Derm Institute Cellular Rejuvenating Serum Review

Derm Institute Cellular Rejuvenating Serum
5.3
/ 10
Moisturizing
10.0 Humectancy icon Humectancy
0.6 Occlusivity icon Occlusivity
0.1Anti-wrinkle icon/ 10
Anti-wrinkle
Rich
in Antioxidants
Ingredients

Derm Institute Cellular Rejuvenating Serum Ingredients

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Full Ingredient List (INCI):

Water, Nelumbo Nucifera Seed Extract, Glycerin, Methyl Gluceth-20, Saccharide Isomerate, Dextran, Trifluoroacetyl Tripeptide-2, Sorbitan Laurate, Acetyl Dipeptide-1 Cetyl Ester, Propanediol, Ornithine, Phospholipids, Glycolipids, Hydrolyzed Collagen, Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Hydrogenated Polydecene, Laureth-8, Hydrolyzed Soy Flour, Polydecene, Solanum Lycopersicum (Tomato) Fruit Extract, Superoxide Dismutase, Catalase, Ergothioneine, Squalane, Ubiquinone, Hydrolyzed Myrtus Communis Leaf Extract, Algae Extract, Lentinus Edodes Extract, Ganoderma Lucidum (Mushroom) Stem Extract, Ascophyllum Nodosum Extract, Carnosine, Vitis Vinifera (Grape) Seed Extract, Resveratrol, Ceramide NP, Ceramide AP, Ceramide EOP, Phytosphingosine, Cholesterol, Sodium Lauroyl Lactylate, Tocopherol, Astaxanthin, Vaccinium Macrocarpon (Cranberry) Seed Oil, Panthenol, Octyldodecanol, Tocopheryl Acetate, Retinyl Palmitate, Ascorbic Acid, Diazolidinyl Urea, Disodium EDTA, Fragrance
Review

Does Derm Institute Cellular Rejuvenating Serum Work?

 
According to CreamScan's analysis of the ingredient list, here’s what Derm Institute Cellular Rejuvenating Serum has to offer:
 
✅ Strong humectant moisturizing. This lightweight, humectant-rich product, ideal for oily skin, has a moisturizing rating of 5.3 out of 10.
✅ Slight anti-wrinkle effect: Derm Institute Cellular Rejuvenating Serum has an anti-wrinkle rating of 0.1 out of 10, so you may expect a positive, although insignificant, effect on wrinkles.
✅ Antioxidant protection

  

Key Benefits of Derm Institute Cellular Rejuvenating Serum

 
These are the key benefits you can expect from using Derm Institute Cellular Rejuvenating Serum:
 

🔵 Lightweight Humectant Moisturizer Ideal for Oily Skin

According to CreamScan analysis, Derm Institute Cellular Rejuvenating Serum is quite moisturizing, with a moisturizing rating of 5.3 out of 10.

Is it more humectant or occlusive? Significantly more humectant. It has a low occlusivity of 0.6 out of 10 and a maximum humectancy of 10 out of 10, primarily due to the high content of Glycerin (est. ≈4.0%), Methyl Gluceth-20 (est. ≈3.0%) and Saccharide Isomerate (est. ≈2.0%).

This humectant-rich product, when used alone as a moisturizer, is ideal for oily skin, offering significant hydration in a lightweight, fast-absorbing formula with a minimal amount of occlusive ingredients.

It’s also a great choice for people with normal skin who prefer lightweight moisturizers.

💧 A Humectant Boost for Any Skincare Routine

But it’s not limited to oily skin - such a humectant boost will also positively contribute to the moisturizing efficacy of any skincare routine when used as a step before applying the main moisturizer. This type of formulation is typically used in serums, where a light, fast-absorbing texture is key.

Please refer to the Ratings section below for details of the moisturizing rating calculation.

🟣 Slight Anti-Wrinkle Efficacy

According to CreamScan analysis, Derm Institute Cellular Rejuvenating Serum has a slight anti-wrinkle rating of 0.1 out of 10.

It contains one ingredient with proven anti-wrinkle efficacy: Ascorbic Acid (est. ≈0.3%),
 or Vitamin C, a popular ingredient, yet with moderate anti-wrinkle efficacy, as confirmed by a single clinical study involving 20 participants (Humbert et al.). This study showed that a cream with a relatively high concentration of 5% ascorbic acid reduced the average wrinkle depth by 7% after 6 months of use, compared to a vehicle (the same formulation without ascorbic acid).
 
Among others, Derm Institute Cellular Rejuvenating Serum also contains some ingredients marketed often as effective in reducing wrinkles, specifically Trifluoroacetyl Tripeptide-2, Ubiquinone, and Retinyl Palmitate. However, the studies supporting the anti-wrinkle claims of these ingredients provide insufficient evidence of efficacy according to CreamScan Research Evaluation Standards.
 
While this does not categorically rule out the possibility that these ingredients may reduce wrinkles, their efficacy is not supported by convincing, vehicle-controlled, double-blind clinical studies - at least none that were available to the CreamScan team at the time of publication.
 
Therefore, these ingredients do not contribute to the anti-wrinkle rating.
 
📌 Moisturizers, when used regularly, are proven to prevent wrinkle formation and even reduce existing wrinkles. Therefore, this product, like any other moisturizer, can deliver some additional anti-wrinkle effects through its moisturizing action.
 

Please refer to the Ratings section below for details of the anti-wrinkle rating calculation.

🍀 Rich in Skin-Protecting Antioxidants

We estimate that Derm Institute Cellular Rejuvenating Serum is rich (> 3%) in antioxidants, specifically Nelumbo Nucifera Seed Extract (est. ≈6.0%).

A key benefit of antioxidants is their ability to reduce oxidative stress caused by free radicals and therefore prevent accelerated skin aging. Studies also show that antioxidants can protect against environmental damage such as UV radiation and pollution, and help reduce inflammation and skin redness.

📌 Please note that this is not a complete list of benefits. We are in the process of enhancing our model to incorporate anti-pigmentation, exfoliation and anti-acne ratings.

Pros & Cons of Derm Institute Cellular Rejuvenating Serum

 
Here’s an overview of the pros and cons of Derm Institute Cellular Rejuvenating Serum to help you decide if it’s the right choice for your skincare routine:
 

🟩 Pros:

✅ When used alone: Provides humectant-rich moisturizing ideal for oily skin
✅ As part of a routine: A humectant moisturizing boost, beneficial for any skin type
✅ Lightweight texture
Provides slight anti-wrinkle efficacy
✅ Rich in antioxidants that combat oxidative stress associated with accelerated skin aging and defend against environmental damage
 

⭕ Cons: 

✅ We couldn't find any
   

Summary: Derm Institute Cellular Rejuvenating Serum

 
Based on the ingredient list analysis, CreamScan AI suggests that Derm Institute Cellular Rejuvenating Serum
, when used alone, delivers lightweight, humectant-rich moisturizing, making it ideal for oily skin. As part of a moisturizing routine, it provides a humectant boost, beneficial for all skin types.
 
Derm Institute Cellular Rejuvenating Serum contains ingredients with proven evidence of anti-wrinkle efficacy that may offer a slight anti-wrinkle effect. As a result, you can expect a positive, though relatively minimal, impact on wrinkles.
 
 
With its high antioxidant content, Derm Institute Cellular Rejuvenating Serum helps protect against free radical damage and offers multiple benefits for all skin types, including preventing premature aging, defending against environmental damage, and calming inflammation.
 
📌 Fact check. At CreamScan, we are committed to accuracy and fairness. If you spot any errors or something that doesn’t seem right, please click here to let us know. We regularly update the ingredient lists and monitor the latest research on ingredient efficacy to ensure that our information remains as complete and precise as possible. The information provided here is for informational purposes only and does not substitute professional advice. We do not guarantee the efficacy or safety of any product, as individual results may vary.

 

Ingredient Breakdown

Est. % Ingredient Origin Functions
70
6
4
3
2
1.5
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Est. %
Water
Function:
Origin:
Nelumbo Nucifera Seed Extract
Function:
Origin:
Glycerin
Function:
Origin:
Methyl Gluceth-20
Function:
Origin:
Saccharide Isomerate
Function:
Origin:
Dextran
Function:
Origin:
Trifluoroacetyl Tripeptide-2
Function:
Origin:
Sorbitan Laurate
Function:
Origin:
Acetyl Dipeptide-1 Cetyl Ester
Function:
Origin:
Propanediol
Function:
Origin:
Ornithine
Function:
Origin:
Phospholipids
Function:
Origin:
Glycolipids
Function:
Origin:
Hydrolyzed Collagen
Function:
Origin:
Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer
Function:
Origin:
Hydrogenated Polydecene
Function:
Origin:
Laureth-8
Function:
Origin:
Hydrolyzed Soy Flour
Function:
Origin:
Polydecene
Function:
Origin:
Solanum Lycopersicum (Tomato) Fruit Extract
Function:
Origin:
Superoxide Dismutase
Function:
Origin:
Catalase
Function:
Origin:
Ergothioneine
Function:
Origin:
Squalane
Function:
Origin:
Ubiquinone
Function:
Origin:
Hydrolyzed Myrtus Communis Leaf Extract
Function:
Origin:
Algae Extract
Function:
Origin:
Lentinus Edodes Extract
Function:
Origin:
Ganoderma Lucidum (Mushroom) Stem Extract
Function:
Origin:
Ascophyllum Nodosum Extract
Function:
Origin:
Carnosine
Function:
Origin:
Vitis Vinifera (Grape) Seed Extract
Function:
Origin:
Resveratrol
Function:
Origin:
Ceramide NP
Function:
Origin:
Ceramide AP
Function:
Origin:
Ceramide EOP
Function:
Origin:
Phytosphingosine
Function:
Origin:
Cholesterol
Function:
Origin:
Sodium Lauroyl Lactylate
Function:
Origin:
Tocopherol
Function:
Origin:
Astaxanthin
Function:
Origin:
Vaccinium Macrocarpon (Cranberry) Seed Oil
Function:
Origin:
Panthenol
Function:
Origin:
Octyldodecanol
Function:
Origin:
Tocopheryl Acetate
Function:
Origin:
Retinyl Palmitate
Function:
Origin:
Ascorbic Acid
Function:
Origin:
Diazolidinyl Urea
Function:
Origin:
Disodium EDTA
Function:
Origin:
Fragrance
Function:
Origin:

Ratings

All humectants
10.5
4
3
2
0.3
0.3
0.3
0.3
0.3
Benchmark
10
All occlusives
1.2
0.3
0.3
0.3
0.3
Benchmark
20
Moisturizing rating
5.3
Ingredient Est. % Benchmark Raiting
Humectancy All humectants 10.5 10
10.0
4
3
2
0.3
0.3
0.3
0.3
0.3
Occlusivity All occlusives 1.2 20
0.6
0.3
0.3
0.3
0.3
Moisturizing rating
5.3
Ingredient Est. % Benchmark Humectancy
4
3
2
0.3
0.3
0.3
0.3
0.3
All humectants 10.5 10
10
All humectants
10.5
4
3
2
0.3
0.3
0.3
0.3
0.3
Benchmark
10
Ingredient Est. % Benchmark Occlusivity
0.3
0.3
0.3
0.3
All occlusives 1.2 20
0.6
All occlusives
1.2
0.3
0.3
0.3
0.3
Benchmark
20
Ingredient
Ingredient anti-wrinkle power
when present at, %
in this formula est. %
Rating
2.5 /10 5 0.3 0.1
n/a
- 0.3 -
n/a
- 0.3 -
n/a
- 0.3 -
Total
0.1
Ascorbic Acid
0.1
Ingredient anti-wrinkle power
2.5 /10
when present at, %
5
in this formula, est. %
0.3
Trifluoroacetyl Tripeptide-2
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Ubiquinone
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Retinyl Palmitate
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Anti-wrinkle rating
0.1
Ingredient Est. % Benchmark
Rich in Antioxidants
6
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
All antioxidants 10.2 3 Rich in antioxidants
All antioxidants
10.2
Nelumbo Nucifera Seed Extract
6
Ascorbic Acid
0.3
Solanum Lycopersicum (Tomato) Fruit Extract
0.3
Superoxide Dismutase
0.3
Ergothioneine
0.3
Ubiquinone
0.3
Algae Extract
0.3
Ascophyllum Nodosum Extract
0.3
Carnosine
0.3
Vitis Vinifera (Grape) Seed Extract
0.3
Resveratrol
0.3
Tocopherol
0.3
Astaxanthin
0.3
Vaccinium Macrocarpon (Cranberry) Seed Oil
0.3
Tocopheryl Acetate
0.3
Benchmark
3
Ingredient Est. % Benchmark
Rich in Soothing
0.3
0.3
0.3
All soothing 0.9 5 No
All soothing
0.9
0.3
0.3
0.3
Benchmark
5

Ingredients explained

Water
Est. %70
Function
Origin
WaterThe most used ingredient in skincare. Its concentration defines the product texture: rich creams may have about 50% of water while a light jelly about 90%. Water doesn’t moisturize the skin by itself and is used in skincare as a solvent for other ingredients.
Nelumbo Nucifera Seed Extract
Est. %6
Function
Origin
Nelumbo Nucifera Seed Extract
Glycerin
Est. %4
Function
Origin
Glycerin

The most popular moisturizing ingredient in the world. It is a powerful humectant – cheap yet very effective.

Methyl Gluceth-20
Est. %3
Function
Origin
Methyl Gluceth-20A humectant synthetically derived from glucose. It takes on the form of a clear, syrupy liquid.
Saccharide Isomerate
Est. %2
Function
Origin
Saccharide IsomerateA naturally-derived humectant that provides moisturization at low levels and is less sticky than other humectants like glycerin.
Dextran
Est. %1.5
Function
Origin
DextranA naturally derived sucrose metabolite that thickens water and bulks emulsions.
Trifluoroacetyl Tripeptide-2
Est. %0.3
Function
Origin
Trifluoroacetyl Tripeptide-2

A synthetically made peptide that was shown to slow down the degradation of elastin in the skin. It is said to be able to reduce sagging and wrinkles in different parts of the face, although this has not been well researched yet.

Sorbitan Laurate
Est. %0.3
Function
Origin
Sorbitan LaurateSorbitan laurate is a sugar-based emulsifier similar to sucrose palmitate. It keeps oil broken into small droplets throughout water because of its chemical shape and nature (this is how most oil-in-water emulsifiers work by the way). These kinds of emulsifiers are mild enough to even be used in food preparations.
Acetyl Dipeptide-1 Cetyl Ester
Est. %0.3
Function
Origin
Acetyl Dipeptide-1 Cetyl EsterA dipeptide-based ingredient claimed to stimulate elastin production and reduce the appearacne of wrinkles and sagging skin.
Propanediol
Est. %0.3
Function
Origin
PropanediolAn excellent solvent capable of mixing water with normally water-insoluble ingredients. It also functions as a humectant due to its water-loving alcohol groups. Propanediol can control the viscosity of a product by reducing its thickness.
Ornithine
Est. %0.3
Function
Origin
OrnithineAn amino acid that is claimed to be able to restore the adipose tissue in the skin, thereby making it look plumper and filled out. This has not been proven by studies as of yet.
Phospholipids
Est. %0.3
Function
Origin
PhospholipidsA large group of lipids that are an essential component of every single cell membrane in the body. They have excellent emollient properties. Phospholipids are also utilized in the manufacturing of ‘fancy’ formulations such as liposomes.
Glycolipids
Est. %0.3
Function
Origin
GlycolipidsVarious lipids combined with one or more sugars. It can be used as an emulsifier or a very gentle cleanser.
Hydrolyzed Collagen
Est. %0.3
Function
Origin
Hydrolyzed Collagen

A humectant, film-forming, and emollient mixture of various proteins and peptides that were created by cutting the huge molecules of normal collagen into smaller pieces for better absorption. It also has some antioxidant properties.

Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer
Est. %0.3
Function
Origin
Sodium Acrylate/Sodium Acryloyldimethyl Taurate CopolymerA multi-functional ingredient that forms a polymeric network, thereby thickening the formula and preventing other ingredients from shifting around.
Hydrogenated Polydecene
Est. %0.3
Function
Origin
Hydrogenated PolydeceneA clear, colorless, highly viscous liquid that commonly serves as an emollient. This rich emollient is on the heavier side but provides a smooth sensorial profile upon application.
Laureth-8
Est. %0.3
Function
Origin
Laureth-8
Hydrolyzed Soy Flour
Est. %0.3
Function
Origin
Hydrolyzed Soy Flour
Polydecene
Est. %0.3
Function
Origin
Polydecene
Solanum Lycopersicum (Tomato) Fruit Extract
Est. %0.3
Function
Origin
Solanum Lycopersicum (Tomato) Fruit ExtractA bright red extract obtained from tomato fruit. Its main bioactive compound is lycopene, a powerful antioxidant. It also contains other antioxidants like various phenolic acids and flavonoids.
Superoxide Dismutase
Est. %0.3
Function
Origin
Superoxide Dismutase
Catalase
Est. %0.3
Function
Origin
Catalase
Ergothioneine
Est. %0.3
Function
Origin
ErgothioneineA naturally-occurring amino acid that functions as a powerful and versatile antioxidant.
Squalane
Est. %0.3
Function
Origin
SqualaneAn occlusive moisturizing and emollient compound that forms part of the skin’s sebum. The main source of squalane had always been shark liver. Now, however, it is manufactured synthetically or derived from plant oils, such as olive and peanut oil.
Ubiquinone
Est. %0.3
Function
Origin
UbiquinoneAlso known as Coenzyme Q10, this bright orange antioxidant supports the skin's energy metabolism. It also offers some anti-pigment action. Dietary supplementation of Ubiquinone improves the appearance of wrinkles.
Hydrolyzed Myrtus Communis Leaf Extract
Est. %0.3
Function
Origin
Hydrolyzed Myrtus Communis Leaf Extract
Algae Extract
Est. %0.3
Function
Origin
Algae ExtractThe name describes any extract made from any kind of algae. Algae extracts are moisturizing humectants – the gelatin-like polysaccharides bind and retain water, thereby hydrating the skin. Algae is a rich source of emollient and antioxidant compounds.
Lentinus Edodes Extract
Est. %0.3
Function
Origin
Lentinus Edodes Extract
Ganoderma Lucidum (Mushroom) Stem Extract
Est. %0.3
Function
Origin
Ganoderma Lucidum (Mushroom) Stem Extract
Ascophyllum Nodosum Extract
Est. %0.3
Function
Origin
Ascophyllum Nodosum ExtractAn extract from brown sea algae, a rich source of gel-forming algae polysaccharides such as fucoids, alginate, and ascophyllan, as well as some antioxidant phenolic compounds and minerals.
Carnosine
Est. %0.3
Function
Origin
CarnosineA skin-identical dipeptide that acts as a powerful antioxidant. It protects our skin from harmful glycation and can enhance the activity of other active ingredients in the skincare product.
Vitis Vinifera (Grape) Seed Extract
Est. %0.3
Function
Origin
Vitis Vinifera (Grape) Seed ExtractA potent antioxidant and emollient extract derived from grape seeds. It contains antioxidant flavonoids, tannins, proanthocyanidins, phytosterols, carotenoids, and vitamin E. It is often used in skincare products aimed at soothing and healing irritated skin.
Resveratrol
Est. %0.3
Function
Origin
ResveratrolA famous plant-based polyphenol found mainly in red grapes. It is a potent antioxidant, soothing, and wound healing ingredient.
Ceramide NP
Est. %0.3
Function
Origin
Ceramide NPAlso known as ceramide 3, it is the most common ceramide in our skin. It helps to restore the skin’s lipid barrier and alleviate the symptoms of dry and cracked skin. Research has shown that skin suffering from conditions such as AD lacks ceramides.
Ceramide AP
Est. %0.3
Function
Origin
Ceramide APPreviously called Ceramide 6 II, Ceramide AP is one of the most common ceramides in the skin. Research has shown that dry, flaky skin has significantly less Ceramide AP. Its application helps to treat dry skin by restoring balance in the skin lipids.
Ceramide EOP
Est. %0.3
Function
Origin
Ceramide EOP

Formerly called Ceramide 1, this ingredient is a skin-identical wax-like lipid with an ultra-long fatty acid chain. It restores and stabilizes the skin’s lipid matrix and helps to treat dry and flaky skin, especially when combined with other ceramides.

Phytosphingosine
Est. %0.3
Function
Origin
PhytosphingosineA key component of ceramides NP, AP, and EOP. It has barrier repair properties and stimulates the production of the skin’s Natural Moisturizing Factor. Phytosphingosine has strong antimicrobial and anti-inflammatory activity, which can be used to treat acne.
Cholesterol
Est. %0.3
Function
Origin
CholesterolAn emollient and important barrier repairing lipid, effective when combined with fatty acids and ceramides. Around 25% of the skin’s lipid layer is made up of cholesterol and it is found in the membrane of every single cell in our body.
Sodium Lauroyl Lactylate
Est. %0.3
Function
Origin
Sodium Lauroyl LactylateA multifunctional ingredient that produces foamy cleansers and allows oil and water to mix.
Tocopherol
Est. %0.3
Function
Origin
Tocopherol

Simply another name for vitamin E. Tocopherol is a fantastic ingredient and especially beneficial for dry and inflamed skin. It has occlusive moisturizing, emollient, antioxidant, and photoprotective properties.

Astaxanthin
Est. %0.3
Function
Origin
AstaxanthinA red natural pigment from the family of antioxidant carotenoids that occurs in many natural sources such as lobster and algae. It is mainly used as a colorant and soothing ingredient.
Vaccinium Macrocarpon (Cranberry) Seed Oil
Est. %0.3
Function
Origin
Vaccinium Macrocarpon (Cranberry) Seed OilDerived from cranberry seeds, this rich-in-antioxidants oil contains a combination of emollient and occlusive moisturizing omega-3,-6, and -9 fatty acids.
Panthenol
Est. %0.3
Function
Origin
PanthenolA popular soothing and moisturizing derivative of vitamin B5. Panthenol is particularly beneficial for dry, flaking, burned, or damaged skin. It is used to alleviate the symptoms of a rash, dermatitis, eczema, chapped lips, and sunburn.
Octyldodecanol
Est. %0.3
Function
Origin
OctyldodecanolAn emollient fatty alcohol that spreads easily without leaving a greasy residue on the skin. It is also used as a solvent and dispersing agent for other ingredients.
Tocopheryl Acetate
Est. %0.3
Function
Origin
Tocopheryl Acetate

An antioxidant derivative of tocopherol (vitamin E). It helps to protect cells from free radicals and UV damage through the conversion to active vitamin E in the skin. It is more stable than tocopherol.

Retinyl Palmitate
Est. %0.3
Function
Origin
Retinyl Palmitate

An esterified form of retinol – it combines retinol and palmitic acid into one molecule. Retinyl palmitate is less irritating than retinol but lacks clinical proves of its anti-aging and acne-reducing efficacy.

Ascorbic Acid
Est. %0.3
Function
Origin
Ascorbic Acid

Also known as vitamin C, this multi-benefit ingredient has proven anti-wrinkle, antioxidant, and anti-pigmentation efficacy. It degrades easily when exposed to air and light, so it requires proper packaging to maintain its stability.

Diazolidinyl Urea
Est. %0.3
Function
Origin
Diazolidinyl UreaA synthetic preservative that is effective against most common bacteria. It is not considered broad-spectrum because it does not act against any type of yeast or mold. It is therefore commonly paired with antifungal preservatives.
Disodium EDTA
Est. %0.3
Function
Origin
Disodium EDTAA synthetic chelator that helps to maintain the look and smell of a product by 'locking up' troublesome metal ions.
Fragrance
Est. %0.3
Function
Origin
FragranceUnder trade secret law, manufacturers have the right not to disclose what exactly went into the fragrance and use the unspecific word Fragrance or Parfum instead. Many fragrances are highly allergenic.