ma:nyo Bifida Complex Ampoule Review

ma:nyo Bifida Complex Ampoule
3.2
/ 10
Moisturizing
6.3 Humectancy icon Humectancy
0.0 Occlusivity icon Occlusivity
4.9Anti-wrinkle icon/ 10
Anti-wrinkle
Rich
in Antioxidants
Rich Skin Soothing icon
in Skin Soothers
Review

Does ma:nyo Bifida Complex Ampoule Work?

 
According to CreamScan AI's analysis of the ingredient list, here’s what ma:nyo Bifida Complex Ampoule has to offer:
 
✅ Light moisturizing. It has a moisturizing rating of 3.2 out of 10.
✅ Considerable anti-wrinkle efficacy: ma:nyo Bifida Complex Ampoule has an anti-wrinkle rating of 4.9 out of 10, indicating a moderate ability to reduce wrinkles.
✅ Soothing: ma:nyo Bifida Complex Ampoule contains a high concentration of soothing ingredients, which may help to reduce irritation and calm the skin.
✅ Antioxidant protection

  

Key Benefits of ma:nyo Bifida Complex Ampoule

 
These are the key benefits you can expect from using ma:nyo Bifida Complex Ampoule:
 

🔵 Lightweight Purely Humectant Moisturizer Well-Suited for Oily Skin

According to CreamScan analysis, ma:nyo Bifida Complex Ampoule is lightly moisturizing, with a moisturizing rating of 3.2 out of 10.

Is it more humectant or occlusive? Purely humectant. It has zero occlusivity (we didn't find any occlusive ingredients on the ingredient list) and a high humectancy of 6.3 out of 10, primarily due to the high content of Niacinamide (est. ≈3.3%).

This humectant-rich product, when used alone as a moisturizer, is well-suited for oily skin, providing moderate hydration in a lightweight, fast-absorbing formula without any occlusive ingredients.

❗️ Certain studies suggest that humectants alone may not effectively moisturize the skin. If you use this product as your only moisturizer, we recommend following it with one that contains at least some occlusive ingredients.

💧 A Humectant Enhancement for Any Skincare Routine

But it’s not limited to oily skin - such a humectant enhancement will also positively contribute to the moisturizing efficacy of any skincare routine when used as a step before applying the main moisturizer. This type of formulation is typically used in serums, where a light, fast-absorbing texture is key.

Please refer to the Ratings section below for details of the moisturizing rating calculation.

🟣🟣 Considerable Anti-Wrinkle Efficacy

According to CreamScan analysis, ma:nyo Bifida Complex Ampoule has a moderate anti-wrinkle rating of 4.9 out of 10.

It contains one ingredient with proven anti-wrinkle efficacy: Niacinamide (est. ≈3.3%),
 one of the most effective and well-researched anti-wrinkle ingredients. A clinical study involving 30 participants (Kawada et al.) confirmed that a cream with 4% niacinamide reduced the average depth of wrinkles around the eyes by 9% after 8 weeks of use, compared to a vehicle (the same formulation without niacinamide).
 
Among others, ma:nyo Bifida Complex Ampoule contains some ingredients often marketed as effective in reducing wrinkles, specifically Acetyl Hexapeptide-8, Caffeine, Copper Tripeptide-1, and Adenosine. However, the studies supporting the anti-wrinkle claims of these ingredients provide insufficient evidence of efficacy according to CreamScan Research Evaluation Standards.
 
While this does not categorically rule out the possibility that these ingredients may reduce wrinkles, their efficacy is not supported by convincing, vehicle-controlled, double-blind clinical studies - at least none that were available to the CreamScan team at the time of publication.
 
Therefore, these ingredients do not contribute to the anti-wrinkle rating.
 
📌 Moisturizers, when used regularly, are proven to prevent wrinkle formation and even reduce existing wrinkles. Therefore, this product, like any other moisturizer, can deliver some additional anti-wrinkle effects through its moisturizing action.
 

Please refer to the Ratings section below for details of the anti-wrinkle rating calculation.

🍀 Rich in Skin-Protecting Antioxidants

We estimate that ma:nyo Bifida Complex Ampoule is rich (> 3%) in antioxidants, specifically Niacinamide (est. ≈3.3%).

A key benefit of antioxidants is their ability to reduce oxidative stress caused by free radicals and therefore prevent accelerated skin aging. Studies also show that antioxidants can protect against environmental damage such as UV radiation and pollution, and help reduce inflammation and skin redness.

🔴 Skin Soothing and Calming Potential

Based on the ingredient list analysis, ma:nyo Bifida Complex Ampoule is rich (> 5%) in soothing ingredients, particularly Bifida Ferment Lysate (est. ≈60.0%) and Niacinamide (est. ≈3.3%).

When applied to the skin, compounds of soothing ingredients, such as triglycerides, phospholipids, fatty acids, phenolic compounds, and antioxidants, work together to soothe the skin through various mechanisms: reducing inflammation, promoting wound healing, repairing the skin barrier, and providing antimicrobial and antioxidant activities.

📌 Please note that this is not a complete list of benefits. We are in the process of enhancing our AI model to incorporate anti-pigmentation, exfoliation and anti-acne ratings.

Things to Be Aware Of: ma:nyo Bifida Complex Ampoule

 
CreamScan AI identified a few things to consider before adding ma:nyo Bifida Complex Ampoule to your skincare routine:
 

⚠️ If It’s Your Only Moisturizer, It Needs to Be Paired with Some Occlusives

While humectants are highly effective at attracting water to the skin, studies (J. N. Kraft, C. W. Lynde) suggest they may not be efficient when used alone.

One major drawback of purely humectant moisturization is that the water attracted by humectants to the upper layers of the skin can evaporate completely into the environment through transepidermal water loss (TEWL). Adding occlusive ingredients helps seal this moisture into the skin and prevent further water loss.

If you’re using ma:nyo Bifida Complex Ampoule as your only moisturizer, consider pairing it with one that contains at least some occlusive ingredients, such as oils, butters, or silicones. These work alongside humectants to create a protective barrier, locking in hydration and ensuring longer-lasting moisturization. The amount of occlusive needed depends on your skin type - the drier the skin, the more occlusives it requires.

If this product is used not as a standalone moisturizer but as part of your skincare routine, such as a toner or serum, it should be applied before your main moisturizer (unless it's a sunscreen), which will provide the necessary occlusivity on top of it.

Pros & Cons of ma:nyo Bifida Complex Ampoule

 
Here’s an overview of the pros and cons of ma:nyo Bifida Complex Ampoule to help you decide if it’s the right choice for your skincare routine:
 

🟩 Pros:

✅ When used alone: Provides humectant-rich moisturizing well-suited for oily skin
✅ As part of a routine: A humectant moisturizing enhancement, beneficial for any skin type
✅ Lightweight texture
Provides considerable anti-wrinkle efficacy thanks to Niacinamide
✅ Rich in antioxidants that combat oxidative stress associated with accelerated skin aging and defend against environmental damage
✅ Potentially soothing, as it contains a high concentration of soothing ingredients like Bifida Ferment Lysate and Niacinamide
 

⭕ Cons: 

⚠️ Only if used as a standalone moisturizer - it needs to be paired with occlusives to seal in humectants
   

Summary: ma:nyo Bifida Complex Ampoule

 
Based on the ingredient list analysis, CreamScan AI suggests that ma:nyo Bifida Complex Ampoule
, when used alone, delivers lightweight, humectant-rich moisturizing that is well-suited for oily skin. As part of a moisturizing routine, it provides a humectant enhancement, beneficial for all skin types.
 
ma:nyo Bifida Complex Ampoule contains ingredients with solid, robust evidence of anti-wrinkle efficacy, in concentrations that may deliver a noticeable anti-wrinkle effect.
 
Rich in antioxidants, ma:nyo Bifida Complex Ampoule helps protect against free radical damage and offers multiple benefits for all skin types, including preventing premature aging, defending against environmental damage, and calming inflammation. This product is also formulated with a high concentration of soothing ingredients, offering the potential to calm and comfort irritated skin. Whether you’re experiencing redness, irritation, or general sensitivity, its soothing properties may help restore balance and provide relief.
 
That said, there are some things about ma:nyo Bifida Complex Ampoule worth noting.
 
Looking at its moisturizing profile, we found that it doesn’t contain any occlusive ingredients, potentially allowing the moisture attracted to the skin by humectants to evaporate. Therefore, if it’s used as the only moisturizer in a routine, it’s recommended to pair it with one that contains at least some occlusive ingredients, such as oils, butters, or silicones.
 
❗️ Fact check. At CreamScan, we are committed to accuracy and fairness. If you spot any errors or something that doesn’t seem right, please click here to let us know. We regularly update the ingredient lists and monitor the latest research on ingredient efficacy to ensure that our information remains as complete and precise as possible.

 

Ingredients

Est. % Ingredient Origin Functions
60
30.1
3.3
1.8
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
Est. %
Bifida Ferment Lysate
Function:
Origin:
Lactobacillus/Pumpkin Fruit Ferment Filtrate
Function:
Origin:
Niacinamide
Function:
Origin:
Butylene Glycol
Function:
Origin:
Acetyl Hexapeptide-8
Function:
Origin:
Aureobasidium Pullulans Ferment
Function:
Origin:
Hydrolyzed Algin
Function:
Origin:
Caffeine
Function:
Origin:
Panax Ginseng Root Extract
Function:
Origin:
Panax Ginseng Callus Culture Extract
Function:
Origin:
Glycerin
Function:
Origin:
Epigallocatechin Gallate
Function:
Origin:
Zanthoxylum Piperitum Fruit Extract
Function:
Origin:
Pulsatilla Koreana Extract
Function:
Origin:
Usnea Barbata (Lichen) Extract
Function:
Origin:
Copper Tripeptide-1
Function:
Origin:
Physalis Alkekengi Fruit Extract
Function:
Origin:
Methyl Gluceth-20
Function:
Origin:
Sodium Hyaluronate
Function:
Origin:
Adenosine
Function:
Origin:

Ratings

All humectants
6.3
3.3
1.8
0.3
0.3
0.3
0.3
Benchmark
10
All occlusives
0.0
None
Benchmark
20
Moisturizing rating
3.2
Ingredient Est. % Benchmark Raiting
Humectancy All humectants 6.3 10
6.3
3.3
1.8
0.3
0.3
0.3
0.3
Occlusivity All occlusives 0.0 20
0.0
None
Moisturizing rating
3.2
Ingredient Est. % Benchmark Humectancy
3.3
1.8
0.3
0.3
0.3
0.3
All humectants 6.3 10
6.3
All humectants
6.3
3.3
1.8
0.3
0.3
0.3
0.3
Benchmark
10
Ingredient Est. % Benchmark Occlusivity
None
All occlusives 0.0 20
0.0
All occlusives
0.0
None
Benchmark
20
Ingredient
Ingredient anti-wrinkle power
when present at, %
in this formula est. %
Rating
6 /10 4 3.3 4.9
n/a
- 0.3 -
n/a
- 0.3 -
n/a
- 0.3 -
n/a
- 0.3 -
Total
4.9
Niacinamide
4.9
Ingredient anti-wrinkle power
6 /10
when present at, %
4
in this formula, est. %
3.3
Acetyl Hexapeptide-8
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Caffeine
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Copper Tripeptide-1
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Adenosine
-
Ingredient anti-wrinkle power
n/a
when present at, %
-
in this formula, est. %
0.3
Anti-wrinkle rating
4.9
Ingredient Est. % Benchmark
Rich in Antioxidants
3.3
0.3
0.3
0.3
0.3
0.3
0.3
0.3
All antioxidants 5.4 3 Rich in antioxidants
All antioxidants
5.4
Niacinamide
3.3
Hydrolyzed Algin
0.3
Caffeine
0.3
Panax Ginseng Root Extract
0.3
Epigallocatechin Gallate
0.3
Zanthoxylum Piperitum Fruit Extract
0.3
Copper Tripeptide-1
0.3
Sodium Hyaluronate
0.3
Benchmark
3
Ingredient Est. % Benchmark
Rich in Soothing
60
3.3
0.3
0.3
0.3
0.3
All soothing 64.5 5 Rich in soothing
All soothing
64.5
60
3.3
0.3
0.3
0.3
0.3
Benchmark
5

Ingredients explained

Bifida Ferment Lysate
Est. %60
Function
Origin
Bifida Ferment LysateA mixture of probiotic bacteria. According to the patent holder, it contains enzymes that are able to repair damaged DNA in skin cells. A single study confirms that it is able to reduce skin sensitivity.
Lactobacillus/Pumpkin Fruit Ferment Filtrate
Est. %30.1
Function
Origin
Lactobacillus/Pumpkin Fruit Ferment Filtrate
Niacinamide
Est. %3.3
Function
Origin
Niacinamide

Also known as vitamin B3, this ingredient is a true superstar with confirmed moisturizing, anti-acne, hyperpigmentation, and antioxidant benefits. Two studies confirm its significant anti-wrinkle efficacy.

Butylene Glycol
Est. %1.8
Function
Origin
Butylene Glycol

A clear, colorless liquid humectant that draws moisture to the skin. The humectancy of butylene glycol, owed to its two hydroxyl groups, is quite considerable, although not as powerful as glycerin, which contains three hydroxyl groups.

Acetyl Hexapeptide-8
Est. %0.3
Function
Origin
Acetyl Hexapeptide-8

A small synthetic peptide that is thought to act similarly to Botox by calming contractions of the facial muscles and reducing expression wrinkles. The effect is only temporary and it does not improve the skin structure in any way.

Aureobasidium Pullulans Ferment
Est. %0.3
Function
Origin
Aureobasidium Pullulans Ferment
Hydrolyzed Algin
Est. %0.3
Function
Origin
Hydrolyzed AlginA humectant moisturizing mixture of algae-based polysaccharides, also known as alginate, that have undergone the process of hydrolysis.
Caffeine
Est. %0.3
Function
Origin
CaffeineAn antioxidant compound that is obtained from coffee and tea leaves. It increases the microcirculation of blood in the skin and is claimed to be able to reduce the appearance of orange peel skin (although the research is lacking).
Panax Ginseng Root Extract
Est. %0.3
Function
Origin
Panax Ginseng Root ExtractDerived from the roots of the Korean Ginseng, this extract contains a mixture of antioxidant and soothing ginsenosides which are proven to reduce inflammation and treat eczema. The root is a major part of Chinese traditional medicine.
Panax Ginseng Callus Culture Extract
Est. %0.3
Function
Origin
Panax Ginseng Callus Culture Extract
Glycerin
Est. %0.3
Function
Origin
Glycerin

The most popular moisturizing ingredient in the world. It is a powerful humectant – cheap yet very effective.

Epigallocatechin Gallate
Est. %0.3
Function
Origin
Epigallocatechin GallateA bioactive compound isolated from green tea with numerous beneficial effects. It is an astringent and antioxidant and can help the skin to heal, reduce redness, and treat UV-induced damage.
Zanthoxylum Piperitum Fruit Extract
Est. %0.3
Function
Origin
Zanthoxylum Piperitum Fruit ExtractA pepper extract that is claimed to have antibacterial and antioxidant properties.
Pulsatilla Koreana Extract
Est. %0.3
Function
Origin
Pulsatilla Koreana ExtractAn extract derived from the Korean pasque flower. It contains various saponins with antimicrobial properties and has been successfully tested against bacteria involved with acne.
Usnea Barbata (Lichen) Extract
Est. %0.3
Function
Origin
Usnea Barbata (Lichen) ExtractA lichen-derivative with proven antibacterial activity.
Copper Tripeptide-1
Est. %0.3
Function
Origin
Copper Tripeptide-1

A skin-identical, copper-binding peptide that promotes the synthesis of all structural elements in the skin.

Physalis Alkekengi Fruit Extract
Est. %0.3
Function
Origin
Physalis Alkekengi Fruit Extract
Methyl Gluceth-20
Est. %0.3
Function
Origin
Methyl Gluceth-20A humectant synthetically derived from glucose. It takes on the form of a clear, syrupy liquid.
Sodium Hyaluronate
Est. %0.3
Function
Origin
Sodium Hyaluronate

A sodium salt of famous hyaluronic acid. A potent humectant that hydrates the skin, supports collagen function, and fills out small wrinkles. Sodium hyaluronate also offers soothing and antioxidant properties.

Adenosine
Est. %0.3
Function
Origin
Adenosine

A key molecule responsible for energy transportation, signaling, and enzyme activity. Adenosine is a popular anti-wrinkle ingredient, however, the key study about its anti-wrinkle efficacy (1) does not meet CreamScan Research Evaluation Standards as it is not double-blind.