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Full Ingredient List (INCI):
According to CreamScan analysis, Plexaderm Rapid Reduction Serum is lightly moisturizing, with a moisturizing rating of 3.4 out of 10.
Is it more humectant or occlusive? Purely humectant. It has zero occlusivity (we didn't find any occlusive ingredients on the ingredient list) and a high humectancy of 6.9 out of 10, primarily due to the high content of Propylene Glycol (est. ≈6.0%).
This humectant-rich product, when used alone as a moisturizer, is well-suited for oily skin, providing moderate hydration in a lightweight, fast-absorbing formula without any occlusive ingredients.
📌 Certain studies suggest that humectants alone may not effectively moisturize the skin. If you use this product as your only moisturizer, we recommend following it with one that contains at least some occlusive ingredients.
But it’s not limited to oily skin - such a humectant enhancement will also positively contribute to the moisturizing efficacy of any skincare routine when used as a step before applying the main moisturizer. This type of formulation is typically used in serums, where a light, fast-absorbing texture is key.
Please refer to the Ratings section below for details of the moisturizing rating calculation.
📌 Please note that this is not a complete list of benefits. We are in the process of enhancing our model to incorporate anti-pigmentation, exfoliation and anti-acne ratings.
While humectants are highly effective at attracting water to the skin, studies (J. N. Kraft, C. W. Lynde) suggest they may not be efficient when used alone.
One major drawback of purely humectant moisturization is that the water attracted by humectants to the upper layers of the skin can evaporate completely into the environment through transepidermal water loss (TEWL). Adding occlusive ingredients helps seal this moisture into the skin and prevent further water loss.
If you’re using Plexaderm Rapid Reduction Serum as your only moisturizer, consider pairing it with one that contains at least some occlusive ingredients, such as oils, butters, or silicones. These work alongside humectants to create a protective barrier, locking in hydration and ensuring longer-lasting moisturization. The amount of occlusive needed depends on your skin type - the drier the skin, the more occlusives it requires.
If this product is used not as a standalone moisturizer but as part of your skincare routine, such as a toner or serum, it should be applied before your main moisturizer (unless it's a sunscreen), which will provide the necessary occlusivity on top of it.
If one of your main reasons for choosing Plexaderm Rapid Reduction Serum is its potential anti-aging effects, please note that, according to CreamScan analysis, it currently has a zero anti-wrinkle rating.
It contains Acetyl Hexapeptide-8, an ingredient often marketed as effective in reducing wrinkles. However, the studies supporting the anti-wrinkle claims of Acetyl Hexapeptide-8 provide insufficient evidence of its efficacy according to CreamScan Research Evaluation Standards.
While this does not categorically rule out the possibility that Acetyl Hexapeptide-8 may reduce wrinkles, its efficacy is not supported by convincing, vehicle-controlled, double-blind clinical studies - at least none that were available to the CreamScan team at the time of publication.
Therefore, this ingredient does not generate the anti-wrinkle rating.
📌 Moisturizers, when used regularly, are proven to prevent wrinkle formation and even reduce existing wrinkles. Therefore, this product, like any other moisturizer, can deliver some anti-wrinkle effects through its moisturizing action.
Please refer to the Ratings section below for details of the anti-wrinkle rating calculation.
Est. %
The Estimated % is our algorithm-based assumption about an ingredient's concentration in a formula. Learn more The Estimated % is our algorithm-based assumption about an ingredient's concentration in a formula. Learn more | Ingredient | Origin | Functions | |
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85 | Water ![]() The most used ingredient in skincare. Its concentration defines the product texture: rich creams may have about 50% of water while a light jelly about 90%. Water doesn’t moisturize the skin by itself and is used in skincare as a solvent for other ingredients. Water ![]() The most used ingredient in skincare. Its concentration defines the product texture: rich creams may have about 50% of water while a light jelly about 90%. Water doesn’t moisturize the skin by itself and is used in skincare as a solvent for other ingredients. | Naturally occurring These are ingredients initially present in nature, such as elements (Zinc, Gold, or Silver), minerals, or water. Naturally occurring These are ingredients initially present in nature, such as elements (Zinc, Gold, or Silver), minerals, or water. | Formula helper
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6 | Propylene Glycol ![]() A clear, thick, odorless liquid of synthetic origin. Its main function is to stabilize cosmetic products exposed to varying temperatures. It is also a moderately strong humectant with similar properties to glycerin. Propylene Glycol ![]() A clear, thick, odorless liquid of synthetic origin. Its main function is to stabilize cosmetic products exposed to varying temperatures. It is also a moderately strong humectant with similar properties to glycerin. | Botanical Ingredients derived from plants, mosses, and lichens: extracts, oils, powders, juices and other types of processed plant materials. Botanical Ingredients derived from plants, mosses, and lichens: extracts, oils, powders, juices and other types of processed plant materials. Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure. Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure. | Moisturizing (Humectant) Humectants are moisturizing ingredients that draw moisture to the skin, either from deeper layers or from the environment (when it's humid). Moisturizing (Humectant) Humectants are moisturizing ingredients that draw moisture to the skin, either from deeper layers or from the environment (when it's humid). Fragrance Fragrance ingredients add scent to a product or hide ('mask') the undesired aroma of other ingredients. Fragrance Fragrance ingredients add scent to a product or hide ('mask') the undesired aroma of other ingredients. Formula helper
Formula helper
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4 | | Naturally occurring These are ingredients initially present in nature, such as elements (Zinc, Gold, or Silver), minerals, or water. Naturally occurring These are ingredients initially present in nature, such as elements (Zinc, Gold, or Silver), minerals, or water. | Formula helper
Formula helper
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3 | Magnesium Aluminum Silicate ![]() A naturally occurring clay that is hygroscopic, which means that it easily absorbs water. This ingredient is thus commonly used as an absorbent and emulsion stabilizer. It also modifies slip by improving the spreadability of the products it is used in. Magnesium Aluminum Silicate ![]() A naturally occurring clay that is hygroscopic, which means that it easily absorbs water. This ingredient is thus commonly used as an absorbent and emulsion stabilizer. It also modifies slip by improving the spreadability of the products it is used in. | Naturally occurring These are ingredients initially present in nature, such as elements (Zinc, Gold, or Silver), minerals, or water. Naturally occurring These are ingredients initially present in nature, such as elements (Zinc, Gold, or Silver), minerals, or water. | Formula helper
Formula helper
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0.3 | Acetyl Hexapeptide-8 ![]() A small synthetic peptide that is thought to act similarly to Botox by calming contractions of the facial muscles and reducing expression wrinkles. The effect is only temporary and it does not improve the skin structure in any way. Acetyl Hexapeptide-8 ![]() A small synthetic peptide that is thought to act similarly to Botox by calming contractions of the facial muscles and reducing expression wrinkles. The effect is only temporary and it does not improve the skin structure in any way. | Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure. Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure. | Moisturizing (Humectant) Humectants are moisturizing ingredients that draw moisture to the skin, either from deeper layers or from the environment (when it's humid). Moisturizing (Humectant) Humectants are moisturizing ingredients that draw moisture to the skin, either from deeper layers or from the environment (when it's humid). Anti-Wrinkle Anti-wrinkle ingredients prevent the formation or reduce the appearance of wrinkles. Anti-Wrinkle Anti-wrinkle ingredients prevent the formation or reduce the appearance of wrinkles. | |
0.3 | Hydrolyzed Rice Protein ![]() A protein derived from rice bran with film-forming abilities. It can help increase moisturization in skin. Hydrolyzed Rice Protein ![]() A protein derived from rice bran with film-forming abilities. It can help increase moisturization in skin. | Botanical Ingredients derived from plants, mosses, and lichens: extracts, oils, powders, juices and other types of processed plant materials. Botanical Ingredients derived from plants, mosses, and lichens: extracts, oils, powders, juices and other types of processed plant materials. | Formula helper
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0.3 | Soluble Collagen ![]() A protein obtained from farm or marine animals. Collagen molecules are too big to penetrate the skin so when they are applied via a skincare product they sit on top of the skin and act as humectant moisturizers. Soluble Collagen ![]() A protein obtained from farm or marine animals. Collagen molecules are too big to penetrate the skin so when they are applied via a skincare product they sit on top of the skin and act as humectant moisturizers. | Animal Ingredients derived from animals (including birds, fish, crustaceans, mollusks, and insects) or produced by animals (e.g. dairy- and egg-derived ingredients, bee products, silk, pearls, etc.) Animal Ingredients derived from animals (including birds, fish, crustaceans, mollusks, and insects) or produced by animals (e.g. dairy- and egg-derived ingredients, bee products, silk, pearls, etc.) | Moisturizing (Humectant) Humectants are moisturizing ingredients that draw moisture to the skin, either from deeper layers or from the environment (when it's humid). Moisturizing (Humectant) Humectants are moisturizing ingredients that draw moisture to the skin, either from deeper layers or from the environment (when it's humid). Formula helper
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0.3 | Cellulose Gum ![]() A polymer that is derived from its namesake, cellulose, which is plant-based. It has many formula-helper benefits, including thickening and product stabilization. Cellulose Gum ![]() A polymer that is derived from its namesake, cellulose, which is plant-based. It has many formula-helper benefits, including thickening and product stabilization. | Botanical Ingredients derived from plants, mosses, and lichens: extracts, oils, powders, juices and other types of processed plant materials. Botanical Ingredients derived from plants, mosses, and lichens: extracts, oils, powders, juices and other types of processed plant materials. | Fragrance Fragrance ingredients add scent to a product or hide ('mask') the undesired aroma of other ingredients. Fragrance Fragrance ingredients add scent to a product or hide ('mask') the undesired aroma of other ingredients. Formula helper
Formula helper
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0.3 | Xanthan Gum ![]() A natural multi-functional ingredient that originates from fermented sugars. Xanthan gum acts as a viscosity-building agent to thicken skincare products. It is also an excellent stabilizer and works well to hold other ingredients together. Xanthan Gum ![]() A natural multi-functional ingredient that originates from fermented sugars. Xanthan gum acts as a viscosity-building agent to thicken skincare products. It is also an excellent stabilizer and works well to hold other ingredients together. | Botanical Ingredients derived from plants, mosses, and lichens: extracts, oils, powders, juices and other types of processed plant materials. Botanical Ingredients derived from plants, mosses, and lichens: extracts, oils, powders, juices and other types of processed plant materials. Biotech The biotech origin of the ingredient implies that it was made in a lab using cultured microorganisms (bacteria or fungi) and a substrate (e.g. through the fermentation process), and then extracted and/or purified. Biotech The biotech origin of the ingredient implies that it was made in a lab using cultured microorganisms (bacteria or fungi) and a substrate (e.g. through the fermentation process), and then extracted and/or purified. | Formula helper
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0.3 | Titanium Dioxide (CI 77891) ![]() One of two the most commonly used mineral sunscreens. It can absorb UV light, including UVB – which causes burning, tanning, and even skin cancer. Also used as a colorant, titanium dioxide gives a product a bright white color. Titanium Dioxide (CI 77891) ![]() One of two the most commonly used mineral sunscreens. It can absorb UV light, including UVB – which causes burning, tanning, and even skin cancer. Also used as a colorant, titanium dioxide gives a product a bright white color. | Naturally occurring These are ingredients initially present in nature, such as elements (Zinc, Gold, or Silver), minerals, or water. Naturally occurring These are ingredients initially present in nature, such as elements (Zinc, Gold, or Silver), minerals, or water. | Sunscreen Sunscreens protect the skin from harmful ultraviolet (UV) radiation by absorbing or reflecting UV light. Sunscreen Sunscreens protect the skin from harmful ultraviolet (UV) radiation by absorbing or reflecting UV light. Colorant Colorants give color to skincare products. Colorant Colorants give color to skincare products. Formula helper
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0.3 | Iron Oxides (CI 77491) ![]() A red colorant also known as red iron oxide. This is an EU-approved colorant used in a wide variety of products. Iron Oxides (CI 77491) ![]() A red colorant also known as red iron oxide. This is an EU-approved colorant used in a wide variety of products. | Naturally occurring These are ingredients initially present in nature, such as elements (Zinc, Gold, or Silver), minerals, or water. Naturally occurring These are ingredients initially present in nature, such as elements (Zinc, Gold, or Silver), minerals, or water. Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure. Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure. | Colorant Colorants give color to skincare products. Colorant Colorants give color to skincare products. | |
0.3 | Iron Oxides (CI 77492) ![]() Also known as iron (III) oxide, this ingredient is a yellow-colored pigment that can either be derived from minerals or produced synthetically. It adds yellow tones to cosmetic products. Iron Oxides (CI 77492) ![]() Also known as iron (III) oxide, this ingredient is a yellow-colored pigment that can either be derived from minerals or produced synthetically. It adds yellow tones to cosmetic products. | Naturally occurring These are ingredients initially present in nature, such as elements (Zinc, Gold, or Silver), minerals, or water. Naturally occurring These are ingredients initially present in nature, such as elements (Zinc, Gold, or Silver), minerals, or water. Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure. Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure. | Colorant Colorants give color to skincare products. Colorant Colorants give color to skincare products. | |
0.3 | Phenoxyethanol ![]() The most frequently used preservative in skincare. It is a clear, oil-like liquid synthetic substance that protects products from harmful bacteria and yeast, whilst still leaving skin microflora unharmed. It is confirmed by research to be harmless. Phenoxyethanol ![]() The most frequently used preservative in skincare. It is a clear, oil-like liquid synthetic substance that protects products from harmful bacteria and yeast, whilst still leaving skin microflora unharmed. It is confirmed by research to be harmless. | Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure. Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure. | Antimicrobial Antimicrobials prevent the growth of harmful microorganisms on the skin. Antimicrobial Antimicrobials prevent the growth of harmful microorganisms on the skin. Preservative Preservatives prevent the growth of bacteria and fungi in a product. Preservative Preservatives prevent the growth of bacteria and fungi in a product. | |
0.3 | Ethylhexylglycerin ![]() A preservative booster derived from glycerin. It is commonly paired with other preservatives to improve their efficacy. Ethylhexylglycerin is also a humectant due to its chemical base of glycerin. Ethylhexylglycerin ![]() A preservative booster derived from glycerin. It is commonly paired with other preservatives to improve their efficacy. Ethylhexylglycerin is also a humectant due to its chemical base of glycerin. | Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure. Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure. | Moisturizing (Humectant) Humectants are moisturizing ingredients that draw moisture to the skin, either from deeper layers or from the environment (when it's humid). Moisturizing (Humectant) Humectants are moisturizing ingredients that draw moisture to the skin, either from deeper layers or from the environment (when it's humid). Preservative Preservatives prevent the growth of bacteria and fungi in a product. Preservative Preservatives prevent the growth of bacteria and fungi in a product. | |
85 ![]() Water Function: Formula helper Formula helper
Formula helper Formula helper
Origin: Naturally occurring Naturally occurring These are ingredients initially present in nature, such as elements (Zinc, Gold, or Silver), minerals, or water. Naturally occurring Naturally occurring These are ingredients initially present in nature, such as elements (Zinc, Gold, or Silver), minerals, or water. |
6 ![]() Propylene Glycol Function: Moisturizing (Humectant), Moisturizing (Humectant) Humectants are moisturizing ingredients that draw moisture to the skin, either from deeper layers or from the environment (when it's humid). Moisturizing (Humectant), Moisturizing (Humectant) Humectants are moisturizing ingredients that draw moisture to the skin, either from deeper layers or from the environment (when it's humid). Fragrance, Fragrance Fragrance ingredients add scent to a product or hide ('mask') the undesired aroma of other ingredients. Fragrance, Fragrance Fragrance ingredients add scent to a product or hide ('mask') the undesired aroma of other ingredients. Formula helper Formula helper
Formula helper Formula helper
Origin: Botanical, Botanical Ingredients derived from plants, mosses, and lichens: extracts, oils, powders, juices and other types of processed plant materials. Botanical, Botanical Ingredients derived from plants, mosses, and lichens: extracts, oils, powders, juices and other types of processed plant materials. Synthetic Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure. Synthetic Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure. |
4 ![]() Sodium Silicate Function: Formula helper Formula helper
Formula helper Formula helper
Origin: Naturally occurring Naturally occurring These are ingredients initially present in nature, such as elements (Zinc, Gold, or Silver), minerals, or water. Naturally occurring Naturally occurring These are ingredients initially present in nature, such as elements (Zinc, Gold, or Silver), minerals, or water. |
3 ![]() Magnesium Aluminum Silicate Function: Formula helper Formula helper
Formula helper Formula helper
Origin: Naturally occurring Naturally occurring These are ingredients initially present in nature, such as elements (Zinc, Gold, or Silver), minerals, or water. Naturally occurring Naturally occurring These are ingredients initially present in nature, such as elements (Zinc, Gold, or Silver), minerals, or water. |
0.3 ![]() Acetyl Hexapeptide-8 Function: Moisturizing (Humectant), Moisturizing (Humectant) Humectants are moisturizing ingredients that draw moisture to the skin, either from deeper layers or from the environment (when it's humid). Moisturizing (Humectant), Moisturizing (Humectant) Humectants are moisturizing ingredients that draw moisture to the skin, either from deeper layers or from the environment (when it's humid). Anti-Wrinkle Anti-Wrinkle Anti-wrinkle ingredients prevent the formation or reduce the appearance of wrinkles. Anti-Wrinkle Anti-Wrinkle Anti-wrinkle ingredients prevent the formation or reduce the appearance of wrinkles. Origin: Synthetic Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure. Synthetic Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure. |
0.3 ![]() Hydrolyzed Rice Protein Function: Formula helper Formula helper
Formula helper Formula helper
Origin: Botanical Botanical Ingredients derived from plants, mosses, and lichens: extracts, oils, powders, juices and other types of processed plant materials. Botanical Botanical Ingredients derived from plants, mosses, and lichens: extracts, oils, powders, juices and other types of processed plant materials. |
0.3 ![]() Soluble Collagen Function: Moisturizing (Humectant), Moisturizing (Humectant) Humectants are moisturizing ingredients that draw moisture to the skin, either from deeper layers or from the environment (when it's humid). Moisturizing (Humectant), Moisturizing (Humectant) Humectants are moisturizing ingredients that draw moisture to the skin, either from deeper layers or from the environment (when it's humid). Formula helper Formula helper
Formula helper Formula helper
Origin: Animal Animal Ingredients derived from animals (including birds, fish, crustaceans, mollusks, and insects) or produced by animals (e.g. dairy- and egg-derived ingredients, bee products, silk, pearls, etc.) Animal Animal Ingredients derived from animals (including birds, fish, crustaceans, mollusks, and insects) or produced by animals (e.g. dairy- and egg-derived ingredients, bee products, silk, pearls, etc.) |
0.3 ![]() Cellulose Gum Function: Fragrance, Fragrance Fragrance ingredients add scent to a product or hide ('mask') the undesired aroma of other ingredients. Fragrance, Fragrance Fragrance ingredients add scent to a product or hide ('mask') the undesired aroma of other ingredients. Formula helper Formula helper
Formula helper Formula helper
Origin: Botanical Botanical Ingredients derived from plants, mosses, and lichens: extracts, oils, powders, juices and other types of processed plant materials. Botanical Botanical Ingredients derived from plants, mosses, and lichens: extracts, oils, powders, juices and other types of processed plant materials. |
0.3 ![]() Xanthan Gum Function: Formula helper Formula helper
Formula helper Formula helper
Origin: Botanical, Botanical Ingredients derived from plants, mosses, and lichens: extracts, oils, powders, juices and other types of processed plant materials. Botanical, Botanical Ingredients derived from plants, mosses, and lichens: extracts, oils, powders, juices and other types of processed plant materials. Biotech Biotech The biotech origin of the ingredient implies that it was made in a lab using cultured microorganisms (bacteria or fungi) and a substrate (e.g. through the fermentation process), and then extracted and/or purified. Biotech Biotech The biotech origin of the ingredient implies that it was made in a lab using cultured microorganisms (bacteria or fungi) and a substrate (e.g. through the fermentation process), and then extracted and/or purified. |
0.3 ![]() Titanium Dioxide (CI 77891) Function: Sunscreen, Sunscreen Sunscreens protect the skin from harmful ultraviolet (UV) radiation by absorbing or reflecting UV light. Sunscreen, Sunscreen Sunscreens protect the skin from harmful ultraviolet (UV) radiation by absorbing or reflecting UV light. Colorant, Colorant Colorants give color to skincare products. Colorant, Colorant Colorants give color to skincare products. Formula helper Formula helper
Formula helper Formula helper
Origin: Naturally occurring Naturally occurring These are ingredients initially present in nature, such as elements (Zinc, Gold, or Silver), minerals, or water. Naturally occurring Naturally occurring These are ingredients initially present in nature, such as elements (Zinc, Gold, or Silver), minerals, or water. |
0.3 ![]() Iron Oxides (CI 77491) Function: Colorant Colorant Colorants give color to skincare products. Colorant Colorant Colorants give color to skincare products. Origin: Naturally occurring, Naturally occurring These are ingredients initially present in nature, such as elements (Zinc, Gold, or Silver), minerals, or water. Naturally occurring, Naturally occurring These are ingredients initially present in nature, such as elements (Zinc, Gold, or Silver), minerals, or water. Synthetic Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure. Synthetic Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure. |
0.3 ![]() Iron Oxides (CI 77492) Function: Colorant Colorant Colorants give color to skincare products. Colorant Colorant Colorants give color to skincare products. Origin: Naturally occurring, Naturally occurring These are ingredients initially present in nature, such as elements (Zinc, Gold, or Silver), minerals, or water. Naturally occurring, Naturally occurring These are ingredients initially present in nature, such as elements (Zinc, Gold, or Silver), minerals, or water. Synthetic Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure. Synthetic Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure. |
0.3 ![]() Phenoxyethanol Function: Antimicrobial, Antimicrobial Antimicrobials prevent the growth of harmful microorganisms on the skin. Antimicrobial, Antimicrobial Antimicrobials prevent the growth of harmful microorganisms on the skin. Preservative Preservative Preservatives prevent the growth of bacteria and fungi in a product. Preservative Preservative Preservatives prevent the growth of bacteria and fungi in a product. Origin: Synthetic Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure. Synthetic Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure. |
0.3 ![]() Ethylhexylglycerin Function: Moisturizing (Humectant), Moisturizing (Humectant) Humectants are moisturizing ingredients that draw moisture to the skin, either from deeper layers or from the environment (when it's humid). Moisturizing (Humectant), Moisturizing (Humectant) Humectants are moisturizing ingredients that draw moisture to the skin, either from deeper layers or from the environment (when it's humid). Preservative Preservative Preservatives prevent the growth of bacteria and fungi in a product. Preservative Preservative Preservatives prevent the growth of bacteria and fungi in a product. Origin: Synthetic Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure. Synthetic Synthetic All kinds of ingredients formulated or produced by a chemical process, or those that have a chemical modification in their structure. |