 so you may expect some, although limited, effect on wrinkles.
✅ Antioxidant protection

  

Key Benefits of iS Clinical Youth Serum

 
These are the key benefits you can expect from using iS Clinical Youth Serum:
 

🔵 Lightweight Purely Humectant Moisturizer Well-Suited for Oily Skin

According to CreamScan analysis, iS Clinical Youth Serum is lightly moisturizing, with a moisturizing rating of 3.0 out of 10.

Is it more humectant or occlusive? Purely humectant. It has zero occlusivity (we didn't find any occlusive ingredients on the ingredient list) and a high humectancy of 6.0 out of 10, primarily due to the high content of Glycerin (est. ≈3.0%).

This humectant-rich product, when used alone as a moisturizer, is well-suited for oily skin, providing moderate hydration in a lightweight, fast-absorbing formula without any occlusive ingredients.

📌 Certain studies suggest that humectants alone may not effectively moisturize the skin. If you use this product as your only moisturizer, we recommend following it with one that contains at least some occlusive ingredients.

💧 A Humectant Enhancement for Any Skincare Routine

But it’s not limited to oily skin - such a humectant enhancement will also positively contribute to the moisturizing efficacy of any skincare routine when used as a step before applying the main moisturizer. This type of formulation is typically used in serums, where a light, fast-absorbing texture is key.

Please refer to the Ratings section below for details of the moisturizing rating calculation.

🟣 Modest Anti-Wrinkle Efficacy

According to CreamScan analysis, iS Clinical Youth Serum has a modest level of anti-wrinkle efficacy, rated 3.0 out of 10.

It contains one ingredient with proven anti-wrinkle efficacy: Asiaticoside (est. ≈0.3%),
 derived from the plant Centella asiatica, an ingredient with moderate anti-wrinkle efficacy, as confirmed by a single clinical study involving 27 participants (Lee et al.). This study demonstrated that a cream containing 0.1% asiaticoside reduced the average wrinkle depth by 8% after 12 weeks of use, compared to a vehicle (the same formulation without asiaticoside).
 
Among others, iS Clinical Youth Serum also contains some ingredients often marketed as effective in reducing wrinkles, specifically Caffeine, Pseudoalteromonas Ferment Extract, Tripeptide-10 Citrulline, Tripeptide-1, Haberlea Rhodopensis Leaf Extract, Retinyl Palmitate, Ascorbyl Palmitate, Asiatic Acid, and some others. However, the studies supporting the anti-wrinkle claims of these ingredients provide insufficient evidence of efficacy according to CreamScan Research Evaluation Standards.
 
While this does not categorically rule out the possibility that these ingredients may reduce wrinkles, their efficacy is not supported by convincing, vehicle-controlled, double-blind clinical studies - at least none that were available to the CreamScan team at the time of publication.
 
Therefore, these ingredients do not contribute to the anti-wrinkle rating.
 
📌 Moisturizers, when used regularly, are proven to prevent wrinkle formation and even reduce existing wrinkles. Therefore, this product, like any other moisturizer, can deliver some additional anti-wrinkle effects through its moisturizing action.
 

Please refer to the Ratings section below for details of the anti-wrinkle rating calculation.

🍀 Rich in Skin-Protecting Antioxidants

We estimate that iS Clinical Youth Serum is rich (> 3%) in antioxidants, specifically Caffeine (est. ≈4.0%).

A key benefit of antioxidants is their ability to reduce oxidative stress caused by free radicals and therefore prevent accelerated skin aging. Studies also show that antioxidants can protect against environmental damage such as UV radiation and pollution, and help reduce inflammation and skin redness.

📌 Please note that this is not a complete list of benefits. We are in the process of enhancing our model to incorporate anti-pigmentation, exfoliation and anti-acne ratings.

Things to Be Aware Of: iS Clinical Youth Serum

 
CreamScan identified a few things to consider before adding iS Clinical Youth Serum to your skincare routine:
 

⚠️ If It’s Your Only Moisturizer, It Needs to Be Paired with Some Occlusives

While humectants are highly effective at attracting water to the skin, studies (J. N. Kraft, C. W. Lynde) suggest they may not be efficient when used alone.

One major drawback of purely humectant moisturization is that the water attracted by humectants to the upper layers of the skin can evaporate completely into the environment through transepidermal water loss (TEWL). Adding occlusive ingredients helps seal this moisture into the skin and prevent further water loss.

If you’re using iS Clinical Youth Serum as your only moisturizer, consider pairing it with one that contains at least some occlusive ingredients, such as oils, butters, or silicones. These work alongside humectants to create a protective barrier, locking in hydration and ensuring longer-lasting moisturization. The amount of occlusive needed depends on your skin type - the drier the skin, the more occlusives it requires.

If this product is used not as a standalone moisturizer but as part of your skincare routine, such as a toner or serum, it should be applied before your main moisturizer (unless it's a sunscreen), which will provide the necessary occlusivity on top of it.

Pros & Cons of iS Clinical Youth Serum

 
Here’s an overview of the pros and cons of iS Clinical Youth Serum to help you decide if it’s the right choice for your skincare routine:
 

🟩 Pros:

✅ When used alone: Provides humectant-rich moisturizing well-suited for oily skin
✅ As part of a routine: A humectant moisturizing enhancement, beneficial for any skin type
✅ Lightweight texture
Offers modest anti-wrinkle efficacy
✅ Rich in antioxidants that combat oxidative stress associated with accelerated skin aging and defend against environmental damage
 

⭕ Cons: 

⚠️ Only if used as a standalone moisturizer - it needs to be paired with occlusives to seal in humectants
   

Summary: iS Clinical Youth Serum

 
Based on the ingredient list analysis, CreamScan AI suggests that iS Clinical Youth Serum
, when used alone, delivers lightweight, humectant-rich moisturizing that is well-suited for oily skin. As part of a moisturizing routine, it provides a humectant enhancement, beneficial for all skin types.
 
iS Clinical Youth Serum contains ingredients with proven evidence of anti-wrinkle efficacy that may provide a modest anti-wrinkle effect. As a result, you can expect a positive, though not very significant, impact on wrinkles.
 
With its high antioxidant content, iS Clinical Youth Serum helps protect against free radical damage and offers multiple benefits for all skin types, including preventing premature aging, defending against environmental damage, and calming inflammation.
 
That said, there are some things about iS Clinical Youth Serum worth noting.
 
Looking at its moisturizing profile, we found that it doesn’t contain any occlusive ingredients, potentially allowing the moisture attracted to the skin by humectants to evaporate. Therefore, if it’s used as the only moisturizer in a routine, it’s recommended to pair it with one that contains at least some occlusive ingredients, such as oils, butters, or silicones.
 
📌 Fact check. At CreamScan, we are committed to accuracy and fairness. If you spot any errors or something that doesn’t seem right, please click here to let us know. We regularly update the ingredient lists and monitor the latest research on ingredient efficacy to ensure that our information remains as complete and precise as possible. The information provided here is for informational purposes only and does not substitute professional advice. We do not guarantee the efficacy or safety of any product, as individual results may vary.

 

Ingredient Breakdown

Est. % Ingredient Origin Functions
75
6
4 , , ,
3 , , , , ,
0.3
0.3 ,
0.3 , ,
0.3
0.3 , ,
0.3
0.3 ,
0.3
0.3 ,
0.3 , , ,
0.3 , , , ,
0.3 ,
0.3
0.3 ,
0.3 , , ,
0.3 ,
0.3
0.3
0.3 ,
0.3
0.3 ,
0.3 ,
0.3
0.3
0.3
0.3 ,
0.3 ,
0.3
0.3 , , ,
0.3 ,
0.3 ,
0.3 , , , ,
0.3 , ,
0.3 , ,
0.3 ,
0.3 , ,
Est. %
Water
Function:
Origin:
PVP
Function:
Origin:
Caffeine
Function:
Origin:
Glycerin
Function:
Origin:
Disodium EDTA
Function:
Origin:
Hydroxyethylcellulose
Function:
Origin:
Ceratonia Siliqua (Carob) Gum
Function:
Origin:
Hydrolyzed Casein
Function:
Origin:
Pseudoalteromonas Ferment Extract
Function:
Origin:
Hydrolyzed Wheat Protein
Function:
Origin:
Hydrolyzed Soy Protein
Function:
Origin:
Tripeptide-10 Citrulline
Function:
Origin:
Tripeptide-1
Function:
Origin:
Lecithin
Function:
Origin:
Butylene Glycol
Function:
Origin:
Xanthan Gum
Function:
Origin:
Carbomer
Function:
Origin:
Triethanolamine
Function:
Origin:
Caprylyl Glycol
Function:
Origin:
Phenoxyethanol
Function:
Origin:
Ahnfeltiopsis Concinna Extract
Function:
Origin:
Beta Vulgaris (Beet) Root Extract
Function:
Origin:
Haberlea Rhodopensis Leaf Extract
Function:
Origin:
Yeast Extract
Function:
Origin:
Acetyl Tyrosine
Function:
Origin:
Proline
Function:
Origin:
Hydrolyzed Vegetable Protein
Function:
Origin:
Adenosine Triphosphate
Function:
Origin:
Ergothioneine
Function:
Origin:
Saccharide Isomerate
Function:
Origin:
Hydrolyzed Wheat Protein/PVP Crosspolymer
Function:
Origin:
VP/Dimethylaminoethylmethacrylate Copolymer
Function:
Origin:
Phospholipids
Function:
Origin:
Tocopheryl Acetate
Function:
Origin:
Retinyl Palmitate
Function:
Origin:
Ascorbyl Palmitate
Function:
Origin:
Asiaticoside
Function:
Origin:
Asiatic Acid
Function:
Origin:
Madecassic Acid
Function:
Origin:
1,2-Hexanediol
Function:
Origin:

Ratings

All humectants
6.0
3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Benchmark
10
All occlusives
0.0
None
Benchmark
20
Moisturizing rating
3.0
Ingredient Est. % Benchmark Raiting
Humectancy All humectants 6.0 10
6.0
3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Occlusivity All occlusives 0.0 20
0.0
None
Moisturizing rating
3.0
Ingredient Est. % Benchmark Humectancy
3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
All humectants 6.0 10
6
All humectants
6.0
3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Benchmark
10
Ingredient Est. % Benchmark Occlusivity
None
All occlusives 0.0 20
0.0
All occlusives
0.0
None
Benchmark
20
Ingredient
Ingredient anti-wrinkle power
when present at, %
in this formula est. %
Rating
3 /10 0.1 0.3 3
n/a
- 4 -
n/a
- 0.3 -
n/a
- 0.3 -
n/a
- 0.3 -
n/a
- 0.3 -
n/a
- 0.3 -
n/a
- 0.3 -
n/a
- 0.3 -
n/a
- 0.3 -
Total
3
Asiaticoside
3
Ingredient anti-wrinkle power
3 /10
when present at, %
0.1
in this formula, est. %
0.3
Caffeine
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
4
Pseudoalteromonas Ferment Extract
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Tripeptide-10 Citrulline
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Tripeptide-1
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Haberlea Rhodopensis Leaf Extract
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Retinyl Palmitate
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Ascorbyl Palmitate
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Asiatic Acid
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Madecassic Acid
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Anti-wrinkle rating
3
Ingredient Est. % Benchmark
Rich in Antioxidants
4
0.3
0.3
0.3
0.3
0.3
All antioxidants 5.5 3 Rich in antioxidants
All antioxidants
5.5
Caffeine
4
Asiaticoside
0.3
Beta Vulgaris (Beet) Root Extract
0.3
Ergothioneine
0.3
Tocopheryl Acetate
0.3
Ascorbyl Palmitate
0.3
Benchmark
3
Ingredient Est. % Benchmark
Rich in Soothing
0.3
All soothing 0.3 5 No
All soothing
0.3
0.3
Benchmark
5

Ingredients explained

Water
Est. %75
Function
Origin
WaterThe most used ingredient in skincare. Its concentration defines the product texture: rich creams may have about 50% of water while a light jelly about 90%. Water doesn’t moisturize the skin by itself and is used in skincare as a solvent for other ingredients.
PVP
Est. %6
Function
Origin
PVPAn excellent film-former used in hairsprays, peel-off masks, and even some self-tanning products. These films are strong and hold onto the skin.
Caffeine
Est. %4
Function
Origin
CaffeineAn antioxidant compound that is obtained from coffee and tea leaves. It increases the microcirculation of blood in the skin and is claimed to be able to reduce the appearance of orange peel skin (although the research is lacking).
Glycerin
Est. %3
Function
Origin
Glycerin

The most popular moisturizing ingredient in the world. It is a powerful humectant – cheap yet very effective.

Disodium EDTA
Est. %0.3
Function
Origin
Disodium EDTAA synthetic chelator that helps to maintain the look and smell of a product by 'locking up' troublesome metal ions.
Hydroxyethylcellulose
Est. %0.3
Function
Origin
HydroxyethylcelluloseA naturally-derived thickener that can form clear gel textures without the slimy feeling, unlike some other natural gel-formers.
Ceratonia Siliqua (Carob) Gum
Est. %0.3
Function
Origin
Ceratonia Siliqua (Carob) GumAlso known as carob gum, this ingredient is a plant-based formula helper extracted from carob tree seeds. It consists of film- and gel-forming polysaccharides called galactomannans.
Hydrolyzed Casein
Est. %0.3
Function
Origin
Hydrolyzed Casein
Pseudoalteromonas Ferment Extract
Est. %0.3
Function
Origin
Pseudoalteromonas Ferment ExtractAn ingredient obtained from a bacterial culture. According to the patent holder, it produces a special glycoprotein that promotes collagen and elastin synthesis and moisturizes the skin by drawing water to it.
Hydrolyzed Wheat Protein
Est. %0.3
Function
Origin
Hydrolyzed Wheat ProteinWheat protein broken down into its individual amino acids. It is commonly used as a film-former and antistatic agent.
Hydrolyzed Soy Protein
Est. %0.3
Function
Origin
Hydrolyzed Soy ProteinA mixture of proteins obtained from soybeans. It can have many different functions depending on the manufacturer, although it is most commonly used in skincare products as a humectant moisturizing ingredient.
Tripeptide-10 Citrulline
Est. %0.3
Function
Origin
Tripeptide-10 CitrullineA synthetically made peptide that controls the proper formation of collagen strands in the skin. It was tested in a clinical trial and showed increased skin flexibility and collagen-repair activity.
Tripeptide-1
Est. %0.3
Function
Origin
Tripeptide-1

A small, skin-identical peptide that boosts collagen renewal in the skin and improves other structural proteins. It may have trouble penetrating the skin in this form, so palmitic acid or biotin is usually added to it.

Lecithin
Est. %0.3
Function
Origin
LecithinA humectant, emollient, and emulsifier best suited for water-in-oil emulsions. Lecithin can come from sunflowers, soy, and eggs. The downside to lecithin is that it causes an extra burden on the formula’s preservative because it is nutritious.
Butylene Glycol
Est. %0.3
Function
Origin
Butylene Glycol

A clear, colorless liquid humectant that draws moisture to the skin. The humectancy of butylene glycol, owed to its two hydroxyl groups, is quite considerable, although not as powerful as glycerin, which contains three hydroxyl groups.

Xanthan Gum
Est. %0.3
Function
Origin
Xanthan GumA natural multi-functional ingredient that originates from fermented sugars. Xanthan gum acts as a viscosity-building agent to thicken skincare products. It is also an excellent stabilizer and works well to hold other ingredients together.
Carbomer
Est. %0.3
Function
Origin
CarbomerA synthetic ingredient with the ability to gel water. When used in emulsions, such as lotions and creams, carbomer can also act as an emulsion stabilizer.
Triethanolamine
Est. %0.3
Function
Origin
TriethanolamineA clear, colorless, and highly viscous liquid, this ingredient is an excellent pH adjuster. When it is necessary to neutralize an acidic solution or to generally increase the pH of a product, triethanolamine is a common choice.
Caprylyl Glycol
Est. %0.3
Function
Origin
Caprylyl GlycolAn emollient that improves product spreadability and offers a silky feel on the skin. It also acts as a preservative booster that improves the efficacy of other preservatives. According to the manufacturer, it is also a humectant moisturizer.
Phenoxyethanol
Est. %0.3
Function
Origin
PhenoxyethanolThe most frequently used preservative in skincare. It is a clear, oil-like liquid synthetic substance that protects products from harmful bacteria and yeast, whilst still leaving skin microflora unharmed. It is confirmed by research to be harmless.
Ahnfeltiopsis Concinna Extract
Est. %0.3
Function
Origin
Ahnfeltiopsis Concinna Extract
Beta Vulgaris (Beet) Root Extract
Est. %0.3
Function
Origin
Beta Vulgaris (Beet) Root ExtractA purple-red extract with antioxidant activity that is obtained from red beetroot.
Haberlea Rhodopensis Leaf Extract
Est. %0.3
Function
Origin
Haberlea Rhodopensis Leaf ExtractA prospective anti-wrinkle extract derived from a rare plant – the Orpheus flower. Studies have shown that it increases skin elasticity and promotes collagen production. It also contains moisturizing polysaccharides.
Yeast Extract
Est. %0.3
Function
Origin
Yeast ExtractAlso labeled as faex extract, this is a natural ingredient derived from fresh yeast. It is used in skincare as a humectant. Yeast extract also helps to shield injured or exposed skin and can aid in the skin’s wound healing process.
Acetyl Tyrosine
Est. %0.3
Function
Origin
Acetyl TyrosineAcetyl tyrosine is a derivative of the amino acid tyrosine. It is used as a tanning agent in skincare, helping pigment cells (melanosomes) to produce more dark skin pigment.
Proline
Est. %0.3
Function
Origin
ProlineThe best humectant moisturizer of all the amino acids. It is a part of the skin's Natural Moisturizing Factor and increases hydration in the top layers of the skin. It also has antioxidant activity and helps to heal damaged skin.
Hydrolyzed Vegetable Protein
Est. %0.3
Function
Origin
Hydrolyzed Vegetable ProteinA blanket term used for plant-based proteins that have been processed into smaller chunks. They add to the skincare product's film-forming and water-binding properties.
Adenosine Triphosphate
Est. %0.3
Function
Origin
Adenosine TriphosphateA cellular energy source that is thought to revitalize skin cells.
Ergothioneine
Est. %0.3
Function
Origin
ErgothioneineA naturally-occurring amino acid that functions as a powerful and versatile antioxidant.
Saccharide Isomerate
Est. %0.3
Function
Origin
Saccharide IsomerateA naturally-derived humectant that provides moisturization at low levels and is less sticky than other humectants like glycerin.
Hydrolyzed Wheat Protein/PVP Crosspolymer
Est. %0.3
Function
Origin
Hydrolyzed Wheat Protein/PVP Crosspolymer
VP/Dimethylaminoethylmethacrylate Copolymer
Est. %0.3
Function
Origin
VP/Dimethylaminoethylmethacrylate Copolymer
Phospholipids
Est. %0.3
Function
Origin
PhospholipidsA large group of lipids that are an essential component of every single cell membrane in the body. They have excellent emollient properties. Phospholipids are also utilized in the manufacturing of ‘fancy’ formulations such as liposomes.
Tocopheryl Acetate
Est. %0.3
Function
Origin
Tocopheryl Acetate

An antioxidant derivative of tocopherol (vitamin E). It helps to protect cells from free radicals and UV damage through the conversion to active vitamin E in the skin. It is more stable than tocopherol.

Retinyl Palmitate
Est. %0.3
Function
Origin
Retinyl PalmitateAn esterified form of retinol – it combines retinol and palmitic acid into one molecule. Retinyl palmitate is less irritating than retinol but also much less effective in its anti-aging and acne-reducing effects.
Ascorbyl Palmitate
Est. %0.3
Function
Origin
Ascorbyl PalmitateA form of vitamin C derived from ascorbic acid and palmitic acid. It is more stable and less irritating than ascorbic acid. Unfortunately, Ascorbyl Palmitate lacks the studies to prove its anti-wrinkle efficacy.
Asiaticoside
Est. %0.3
Function
Origin
Asiaticoside

A Gotu Kola or Centella Asiatica derivative with confirmed anti-wrinkle efficacy.

Asiatic Acid
Est. %0.3
Function
Origin
Asiatic AcidA compound isolated from Gotu Kola, a promising anti-wrinkle medicinal plant from Southeast Asia. It is claimed to increase the production of collagen and help with the wound healing process.
Madecassic Acid
Est. %0.3
Function
Origin
Madecassic AcidAn isolated bioactive compound from Gotu Kola. It increases collagen and hyaluronic acid production in the skin and helps to treat wounds, scars, and burns.
1,2-Hexanediol
Est. %0.3
Function
Origin
1,2-HexanediolA multi-functional formula helper. It is a well-studied preservtive against bacteria and can help pigments and fragrances disperse evenly in a formula.