Nature Republic Hyathenol Hydra Ampoule

Nature Republic Hyathenol Hydra Ampoule
5.0
/ 10
Moisturizing
10.0 Humectancy icon Humectancy
0.0 Occlusivity icon Occlusivity
3Anti-wrinkle icon/ 10
Anti-wrinkle
Rich
in Antioxidants

Review

Does Nature Republic Hyathenol Hydra Ampoule work?

Based on the ingredient list analysis by CreamScan AI, these are the key benefits you can expect from using Nature Republic Hyathenol Hydra Ampoule:

  • Strong humectant moisturizing. This lightweight, humectant-rich product, ideal for oily skin, has a moisturizing rating of 5.0 out of 10.
  • Some anti-wrinkle efficacy: Nature Republic Hyathenol Hydra Ampoule has an anti-wrinkle rating of 3.0 out of 10 so you may expect some, although limited, effect on wrinkles.
  • Antioxidant protection.

Lightweight moisturizer ideal for oily skin and a humectant boost for any skincare routine

According to CreamScan analysis, Nature Republic Hyathenol Hydra Ampoule is quite moisturizing, with a moisturizing rating of 5.0 out of 10.

Is it more humectant or occlusive? It is purely humectant. It has zero occlusivity (we didn't find any occlusive ingredients on the ingredient list) and a maximum humectancy of 10 out of 10, primarily due to the high content of Butylene Glycol (est. ≈6.0%), Methylpropanediol (est. ≈3.0%) and Niacinamide (est. ≈2.0%).

This humectant-rich product, when used alone as a moisturizer, is ideal for oily skin, providing significant hydration in a lightweight, fast-absorbing formula without any occlusive ingredients.

Tip: Certain studies suggest that humectants alone may not effectively moisturize the skin. If you use this product as your only moisturizer, we recommend following it with one that contains at least some occlusive ingredients.

But it’s not limited to oily skin - such a humectant boost will also positively contribute to the moisturizing efficacy of any skincare routine when used as a step before applying the main moisturizer. This type of formulation is typically used in serums, where a light, fast-absorbing texture is key.

Please refer to the Ratings section below for details of the moisturizing rating calculation.

Some anti-wrinkle efficacy

According to CreamScan analysis, Nature Republic Hyathenol Hydra Ampoule has a slight anti-wrinkle rating of 3.0 out of 10.

It contains one ingredient with proven anti-wrinkle efficacy: Niacinamide (est. ≈2.0%), 
 one of the most effective and well-researched anti-wrinkle ingredients. A clinical study involving 30 participants (Kawada et al.) confirmed that a cream with 4% niacinamide reduced the average depth of wrinkles around the eyes by 9% after 8 weeks of use, compared to a vehicle (the same formulation without niacinamide).
 
Among others, Nature Republic Hyathenol Hydra Ampoule also contains Adenosine, an ingredient often marketed as effective in reducing wrinkles. However, the studies supporting the anti-wrinkle claims of Adenosine provide insufficient evidence of its efficacy according to CreamScan Research Evaluation Standards. Therefore, this ingredient does not contribute to the anti-wrinkle rating.
 
Moisturizers, when used regularly, are proven to prevent wrinkle formation and even reduce existing wrinkles. Therefore, this product, like any other moisturizer, can deliver some anti-wrinkle effects through its moisturizing action.
 

Please refer to the Ratings section below for details of the anti-wrinkle rating calculation.

Rich in skin-protecting antioxidants

We estimate that Nature Republic Hyathenol Hydra Ampoule is rich (> 3%) in antioxidants, specifically Niacinamide (est. ≈2.0%).

A key benefit of antioxidants is their ability to reduce oxidative stress caused by free radicals and therefore prevent accelerated skin aging. Studies also show that antioxidants can protect against environmental damage such as UV radiation and pollution, and help reduce inflammation and skin redness.

Ingredients

Est. % Ingredient Origin Functions
75
6
4
3
2
1.5
1.3
1
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Est. %
Water
Function:
Origin:
Butylene Glycol
Function:
Origin:
1,2-Hexanediol
Function:
Origin:
Methylpropanediol
Function:
Origin:
Niacinamide
Function:
Origin:
Sodium Hyaluronate
Function:
Origin:
Hibiscus Esculentus Fruit Extract
Function:
Origin:
Tamarindus Indica Seed Extract
Function:
Origin:
Panthenol
Function:
Origin:
Carbomer
Function:
Origin:
Tromethamine
Function:
Origin:
Chamomilla Recutita (Matricaria) Flower Extract
Function:
Origin:
Hydrogenated Lecithin
Function:
Origin:
Ethylhexylglycerin
Function:
Origin:
Adenosine
Function:
Origin:
Disodium EDTA
Function:
Origin:
Betaine
Function:
Origin:
Raffinose
Function:
Origin:
Hydrolyzed Vegetable Protein
Function:
Origin:
Maltodextrin
Function:
Origin:
Sodium Acetate
Function:
Origin:
Dipeptide-2
Function:
Origin:

Ratings

All humectants
14.4
6
3
2
1.5
1
0.3
0.3
0.3
Benchmark
10
All occlusives
0.0
None
Benchmark
20
Moisturizing rating
5.0
Ingredient Est. % Benchmark Raiting
Humectancy All humectants 14.4 10
10.0
6
3
2
1.5
1
0.3
0.3
0.3
Occlusivity All occlusives 0.0 20
0.0
None
Moisturizing rating
5.0
Ingredient Est. % Benchmark Humectancy
6
3
2
1.5
1
0.3
0.3
0.3
All humectants 14.4 10
10
All humectants
14.4
6
3
2
1.5
1
0.3
0.3
0.3
Benchmark
10
Ingredient Est. % Benchmark Occlusivity
None
All occlusives 0.0 20
0.0
All occlusives
0.0
None
Benchmark
20
Ingredient
Ingredient anti-wrinkle power
when present at, %
in this formula est. %
Rating
6 /10 4 2 3
n/a
- 0.3 -
Total
3
Niacinamide
3
Ingredient anti-wrinkle power
6 /10
when present at, %
4
in this formula, est. %
2
Adenosine
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Anti-wrinkle rating
3
Ingredient Est. % Benchmark
Rich in Antioxidants
2
1.5
0.3
All antioxidants 3.8 3 Rich in antioxidants
All antioxidants
3.8
Niacinamide
2
Sodium Hyaluronate
1.5
Chamomilla Recutita (Matricaria) Flower Extract
0.3
Benchmark
3
Ingredient Est. % Benchmark
Rich in Soothing
2
0.3
0.3
0.3
All soothing 2.9 5 No
All soothing
2.9
2
0.3
0.3
0.3
Benchmark
5

Ingredients explained

Water
Est. %75
Function
Origin
WaterThe most used ingredient in skincare. Its concentration defines the product texture: rich creams may have about 50% of water while a light jelly about 90%. Water doesn’t moisturize the skin by itself and is used in skincare as a solvent for other ingredients.
Butylene Glycol
Est. %6
Function
Origin
Butylene Glycol

A clear, colorless liquid humectant that draws moisture to the skin. The humectancy of butylene glycol, owed to its two hydroxyl groups, is quite considerable, although not as powerful as glycerin, which contains three hydroxyl groups.

1,2-Hexanediol
Est. %4
Function
Origin
1,2-HexanediolA multi-functional formula helper. It is a well-studied preservtive against bacteria and can help pigments and fragrances disperse evenly in a formula.
Methylpropanediol
Est. %3
Function
Origin
MethylpropanediolMethylpropanediol is a unique glycol that contains two primary hydroxyl groups. That makes methylpropanediol a powerful humectant and an excellent solvent.
Niacinamide
Est. %2
Function
Origin
Niacinamide

Also known as vitamin B3, this ingredient is a true superstar with confirmed moisturizing, anti-acne, hyperpigmentation, and antioxidant benefits. Two studies confirm its significant anti-wrinkle efficacy.

Sodium Hyaluronate
Est. %1.5
Function
Origin
Sodium Hyaluronate

A sodium salt of famous hyaluronic acid. A potent humectant that hydrates the skin, supports collagen function, and fills out small wrinkles. Sodium hyaluronate also offers soothing and antioxidant properties.

Hibiscus Esculentus Fruit Extract
Est. %1.3
Function
Origin
Hibiscus Esculentus Fruit Extract
Tamarindus Indica Seed Extract
Est. %1
Function
Origin
Tamarindus Indica Seed Extract
Panthenol
Est. %0.3
Function
Origin
PanthenolA popular soothing and moisturizing derivative of vitamin B5. Panthenol is particularly beneficial for dry, flaking, burned, or damaged skin. It is used to alleviate the symptoms of a rash, dermatitis, eczema, chapped lips, and sunburn.
Carbomer
Est. %0.3
Function
Origin
CarbomerA synthetic ingredient with the ability to gel water. When used in emulsions, such as lotions and creams, carbomer can also act as an emulsion stabilizer.
Tromethamine
Est. %0.3
Function
Origin
TromethamineAn ingredient based on amino acids that is commonly used as a pH adjuster. It has a high pH, which means that it is basic (alkaline), so adding tromethamine to a skincare product will increase its overall pH level.
Chamomilla Recutita (Matricaria) Flower Extract
Est. %0.3
Function
Origin
Chamomilla Recutita (Matricaria) Flower ExtractDerived from German chamomile flowers, this extract is especially known for its anti-inflammatory and soothing benefits. It contains two soothing compounds called chamazulene and bisabolol, as well as antioxidant flavonoids.
Hydrogenated Lecithin
Est. %0.3
Function
Origin
Hydrogenated LecithinA version of plain lecithin that has been saturated with hydrogen atoms. This ingredient can be derived from plants, like soy or sunflower, from egg yolks, or made synthetically. Its major function is to emulsify water and oils.
Ethylhexylglycerin
Est. %0.3
Function
Origin
EthylhexylglycerinA preservative booster derived from glycerin. It is commonly paired with other preservatives to improve their efficacy. Ethylhexylglycerin is also a humectant due to its chemical base of glycerin.
Adenosine
Est. %0.3
Function
Origin
Adenosine

A key molecule responsible for energy transportation, signaling, and enzyme activity. Adenosine is a popular anti-wrinkle ingredient, however, the key study about its anti-wrinkle efficacy (1) does not meet CreamScan Research Evaluation Standards as it is not double-blind.

Disodium EDTA
Est. %0.3
Function
Origin
Disodium EDTAA synthetic chelator that helps to maintain the look and smell of a product by 'locking up' troublesome metal ions.
Betaine
Est. %0.3
Function
Origin
BetaineAn ingredient derived from the sucrose in sugar beets. It has a negative chemical charge and a positive chemical charge on the same molecule. This allows betaine to be hygroscopic or humectant and thus provide moisturization by drawing water to the skin.
Raffinose
Est. %0.3
Function
Origin
RaffinoseA sugar-based ingredient that can make skin feel soft and hydrated.
Hydrolyzed Vegetable Protein
Est. %0.3
Function
Origin
Hydrolyzed Vegetable ProteinA blanket term used for plant-based proteins that have been processed into smaller chunks. They add to the skincare product's film-forming and water-binding properties.
Maltodextrin
Est. %0.3
Function
Origin
MaltodextrinA formula helper manufactured from starch. It has a sweet flavor and is often used in rinse-off products to support their foaming structure. Maltodextrin is also used to stabilize emulsions and to absorb and bind other ingredients in the formula.
Sodium Acetate
Est. %0.3
Function
Origin
Sodium AcetateA sodium salt that can increase the basicity of a product.
Dipeptide-2
Est. %0.3
Function
Origin
Dipeptide-2