Dr.Leo Multi Effect Isolation Cream Review

Dr.Leo Multi Effect Isolation Cream
5.1
/ 10
Moisturizing
10.0 Humectancy icon Humectancy
0.2 Occlusivity icon Occlusivity
6Anti-wrinkle icon/ 10
Anti-wrinkle
Rich
in Antioxidants
Rich Skin Soothing icon
in Skin Soothers
Review

Does Dr.Leo Multi Effect Isolation Cream Work?

 
According to CreamScan AI's analysis of the ingredient list, here’s what Dr.Leo Multi Effect Isolation Cream has to offer:
 
  • Strong humectant moisturizing. This lightweight, humectant-rich product, ideal for oily skin, has a moisturizing rating of 5.1 out of 10.
  • Significant anti-wrinkle efficacy. With an anti-wrinkle rating of 6.0 out of 10, Dr.Leo Multi Effect Isolation Cream is effective in minimizing wrinkles.
  • Soothing: Dr.Leo Multi Effect Isolation Cream contains a high concentration of soothing ingredients, which may help to reduce irritation and calm the skin.
  • Antioxidant protection.

Key Benefits of Dr.Leo Multi Effect Isolation Cream

 
These are the key benefits you can expect from using Dr.Leo Multi Effect Isolation Cream:
 

Lightweight Humectant Moisturizer Ideal for Oily Skin

According to CreamScan analysis, Dr.Leo Multi Effect Isolation Cream is quite moisturizing, with a moisturizing rating of 5.1 out of 10.

Is it more humectant or occlusive? Significantly more humectant. It has a low occlusivity of 0.2 out of 10 and a maximum humectancy of 10 out of 10, primarily due to the high content of Glycerin (est. ≈9.0%), Niacinamide (est. ≈5.0%) and Sodium Hyaluronate (est. ≈2.5%).

This humectant-rich product, when used alone as a moisturizer, is ideal for oily skin, offering significant hydration in a lightweight, fast-absorbing formula with a minimal amount of occlusive ingredients.

It’s also a great choice for people with normal skin who prefer lightweight moisturizers.

A Humectant Boost for Any Skincare Routine

But it’s not limited to oily skin - such a humectant boost will also positively contribute to the moisturizing efficacy of any skincare routine when used as a step before applying the main moisturizer. This type of formulation is typically used in serums, where a light, fast-absorbing texture is key.

Please refer to the Ratings section below for details of the moisturizing rating calculation.

Significant Anti-Wrinkle Efficacy

According to CreamScan analysis, Dr.Leo Multi Effect Isolation Cream has a high anti-wrinkle rating of 6.0 out of 10.

It contains one ingredient with proven anti-wrinkle efficacy: Niacinamide (est. ≈5.0%), 
 one of the most effective and well-researched anti-wrinkle ingredients. A clinical study involving 30 participants (Kawada et al.) confirmed that a cream with 4% niacinamide reduced the average depth of wrinkles around the eyes by 9% after 8 weeks of use, compared to a vehicle (the same formulation without niacinamide).
 
Among others, Dr.Leo Multi Effect Isolation Cream also contains contains Camellia Sinensis Leaf Extract and Centella Asiatica Extract, two ingredients often marketed as effective in reducing wrinkles. However, the studies supporting the anti-wrinkle claims of these ingredients provide insufficient evidence of efficacy according to CreamScan Research Evaluation Standards. Therefore, these ingredients do not contribute to the anti-wrinkle rating.
 

Please refer to the Ratings section below for details of the anti-wrinkle rating calculation.

Rich in Skin-Protecting Antioxidants

We estimate that Dr.Leo Multi Effect Isolation Cream is rich (> 3%) in antioxidants, specifically Niacinamide (est. ≈5.0%), Sodium Hyaluronate (est. ≈2.5%) and Tremella Fuciformis Sporocarp Extract (est. ≈2.3%).

A key benefit of antioxidants is their ability to reduce oxidative stress caused by free radicals and therefore prevent accelerated skin aging. Studies also show that antioxidants can protect against environmental damage such as UV radiation and pollution, and help reduce inflammation and skin redness.

Skin Soothing and Calming Potential

Based on the ingredient list analysis, Dr.Leo Multi Effect Isolation Cream is rich (> 5%) in soothing ingredients, particularly Niacinamide (est. ≈5.0%) and Bifida Ferment Lysate (est. ≈2.4%).

When applied to the skin, compounds of soothing ingredients, such as triglycerides, phospholipids, fatty acids, phenolic compounds, and antioxidants, work together to soothe the skin through various mechanisms: reducing inflammation, promoting wound healing, repairing the skin barrier, and providing antimicrobial and antioxidant activities.

Please note that this is not a complete list of benefits. We are in the process of enhancing our AI model to incorporate anti-pigmentation, exfoliation and anti-acne ratings.

Pros & Cons of Dr.Leo Multi Effect Isolation Cream

 
Here’s an overview of the pros and cons of Dr.Leo Multi Effect Isolation Cream to help you decide if it’s the right choice for your skincare routine:
 

Pros:

  • When used alone: Provides humectant-rich moisturizing ideal for oily skin
  • As part of a routine: A humectant moisturizing boost, beneficial for any skin type
  • Lightweight texture
  • Delivers signficant anti-wrinkle efficacy thanks to Niacinamide
  • Rich in antioxidants that combat oxidative stress associated with accelerated skin aging and defend against environmental damage
  • Potentially soothing, as it contains a high concentration of soothing ingredients like Niacinamide and Bifida Ferment Lysate

Cons: 

  • We couldn't find any

Ingredients

Est. % Ingredient Origin Functions
65
9
5
2.5
2.4
2.3
2
1.5
1.3
1
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Est. %
Water
Function:
Origin:
Glycerin
Function:
Origin:
Niacinamide
Function:
Origin:
Sodium Hyaluronate
Function:
Origin:
Bifida Ferment Lysate
Function:
Origin:
Tremella Fuciformis Sporocarp Extract
Function:
Origin:
Abelmoschus Esculentus Fruit Extract
Function:
Origin:
Chamomilla Recutita (Matricaria) Flower Extract
Function:
Origin:
Glycyrrhiza Glabra (Licorice) Root Extract
Function:
Origin:
Camellia Sinensis Leaf Extract
Function:
Origin:
Cladosiphon Novae-Caledoniae Extract
Function:
Origin:
Polygonum Cuspidatum Root Extract
Function:
Origin:
Centella Asiatica Extract
Function:
Origin:
Sodium Acetylated Hyaluronate
Function:
Origin:
Rosmarinus Officinalis (Rosemary) Leaf Extract
Function:
Origin:
Scutellaria Baicalensis Root Extract
Function:
Origin:
Sodium Hyaluronate Crosspolymer
Function:
Origin:
Hydrolyzed Sodium Hyaluronate
Function:
Origin:
Cyclopentasiloxane
Function:
Origin:
Propylene Glycol
Function:
Origin:
Titanium Dioxide (CI 77891)
Function:
Origin:
Cyclohexasiloxane
Function:
Origin:
Glycereth-26
Function:
Origin:
PEG-10 Dimethicone
Function:
Origin:
Magnesium Sulfate
Function:
Origin:
Isononyl Isononanoate
Function:
Origin:
1,2-Hexanediol
Function:
Origin:
Hydroxyacetophenone
Function:
Origin:
Ultramarines (CI 77007)
Function:
Origin:
Magnesium Stearate
Function:
Origin:
C12-15 Alkyl Benzoate
Function:
Origin:
Phenyl Trimethicone
Function:
Origin:
Butylene Glycol
Function:
Origin:
Pentylene Glycol
Function:
Origin:
Cetyl PEG/PPG-10/1 Dimethicone
Function:
Origin:
Triethoxycaprylylsilane
Function:
Origin:
Flavor (Aroma)
Function:
Origin:

Ratings

All humectants
23.8
9
5
2.5
2.3
1.3
1
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Benchmark
10
All occlusives
0.3
0.3
Benchmark
20
Moisturizing rating
5.1
Ingredient Est. % Benchmark Raiting
Humectancy All humectants 23.8 10
10.0
9
5
2.5
2.3
1.3
1
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Occlusivity All occlusives 0.3 20
0.2
0.3
Moisturizing rating
5.1
Ingredient Est. % Benchmark Humectancy
9
5
2.5
2.3
1.3
1
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
All humectants 23.8 10
10
All humectants
23.8
9
5
2.5
2.3
1.3
1
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Benchmark
10
Ingredient Est. % Benchmark Occlusivity
0.3
All occlusives 0.3 20
0.2
All occlusives
0.3
0.3
Benchmark
20
Ingredient
Ingredient anti-wrinkle power
when present at, %
in this formula est. %
Rating
6 /10 4 5 6
n/a
- 1 -
n/a
- 0.3 -
Total
6
Niacinamide
6
Ingredient anti-wrinkle power
6 /10
when present at, %
4
in this formula, est. %
5
Camellia Sinensis Leaf Extract
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
1
Centella Asiatica Extract
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Anti-wrinkle rating
6
Ingredient Est. % Benchmark
Rich in Antioxidants
5
2.5
2.3
1.5
1.3
1
0.3
0.3
0.3
0.3
0.3
0.3
All antioxidants 15.4 3 Rich in antioxidants
All antioxidants
15.4
Niacinamide
5
Sodium Hyaluronate
2.5
Tremella Fuciformis Sporocarp Extract
2.3
Chamomilla Recutita (Matricaria) Flower Extract
1.5
Glycyrrhiza Glabra (Licorice) Root Extract
1.3
Camellia Sinensis Leaf Extract
1
Polygonum Cuspidatum Root Extract
0.3
Centella Asiatica Extract
0.3
Rosmarinus Officinalis (Rosemary) Leaf Extract
0.3
Scutellaria Baicalensis Root Extract
0.3
Hydrolyzed Sodium Hyaluronate
0.3
Hydroxyacetophenone
0.3
Benchmark
3
Ingredient Est. % Benchmark
Rich in Soothing
5
2.4
1.5
1.3
1
0.3
0.3
0.3
0.3
All soothing 12.4 5 Rich in soothing
All soothing
12.4
5
2.4
1.5
1.3
1
0.3
0.3
0.3
0.3
Benchmark
5

Ingredients explained

Water
Est. %65
Function
Origin
WaterThe most used ingredient in skincare. Its concentration defines the product texture: rich creams may have about 50% of water while a light jelly about 90%. Water doesn’t moisturize the skin by itself and is used in skincare as a solvent for other ingredients.
Glycerin
Est. %9
Function
Origin
Glycerin

The most popular moisturizing ingredient in the world. It is a powerful humectant – cheap yet very effective.

Niacinamide
Est. %5
Function
Origin
Niacinamide

Also known as vitamin B3, this ingredient is a true superstar with confirmed moisturizing, anti-acne, hyperpigmentation, and antioxidant benefits. Two studies confirm its significant anti-wrinkle efficacy.

Sodium Hyaluronate
Est. %2.5
Function
Origin
Sodium Hyaluronate

A sodium salt of famous hyaluronic acid. A potent humectant that hydrates the skin, supports collagen function, and fills out small wrinkles. Sodium hyaluronate also offers soothing and antioxidant properties.

Bifida Ferment Lysate
Est. %2.4
Function
Origin
Bifida Ferment LysateA mixture of probiotic bacteria. According to the patent holder, it contains enzymes that are able to repair damaged DNA in skin cells. A single study confirms that it is able to reduce skin sensitivity.
Tremella Fuciformis Sporocarp Extract
Est. %2.3
Function
Origin
Tremella Fuciformis Sporocarp ExtractA fungi extract. The mushroom contains various proteins, fiber, and humectant and antioxidant polysaccharides - which help to restore the water and collagen content in the skin.
Abelmoschus Esculentus Fruit Extract
Est. %2
Function
Origin
Abelmoschus Esculentus Fruit Extract
Chamomilla Recutita (Matricaria) Flower Extract
Est. %1.5
Function
Origin
Chamomilla Recutita (Matricaria) Flower ExtractDerived from German chamomile flowers, this extract is especially known for its anti-inflammatory and soothing benefits. It contains two soothing compounds called chamazulene and bisabolol, as well as antioxidant flavonoids.
Glycyrrhiza Glabra (Licorice) Root Extract
Est. %1.3
Function
Origin
Glycyrrhiza Glabra (Licorice) Root ExtractAn extract from the licorice root. It contains a well-researched anti-inflammatory compound called glycyrrhizin that can reduce inflammation. Licorice root extract is also used for its powerful antioxidant effects and ability to treat pigmentation.
Camellia Sinensis Leaf Extract
Est. %1
Function
Origin
Camellia Sinensis Leaf Extract

An antioxidant green tea extract. In the deeper layers, it slows down the destruction of collagen, elastin, and hyaluronic acid – thus delaying the signs of aging. It also acts as an anti-acne, soothing, moisturizing, and emollient ingredient.

Cladosiphon Novae-Caledoniae Extract
Est. %0.3
Function
Origin
Cladosiphon Novae-Caledoniae Extract
Polygonum Cuspidatum Root Extract
Est. %0.3
Function
Origin
Polygonum Cuspidatum Root ExtractAn extract from the roots of the Japanese knotweed, a plant from East Asia that has spread around the world as an invasive plant. It contains various antioxidant, anti-inflammatory, and potentially anti-pigment (more tests are necessary) phytochemicals.
Centella Asiatica Extract
Est. %0.3
Function
Origin
Centella Asiatica ExtractAn extract from the leaves of the Gotu kola. It is used in skincare for its antioxidant, wound healing, anti-inflammatory, and anti-aging properties. It increases the production of collagen and hyaluronic acid in the skin.
Sodium Acetylated Hyaluronate
Est. %0.3
Function
Origin
Sodium Acetylated HyaluronateA chemically modified version of hyaluronic acid. It is more stable and less sticky than regular HA, while still providing the same humectant moisturizing properties (according to the manufacturer). There have been no clinical studies to confirm this.
Rosmarinus Officinalis (Rosemary) Leaf Extract
Est. %0.3
Function
Origin
Rosmarinus Officinalis (Rosemary) Leaf ExtractA soothing and astringent extract derived from the fragrant, spicy leaves of rosemary. It has strong antioxidant properties. Rosemary extract can reduce signs of inflammation and also acts as an emollient and antimicrobial agent.
Scutellaria Baicalensis Root Extract
Est. %0.3
Function
Origin
Scutellaria Baicalensis Root ExtractA powerful antioxidant, soothing, and astringent extract derived from the roots of Baikal/Chinese skullcap. It contains various unique flavonoids that are believed to soothe irritated and inflamed skin and protect from UV-induced oxidative damage.
Sodium Hyaluronate Crosspolymer
Est. %0.3
Function
Origin
Sodium Hyaluronate CrosspolymerA modified version of regular hyaluronic acid. It attracts large volumes of water, thereby making it an effective humectant moisturizing ingredient.
Hydrolyzed Sodium Hyaluronate
Est. %0.3
Function
Origin
Hydrolyzed Sodium HyaluronateA very small-molecule version of regular sodium hyaluronate. It is a powerful humectant skin-identical ingredient that absorbs into the skin and offers plumping, smoothing, and anti-wrinkle effects.
Cyclopentasiloxane
Est. %0.3
Function
Origin
CyclopentasiloxaneA lightweight, fast-spreading emollient that leaves a very soft and silky after-feel on the skin. Supplied as a clear and colorless liquid, cyclopentasiloxane is often used as a solvent to dissolve other silicones in.
Propylene Glycol
Est. %0.3
Function
Origin
Propylene GlycolA clear, thick, odorless liquid of synthetic origin. Its main function is to stabilize cosmetic products exposed to varying temperatures. It is also a moderately strong humectant with similar properties to glycerin.
Titanium Dioxide (CI 77891)
Est. %0.3
Function
Origin
Titanium Dioxide (CI 77891)One of two the most commonly used mineral sunscreens. It can absorb UV light, including UVB – which causes burning, tanning, and even skin cancer. Also used as a colorant, titanium dioxide gives a product a bright white color.
Cyclohexasiloxane
Est. %0.3
Function
Origin
CyclohexasiloxaneA clear silicone fluid with very low viscosity that is commonly used as a solvent and emollient. It has excellent spreadability, rubs in quickly, and leaves a silky smooth after-feel on the skin.
Glycereth-26
Est. %0.3
Function
Origin
Glycereth-26

A glycerin-based ingredient with humectant moisturizing properties. It is an excellent emulsifier and thickener.

PEG-10 Dimethicone
Est. %0.3
Function
Origin
PEG-10 DimethiconeA polyethylene-based emulsifying ingredient. It has a water-loving portion and an oil-loving portion that help to keep the water and oil phases connected to form an emulsion.
Magnesium Sulfate
Est. %0.3
Function
Origin
Magnesium SulfateA naturally occurring mineral that is commonly used in skincare products as a bulking agent. It helps to control the viscosity of products by making them thicker.
Isononyl Isononanoate
Est. %0.3
Function
Origin
Isononyl IsononanoateAn ester of a branched fatty acid with a branched fatty alcohol. It is an easily spreadable emollient that has a silky, dry, non-greasy feel on the skin.
1,2-Hexanediol
Est. %0.3
Function
Origin
1,2-HexanediolA multi-functional formula helper. It is a well-studied preservtive against bacteria and can help pigments and fragrances disperse evenly in a formula.
Hydroxyacetophenone
Est. %0.3
Function
Origin
HydroxyacetophenoneAn antioxidant compound that can be found in many plants, although it is manufactured synthetically for skincare purposes. It can boost the preservative action of other conservants.
Ultramarines (CI 77007)
Est. %0.3
Function
Origin
Ultramarines (CI 77007)
Magnesium Stearate
Est. %0.3
Function
Origin
Magnesium StearateA multifunctional ester that thickens and prevents clumping.
C12-15 Alkyl Benzoate
Est. %0.3
Function
Origin
C12-15 Alkyl BenzoateA synthetic emollient ester. It works to improve the appearance of the skin by filling in the microcracks on the surface, thereby making the skin appear softer and smoother. It imparts a lightweight, velvety feel.
Phenyl Trimethicone
Est. %0.3
Function
Origin
Phenyl TrimethiconeA silicone fluid that is used as an occlusive moisturizer. It applies smoothly to the skin and reduces the tack associated with organic oils.
Butylene Glycol
Est. %0.3
Function
Origin
Butylene Glycol

A clear, colorless liquid humectant that draws moisture to the skin. The humectancy of butylene glycol, owed to its two hydroxyl groups, is quite considerable, although not as powerful as glycerin, which contains three hydroxyl groups.

Pentylene Glycol
Est. %0.3
Function
Origin
Pentylene Glycol

A naturally or synthetically derived preservative that exhibits effective antifungal and antibacterial traits. It also acts as a booster for more traditional preservatives. Pentylene glycol can also serve as a moisturizing humectant and solvent.

Cetyl PEG/PPG-10/1 Dimethicone
Est. %0.3
Function
Origin
Cetyl PEG/PPG-10/1 DimethiconeA silicone-based powerful emulsifier that helps to create lightweight and pleasant feeling lotions and creams.
Triethoxycaprylylsilane
Est. %0.3
Function
Origin
TriethoxycaprylylsilaneA binding and coating ingredient that allows pigments like iron oxides and mica to disperse better in oily environments. This leads to more vibrant colors.
Flavor (Aroma)
Est. %0.3
Function
Origin
Flavor (Aroma)Under trade secret law, manufacturers have the right not to disclose what exactly went into the flavor and use the unspecific word 'flavor' instead. Flavor is added to products that have the potential to be consumed, such as lipsticks.