Depology Peptide Complex 10% Wrinkle Defense Serum Review

Depology Peptide Complex 10% Wrinkle Defense Serum
5.1
/ 10
Moisturizing
10.0 Humectancy icon Humectancy
0.2 Occlusivity icon Occlusivity
Review

Does Depology Peptide Complex 10% Wrinkle Defense Serum Work?

 
According to CreamScan AI's analysis of the ingredient list, here’s what Depology Peptide Complex 10% Wrinkle Defense Serum has to offer:
 
  • Strong humectant moisturizing. This lightweight, humectant-rich product, ideal for oily skin, has a moisturizing rating of 5.1 out of 10.

Key Benefits of Depology Peptide Complex 10% Wrinkle Defense Serum

 
These are the key benefits you can expect from using Depology Peptide Complex 10% Wrinkle Defense Serum:
 

Lightweight Humectant Moisturizer Ideal for Oily Skin

According to CreamScan analysis, Depology Peptide Complex 10% Wrinkle Defense Serum is quite moisturizing, with a moisturizing rating of 5.1 out of 10.

Is it more humectant or occlusive? Significantly more humectant. It has a low occlusivity of 0.2 out of 10 and a maximum humectancy of 10 out of 10, primarily due to the high content of Isopentyldiol (est. ≈6.0%), Panthenol (est. ≈3.0%) and Hydroxyethyl Urea (est. ≈2.0%).

This humectant-rich product, when used alone as a moisturizer, is ideal for oily skin, offering significant hydration in a lightweight, fast-absorbing formula with a minimal amount of occlusive ingredients.

It’s also a great choice for people with normal skin who prefer lightweight moisturizers.

A Humectant Boost for Any Skincare Routine

But it’s not limited to oily skin - such a humectant boost will also positively contribute to the moisturizing efficacy of any skincare routine when used as a step before applying the main moisturizer. This type of formulation is typically used in serums, where a light, fast-absorbing texture is key.

Please refer to the Ratings section below for details of the moisturizing rating calculation.

Please note that this is not a complete list of benefits. We are in the process of enhancing our AI model to incorporate anti-pigmentation, exfoliation and anti-acne ratings.

Things to Be Aware Of: Depology Peptide Complex 10% Wrinkle Defense Serum

 
CreamScan AI identified a few things to consider before adding Depology Peptide Complex 10% Wrinkle Defense Serum to your skincare routine:
 

Questionable anti-wrinkle efficacy

If one of your main reasons for choosing Depology Peptide Complex 10% Wrinkle Defense Serum is its potential anti-aging effects, please note that, according to CreamScan analysis, it currently has a zero anti-wrinkle rating.

It contains some ingredients often marketed as effective in reducing wrinkles, specifically Centella Asiatica Extract, Acetyl Hexapeptide-8, and Palmitoyl Tripeptide-5. However, the studies supporting the anti-wrinkle claims of these ingredients provide insufficient evidence of efficacy according to CreamScan Research Evaluation Standards. 

While this does not categorically exclude the possibility that these ingredients may reduce wrinkles, their efficacy is not supported by convincing, vehicle-controlled, double-blind clinical studies - at least none that were accessible to the CreamScan team at the time of publication.

Therefore, these ingredients do not generate the anti-wrinkle rating.

Moisturizers, when used regularly, are proven to prevent wrinkle formation and even reduce existing wrinkles. Therefore, this product, like any other moisturizer, can deliver some anti-wrinkle effects through its moisturizing action.

Please refer to the Ratings section below for details of the anti-wrinkle rating calculation.

Pros & Cons of Depology Peptide Complex 10% Wrinkle Defense Serum

 
Here’s an overview of the pros and cons of Depology Peptide Complex 10% Wrinkle Defense Serum to help you decide if it’s the right choice for your skincare routine:
 

Pros:

  • When used alone: Provides humectant-rich moisturizing ideal for oily skin
  • As part of a routine: A humectant moisturizing boost, beneficial for any skin type
  • Lightweight texture

Cons: 

  • Questionable anti-wrinkle efficacy

Ingredients

Est. % Ingredient Origin Functions
75
6
4
3
2
1.5
1.3
1
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Est. %
Water
Function:
Origin:
Isopentyldiol
Function:
Origin:
1,2-Hexanediol
Function:
Origin:
Panthenol
Function:
Origin:
Hydroxyethyl Urea
Function:
Origin:
Butylene Glycol
Function:
Origin:
Propanediol
Function:
Origin:
Caprylyl Glycol
Function:
Origin:
Glycerin
Function:
Origin:
Sodium Hyaluronate
Function:
Origin:
Ficus Carica (Fig) Fruit Extract
Function:
Origin:
Centella Asiatica Extract
Function:
Origin:
Acetyl Hexapeptide-8
Function:
Origin:
Ceramide NP
Function:
Origin:
Hydrogenated Lecithin
Function:
Origin:
Anthemis Nobilis Flower Oil
Function:
Origin:
Tocopherol
Function:
Origin:
Houttuynia Cordata Extract
Function:
Origin:
Tocopheryl Acetate
Function:
Origin:
Ascorbic Acid Polypeptide
Function:
Origin:
Ammonium Acryloyldimethyltaurate/VP Copolymer
Function:
Origin:
Tromethamine
Function:
Origin:
Carbomer
Function:
Origin:
Octyldodeceth-16
Function:
Origin:
Ethylhexylglycerin
Function:
Origin:
Acrylates/C10-30 Alkyl Acrylate Crosspolymer
Function:
Origin:
Disodium EDTA
Function:
Origin:
Palmitoyl Tripeptide-5
Function:
Origin:
Pinus Strobus Bark Extract
Function:
Origin:
Hexapeptide-9
Function:
Origin:
Maltodextrin
Function:
Origin:
Lavandula Angustifolia (Lavender) Oil
Function:
Origin:
Linalool
Function:
Origin:

Ratings

All humectants
16.3
6
3
2
1.5
1.3
1
0.3
0.3
0.3
0.3
0.3
Benchmark
10
All occlusives
0.3
0.3
Benchmark
20
Moisturizing rating
5.1
Ingredient Est. % Benchmark Raiting
Humectancy All humectants 16.3 10
10.0
6
3
2
1.5
1.3
1
0.3
0.3
0.3
0.3
0.3
Occlusivity All occlusives 0.3 20
0.2
0.3
Moisturizing rating
5.1
Ingredient Est. % Benchmark Humectancy
6
3
2
1.5
1.3
1
0.3
0.3
0.3
0.3
0.3
All humectants 16.3 10
10
All humectants
16.3
6
3
2
1.5
1.3
1
0.3
0.3
0.3
0.3
0.3
Benchmark
10
Ingredient Est. % Benchmark Occlusivity
0.3
All occlusives 0.3 20
0.2
All occlusives
0.3
0.3
Benchmark
20
Ingredient
Ingredient anti-wrinkle power
when present at, %
in this formula est. %
Rating
n/a
- 0.3 -
n/a
- 0.3 -
n/a
- 0.3 -
Total
0
Centella Asiatica Extract
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Acetyl Hexapeptide-8
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Palmitoyl Tripeptide-5
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Anti-wrinkle rating
0
Ingredient Est. % Benchmark
Rich in Antioxidants
0.3
0.3
0.3
0.3
0.3
0.3
All antioxidants 1.8 3 No
All antioxidants
1.8
Sodium Hyaluronate
0.3
Centella Asiatica Extract
0.3
Tocopherol
0.3
Houttuynia Cordata Extract
0.3
Tocopheryl Acetate
0.3
Ascorbic Acid Polypeptide
0.3
Benchmark
3
Ingredient Est. % Benchmark
Rich in Soothing
3
0.3
0.3
0.3
All soothing 3.9 5 No
All soothing
3.9
3
0.3
0.3
0.3
Benchmark
5

Ingredients explained

Water
Est. %75
Function
Origin
WaterThe most used ingredient in skincare. Its concentration defines the product texture: rich creams may have about 50% of water while a light jelly about 90%. Water doesn’t moisturize the skin by itself and is used in skincare as a solvent for other ingredients.
Isopentyldiol
Est. %6
Function
Origin
Isopentyldiol

An alcohol that improves moisturization by drawing in water.

1,2-Hexanediol
Est. %4
Function
Origin
1,2-HexanediolA multi-functional formula helper. It is a well-studied preservtive against bacteria and can help pigments and fragrances disperse evenly in a formula.
Panthenol
Est. %3
Function
Origin
PanthenolA popular soothing and moisturizing derivative of vitamin B5. Panthenol is particularly beneficial for dry, flaking, burned, or damaged skin. It is used to alleviate the symptoms of a rash, dermatitis, eczema, chapped lips, and sunburn.
Hydroxyethyl Urea
Est. %2
Function
Origin
Hydroxyethyl UreaHydroxyethyl urea is a synthetic derivative of regular urea (read about it here). This ingredient, similarly to urea, is humectant moisturizing and helps to retain more water to the skin’s surface, leaving it more moisturized. There aren't any studies that analyze the effects of this ingredient in great detail.
Butylene Glycol
Est. %1.5
Function
Origin
Butylene Glycol

A clear, colorless liquid humectant that draws moisture to the skin. The humectancy of butylene glycol, owed to its two hydroxyl groups, is quite considerable, although not as powerful as glycerin, which contains three hydroxyl groups.

Propanediol
Est. %1.3
Function
Origin
PropanediolAn excellent solvent capable of mixing water with normally water-insoluble ingredients. It also functions as a humectant due to its water-loving alcohol groups. Propanediol can control the viscosity of a product by reducing its thickness.
Caprylyl Glycol
Est. %1
Function
Origin
Caprylyl GlycolAn emollient that improves product spreadability and offers a silky feel on the skin. It also acts as a preservative booster that improves the efficacy of other preservatives. According to the manufacturer, it is also a humectant moisturizer.
Glycerin
Est. %0.3
Function
Origin
Glycerin

The most popular moisturizing ingredient in the world. It is a powerful humectant – cheap yet very effective.

Sodium Hyaluronate
Est. %0.3
Function
Origin
Sodium Hyaluronate

A sodium salt of famous hyaluronic acid. A potent humectant that hydrates the skin, supports collagen function, and fills out small wrinkles. Sodium hyaluronate also offers soothing and antioxidant properties.

Ficus Carica (Fig) Fruit Extract
Est. %0.3
Function
Origin
Ficus Carica (Fig) Fruit ExtractA humectant and emollient extract derived from fig fruits. It contains a variety of good phytochemicals such as phenolic acids, flavonoids, and tannins.
Centella Asiatica Extract
Est. %0.3
Function
Origin
Centella Asiatica ExtractAn extract from the leaves of the Gotu kola. It is used in skincare for its antioxidant, wound healing, anti-inflammatory, and anti-aging properties. It increases the production of collagen and hyaluronic acid in the skin.
Acetyl Hexapeptide-8
Est. %0.3
Function
Origin
Acetyl Hexapeptide-8

A small synthetic peptide that is thought to act similarly to Botox by calming contractions of the facial muscles and reducing expression wrinkles. The effect is only temporary and it does not improve the skin structure in any way.

Ceramide NP
Est. %0.3
Function
Origin
Ceramide NPAlso known as ceramide 3, it is the most common ceramide in our skin. It helps to restore the skin’s lipid barrier and alleviate the symptoms of dry and cracked skin. Research has shown that skin suffering from conditions such as AD lacks ceramides.
Hydrogenated Lecithin
Est. %0.3
Function
Origin
Hydrogenated LecithinA version of plain lecithin that has been saturated with hydrogen atoms. This ingredient can be derived from plants, like soy or sunflower, from egg yolks, or made synthetically. Its major function is to emulsify water and oils.
Anthemis Nobilis Flower Oil
Est. %0.3
Function
Origin
Anthemis Nobilis Flower OilDistilled from the flowers of Roman chamomile, this fragrant essential oil is mainly constituted of esters of angelic and tiglic acid, which give it a sweet, crisp, fruity, and herbaceous scent.
Tocopherol
Est. %0.3
Function
Origin
Tocopherol

Simply another name for vitamin E. Tocopherol is a fantastic ingredient and especially beneficial for dry and inflamed skin. It has occlusive moisturizing, emollient, antioxidant, and photoprotective properties.

Houttuynia Cordata Extract
Est. %0.3
Function
Origin
Houttuynia Cordata ExtractAn extract from a herbaceous plant fish leaf. It contains various antioxidant and anti-inflammatory compounds. It shows interesting antimicrobial potential due to its unique phytochemical composition.
Tocopheryl Acetate
Est. %0.3
Function
Origin
Tocopheryl Acetate

An antioxidant derivative of tocopherol (vitamin E). It helps to protect cells from free radicals and UV damage through the conversion to active vitamin E in the skin. It is more stable than tocopherol.

Ascorbic Acid Polypeptide
Est. %0.3
Function
Origin
Ascorbic Acid Polypeptide
Ammonium Acryloyldimethyltaurate/VP Copolymer
Est. %0.3
Function
Origin
Ammonium Acryloyldimethyltaurate/VP CopolymerA polymeric ingredient that creates lightweight and refreshing gel textures. It also works as a viscosity controlling agent.
Tromethamine
Est. %0.3
Function
Origin
TromethamineAn ingredient based on amino acids that is commonly used as a pH adjuster. It has a high pH, which means that it is basic (alkaline), so adding tromethamine to a skincare product will increase its overall pH level.
Carbomer
Est. %0.3
Function
Origin
CarbomerA synthetic ingredient with the ability to gel water. When used in emulsions, such as lotions and creams, carbomer can also act as an emulsion stabilizer.
Octyldodeceth-16
Est. %0.3
Function
Origin
Octyldodeceth-16
Ethylhexylglycerin
Est. %0.3
Function
Origin
EthylhexylglycerinA preservative booster derived from glycerin. It is commonly paired with other preservatives to improve their efficacy. Ethylhexylglycerin is also a humectant due to its chemical base of glycerin.
Acrylates/C10-30 Alkyl Acrylate Crosspolymer
Est. %0.3
Function
Origin
Acrylates/C10-30 Alkyl Acrylate CrosspolymerA synthetic ingredient that is used to thicken water and alcohol. It results in a more lightweight formula and is commonly found in gel products.
Disodium EDTA
Est. %0.3
Function
Origin
Disodium EDTAA synthetic chelator that helps to maintain the look and smell of a product by 'locking up' troublesome metal ions.
Palmitoyl Tripeptide-5
Est. %0.3
Function
Origin
Palmitoyl Tripeptide-5

A small synthetic peptide that signals the skin to produce more collagen. It has been clinically tested and proven to reduce skin roughness and the appearance of wrinkles.

Pinus Strobus Bark Extract
Est. %0.3
Function
Origin
Pinus Strobus Bark Extract
Hexapeptide-9
Est. %0.3
Function
Origin
Hexapeptide-9

Description is coming soon

Maltodextrin
Est. %0.3
Function
Origin
MaltodextrinA formula helper manufactured from starch. It has a sweet flavor and is often used in rinse-off products to support their foaming structure. Maltodextrin is also used to stabilize emulsions and to absorb and bind other ingredients in the formula.
Lavandula Angustifolia (Lavender) Oil
Est. %0.3
Function
Origin
Lavandula Angustifolia (Lavender) OilAn essential oil derived from common, or true, lavender. It is used in skincare for its lovely, calming scent. Like all essential oils, however, it may cause a contact skin allergy in more sensitive individuals.
Linalool
Est. %0.3
Function
Origin
LinaloolA fragrant, volatile compound naturally present in many essential oils. It has a pleasant scent and is often used in skincare products as a fragrance. People with sensitive skin should try to avoid it, or at least do a patch test before using it.