Uriage 1st CU-ZN+ Anti-Irritation Spray Review

Uriage 1st CU-ZN+ Anti-Irritation Spray
4.0
/ 10
Moisturizing
8.0 Humectancy icon Humectancy
0.0 Occlusivity icon Occlusivity
3Anti-wrinkle icon/ 10
Anti-wrinkle
Review

Does Uriage 1st CU-ZN+ Anti-Irritation Spray Work?

 
According to CreamScan AI's analysis of the ingredient list, here’s what Uriage 1st CU-ZN+ Anti-Irritation Spray has to offer:
 
Moderate moisturizing. It has a moisturizing rating of 4.0 out of 10.
✅ Modest anti-wrinkle efficacy: Uriage 1st CU-ZN+ Anti-Irritation Spray has an anti-wrinkle rating of 3.0 out of 10 so you may expect some, although limited, effect on wrinkles.

  

Key Benefits of Uriage 1st CU-ZN+ Anti-Irritation Spray

 
These are the key benefits you can expect from using Uriage 1st CU-ZN+ Anti-Irritation Spray:
 

🔵 Lightweight Purely Humectant Moisturizing, Ideal for Oily Skin

According to CreamScan analysis, Uriage 1st CU-ZN+ Anti-Irritation Spray is quite moisturizing, with a moisturizing rating of 4.0 out of 10.

Is it more humectant or occlusive? Purely humectant. It has zero occlusivity (we didn't find any occlusive ingredients on the ingredient list) and a very high humectancy of 8.0 out of 10, due to the high content of Glycerin (est. ≈6.0%) and Propanediol (est. ≈2.0%).

This humectant-rich product, when used alone as a moisturizer, is ideal for oily skin, providing significant hydration in a lightweight, fast-absorbing formula without any occlusive ingredients.

📌 Certain studies suggest that humectants alone may not effectively moisturize the skin. If you use this product as your only moisturizer, we recommend following it with one that contains at least some occlusive ingredients.

💧 A Humectant Boost for Any Skincare Routine

But it’s not limited to oily skin - such a humectant boost will also positively contribute to the moisturizing efficacy of any skincare routine when used as a step before applying the main moisturizer. This type of formulation is typically used in serums, where a light, fast-absorbing texture is key.

Please refer to the Ratings section below for details of the moisturizing rating calculation.

🟣 Modest Anti-Wrinkle Efficacy

According to CreamScan analysis, Uriage 1st CU-ZN+ Anti-Irritation Spray has a modest level of anti-wrinkle efficacy, rated 3.0 out of 10.

It contains one ingredient with proven anti-wrinkle efficacy: Asiaticoside (est. ≈0.3%),
 derived from the plant Centella asiatica, an ingredient with moderate anti-wrinkle efficacy, as confirmed by a single clinical study involving 27 participants (Lee et al.). This study demonstrated that a cream containing 0.1% asiaticoside reduced the average wrinkle depth by 8% after 12 weeks of use, compared to a vehicle (the same formulation without asiaticoside).
 
Among others, Uriage 1st CU-ZN+ Anti-Irritation Spray also contains Copper Gluconate, an ingredient often marketed as effective in reducing wrinkles. However, the studies supporting the anti-wrinkle claims of Copper Gluconate provide insufficient evidence of its efficacy according to CreamScan Research Evaluation Standards.
 
While this does not categorically rule out the possibility that Copper Gluconate may reduce wrinkles, its efficacy is not supported by convincing, vehicle-controlled, double-blind clinical studies - at least none that were available to the CreamScan team at the time of publication.
 
Therefore, this ingredient does not contribute to the anti-wrinkle rating.
 
📌 Moisturizers, when used regularly, are proven to prevent wrinkle formation and even reduce existing wrinkles. Therefore, this product, like any other moisturizer, can deliver some additional anti-wrinkle effects through its moisturizing action.
 

Please refer to the Ratings section below for details of the anti-wrinkle rating calculation.

📌 Please note that this is not a complete list of benefits. We are in the process of enhancing our AI model to incorporate anti-pigmentation, exfoliation and anti-acne ratings.

Things to Be Aware Of: Uriage 1st CU-ZN+ Anti-Irritation Spray

 
CreamScan AI identified a few things to consider before adding Uriage 1st CU-ZN+ Anti-Irritation Spray to your skincare routine:
 

⚠️ If It’s Your Only Moisturizer, It Needs to Be Paired with Some Occlusives

While humectants are highly effective at attracting water to the skin, studies (J. N. Kraft, C. W. Lynde) suggest they may not be efficient when used alone.

One major drawback of purely humectant moisturization is that the water attracted by humectants to the upper layers of the skin can evaporate completely into the environment through transepidermal water loss (TEWL). Adding occlusive ingredients helps seal this moisture into the skin and prevent further water loss.

If you’re using Uriage 1st CU-ZN+ Anti-Irritation Spray as your only moisturizer, consider pairing it with one that contains at least some occlusive ingredients, such as oils, butters, or silicones. These work alongside humectants to create a protective barrier, locking in hydration and ensuring longer-lasting moisturization. The amount of occlusive needed depends on your skin type - the drier the skin, the more occlusives it requires.

If this product is used not as a standalone moisturizer but as part of your skincare routine, such as a toner or serum, it should be applied before your main moisturizer (unless it's a sunscreen), which will provide the necessary occlusivity on top of it.

Pros & Cons of Uriage 1st CU-ZN+ Anti-Irritation Spray

 
Here’s an overview of the pros and cons of Uriage 1st CU-ZN+ Anti-Irritation Spray to help you decide if it’s the right choice for your skincare routine:
 

🟩 Pros:

✅ When used alone: Provides humectant-rich moisturizing ideal for oily skin
✅ As part of a routine: A humectant moisturizing boost, beneficial for any skin type
✅ Lightweight texture
Offers modest anti-wrinkle efficacy
 

⭕ Cons: 

⚠️ Only if used as a standalone moisturizer - it needs to be paired with occlusives to seal in humectants
   

Summary: Uriage 1st CU-ZN+ Anti-Irritation Spray

 
Based on the ingredient list analysis, CreamScan AI suggests that Uriage 1st CU-ZN+ Anti-Irritation Spray
, when used alone, delivers lightweight, humectant-rich moisturizing, making it ideal for oily skin. As part of a moisturizing routine, it provides a humectant boost, beneficial for all skin types.
 
Uriage 1st CU-ZN+ Anti-Irritation Spray contains ingredients with proven evidence of anti-wrinkle efficacy that may provide a modest anti-wrinkle effect. As a result, you can expect a positive, though not very significant, impact on wrinkles.
 
That said, there are some things about Uriage 1st CU-ZN+ Anti-Irritation Spray worth noting.
 
Looking at its moisturizing profile, we found that it doesn’t contain any occlusive ingredients, potentially allowing the moisture attracted to the skin by humectants to evaporate. Therefore, if it’s used as the only moisturizer in a routine, it’s recommended to pair it with one that contains at least some occlusive ingredients, such as oils, butters, or silicones.
 
📌 Fact check. At CreamScan, we are committed to accuracy and fairness. If you spot any errors or something that doesn’t seem right, please click here to let us know. We regularly update the ingredient lists and monitor the latest research on ingredient efficacy to ensure that our information remains as complete and precise as possible. The information provided here is for informational purposes only and does not substitute professional advice. We do not guarantee the efficacy or safety of any product, as individual results may vary.

 

Ingredients

Est. % Ingredient Origin Functions
80
6
4
3
2
1.5
1.3
1
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Est. %
Water
Function:
Origin:
Glycerin
Function:
Origin:
1,2-Hexanediol
Function:
Origin:
Bentonite
Function:
Origin:
Propanediol
Function:
Origin:
Xanthan Gum
Function:
Origin:
Copper Gluconate
Function:
Origin:
Sodium Dextran Sulfate
Function:
Origin:
Manganese Gluconate
Function:
Origin:
Zinc Gluconate
Function:
Origin:
Phytosphingosine
Function:
Origin:
Asiaticoside
Function:
Origin:
Leontopodium Alpinum Flower/Leaf Extract
Function:
Origin:
Citric Acid
Function:
Origin:
Sodium Hydroxide
Function:
Origin:

Ratings

All humectants
8.0
6
2
Benchmark
10
All occlusives
0.0
None
Benchmark
20
Moisturizing rating
4.0
Ingredient Est. % Benchmark Raiting
Humectancy All humectants 8 10
8.0
6
2
Occlusivity All occlusives 0.0 20
0.0
None
Moisturizing rating
4.0
Ingredient Est. % Benchmark Humectancy
6
2
All humectants 8 10
8
All humectants
8.0
6
2
Benchmark
10
Ingredient Est. % Benchmark Occlusivity
None
All occlusives 0.0 20
0.0
All occlusives
0.0
None
Benchmark
20
Ingredient
Ingredient anti-wrinkle power
when present at, %
in this formula est. %
Rating
3 /10 0.1 0.3 3
n/a
- 1.3 -
Total
3
Asiaticoside
3
Ingredient anti-wrinkle power
3 /10
when present at, %
0.1
in this formula, est. %
0.3
Copper Gluconate
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
1.3
Anti-wrinkle rating
3
Ingredient Est. % Benchmark
Rich in Antioxidants
0.3
0.3
All antioxidants 0.6 3 No
All antioxidants
0.6
Asiaticoside
0.3
Manganese Gluconate
0.3
Benchmark
3
Ingredient Est. % Benchmark
Rich in Soothing
1.3
0.3
0.3
All soothing 1.9 5 No
All soothing
1.9
1.3
0.3
0.3
Benchmark
5

Ingredients explained

Water
Est. %80
Function
Origin
WaterThe most used ingredient in skincare. Its concentration defines the product texture: rich creams may have about 50% of water while a light jelly about 90%. Water doesn’t moisturize the skin by itself and is used in skincare as a solvent for other ingredients.
Glycerin
Est. %6
Function
Origin
Glycerin

The most popular moisturizing ingredient in the world. It is a powerful humectant – cheap yet very effective.

1,2-Hexanediol
Est. %4
Function
Origin
1,2-HexanediolA multi-functional formula helper. It is a well-studied preservtive against bacteria and can help pigments and fragrances disperse evenly in a formula.
Bentonite
Est. %3
Function
Origin
BentoniteA naturally occurring material that has a variety of functions. It is used as absorbent, since the bentonite can absorb oils produced by the skin and prevent a greasy appearance. It is also a great opacifier.
Propanediol
Est. %2
Function
Origin
PropanediolAn excellent solvent capable of mixing water with normally water-insoluble ingredients. It also functions as a humectant due to its water-loving alcohol groups. Propanediol can control the viscosity of a product by reducing its thickness.
Xanthan Gum
Est. %1.5
Function
Origin
Xanthan GumA natural multi-functional ingredient that originates from fermented sugars. Xanthan gum acts as a viscosity-building agent to thicken skincare products. It is also an excellent stabilizer and works well to hold other ingredients together.
Copper Gluconate
Est. %1.3
Function
Origin
Copper GluconateAn organic salt of copper that can aid in the wound healing process. The manufacturer claims it also has soothing and anti-inflammatory properties, although this has yet to be confirmed. Copper gluconate is also a perspective anti-wrinkle ingredient.
Sodium Dextran Sulfate
Est. %1
Function
Origin
Sodium Dextran Sulfate
Manganese Gluconate
Est. %0.3
Function
Origin
Manganese Gluconate
Zinc Gluconate
Est. %0.3
Function
Origin
Zinc GluconateOne of the most commonly used ingredients in anti-acne products. It is an organic salt of zinc that helps to combat microbial infections, soothes and heals inflamed pimples, and regulates hormones in the skin.
Phytosphingosine
Est. %0.3
Function
Origin
PhytosphingosineA key component of ceramides NP, AP, and EOP. It has barrier repair properties and stimulates the production of the skin’s Natural Moisturizing Factor. Phytosphingosine has strong antimicrobial and anti-inflammatory activity, which can be used to treat acne.
Asiaticoside
Est. %0.3
Function
Origin
Asiaticoside

A Gotu Kola or Centella Asiatica derivative with confirmed anti-wrinkle efficacy.

Leontopodium Alpinum Flower/Leaf Extract
Est. %0.3
Function
Origin
Leontopodium Alpinum Flower/Leaf Extract
Citric Acid
Est. %0.3
Function
Origin
Citric AcidA gently exfoliating AHA that helps to remove the top layer of dead skin cells. In comparison to other AHAs, citric acid has been shown to be one of the least effective. It is also very commonly used as a stabilizing and pH-controlling agent.
Sodium Hydroxide
Est. %0.3
Function
Origin
Sodium Hydroxide

An ingredient that is able to bring the pH of a product up, thereby making it less harsh on the skin.